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Home / Equine Research Bank / Int J Parasitol Drugs Drug Resist / Risk factor analysis of equine strongyle resistance to anthe...
International journal for parasitology. Drugs and drug resistance2017; 7(3); 407-415; doi: 10.1016/j.ijpddr.2017.10.007

Risk factor analysis of equine strongyle resistance to anthelmintics.

Abstract: Intestinal strongyles are the most problematic endoparasites of equids as a result of their wide distribution and the spread of resistant isolates throughout the world. While abundant literature can be found on the extent of anthelmintic resistance across continents, empirical knowledge about associated risk factors is missing. This study brought together results from anthelmintic efficacy testing and risk factor analysis to provide evidence-based guidelines in the field. It involved 688 horses from 39 French horse farms and riding schools to both estimate Faecal Egg Count Reduction (FECR) after anthelmintic treatment and to interview farm and riding school managers about their practices. Risk factors associated with reduced anthelmintic efficacy in equine strongyles were estimated across drugs using a marginal modelling approach. Results demonstrated ivermectin efficacy (96.3% ± 14.5% FECR), the inefficacy of fenbendazole (42.8% ± 33.4% FECR) and an intermediate profile for pyrantel (90.3% ± 19.6% FECR). Risk factor analysis provided support to advocate for FEC-based treatment regimens combined with individual anthelmintic dosage and the enforcement of tighter biosecurity around horse introduction. The combination of these measures resulted in a decreased risk of drug resistance (relative risk of 0.57, p = 0.02). Premises falling under this typology also relied more on their veterinarians suggesting practitionners play an important role in the sustainability of anthelmintic usage. Similarly, drug resistance risk was halved in premises with frequent pasture rotation and with stocking rate below five horses/ha (relative risk of 0.53, p < 0.01). This is the first empirical risk factor analysis for anthelmintic resistance in equids. Our findings should guide the implementation of more sustained strongyle management in the field.
Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
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Publication Date: 2017-11-02 PubMed ID: 29149701PubMed Central: PMC5727347DOI: 10.1016/j.ijpddr.2017.10.007Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the factors contributing to the resistance of horse intestinal parasites, or strongyles, to deworming drugs. By studying 688 horses across 39 French horse farms and riding schools, the researchers were able to identify key practices that can help delay drug resistance, such as individual drug dosage, stricter biosecurity, frequent pasture rotation, and a lower number of horses per hectare.

Study Overview

  • The paper analyzes the risk factors associated with equine strongyles developing resistance to anthelmintic drugs, common treatments for parasitic worm infections in horses.
  • The study was conducted on 39 French horse farms and riding schools involving 688 horses. The aim was to estimate the Faecal Egg Count Reduction (FECR) after anthelmintic treatment and to understand the practices of farm and riding school managers.

Drugs Efficacy

  • Three anthelmintic drugs were tested for efficacy: ivermectin, fenbendazole, and pyrantel.
  • Results showed ivermectin to be the most effective with a reduction of 96.3% in faecal egg count. Pyrantel was intermediate with a 90.3% reduction, whereas fenbendazole was shown to be largely ineffective, with a 42.8% reduction.

Risk Factor Analysis

  • An analysis of risk factors was conducted to identify the practices associated with reduced anthelmintic efficacy.
  • Evidence-based guidelines were established from this study to ensure sustainable use of anthelmintics and slow down the spread of drug-resistant strongyles.
  • Factors reducing drug resistance risk included FEC-based treatment regimens, individual drug dosage, stricter biosecurity measures, frequent pasture rotation, and maintaining a stocking rate below five horses per hectare.
  • The study highlighted veterinarians’ crucial role in implementing these measures effectively, as it was observed that farms following these practices relied more heavily on their veterinarians.

Implications and Findings

  • This study is significant as it’s the first empirical risk factor analysis for anthelmintic resistance in horses, providing actionable insights to manage strongyles in the field more sustainably.
  • The recommended practices from this study can help reduce the risk of drug resistance, contributing to the longevity of anthelmintic drug efficacy and overall equine health.

Cite This Article

APA
Sallé G, Cortet J, Bois I, Dubès C, Guyot-Sionest Q, Larrieu C, Landrin V, Majorel G, Wittreck S, Woringer E, Couroucé A, Guillot J, Jacquiet P, Guégnard F, Blanchard A, Leblond A. (2017). Risk factor analysis of equine strongyle resistance to anthelmintics. Int J Parasitol Drugs Drug Resist, 7(3), 407-415. https://doi.org/10.1016/j.ijpddr.2017.10.007

Publication

International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
NlmUniqueID: 101576715
Country: Netherlands
Language: English
Volume: 7
Issue: 3
Pages: 407-415

Researcher Affiliations

Sallé, G
  • INRA/Université de Tours UMR1282 Infectiologie et Santé Publique, France. Electronic address: Guillaume.Salle@inra.fr.
Cortet, J
  • INRA/Université de Tours UMR1282 Infectiologie et Santé Publique, France.
Bois, I
  • UMR INRA/ENV Toulouse 1225 IHAP, Ecole Nationale Vétérinaire de Toulouse, France.
Dubès, C
  • UMR INRA/ENV Toulouse 1225 IHAP, Ecole Nationale Vétérinaire de Toulouse, France.
Guyot-Sionest, Q
  • LUNAM University, Oniris, Unité de Recherche NP3, 102 Route de Gachet, 44300 Nantes, France.
Larrieu, C
  • LUNAM University, Oniris, Unité de Recherche NP3, 102 Route de Gachet, 44300 Nantes, France.
Landrin, V
  • Parasitology Dept, Dynamyc EnvA, UPEC, Ecole Nationale Vétérinaire D'Alfort, UPE, Maisons-Alfort, France.
Majorel, G
  • EPIA, INRA, VetAgroSup, University of Lyon, 69280 Marcy L'Etoile, France.
Wittreck, S
  • Merial SAS, 29 Avenue Tony Garnier, 69007 Lyon, France.
Woringer, E
  • Zoetis, 10 Rue Raymond David, 92240 Malakoff, France.
Couroucé, A
  • LUNAM University, Oniris, Unité de Recherche NP3, 102 Route de Gachet, 44300 Nantes, France.
Guillot, J
  • Parasitology Dept, Dynamyc EnvA, UPEC, Ecole Nationale Vétérinaire D'Alfort, UPE, Maisons-Alfort, France.
Jacquiet, P
  • UMR INRA/ENV Toulouse 1225 IHAP, Ecole Nationale Vétérinaire de Toulouse, France.
Guégnard, F
  • INRA/Université de Tours UMR1282 Infectiologie et Santé Publique, France.
Blanchard, A
  • INRA/Université de Tours UMR1282 Infectiologie et Santé Publique, France.
Leblond, A
  • EPIA, INRA, VetAgroSup, University of Lyon, 69280 Marcy L'Etoile, France.

MeSH Terms

  • Animals
  • Anthelmintics / pharmacology
  • Data Interpretation, Statistical
  • Drug Resistance
  • Feces / parasitology
  • Fenbendazole / pharmacology
  • Horses
  • Ivermectin / pharmacology
  • Parasite Egg Count / veterinary
  • Risk Factors
  • Strongyle Infections, Equine / drug therapy
  • Strongyle Infections, Equine / parasitology
  • Strongyloidea / drug effects

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