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Sports medicine (Auckland, N.Z.)2012; 42(10); 871-890; doi: 10.1007/BF03262300

Tendon regeneration in human and equine athletes: Ubi Sumus-Quo Vadimus (where are we and where are we going to)?

Abstract: Tendon injuries are one of the most common orthopaedic problems in both human and equine athletes. When a damaged tendon heals naturally, it loses a substantial part of the original strength and elasticity. Therefore, tendons recover structurally (reparation) but not functionally (regeneration) after conservative medical or surgical treatment. Since the structure and matrix composition of human and equine tendons share many similarities, the nature of tendon injuries are also strongly comparable in both species. Therefore, the evaluation of regenerative therapies in horses may have applications for future human medicine and vice versa. The current review focuses briefly on the physiology of human and equine tendon in order to better comprehend the modus operandi of this structure under pathophysiological circumstances. In addition, the reparative effects of conservative medical and surgical interventions are discussed concisely, and an extensive overview is given on the regenerative therapies that are currently being explored. For the latter, the results of equine clinical studies might prove invaluable for gaining additional insights into the treatment of human tendinopathies, since not all of these novel regenerative therapies have been evaluated in humans yet.
Publication Date: 2012-09-12 PubMed ID: 22963225DOI: 10.1007/BF03262300Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article seeks to understand the similarities between equine and human tendons, focusing on their healing process after injury and exploring the potential benefits of regenerative therapies.

Overview of Tendon Injuries and Healing Process

  • The paper begins by clarifying the high prevalence of tendon injuries in both human and equine athletes.
  • It notes that while traditionally treated tendons may recover in structure (reparation), they rarely regain their original function (regeneration).
  • This is concerning because a fully recovered tendon should ideally replicate its original functionality in strength and elasticity.

Comparing Human and Equine Tendons

  • The researchers point out the many structural and compositional similarities between human and equine tendons, leading to the understanding that tendon injuries exhibit comparable pathophysiology in both species.
  • Therefore, they propose that studying the effect and effectiveness of particular therapies in horses could potentially provide insights into the treatment of similar tendon injuries in humans and vice versa.

Review of Tendon Physiology

  • The paper provides a brief review of the physiology of human and equine tendons with the aim to better understand how they operate under pathophysiological circumstances, that is, when they are diseased or injured.

Role of Medical and Surgical Interventions

  • The researchers also discuss the effects of various conservative medical and surgical interventions on the reparative process of tendons.

Exploring Regenerative Therapies

  • An extensive overview is provided on the regenerative therapies that are currently being researched for their potential in treating tendon injuries.
  • Importantly, the authors emphasise that the results of clinical studies conducted on horses could enhance our understanding of human tendinopathies, particularly since all these regenerative therapies have not yet been tested in humans.
  • This reinforces the importance of cross-species Understandings, highlighting the potential benefits of studies in equine medicine for human medical advancements.

Cite This Article

APA
Spaas JH, Guest DJ, Van de Walle GR. (2012). Tendon regeneration in human and equine athletes: Ubi Sumus-Quo Vadimus (where are we and where are we going to)? Sports Med, 42(10), 871-890. https://doi.org/10.1007/BF03262300

Publication

ISSN: 1179-2035
NlmUniqueID: 8412297
Country: New Zealand
Language: English
Volume: 42
Issue: 10
Pages: 871-890

Researcher Affiliations

Spaas, Jan H
  • Department of Comparative Physiology and Biometrics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Guest, Deborah J
    Van de Walle, Gerlinde R

      MeSH Terms

      • Animals
      • Athletes
      • Elasticity / physiology
      • Female
      • Guided Tissue Regeneration / adverse effects
      • Guided Tissue Regeneration / methods
      • Guided Tissue Regeneration / veterinary
      • Horses / injuries
      • Horses / physiology
      • Horses / surgery
      • Humans
      • Male
      • Stem Cell Transplantation / adverse effects
      • Stem Cell Transplantation / methods
      • Stem Cell Transplantation / veterinary
      • Tendon Injuries / physiopathology
      • Tendon Injuries / surgery
      • Tendon Injuries / therapy
      • Tendon Injuries / veterinary
      • Tendons / physiology
      • Treatment Outcome

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