The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma.
Abstract: Aging is associated with a dysregulation of the immune system, leading to a general pro-inflammatory state of the organism, a process that has been named inflamm-aging. Oxidative stress has an important role in aging and in the regulation of immune responses, probably playing a role in the development of age-related diseases. The respiratory system function physiologically declines with the advancement of age. In elderly asthmatic patients, this may contribute to disease expression. In this review, we will focus on age-related changes affecting the immune system and in respiratory structure and function that could contribute to asthma occurrence, and/or clinical presentation in the elderly. Also, naturally occurring equine asthma will be discussed as a possible model for studying the importance of oxidative stress and immun-aging/inflamm-aging in humans.
Publication Date: 2017-12-05 PubMed ID: 29206130PubMed Central: PMC5751215DOI: 10.3390/ijms18122612Google Scholar: Lookup
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Summary
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This research investigates the role of oxidative stress and inflammation-aging, a general pro-inflammatory state associated with aging, in the development of age-related diseases, particularly asthma. It also examines how naturally occurring equine asthma might serve as a model for studying these processes in humans.
What is Inflamm-Aging and Oxidative Stress?
- Inflamm-aging is a term that refers to an inflammation process associated with aging. Characterized by a general pro-inflammatory state, this process is associated with a dysregulation of the immune system that can lead to various age-related diseases.
- Oxidative stress, on the other hand, is associated with the overproduction of reactive oxygen species which are known to cause damage to cells and tissues in the body, including the respiratory system. It plays a vital role in the regulation of immune responses and the development of age-related diseases.
Impact on Asthma Occurrence in the Elderly
- The researchers note that as one ages, there are observable changes in the immune system, as well as in respiratory structure and function. For elderly patients with asthma, these changes may manifest and contribute to the presentation of the disease.
- However, the correlation between these age-related immunological changes and increased susceptibility to asthma is currently under scrutiny. A clearer understanding of this relationship could unveil novel strategies for managing or preventing asthma in older individuals.
Equine Asthma as a Potential Model
- The study also highlighted the potential of studying naturally occurring equine asthma – a common health issue among horses – as a possible model to understand the importance of oxidative stress and inflamm-aging in humans.
- Studying similar disease processes in animals and in humans may provide a more holistic understanding of age-related diseases and could contribute significantly to the development of novel therapeutic strategies.
Cite This Article
APA
Bullone M, Lavoie JP.
(2017).
The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma.
Int J Mol Sci, 18(12), 2612.
https://doi.org/10.3390/ijms18122612 Publication
Researcher Affiliations
- Department of Clinical and Biological Sciences, University of Turin, AUO San Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano, Italy. michelabullone@gmail.com.
- Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, 3200 Rue Sicotte, St-Hyacinthe, QC J2S 2M2, Canada. jean-pierre.lavoie@umontreal.ca.
MeSH Terms
- Aging / genetics
- Aging / immunology
- Aging / physiology
- Animals
- Asthma / immunology
- Asthma / metabolism
- Horses
- Humans
- Inflammation / immunology
- Inflammation / metabolism
- Neutrophils / metabolism
- Oxidative Stress / genetics
- Oxidative Stress / immunology
- Oxidative Stress / physiology
Conflict of Interest Statement
The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.
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