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International journal of molecular sciences2017; 18(12); 2612; doi: 10.3390/ijms18122612

The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma.

Abstract: Aging is associated with a dysregulation of the immune system, leading to a general pro-inflammatory state of the organism, a process that has been named inflamm-aging. Oxidative stress has an important role in aging and in the regulation of immune responses, probably playing a role in the development of age-related diseases. The respiratory system function physiologically declines with the advancement of age. In elderly asthmatic patients, this may contribute to disease expression. In this review, we will focus on age-related changes affecting the immune system and in respiratory structure and function that could contribute to asthma occurrence, and/or clinical presentation in the elderly. Also, naturally occurring equine asthma will be discussed as a possible model for studying the importance of oxidative stress and immun-aging/inflamm-aging in humans.
Publication Date: 2017-12-05 PubMed ID: 29206130PubMed Central: PMC5751215DOI: 10.3390/ijms18122612Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the role of oxidative stress and inflammation-aging, a general pro-inflammatory state associated with aging, in the development of age-related diseases, particularly asthma. It also examines how naturally occurring equine asthma might serve as a model for studying these processes in humans.

What is Inflamm-Aging and Oxidative Stress?

  • Inflamm-aging is a term that refers to an inflammation process associated with aging. Characterized by a general pro-inflammatory state, this process is associated with a dysregulation of the immune system that can lead to various age-related diseases.
  • Oxidative stress, on the other hand, is associated with the overproduction of reactive oxygen species which are known to cause damage to cells and tissues in the body, including the respiratory system. It plays a vital role in the regulation of immune responses and the development of age-related diseases.

Impact on Asthma Occurrence in the Elderly

  • The researchers note that as one ages, there are observable changes in the immune system, as well as in respiratory structure and function. For elderly patients with asthma, these changes may manifest and contribute to the presentation of the disease.
  • However, the correlation between these age-related immunological changes and increased susceptibility to asthma is currently under scrutiny. A clearer understanding of this relationship could unveil novel strategies for managing or preventing asthma in older individuals.

Equine Asthma as a Potential Model

  • The study also highlighted the potential of studying naturally occurring equine asthma – a common health issue among horses – as a possible model to understand the importance of oxidative stress and inflamm-aging in humans.
  • Studying similar disease processes in animals and in humans may provide a more holistic understanding of age-related diseases and could contribute significantly to the development of novel therapeutic strategies.

Cite This Article

APA
Bullone M, Lavoie JP. (2017). The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma. Int J Mol Sci, 18(12), 2612. https://doi.org/10.3390/ijms18122612

Publication

ISSN: 1422-0067
NlmUniqueID: 101092791
Country: Switzerland
Language: English
Volume: 18
Issue: 12
PII: 2612

Researcher Affiliations

Bullone, Michela
  • Department of Clinical and Biological Sciences, University of Turin, AUO San Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano, Italy. michelabullone@gmail.com.
Lavoie, Jean-Pierre
  • Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, 3200 Rue Sicotte, St-Hyacinthe, QC J2S 2M2, Canada. jean-pierre.lavoie@umontreal.ca.

MeSH Terms

  • Aging / genetics
  • Aging / immunology
  • Aging / physiology
  • Animals
  • Asthma / immunology
  • Asthma / metabolism
  • Horses
  • Humans
  • Inflammation / immunology
  • Inflammation / metabolism
  • Neutrophils / metabolism
  • Oxidative Stress / genetics
  • Oxidative Stress / immunology
  • Oxidative Stress / physiology

Conflict of Interest Statement

The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

References

This article includes 217 references
  1. Vaupel JW. Biodemography of human ageing.. Nature 2010 Mar 25;464(7288):536-42.
    doi: 10.1038/nature08984pmc: PMC4010874pubmed: 20336136google scholar: lookup
  2. Martin JE, Sheaff MT. The pathology of ageing: concepts and mechanisms.. J Pathol 2007 Jan;211(2):111-3.
    doi: 10.1002/path.2122pubmed: 17200949google scholar: lookup
  3. WALFORD RL. THE IMMUNOLOGIC THEORY OF AGING.. Gerontologist 1964 Dec;4:195-7.
    doi: 10.1093/geront/4.4.195pubmed: 14289265google scholar: lookup
  4. Fülöp T, Dupuis G, Witkowski JM, Larbi A. The Role of Immunosenescence in the Development of Age-Related Diseases.. Rev Invest Clin 2016 Mar-Apr;68(2):84-91.
    pubmed: 27103044
  5. Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence.. Ann N Y Acad Sci 2000 Jun;908:244-54.
  6. Boe DM, Boule LA, Kovacs EJ. Innate immune responses in the ageing lung.. Clin Exp Immunol 2017 Jan;187(1):16-25.
    doi: 10.1111/cei.12881pmc: PMC5167032pubmed: 27711979google scholar: lookup
  7. Lowery EM, Brubaker AL, Kuhlmann E, Kovacs EJ. The aging lung.. Clin Interv Aging 2013;8:1489-96.
    pmc: PMC3825547pubmed: 24235821doi: 10.2147/cia.s51152google scholar: lookup
  8. Davalli P, Mitic T, Caporali A, Lauriola A, D'Arca D. ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases.. Oxid Med Cell Longev 2016;2016:3565127.
    doi: 10.1155/2016/3565127pmc: PMC4877482pubmed: 27247702google scholar: lookup
  9. Kovacs EJ, Boe DM, Boule LA, Curtis BJ. Inflammaging and the Lung.. Clin Geriatr Med 2017 Nov;33(4):459-471.
    doi: 10.1016/j.cger.2017.06.002pmc: PMC5653264pubmed: 28991644google scholar: lookup
  10. De la Fuente M, Miquel J. An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging.. Curr Pharm Des 2009;15(26):3003-26.
    doi: 10.2174/138161209789058110pubmed: 19754376google scholar: lookup
  11. Reddy PH. Mitochondrial Dysfunction and Oxidative Stress in Asthma: Implications for Mitochondria-Targeted Antioxidant Therapeutics.. Pharmaceuticals (Basel) 2011 Feb 25;4(3):429-456.
    doi: 10.3390/ph4030429pmc: PMC3066010pubmed: 21461182google scholar: lookup
  12. Battaglia S, Benfante A, Spatafora M, Scichilone N. Asthma in the elderly: a different disease?. Breathe (Sheff) 2016 Mar;12(1):18-28.
    doi: 10.1183/20734735.002816pmc: PMC4818235pubmed: 27064568google scholar: lookup
  13. Busse PJ, Mathur SK. Age-related changes in immune function: effect on airway inflammation.. J Allergy Clin Immunol 2010 Oct;126(4):690-9; quiz 700-1.
    doi: 10.1016/j.jaci.2010.08.011pmc: PMC3297963pubmed: 20920759google scholar: lookup
  14. Dunn RM, Busse PJ, Wechsler ME. Asthma in the elderly and late-onset adult asthma.. Allergy 2018 Feb;73(2):284-294.
    doi: 10.1111/all.13258pubmed: 28722758google scholar: lookup
  15. Park HS, Kim SR, Lee YC. Impact of oxidative stress on lung diseases.. Respirology 2009 Jan;14(1):27-38.
  16. Boulet LP. Asthma in the elderly patient.. Asthma Res Pract 2016;2:3.
    doi: 10.1186/s40733-015-0015-1pmc: PMC5142394pubmed: 27965771google scholar: lookup
  17. Kleniewska P, Pawliczak R. The participation of oxidative stress in the pathogenesis of bronchial asthma.. Biomed Pharmacother 2017 Oct;94:100-108.
    doi: 10.1016/j.biopha.2017.07.066pubmed: 28756367google scholar: lookup
  18. Sugiura H, Ichinose M. [ROLE OF OXIDATIVE STRESS IN AGGRAVATION OF ASTHMA].. Arerugi 2017;66(7):931-935.
    pubmed: 28824034doi: 10.15036/arerugi.66.931google scholar: lookup
  19. Bullone M, Lavoie JP. Asthma "of horses and men"--how can equine heaves help us better understand human asthma immunopathology and its functional consequences?. Mol Immunol 2015 Jul;66(1):97-105.
    doi: 10.1016/j.molimm.2014.12.005pubmed: 25547716google scholar: lookup
  20. Partridge L. Some highlights of research on aging with invertebrates, 2010.. Aging Cell 2011 Feb;10(1):5-9.
  21. Chandrasekaran A, Idelchik MDPS, Melendez JA. Redox control of senescence and age-related disease.. Redox Biol 2017 Apr;11:91-102.
    doi: 10.1016/j.redox.2016.11.005pmc: PMC5126126pubmed: 27889642google scholar: lookup
  22. Cannizzo ES, Clement CC, Sahu R, Follo C, Santambrogio L. Oxidative stress, inflamm-aging and immunosenescence.. J Proteomics 2011 Oct 19;74(11):2313-23.
    doi: 10.1016/j.jprot.2011.06.005pubmed: 21718814google scholar: lookup
  23. GERSCHMAN R, GILBERT DL, NYE SW, DWYER P, FENN WO. Oxygen poisoning and x-irradiation: a mechanism in common.. Science 1954 May 7;119(3097):623-6.
    doi: 10.1126/science.119.3097.623pubmed: 13156638google scholar: lookup
  24. GERSCHMAN R, GILBERT DL, NYE SW, FENN WO. Influence of x-irradiation on oxygen poisoning in mice.. Proc Soc Exp Biol Med 1954 May;86(1):27-9.
    doi: 10.3181/00379727-86-21002pubmed: 13177582google scholar: lookup
  25. HARMAN D. Aging: a theory based on free radical and radiation chemistry.. J Gerontol 1956 Jul;11(3):298-300.
    doi: 10.1093/geronj/11.3.298pubmed: 13332224google scholar: lookup
  26. Harman D. The biologic clock: the mitochondria?. J Am Geriatr Soc 1972 Apr;20(4):145-7.
  27. Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Trends in oxidative aging theories.. Free Radic Biol Med 2007 Aug 15;43(4):477-503.
  28. Chandel NS. Mitochondrial regulation of oxygen sensing.. Adv Exp Med Biol 2010;661:339-54.
    pubmed: 20204741doi: 10.1007/978-1-60761-500-2_22google scholar: lookup
  29. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs.. Physiol Rev 1979 Jul;59(3):527-605.
    pubmed: 37532doi: 10.1152/physrev.1979.59.3.527google scholar: lookup
  30. Ye J, Keller JN. Regulation of energy metabolism by inflammation: a feedback response in obesity and calorie restriction.. Aging (Albany NY) 2010 Jun;2(6):361-8.
    doi: 10.18632/aging.100155pmc: PMC2919256pubmed: 20606248google scholar: lookup
  31. Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling.. Am J Physiol Lung Cell Mol Physiol 2000 Dec;279(6):L1005-28.
  32. Rahman I, Biswas SK, Kode A. Oxidant and antioxidant balance in the airways and airway diseases.. Eur J Pharmacol 2006 Mar 8;533(1-3):222-39.
    doi: 10.1016/j.ejphar.2005.12.087pubmed: 16500642google scholar: lookup
  33. Ricciardolo FL, Sterk PJ, Gaston B, Folkerts G. Nitric oxide in health and disease of the respiratory system.. Physiol Rev 2004 Jul;84(3):731-65.
    doi: 10.1152/physrev.00034.2003pubmed: 15269335google scholar: lookup
  34. Erzurum SC. New Insights in Oxidant Biology in Asthma.. Ann Am Thorac Soc 2016 Mar;13 Suppl 1(Suppl 1):S35-9.
  35. Fulop T, Larbi A, Douziech N, Fortin C, Guérard KP, Lesur O, Khalil A, Dupuis G. Signal transduction and functional changes in neutrophils with aging.. Aging Cell 2004 Aug;3(4):217-26.
  36. Kudo M, Ishigatsubo Y, Aoki I. Pathology of asthma.. Front Microbiol 2013 Sep 10;4:263.
    doi: 10.3389/fmicb.2013.00263pmc: PMC3768124pubmed: 24032029google scholar: lookup
  37. Alam R, Good J, Rollins D, Verma M, Chu H, Pham TH, Martin RJ. Airway and serum biochemical correlates of refractory neutrophilic asthma.. J Allergy Clin Immunol 2017 Oct;140(4):1004-1014.e13.
    doi: 10.1016/j.jaci.2016.12.963pmc: PMC5540819pubmed: 28163052google scholar: lookup
  38. Carr TF, Zeki AA, Kraft M. Eosinophilic and Noneosinophilic Asthma.. Am J Respir Crit Care Med 2018 Jan 1;197(1):22-37.
    doi: 10.1164/rccm.201611-2232PPpmc: PMC5765385pubmed: 28910134google scholar: lookup
  39. Chang HS, Lee TH, Jun JA, Baek AR, Park JS, Koo SM, Kim YK, Lee HS, Park CS. Neutrophilic inflammation in asthma: mechanisms and therapeutic considerations.. Expert Rev Respir Med 2017 Jan;11(1):29-40.
    doi: 10.1080/17476348.2017.1268919pubmed: 27918221google scholar: lookup
  40. Chung KF. Neutrophilic asthma: a distinct target for treatment?. Lancet Respir Med 2016 Oct;4(10):765-767.
    doi: 10.1016/S2213-2600(16)30232-6pubmed: 27574789google scholar: lookup
  41. Panettieri RA Jr. Neutrophilic and Pauci-immune Phenotypes in Severe Asthma.. Immunol Allergy Clin North Am 2016 Aug;36(3):569-79.
    doi: 10.1016/j.iac.2016.03.007pubmed: 27401627google scholar: lookup
  42. Ray A, Kolls JK. Neutrophilic Inflammation in Asthma and Association with Disease Severity.. Trends Immunol 2017 Dec;38(12):942-954.
    doi: 10.1016/j.it.2017.07.003pmc: PMC5711587pubmed: 28784414google scholar: lookup
  43. Bishopp A, Sathyamurthy R, Manney S, Webbster C, Krishna MT, Mansur AH. Biomarkers of oxidative stress and antioxidants in severe asthma: A Prospective Case-Control Study.. Ann Allergy Asthma Immunol 2017 Apr;118(4):445-451.
    doi: 10.1016/j.anai.2017.02.004pubmed: 28390585google scholar: lookup
  44. Sugiura H, Ichinose M. Oxidative and nitrative stress in bronchial asthma.. Antioxid Redox Signal 2008 Apr;10(4):785-97.
    doi: 10.1089/ars.2007.1937pubmed: 18177234google scholar: lookup
  45. To M, Kono Y, Ogura N, Mikami S, Honda N, Hitani A, Kano I, Haruki K, To Y. Obesity-related systemic oxidative stress: An important factor of poor asthma control.. Allergol Int 2018 Jan;67(1):147-149.
    doi: 10.1016/j.alit.2017.06.002pubmed: 28648979google scholar: lookup
  46. Suzuki S, Matsukura S, Takeuchi H, Kawaguchi M, Ieki K, Odaka M, Watanabe S, Homma T, Dohi K, Aruga T, Sato M, Kurokawa M, Kokubu F, Adachi M. Increase in reactive oxygen metabolite level in acute exacerbations of asthma.. Int Arch Allergy Immunol 2008;146 Suppl 1:67-72.
    doi: 10.1159/000126064pubmed: 18504410google scholar: lookup
  47. Sideleva O, Black K, Dixon AE. Effects of obesity and weight loss on airway physiology and inflammation in asthma.. Pulm Pharmacol Ther 2013 Aug;26(4):455-8.
    doi: 10.1016/j.pupt.2012.05.002pmc: PMC3502699pubmed: 22609067google scholar: lookup
  48. Maneechotesuwan K, Essilfie-Quaye S, Kharitonov SA, Adcock IM, Barnes PJ. Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils.. Chest 2007 Jul;132(1):98-105.
    doi: 10.1378/chest.06-2982pubmed: 17550933google scholar: lookup
  49. Kelly C, Ward C, Stenton CS, Bird G, Hendrick DJ, Walters EH. Number and activity of inflammatory cells in bronchoalveolar lavage fluid in asthma and their relation to airway responsiveness.. Thorax 1988 Sep;43(9):684-92.
    doi: 10.1136/thx.43.9.684pmc: PMC461456pubmed: 3194874google scholar: lookup
  50. Calhoun WJ, Reed HE, Moest DR, Stevens CA. Enhanced superoxide production by alveolar macrophages and air-space cells, airway inflammation, and alveolar macrophage density changes after segmental antigen bronchoprovocation in allergic subjects.. Am Rev Respir Dis 1992 Feb;145(2 Pt 1):317-25.
    doi: 10.1164/ajrccm/145.2_Pt_1.317pubmed: 1310575google scholar: lookup
  51. Simpson JL, Phipps S, Baines KJ, Oreo KM, Gunawardhana L, Gibson PG. Elevated expression of the NLRP3 inflammasome in neutrophilic asthma.. Eur Respir J 2014 Apr;43(4):1067-76.
    doi: 10.1183/09031936.00105013pubmed: 24136334google scholar: lookup
  52. Lugrin J, Rosenblatt-Velin N, Parapanov R, Liaudet L. The role of oxidative stress during inflammatory processes.. Biol Chem 2014 Feb;395(2):203-30.
    doi: 10.1515/hsz-2013-0241pubmed: 24127541google scholar: lookup
  53. Bergeron C, Tulic MK, Hamid Q. Airway remodelling in asthma: from benchside to clinical practice.. Can Respir J 2010 Jul-Aug;17(4):e85-93.
    doi: 10.1155/2010/318029pmc: PMC2933777pubmed: 20808979google scholar: lookup
  54. Chan TK, Tan WSD, Peh HY, Wong WSF. Aeroallergens Induce Reactive Oxygen Species Production and DNA Damage and Dampen Antioxidant Responses in Bronchial Epithelial Cells.. J Immunol 2017 Jul 1;199(1):39-47.
    doi: 10.4049/jimmunol.1600657pubmed: 28526682google scholar: lookup
  55. Pattnaik B, Bodas M, Bhatraju NK, Ahmad T, Pant R, Guleria R, Ghosh B, Agrawal A. IL-4 promotes asymmetric dimethylarginine accumulation, oxo-nitrative stress, and hypoxic response-induced mitochondrial loss in airway epithelial cells.. J Allergy Clin Immunol 2016 Jul;138(1):130-141.e9.
    doi: 10.1016/j.jaci.2015.11.036pubmed: 26915676google scholar: lookup
  56. Bauer V, Sotníková R, Machová J, Mátyás S, Pucovský V, Stefek M. Reactive oxygen species induced smooth muscle responses in the intestine, vessels and airways and the effect of antioxidants.. Life Sci 1999;65(18-19):1909-17.
    doi: 10.1016/S0024-3205(99)00446-4pubmed: 10576436google scholar: lookup
  57. Katsumata U, Miura M, Ichinose M, Kimura K, Takahashi T, Inoue H, Takishima T. Oxygen radicals produce airway constriction and hyperresponsiveness in anesthetized cats.. Am Rev Respir Dis 1990 May;141(5 Pt 1):1158-61.
    doi: 10.1164/ajrccm/141.5_Pt_1.1158pubmed: 2131784google scholar: lookup
  58. Zuo L, Clanton TL. Reactive oxygen species formation in the transition to hypoxia in skeletal muscle.. Am J Physiol Cell Physiol 2005 Jul;289(1):C207-16.
    doi: 10.1152/ajpcell.00449.2004pubmed: 15788484google scholar: lookup
  59. Wiegman CH, Michaeloudes C, Haji G, Narang P, Clarke CJ, Russell KE, Bao W, Pavlidis S, Barnes PJ, Kanerva J, Bittner A, Rao N, Murphy MP, Kirkham PA, Chung KF, Adcock IM. Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease.. J Allergy Clin Immunol 2015 Sep;136(3):769-80.
    doi: 10.1016/j.jaci.2015.01.046pmc: PMC4559140pubmed: 25828268google scholar: lookup
  60. Tuo QR, Ma YF, Chen W, Luo XJ, Shen J, Guo D, Zheng YM, Wang YX, Ji G, Liu QH. Reactive oxygen species induce a Ca(2+)-spark increase in sensitized murine airway smooth muscle cells.. Biochem Biophys Res Commun 2013 May 10;434(3):498-502.
    doi: 10.1016/j.bbrc.2013.03.102pubmed: 23583396google scholar: lookup
  61. Poli G, Parola M. Oxidative damage and fibrogenesis.. Free Radic Biol Med 1997;22(1-2):287-305.
    doi: 10.1016/S0891-5849(96)00327-9pubmed: 8958154google scholar: lookup
  62. Sutcliffe A, Hollins F, Gomez E, Saunders R, Doe C, Cooke M, Challiss RA, Brightling CE. Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma.. Am J Respir Crit Care Med 2012 Feb 1;185(3):267-74.
    doi: 10.1164/rccm.201107-1281OCpmc: PMC3402550pubmed: 22108207google scholar: lookup
  63. Prakash YS, Pabelick CM, Sieck GC. Mitochondrial Dysfunction in Airway Disease.. Chest 2017 Sep;152(3):618-626.
    doi: 10.1016/j.chest.2017.03.020pmc: PMC5812762pubmed: 28336486google scholar: lookup
  64. Gansauge S, Gansauge F, Nussler AK, Rau B, Poch B, Schoenberg MH, Beger HG. Exogenous, but not endogenous, nitric oxide increases proliferation rates in senescent human fibroblasts.. FEBS Lett 1997 Jun 30;410(2-3):160-4.
    doi: 10.1016/S0014-5793(97)00544-9pubmed: 9237621google scholar: lookup
  65. Dasgupta J, Kar S, Liu R, Joseph J, Kalyanaraman B, Remington SJ, Chen C, Melendez JA. Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase.. J Cell Physiol 2010 Oct;225(1):52-62.
    doi: 10.1002/jcp.22193pmc: PMC2913426pubmed: 20648623google scholar: lookup
  66. Doelman CJ, Bast A. Oxygen radicals in lung pathology.. Free Radic Biol Med 1990;9(5):381-400.
    doi: 10.1016/0891-5849(90)90015-Bpubmed: 1705530google scholar: lookup
  67. Gillissen A, Nowak D. Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy.. Respir Med 1998 Apr;92(4):609-23.
    doi: 10.1016/S0954-6111(98)90506-6pubmed: 9659525google scholar: lookup
  68. Henricks PA, Nijkamp FP. Reactive oxygen species as mediators in asthma.. Pulm Pharmacol Ther 2001;14(6):409-20.
    doi: 10.1006/pupt.2001.0319pubmed: 11782121google scholar: lookup
  69. Jabbour AJ, Altman LC, Wight TN, Luchtel DL. Ozone alters the distribution of beta1 integrins in cultured primate bronchial epithelial cells.. Am J Respir Cell Mol Biol 1998 Sep;19(3):357-65.
    doi: 10.1165/ajrcmb.19.3.2961pubmed: 9730863google scholar: lookup
  70. Jaffer OA, Carter AB, Sanders PN, Dibbern ME, Winters CJ, Murthy S, Ryan AJ, Rokita AG, Prasad AM, Zabner J, Kline JN, Grumbach IM, Anderson ME. Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model.. Am J Respir Cell Mol Biol 2015 Jan;52(1):106-15.
    doi: 10.1165/rcmb.2013-0519OCpmc: PMC4370251pubmed: 24988374google scholar: lookup
  71. Uchida M, Anderson EL, Squillace DL, Patil N, Maniak PJ, Iijima K, Kita H, O'Grady SM. Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium.. Allergy 2017 Oct;72(10):1521-1531.
    doi: 10.1111/all.13158pmc: PMC5591045pubmed: 28273344google scholar: lookup
  72. Wan WY, Hollins F, Haste L, Woodman L, Hirst RA, Bolton S, Gomez E, Sutcliffe A, Desai D, Chachi L, Mistry V, Szyndralewiez C, Wardlaw A, Saunders R, O'Callaghan C, Andrew PW, Brightling CE. NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma.. Chest 2016 Jun;149(6):1445-59.
    doi: 10.1016/j.chest.2016.01.024pmc: PMC4893823pubmed: 26836936google scholar: lookup
  73. Rada B, Boudreau HE, Park JJ, Leto TL. Histamine stimulates hydrogen peroxide production by bronchial epithelial cells via histamine H1 receptor and dual oxidase.. Am J Respir Cell Mol Biol 2014 Jan;50(1):125-34.
    pmc: PMC3930938pubmed: 23962049doi: 10.1165/rcmb.2013-0254ocgoogle scholar: lookup
  74. Heiss LN, Lancaster JR Jr, Corbett JA, Goldman WE. Epithelial autotoxicity of nitric oxide: role in the respiratory cytopathology of pertussis.. Proc Natl Acad Sci U S A 1994 Jan 4;91(1):267-70.
    doi: 10.1073/pnas.91.1.267pmc: PMC42928pubmed: 7506415google scholar: lookup
  75. NAYLOR B. The shedding of the mucosa of the bronchial tree in asthma.. Thorax 1962 Mar;17(1):69-72.
    doi: 10.1136/thx.17.1.69pmc: PMC1018672pubmed: 14478653google scholar: lookup
  76. Folkerts G, Kloek J, Muijsers RB, Nijkamp FP. Reactive nitrogen and oxygen species in airway inflammation.. Eur J Pharmacol 2001 Oct 19;429(1-3):251-62.
    doi: 10.1016/S0014-2999(01)01324-3pubmed: 11698045google scholar: lookup
  77. Nagata M. Inflammatory cells and oxygen radicals.. Curr Drug Targets Inflamm Allergy 2005 Aug;4(4):503-4.
    doi: 10.2174/1568010054526322pubmed: 16101529google scholar: lookup
  78. Comhair SA, Bhathena PR, Dweik RA, Kavuru M, Erzurum SC. Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response.. Lancet 2000 Feb 19;355(9204):624.
    doi: 10.1016/S0140-6736(99)04736-4pubmed: 10696986google scholar: lookup
  79. Comhair SA, Xu W, Ghosh S, Thunnissen FB, Almasan A, Calhoun WJ, Janocha AJ, Zheng L, Hazen SL, Erzurum SC. Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity.. Am J Pathol 2005 Mar;166(3):663-74.
  80. Ghosh S, Janocha AJ, Aronica MA, Swaidani S, Comhair SA, Xu W, Zheng L, Kaveti S, Kinter M, Hazen SL, Erzurum SC. Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation.. J Immunol 2006 May 1;176(9):5587-97.
    doi: 10.4049/jimmunol.176.9.5587pubmed: 16622028google scholar: lookup
  81. Varshavskiĭ BIa, Trubnikov GV, Galaktipmpva LP, Koreniak NA, Koledeznaia IL, Oberemok AN. [Oxidant-antioxidant status of patients with bronchial asthma during inhalation and systemic glucocorticoid therapy].. Ter Arkh 2003;75(3):21-4.
    pubmed: 12718214
  82. Smith LJ, Shamsuddin M, Sporn PH, Denenberg M, Anderson J. Reduced superoxide dismutase in lung cells of patients with asthma.. Free Radic Biol Med 1997;22(7):1301-7.
    doi: 10.1016/S0891-5849(96)00550-3pubmed: 9098106google scholar: lookup
  83. Kinnula VL, Crapo JD. Superoxide dismutases in the lung and human lung diseases.. Am J Respir Crit Care Med 2003 Jun 15;167(12):1600-19.
    doi: 10.1164/rccm.200212-1479SOpubmed: 12796054google scholar: lookup
  84. Comhair SA, Ricci KS, Arroliga M, Lara AR, Dweik RA, Song W, Hazen SL, Bleecker ER, Busse WW, Chung KF, Gaston B, Hastie A, Hew M, Jarjour N, Moore W, Peters S, Teague WG, Wenzel SE, Erzurum SC. Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma.. Am J Respir Crit Care Med 2005 Aug 1;172(3):306-13.
    doi: 10.1164/rccm.200502-180OCpmc: PMC2718470pubmed: 15883124google scholar: lookup
  85. Burbank AJ, Duran CG, Pan Y, Burns P, Jones S, Jiang Q, Yang C, Jenkins S, Wells H, Alexis N, Kesimer M, Bennett WD, Zhou H, Peden DB, Hernandez ML. Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma.. J Allergy Clin Immunol 2018 Apr;141(4):1231-1238.e1.
    doi: 10.1016/j.jaci.2017.06.029pmc: PMC5775926pubmed: 28736267google scholar: lookup
  86. Lang MR, Fiaux GW, Gillooly M, Stewart JA, Hulmes DJ, Lamb D. Collagen content of alveolar wall tissue in emphysematous and non-emphysematous lungs.. Thorax 1994 Apr;49(4):319-26.
    doi: 10.1136/thx.49.4.319pmc: PMC475363pubmed: 8202900google scholar: lookup
  87. Janssens JP, Pache JC, Nicod LP. Physiological changes in respiratory function associated with ageing.. Eur Respir J 1999 Jan;13(1):197-205.
    doi: 10.1183/09031936.99.14614549pubmed: 10836348google scholar: lookup
  88. Verbeken EK, Cauberghs M, Mertens I, Clement J, Lauweryns JM, Van de Woestijne KP. The senile lung. Comparison with normal and emphysematous lungs. 1. Structural aspects.. Chest 1992 Mar;101(3):793-9.
    doi: 10.1378/chest.101.3.793pubmed: 1541148google scholar: lookup
  89. Dyer C. The interaction of ageing and lung disease.. Chron Respir Dis 2012 Feb;9(1):63-7.
    doi: 10.1177/1479972311433766pubmed: 22308556google scholar: lookup
  90. Miller MR. Structural and physiological age-associated changes in aging lungs.. Semin Respir Crit Care Med 2010 Oct;31(5):521-7.
    doi: 10.1055/s-0030-1265893pubmed: 20941653google scholar: lookup
  91. Niewoehner DE, Kleinerman J. Morphologic basis of pulmonary resistance in the human lung and effects of aging.. J Appl Physiol 1974 Apr;36(4):412-8.
    pubmed: 4820322doi: 10.1152/jappl.1974.36.4.412google scholar: lookup
  92. Kim J, Heise RL, Reynolds AM, Pidaparti RM. Aging effects on airflow dynamics and lung function in human bronchioles.. PLoS One 2017;12(8):e0183654.
  93. Childs BG, Durik M, Baker DJ, van Deursen JM. Cellular senescence in aging and age-related disease: from mechanisms to therapy.. Nat Med 2015 Dec;21(12):1424-35.
    doi: 10.1038/nm.4000pmc: PMC4748967pubmed: 26646499google scholar: lookup
  94. Chen JH, Hales CN, Ozanne SE. DNA damage, cellular senescence and organismal ageing: causal or correlative?. Nucleic Acids Res 2007;35(22):7417-28.
    doi: 10.1093/nar/gkm681pmc: PMC2190714pubmed: 17913751google scholar: lookup
  95. Ochs M, Weibel ER. Functional design of the human lung for gas exchange. Fishman’s Pulmonary Disease and Disorders 4th ed. McGraw Hill; New York, NY, USA: 2008. pp. 23–70.
  96. Pignatti P, Ragnoli B, Radaeli A, Moscato G, Malerba M. Age-related increase of airway neutrophils in older healthy nonsmoking subjects.. Rejuvenation Res 2011 Aug;14(4):365-70.
    doi: 10.1089/rej.2010.1150pubmed: 21595513google scholar: lookup
  97. Meyer KC, Rosenthal NS, Soergel P, Peterson K. Neutrophils and low-grade inflammation in the seemingly normal aging human lung.. Mech Ageing Dev 1998 Aug 14;104(2):169-81.
    doi: 10.1016/S0047-6374(98)00065-7pubmed: 9792195google scholar: lookup
  98. Carpagnano GE, Turchiarelli V, Spanevello A, Palladino GP, Barbaro MP. Aging and airway inflammation.. Aging Clin Exp Res 2013 Jun;25(3):239-45.
    doi: 10.1007/s40520-013-0040-ypubmed: 23740581google scholar: lookup
  99. Spanevello A, Confalonieri M, Sulotto F, Romano F, Balzano G, Migliori GB, Bianchi A, Michetti G. Induced sputum cellularity. Reference values and distribution in normal volunteers.. Am J Respir Crit Care Med 2000 Sep;162(3 Pt 1):1172-4.
    doi: 10.1164/ajrccm.162.3.9908057pubmed: 10988149google scholar: lookup
  100. Thomas RA, Green RH, Brightling CE, Birring SS, Parker D, Wardlaw AJ, Pavord ID. The influence of age on induced sputum differential cell counts in normal subjects.. Chest 2004 Dec;126(6):1811-4.
    doi: 10.1016/S0012-3692(15)31427-6pubmed: 15596678google scholar: lookup
  101. Fülöp T Jr, Fouquet C, Allaire P, Perrin N, Lacombe G, Stankova J, Rola-Pleszczynski M, Gagné D, Wagner JR, Khalil A, Dupuis G. Changes in apoptosis of human polymorphonuclear granulocytes with aging.. Mech Ageing Dev 1997 Jun;96(1-3):15-34.
    doi: 10.1016/S0047-6374(96)01881-7pubmed: 9223108google scholar: lookup
  102. Fortin CF, Lesur O, Fulop T Jr. Effects of aging on triggering receptor expressed on myeloid cells (TREM)-1-induced PMN functions.. FEBS Lett 2007 Mar 20;581(6):1173-8.
    doi: 10.1016/j.febslet.2007.02.029pubmed: 17336301google scholar: lookup
  103. Tortorella C, Simone O, Piazzolla G, Stella I, Cappiello V, Antonaci S. Role of phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways in granulocyte macrophage-colony-stimulating factor failure to delay fas-induced neutrophil apoptosis in elderly humans.. J Gerontol A Biol Sci Med Sci 2006 Nov;61(11):1111-8.
    doi: 10.1093/gerona/61.11.1111pubmed: 17167151google scholar: lookup
  104. Hearps AC, Martin GE, Angelovich TA, Cheng WJ, Maisa A, Landay AL, Jaworowski A, Crowe SM. Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function.. Aging Cell 2012 Oct;11(5):867-75.
  105. Plowden J, Renshaw-Hoelscher M, Engleman C, Katz J, Sambhara S. Innate immunity in aging: impact on macrophage function.. Aging Cell 2004 Aug;3(4):161-7.
  106. Plackett TP, Boehmer ED, Faunce DE, Kovacs EJ. Aging and innate immune cells.. J Leukoc Biol 2004 Aug;76(2):291-9.
    doi: 10.1189/jlb.1103592pubmed: 15039467google scholar: lookup
  107. Esparza B, Sanchez H, Ruiz M, Barranquero M, Sabino E, Merino F. Neutrophil function in elderly persons assessed by flow cytometry.. Immunol Invest 1996 May;25(3):185-90.
    doi: 10.3109/08820139609059301pubmed: 9157053google scholar: lookup
  108. Nogueira-Neto J, Cardoso AS, Monteiro HP, Fonseca FL, Ramos LR, Junqueira VB, Simon KA. Basal neutrophil function in human aging: Implications in endothelial cell adhesion.. Cell Biol Int 2016 Jul;40(7):796-802.
    doi: 10.1002/cbin.10618pubmed: 27109745google scholar: lookup
  109. Hazeldine J, Harris P, Chapple IL, Grant M, Greenwood H, Livesey A, Sapey E, Lord JM. Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals.. Aging Cell 2014 Aug;13(4):690-8.
    doi: 10.1111/acel.12222pmc: PMC4326942pubmed: 24779584google scholar: lookup
  110. Wessels I, Jansen J, Rink L, Uciechowski P. Immunosenescence of polymorphonuclear neutrophils.. ScientificWorldJournal 2010 Jan 21;10:145-60.
    doi: 10.1100/tsw.2010.14pmc: PMC5763979pubmed: 20098958google scholar: lookup
  111. Di Lorenzo G, Balistreri CR, Candore G, Cigna D, Colombo A, Romano GC, Colucci AT, Gervasi F, Listì F, Potestio M, Caruso C. Granulocyte and natural killer activity in the elderly.. Mech Ageing Dev 1999 Apr 1;108(1):25-38.
    doi: 10.1016/S0047-6374(98)00156-0pubmed: 10366037google scholar: lookup
  112. Kovalenko EI, Boyko AA, Semenkov VF, Lutsenko GV, Grechikhina MV, Kanevskiy LM, Azhikina TL, Telford WG, Sapozhnikov AM. ROS production, intracellular HSP70 levels and their relationship in human neutrophils: effects of age.. Oncotarget 2014 Dec 15;5(23):11800-12.
    doi: 10.18632/oncotarget.2856pmc: PMC4322963pubmed: 25514461google scholar: lookup
  113. Castelo-Branco C, Soveral I. The immune system and aging: a review.. Gynecol Endocrinol 2014 Jan;30(1):16-22.
    doi: 10.3109/09513590.2013.852531pubmed: 24219599google scholar: lookup
  114. Huang YJ, Nelson CE, Brodie EL, Desantis TZ, Baek MS, Liu J, Woyke T, Allgaier M, Bristow J, Wiener-Kronish JP, Sutherland ER, King TS, Icitovic N, Martin RJ, Calhoun WJ, Castro M, Denlinger LC, Dimango E, Kraft M, Peters SP, Wasserman SI, Wechsler ME, Boushey HA, Lynch SV. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma.. J Allergy Clin Immunol 2011 Feb;127(2):372-381.e1-3.
    doi: 10.1016/j.jaci.2010.10.048pmc: PMC3037020pubmed: 21194740google scholar: lookup
  115. Chotirmall SH, Burke CM. Aging and the microbiome: implications for asthma in the elderly?. Expert Rev Respir Med 2015 Apr;9(2):125-8.
    doi: 10.1586/17476348.2015.1002473pubmed: 25582135google scholar: lookup
  116. Murray MA, Chotirmall SH. The Impact of Immunosenescence on Pulmonary Disease.. Mediators Inflamm 2015;2015:692546.
    doi: 10.1155/2015/692546pmc: PMC4495178pubmed: 26199462google scholar: lookup
  117. Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas.. J Clin Invest 2012 Mar;122(3):787-95.
    doi: 10.1172/JCI59643pmc: PMC3287223pubmed: 22378047google scholar: lookup
  118. Nyugen J, Agrawal S, Gollapudi S, Gupta S. Impaired functions of peripheral blood monocyte subpopulations in aged humans.. J Clin Immunol 2010 Nov;30(6):806-13.
    doi: 10.1007/s10875-010-9448-8pmc: PMC2970801pubmed: 20703784google scholar: lookup
  119. Mahbub S, Deburghgraeve CR, Kovacs EJ. Advanced age impairs macrophage polarization.. J Interferon Cytokine Res 2012 Jan;32(1):18-26.
    doi: 10.1089/jir.2011.0058pmc: PMC3255514pubmed: 22175541google scholar: lookup
  120. Brandenberger C, Mühlfeld C. Mechanisms of lung aging.. Cell Tissue Res 2017 Mar;367(3):469-480.
    doi: 10.1007/s00441-016-2511-xpubmed: 27743206google scholar: lookup
  121. van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, Allore HG, Medzhitov R, Shaw AC. Age-associated defect in human TLR-1/2 function.. J Immunol 2007 Jan 15;178(2):970-5.
    doi: 10.4049/jimmunol.178.2.970pubmed: 17202359google scholar: lookup
  122. Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR. Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly.. J Virol 2008 Aug;82(15):7613-23.
    doi: 10.1128/JVI.00618-08pmc: PMC2493309pubmed: 18508883google scholar: lookup
  123. van Duin D, Allore HG, Mohanty S, Ginter S, Newman FK, Belshe RB, Medzhitov R, Shaw AC. Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults.. J Infect Dis 2007 Jun 1;195(11):1590-7.
    doi: 10.1086/516788pubmed: 17471428google scholar: lookup
  124. Villanueva JL, Solana R, Alonso MC, Peña J. Changes in the expression of HLA-class II antigens on peripheral blood monocytes from aged humans.. Dis Markers 1990 Mar-Apr;8(2):85-91.
    pubmed: 2387126
  125. Gayoso I, Sanchez-Correa B, Campos C, Alonso C, Pera A, Casado JG, Morgado S, Tarazona R, Solana R. Immunosenescence of human natural killer cells.. J Innate Immun 2011;3(4):337-43.
    doi: 10.1159/000328005pubmed: 21576928google scholar: lookup
  126. Campos C, Pera A, Lopez-Fernandez I, Alonso C, Tarazona R, Solana R. Proinflammatory status influences NK cells subsets in the elderly.. Immunol Lett 2014 Nov;162(1 Pt B):298-302.
    doi: 10.1016/j.imlet.2014.06.015pubmed: 24998470google scholar: lookup
  127. Campos C, Pera A, Sanchez-Correa B, Alonso C, Lopez-Fernandez I, Morgado S, Tarazona R, Solana R. Effect of age and CMV on NK cell subpopulations.. Exp Gerontol 2014 Jun;54:130-7.
    doi: 10.1016/j.exger.2014.01.008pubmed: 24440462google scholar: lookup
  128. Beli E, Clinthorne JF, Duriancik DM, Hwang I, Kim S, Gardner EM. Natural killer cell function is altered during the primary response of aged mice to influenza infection.. Mech Ageing Dev 2011 Oct;132(10):503-10.
    doi: 10.1016/j.mad.2011.08.005pmc: PMC3185116pubmed: 21893080google scholar: lookup
  129. Ho JC, Chan KN, Hu WH, Lam WK, Zheng L, Tipoe GL, Sun J, Leung R, Tsang KW. The effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia.. Am J Respir Crit Care Med 2001 Mar;163(4):983-8.
    doi: 10.1164/ajrccm.163.4.9909121pubmed: 11282777google scholar: lookup
  130. Svartengren M, Falk R, Philipson K. Long-term clearance from small airways decreases with age.. Eur Respir J 2005 Oct;26(4):609-15.
    doi: 10.1183/09031936.05.00002105pubmed: 16204590google scholar: lookup
  131. Bailey KL, Bonasera SJ, Wilderdyke M, Hanisch BW, Pavlik JA, DeVasure J, Robinson JE, Sisson JH, Wyatt TA. Aging causes a slowing in ciliary beat frequency, mediated by PKCε.. Am J Physiol Lung Cell Mol Physiol 2014 Mar 15;306(6):L584-9.
    doi: 10.1152/ajplung.00175.2013pmc: PMC4116422pubmed: 24487393google scholar: lookup
  132. Ortega-Martínez M, Rodríguez-Flores LE, Ancer-Arellano A, Cerda-Flores RM, de-la-Garza-González C, Ancer-Rodríguez J, Jaramillo-Rangel G. Analysis of Cell Turnover in the Bronchiolar Epithelium Through the Normal Aging Process.. Lung 2016 Aug;194(4):581-7.
    doi: 10.1007/s00408-016-9890-3pubmed: 27164984google scholar: lookup
  133. Yin L, Zheng D, Limmon GV, Leung NH, Xu S, Rajapakse JC, Yu H, Chow VT, Chen J. Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia.. Respir Res 2014 Sep 30;15(1):116.
    doi: 10.1186/s12931-014-0116-zpmc: PMC4189598pubmed: 25265939google scholar: lookup
  134. Zhou L, Zhang H, Davies KJA, Forman HJ. Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells.. Redox Biol 2018 Apr;14:35-40.
    doi: 10.1016/j.redox.2017.08.014pmc: PMC5576992pubmed: 28863281google scholar: lookup
  135. Alder JK, Barkauskas CE, Limjunyawong N, Stanley SE, Kembou F, Tuder RM, Hogan BL, Mitzner W, Armanios M. Telomere dysfunction causes alveolar stem cell failure.. Proc Natl Acad Sci U S A 2015 Apr 21;112(16):5099-104.
    doi: 10.1073/pnas.1504780112pmc: PMC4413294pubmed: 25840590google scholar: lookup
  136. Mason RJ, Greene K, Voelker DR. Surfactant protein A and surfactant protein D in health and disease.. Am J Physiol 1998 Jul;275(1):L1-13.
    pubmed: 9688929doi: 10.1152/ajplung.1998.275.1.l1google scholar: lookup
  137. Whitsett JA. Surfactant proteins in innate host defense of the lung.. Biol Neonate 2005;88(3):175-80.
    doi: 10.1159/000087580pubmed: 16210839google scholar: lookup
  138. Moliva JI, Rajaram MV, Sidiki S, Sasindran SJ, Guirado E, Pan XJ, Wang SH, Ross P Jr, Lafuse WP, Schlesinger LS, Turner J, Torrelles JB. Molecular composition of the alveolar lining fluid in the aging lung.. Age (Dordr) 2014 Jun;36(3):9633.
    doi: 10.1007/s11357-014-9633-4pmc: PMC4082594pubmed: 24584696google scholar: lookup
  139. Ilumets H, Mazur W, Toljamo T, Louhelainen N, Nieminen P, Kobayashi H, Ishikawa N, Kinnula VL. Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction.. BMC Pulm Med 2011 Apr 19;11:19.
    doi: 10.1186/1471-2466-11-19pmc: PMC3103485pubmed: 21504569google scholar: lookup
  140. Agrawal A, Agrawal S, Cao JN, Su H, Osann K, Gupta S. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway.. J Immunol 2007 Jun 1;178(11):6912-22.
    doi: 10.4049/jimmunol.178.11.6912pubmed: 17513740google scholar: lookup
  141. Zhao J, Zhao J, Legge K, Perlman S. Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice.. J Clin Invest 2011 Dec;121(12):4921-30.
    doi: 10.1172/JCI59777pmc: PMC3226008pubmed: 22105170google scholar: lookup
  142. Chougnet CA, Thacker RI, Shehata HM, Hennies CM, Lehn MA, Lages CS, Janssen EM. Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction.. J Immunol 2015 Sep 15;195(6):2624-32.
    doi: 10.4049/jimmunol.1501006pmc: PMC4561185pubmed: 26246142google scholar: lookup
  143. Prakash S, Agrawal S, Vahed H, Ngyuen M, BenMohamed L, Gupta S, Agrawal A. Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state.. Mucosal Immunol 2014 Nov;7(6):1386-94.
    doi: 10.1038/mi.2014.28pmc: PMC4205198pubmed: 24759206google scholar: lookup
  144. Agrawal A, Tay J, Ton S, Agrawal S, Gupta S. Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA.. J Immunol 2009 Jan 15;182(2):1138-45.
    doi: 10.4049/jimmunol.182.2.1138pmc: PMC2621318pubmed: 19124757google scholar: lookup
  145. Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.. J Immunol 2010 Mar 1;184(5):2518-27.
    doi: 10.4049/jimmunol.0901022pmc: PMC3867271pubmed: 20100933google scholar: lookup
  146. Ademokun A, Wu YC, Dunn-Walters D. The ageing B cell population: composition and function.. Biogerontology 2010 Apr;11(2):125-37.
    doi: 10.1007/s10522-009-9256-9pubmed: 19937382google scholar: lookup
  147. Chong Y, Ikematsu H, Yamaji K, Nishimura M, Nabeshima S, Kashiwagi S, Hayashi J. CD27(+) (memory) B cell decrease and apoptosis-resistant CD27(-) (naive) B cell increase in aged humans: implications for age-related peripheral B cell developmental disturbances.. Int Immunol 2005 Apr;17(4):383-90.
    doi: 10.1093/intimm/dxh218pubmed: 15724062google scholar: lookup
  148. Koch S, Larbi A, Derhovanessian E, Ozcelik D, Naumova E, Pawelec G. Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people.. Immun Ageing 2008 Jul 25;5:6.
    doi: 10.1186/1742-4933-5-6pmc: PMC2515281pubmed: 18657274google scholar: lookup
  149. Larbi A, Dupuis G, Douziech N, Khalil A, Fülöp T Jr. Low-grade inflammation with aging has consequences for T-lymphocyte signaling.. Ann N Y Acad Sci 2004 Dec;1030:125-33.
    doi: 10.1196/annals.1329.016pubmed: 15659789google scholar: lookup
  150. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, Jamieson BD, Zack JA, Picker LJ, Koup RA. Changes in thymic function with age and during the treatment of HIV infection.. Nature 1998 Dec 17;396(6712):690-5.
    doi: 10.1038/25374pubmed: 9872319google scholar: lookup
  151. Fagnoni FF, Vescovini R, Passeri G, Bologna G, Pedrazzoni M, Lavagetto G, Casti A, Franceschi C, Passeri M, Sansoni P. Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging.. Blood 2000 May 1;95(9):2860-8.
    pubmed: 10779432
  152. Gupta S, Bi R, Su K, Yel L, Chiplunkar S, Gollapudi S. Characterization of naïve, memory and effector CD8+ T cells: effect of age.. Exp Gerontol 2004 Apr;39(4):545-50.
    doi: 10.1016/j.exger.2003.08.013pubmed: 15050289google scholar: lookup
  153. Doe C, Bafadhel M, Siddiqui S, Desai D, Mistry V, Rugman P, McCormick M, Woods J, May R, Sleeman MA, Anderson IK, Brightling CE. Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.. Chest 2010 Nov;138(5):1140-7.
    doi: 10.1378/chest.09-3058pmc: PMC2972626pubmed: 20538817google scholar: lookup
  154. Vanaudenaerde BM, Verleden SE, Vos R, De Vleeschauwer SI, Willems-Widyastuti A, Geenens R, Van Raemdonck DE, Dupont LJ, Verbeken EK, Meyts I. Innate and adaptive interleukin-17-producing lymphocytes in chronic inflammatory lung disorders.. Am J Respir Crit Care Med 2011 Apr 15;183(8):977-86.
    doi: 10.1164/rccm.201007-1196PPpubmed: 21097694google scholar: lookup
  155. Brandenberger C, Li N, Jackson-Humbles DN, Rockwell CE, Wagner JG, Harkema JR. Enhanced allergic airway disease in old mice is associated with a Th17 response.. Clin Exp Allergy 2014 Oct;44(10):1282-92.
    doi: 10.1111/cea.12388pubmed: 25109604google scholar: lookup
  156. Diller ML, Kudchadkar RR, Delman KA, Lawson DH, Ford ML. Balancing Inflammation: The Link between Th17 and Regulatory T Cells.. Mediators Inflamm 2016;2016:6309219.
    doi: 10.1155/2016/6309219pmc: PMC4930807pubmed: 27413254google scholar: lookup
  157. Kinnula VL, Chang L, Everitt JI, Crapo JD. Oxidants and antioxidants in alveolar epithelial type II cells: in situ, freshly isolated, and cultured cells.. Am J Physiol 1992 Jan;262(1 Pt 1):L69-77.
    pubmed: 1733283doi: 10.1152/ajplung.1992.262.1.l69google scholar: lookup
  158. Kinnula VL, Crapo JD, Raivio KO. Generation and disposal of reactive oxygen metabolites in the lung.. Lab Invest 1995 Jul;73(1):3-19.
    pubmed: 7603038
  159. Kinnula VL, Whorton AR, Chang LY, Crapo JD. Regulation of hydrogen peroxide generation in cultured endothelial cells.. Am J Respir Cell Mol Biol 1992 Feb;6(2):175-82.
    doi: 10.1165/ajrcmb/6.2.175pubmed: 1540380google scholar: lookup
  160. Nadeem A, Siddiqui N, Alharbi NO, Alharbi MM. Airway and systemic oxidant-antioxidant dysregulation in asthma: a possible scenario of oxidants spill over from lung into blood.. Pulm Pharmacol Ther 2014 Oct;29(1):31-40.
    doi: 10.1016/j.pupt.2014.06.001pubmed: 24929073google scholar: lookup
  161. Dunn R, Wechsler ME. Reducing asthma attacks in patients with severe asthma: The role of bronchial thermoplasty.. Allergy Asthma Proc 2015 Jul-Aug;36(4):242-50.
    doi: 10.2500/aap.2015.36.3851pubmed: 26108080google scholar: lookup
  162. Oraka E, Kim HJ, King ME, Callahan DB. Asthma prevalence among US elderly by age groups: age still matters.. J Asthma 2012 Aug;49(6):593-9.
    doi: 10.3109/02770903.2012.684252pubmed: 22765313google scholar: lookup
  163. Hanania NA, King MJ, Braman SS, Saltoun C, Wise RA, Enright P, Falsey AR, Mathur SK, Ramsdell JW, Rogers L, Stempel DA, Lima JJ, Fish JE, Wilson SR, Boyd C, Patel KV, Irvin CG, Yawn BP, Halm EA, Wasserman SI, Sands MF, Ershler WB, Ledford DK. Asthma in the elderly: Current understanding and future research needs--a report of a National Institute on Aging (NIA) workshop.. J Allergy Clin Immunol 2011 Sep;128(3 Suppl):S4-24.
    doi: 10.1016/j.jaci.2011.06.048pmc: PMC3164961pubmed: 21872730google scholar: lookup
  164. Park HW, Song WJ, Kim SH, Park HK, Kim SH, Kwon YE, Kwon HS, Kim TB, Chang YS, Cho YS, Lee BJ, Jee YK, Jang AS, Nahm DH, Park JW, Yoon HJ, Cho YJ, Choi BW, Moon HB, Cho SH. Classification and implementation of asthma phenotypes in elderly patients.. Ann Allergy Asthma Immunol 2015 Jan;114(1):18-22.
    doi: 10.1016/j.anai.2014.09.020pubmed: 25455518google scholar: lookup
  165. Busse PJ, Birmingham JM, Calatroni A, Manzi J, Goryachokovsky A, Fontela G, Federman AD, Wisnivesky JP. Effect of aging on sputum inflammation and asthma control.. J Allergy Clin Immunol 2017 Jun;139(6):1808-1818.e6.
    doi: 10.1016/j.jaci.2016.09.015pmc: PMC5385166pubmed: 27725186google scholar: lookup
  166. Ducharme ME, Prince P, Hassan N, Nair P, Boulet LP. Expiratory flows and airway inflammation in elderly asthmatic patients.. Respir Med 2011 Sep;105(9):1284-9.
    doi: 10.1016/j.rmed.2011.04.006pubmed: 21546232google scholar: lookup
  167. Nyenhuis SM, Schwantes EA, Evans MD, Mathur SK. Airway neutrophil inflammatory phenotype in older subjects with asthma.. J Allergy Clin Immunol 2010 May;125(5):1163-5.
    doi: 10.1016/j.jaci.2010.02.015pmc: PMC3298970pubmed: 20381851google scholar: lookup
  168. Chang S, Linderholm A, Franzi L, Kenyon N, Grasberger H, Harper R. Dual oxidase regulates neutrophil recruitment in allergic airways.. Free Radic Biol Med 2013 Dec;65:38-46.
  169. Summers C, Rankin SM, Condliffe AM, Singh N, Peters AM, Chilvers ER. Neutrophil kinetics in health and disease.. Trends Immunol 2010 Aug;31(8):318-24.
    doi: 10.1016/j.it.2010.05.006pmc: PMC2930213pubmed: 20620114google scholar: lookup
  170. Bai TR, Cooper J, Koelmeyer T, Paré PD, Weir TD. The effect of age and duration of disease on airway structure in fatal asthma.. Am J Respir Crit Care Med 2000 Aug;162(2 Pt 1):663-9.
    doi: 10.1164/ajrccm.162.2.9907151pubmed: 10934103google scholar: lookup
  171. Inoue H, Niimi A, Takeda T, Matsumoto H, Ito I, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Nakaji H, Tajiri T, Iwata T, Nagasaki T, Kanemitsu Y, Chin K, Mishima M. Pathophysiological characteristics of asthma in the elderly: a comprehensive study.. Ann Allergy Asthma Immunol 2014 Nov;113(5):527-33.
    doi: 10.1016/j.anai.2014.08.002pubmed: 25216975google scholar: lookup
  172. Leclere M, Lavoie-Lamoureux A, Lavoie JP. Heaves, an asthma-like disease of horses.. Respirology 2011 Oct;16(7):1027-46.
  173. Horohov DW. The equine immune responses to infectious and allergic disease: a model for humans?. Mol Immunol 2015 Jul;66(1):89-96.
    doi: 10.1016/j.molimm.2014.09.020pubmed: 25457878google scholar: lookup
  174. Couëtil LL, Cardwell JM, Gerber V, Lavoie JP, Léguillette R, Richard EA. Inflammatory Airway Disease of Horses--Revised Consensus Statement.. J Vet Intern Med 2016 Mar-Apr;30(2):503-15.
    doi: 10.1111/jvim.13824pmc: PMC4913592pubmed: 26806374google scholar: lookup
  175. ALEXANDER AF. Chronic alveolar emphysema in the horse.. Am Rev Respir Dis 1959 Jul;80(1, Part 2):141-6.
    pubmed: 13670415doi: 10.1164/arrd.1959.80.1p2.141google scholar: lookup
  176. Bosshard S, Gerber V. Evaluation of coughing and nasal discharge as early indicators for an increased risk to develop equine recurrent airway obstruction (RAO).. J Vet Intern Med 2014 Mar-Apr;28(2):618-23.
    doi: 10.1111/jvim.12279pmc: PMC4858023pubmed: 24417562google scholar: lookup
  177. Hotchkiss JW, Reid SW, Christley RM. A survey of horse owners in Great Britain regarding horses in their care. Part 2: Risk factors for recurrent airway obstruction.. Equine Vet J 2007 Jul;39(4):301-8.
    doi: 10.2746/042516407X180129pubmed: 17722720google scholar: lookup
  178. Hansen S, Baptiste KE, Fjeldborg J, Horohov DW. A review of the equine age-related changes in the immune system: comparisons between human and equine aging, with focus on lung-specific immune-aging.. Ageing Res Rev 2015 Mar;20:11-23.
    doi: 10.1016/j.arr.2014.12.002pubmed: 25497559google scholar: lookup
  179. McFarlane D. Immune Dysfunction in Aged Horses.. Vet Clin North Am Equine Pract 2016 Aug;32(2):333-41.
    doi: 10.1016/j.cveq.2016.04.009pubmed: 27329495google scholar: lookup
  180. Adams AA, Breathnach CC, Katepalli MP, Kohler K, Horohov DW. Advanced age in horses affects divisional history of T cells and inflammatory cytokine production.. Mech Ageing Dev 2008 Nov;129(11):656-64.
    doi: 10.1016/j.mad.2008.09.004pubmed: 18926847google scholar: lookup
  181. Adams AA, Katepalli MP, Kohler K, Reedy SE, Stilz JP, Vick MM, Fitzgerald BP, Lawrence LM, Horohov DW. Effect of body condition, body weight and adiposity on inflammatory cytokine responses in old horses.. Vet Immunol Immunopathol 2009 Feb 15;127(3-4):286-94.
    doi: 10.1016/j.vetimm.2008.10.323pubmed: 19097648google scholar: lookup
  182. Hansen S, Sun L, Baptiste KE, Fjeldborg J, Horohov DW. Age-related changes in intracellular expression of IFN-γ and TNF-α in equine lymphocytes measured in bronchoalveolar lavage and peripheral blood.. Dev Comp Immunol 2013 Mar;39(3):228-33.
    doi: 10.1016/j.dci.2012.11.007pubmed: 23219905google scholar: lookup
  183. Lavoie-Lamoureux A, Leclere M, Lemos K, Wagner B, Lavoie JP. Markers of systemic inflammation in horses with heaves.. J Vet Intern Med 2012 Nov-Dec;26(6):1419-26.
  184. Leclere M, Bédard C, Cortes-Dubly ML, Lavoie JP. Blood hypercoagulability and systemic inflammation in horses with heaves.. Vet J 2015 Oct;206(1):105-7.
    doi: 10.1016/j.tvjl.2015.04.012pubmed: 26164529google scholar: lookup
  185. Debrue M, Hamilton E, Joubert P, Lajoie-Kadoch S, Lavoie JP. Chronic exacerbation of equine heaves is associated with an increased expression of interleukin-17 mRNA in bronchoalveolar lavage cells.. Vet Immunol Immunopathol 2005 May 1;105(1-2):25-31.
    doi: 10.1016/j.vetimm.2004.12.013pubmed: 15797472google scholar: lookup
  186. Cordeau ME, Joubert P, Dewachi O, Hamid Q, Lavoie JP. IL-4, IL-5 and IFN-gamma mRNA expression in pulmonary lymphocytes in equine heaves.. Vet Immunol Immunopathol 2004 Jan;97(1-2):87-96.
    doi: 10.1016/j.vetimm.2003.08.013pubmed: 14700540google scholar: lookup
  187. Lavoie JP, Maghni K, Desnoyers M, Taha R, Martin JG, Hamid QA. Neutrophilic airway inflammation in horses with heaves is characterized by a Th2-type cytokine profile.. Am J Respir Crit Care Med 2001 Oct 15;164(8 Pt 1):1410-3.
    doi: 10.1164/ajrccm.164.8.2012091pubmed: 11704587google scholar: lookup
  188. Ainsworth DM, Grünig G, Matychak MB, Young J, Wagner B, Erb HN, Antczak DF. Recurrent airway obstruction (RAO) in horses is characterized by IFN-gamma and IL-8 production in bronchoalveolar lavage cells.. Vet Immunol Immunopathol 2003 Nov 15;96(1-2):83-91.
    doi: 10.1016/S0165-2427(03)00142-9pubmed: 14522137google scholar: lookup
  189. Ainsworth DM, Wagner B, Erb HN, Young JC, Retallick DE. Effects of in vitro exposure to hay dust on expression of interleukin-17, -23, -8, and -1beta and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells isolated from horses chronically affected with recurrent airway disease.. Am J Vet Res 2007 Dec;68(12):1361-9.
    doi: 10.2460/ajvr.68.12.1361pubmed: 18052742google scholar: lookup
  190. McFarlane D, Hill K, Anton J. Neutrophil function in healthy aged horses and horses with pituitary dysfunction.. Vet Immunol Immunopathol 2015 Jun 15;165(3-4):99-106.
    doi: 10.1016/j.vetimm.2015.04.006pubmed: 25962580google scholar: lookup
  191. Herteman N, Vargas A, Lavoie JP. Characterization of Circulating Low-Density Neutrophils Intrinsic Properties in Healthy and Asthmatic Horses.. Sci Rep 2017 Aug 10;7(1):7743.
    doi: 10.1038/s41598-017-08089-5pmc: PMC5552858pubmed: 28798364google scholar: lookup
  192. Christmann U, Hite RD, Witonsky SG, Elvinger F, Werre SR, Thatcher CD, Tan RH, Buechner-Maxwell VA. Influence of age on surfactant isolated from healthy horses maintained on pasture.. J Vet Intern Med 2009 May-Jun;23(3):612-8.
  193. Gerber V, Robinson NE, Luethi S, Marti E, Wampfler B, Straub R. Airway inflammation and mucus in two age groups of asymptomatic well-performing sport horses.. Equine Vet J 2003 Jul;35(5):491-5.
    doi: 10.2746/042516403775600424pubmed: 12875328google scholar: lookup
  194. Christmann U, Hite RD, Tan RH, Thatcher CD, Witonsky SG, Werre SR, Buechner-Maxwell VA. Surfactant alterations in horses with recurrent airway obstruction at various clinical stages.. Am J Vet Res 2010 Apr;71(4):468-75.
    doi: 10.2460/ajvr.71.4.468pubmed: 20367056google scholar: lookup
  195. Christmann U, Welles EG, Waldridge BM, Schumacher J, Grier BL, Hite RD. Abnormalities in lung surfactant in horses clinically affected with recurrent airway obstruction (RAO).. J Vet Intern Med 2008 Nov-Dec;22(6):1452-5.
  196. Andersson S, Kheiter A, Merritt TA. Oxidative inactivation of surfactants.. Lung 1999;177(3):179-89.
    doi: 10.1007/PL00007639pubmed: 10192765google scholar: lookup
  197. Aguilera-Tejero E, Estepa JC, López I, Mayer-Valor R, Rodríguez M. Arterial blood gases and acid-base balance in healthy young and aged horses.. Equine Vet J 1998 Jul;30(4):352-4.
  198. Horohov DW, Adams AA, Chambers TM. Immunosenescence of the equine immune system.. J Comp Pathol 2010 Jan;142 Suppl 1:S78-84.
    doi: 10.1016/j.jcpa.2009.10.007pubmed: 19897209google scholar: lookup
  199. Lavoie-Lamoureux A, Beauchamp G, Quessy S, Martin JG, Lavoie JP. Systemic inflammation and priming of peripheral blood leukocytes persist during clinical remission in horses with heaves.. Vet Immunol Immunopathol 2012 Mar 15;146(1):35-45.
    doi: 10.1016/j.vetimm.2012.01.020pubmed: 22342218google scholar: lookup
  200. Katepalli MP, Adams AA, Lear TL, Horohov DW. The effect of age and telomere length on immune function in the horse.. Dev Comp Immunol 2008;32(12):1409-15.
    doi: 10.1016/j.dci.2008.06.007pubmed: 18619486google scholar: lookup
  201. Wnuk M, Bugno-Poniewierska M, Lewinska A, Oklejewicz B, Zabek T, Bartosz G, Słota E. Age-related changes in genomic stability of horses.. Mech Ageing Dev 2011 May;132(5):257-68.
    doi: 10.1016/j.mad.2011.04.009pubmed: 21557962google scholar: lookup
  202. Marlin DJ, Johnson L, Kingston DA, Smith NC, Deaton CM, Mann S, Heaton P, Van Vugt F, Saunders K, Kydd J, Harris PA. Application of the comet assay for investigation of oxidative DNA damage in equine peripheral blood mononuclear cells.. J Nutr 2004 Aug;134(8 Suppl):2133S-2140S.
    pubmed: 15284420doi: 10.1093/jn/134.8.2133sgoogle scholar: lookup
  203. Williams CA, Gordon ME, Betros CL, McKeever KH. Apoptosis and antioxidant status are influenced by age and exercise training in horses.. J Anim Sci 2008 Mar;86(3):576-83.
    doi: 10.2527/jas.2007-0585pubmed: 18156356google scholar: lookup
  204. Deaton CM. The role of oxidative stress in an equine model of human asthma.. Redox Rep 2006;11(2):46-52.
    doi: 10.1179/135100006X101057pubmed: 16686994google scholar: lookup
  205. Deaton CM, Marlin DJ, Smith NC, Harris PA, Roberts CA, Schroter RC, Kelly FJ. Pulmonary epithelial lining fluid and plasma ascorbic acid concentrations in horses affected by recurrent airway obstruction.. Am J Vet Res 2004 Jan;65(1):80-7.
    doi: 10.2460/ajvr.2004.65.80pubmed: 14719707google scholar: lookup
  206. Kirschvink N, Bureau F, Art T, Lekeux P. Bronchoconstrictive properties of inhaled 8-epi-PGF2alpha in healthy and heaves-susceptible horses.. Vet Res 2001 Sep-Oct;32(5):397-407.
    doi: 10.1051/vetres:2001132pubmed: 11592610google scholar: lookup
  207. Art T, Kirschvink N, Smith N, Lekeux P. Indices of oxidative stress in blood and pulmonary epithelium lining fluid in horses suffering from recurrent airway obstruction.. Equine Vet J 1999 Sep;31(5):397-401.
  208. Niedzwiedz A, Jaworski Z. Oxidant-antioxidant status in the blood of horses with symptomatic recurrent airway obstruction (RAO).. J Vet Intern Med 2014 Nov-Dec;28(6):1845-52.
    doi: 10.1111/jvim.12452pmc: PMC4895620pubmed: 25231643google scholar: lookup
  209. Deaton CM, Marlin DJ, Smith NC, Smith KC, Newton RJ, Gower SM, Cade SM, Roberts CA, Harris PA, Schroter RC, Kelly FJ. Breath condensate hydrogen peroxide correlates with both airway cytology and epithelial lining fluid ascorbic acid concentration in the horse.. Free Radic Res 2004 Feb;38(2):201-8.
    doi: 10.1080/10715160310001638047pubmed: 15104214google scholar: lookup
  210. Deaton CM, Marlin DJ, Smith NC, Harris PA, Dagleish MP, Schroter RC, Kelly FJ. Effect of acute airway inflammation on the pulmonary antioxidant status.. Exp Lung Res 2005 Sep;31(7):653-70.
    doi: 10.1080/01902140591007092pubmed: 16203621google scholar: lookup
  211. Deaton CM, Marlin DJ, Smith NC, Harris PA, Schroter RC, Kelly FJ. Antioxidant supplementation in horses affected by recurrent airway obstruction.. J Nutr 2004 Aug;134(8 Suppl):2065S-2067S.
    pubmed: 15284404doi: 10.1093/jn/134.8.2065sgoogle scholar: lookup
  212. Kirschvink N, Fiévez L, Bougnet V, Art T, Degand G, Smith N, Marlin D, Roberts C, Harris P, Lekeux P. Effect of nutritional antioxidant supplementation on systemic and pulmonary antioxidant status, airway inflammation and lung function in heaves-affected horses.. Equine Vet J 2002 Nov;34(7):705-12.
    doi: 10.2746/042516402776250298pubmed: 12455842google scholar: lookup
  213. Nogradi N, Couetil LL, Messick J, Stochelski MA, Burgess JR. Omega-3 fatty acid supplementation provides an additional benefit to a low-dust diet in the management of horses with chronic lower airway inflammatory disease.. J Vet Intern Med 2015 Jan;29(1):299-306.
    doi: 10.1111/jvim.12488pmc: PMC4858086pubmed: 25307169google scholar: lookup
  214. Williams CA. The effect of oxidative stress during exercise in the horse.. J Anim Sci 2016 Oct;94(10):4067-4075.
    doi: 10.2527/jas.2015-9988pubmed: 27898872google scholar: lookup
  215. Zuo L, Pannell BK, Liu Z. Characterization and redox mechanism of asthma in the elderly.. Oncotarget 2016 May 3;7(18):25010-21.
    doi: 10.18632/oncotarget.7075pmc: PMC5041886pubmed: 26843624google scholar: lookup
  216. Connolly MJ, Crowley JJ, Charan NB, Nielson CP, Vestal RE. Reduced subjective awareness of bronchoconstriction provoked by methacholine in elderly asthmatic and normal subjects as measured on a simple awareness scale.. Thorax 1992 Jun;47(6):410-3.
    doi: 10.1136/thx.47.6.410pmc: PMC463802pubmed: 1496497google scholar: lookup
  217. Braman SS. Asthma in the Elderly.. Clin Geriatr Med 2017 Nov;33(4):523-537.
    doi: 10.1016/j.cger.2017.06.005pubmed: 28991648google scholar: lookup

Citations

This article has been cited 31 times.
  1. Shaikh SB, Goracci C, Tjitropranoto A, Rahman I. Impact of aging on immune function in the pathogenesis of pulmonary diseases: potential for therapeutic targets. Expert Rev Respir Med 2023 May;17(5):351-364.
    doi: 10.1080/17476348.2023.2205127pubmed: 37078192google scholar: lookup
  2. DeNotta S, McFarlane D. Immunosenescence and inflammaging in the aged horse. Immun Ageing 2023 Jan 6;20(1):2.
    doi: 10.1186/s12979-022-00325-5pubmed: 36609345google scholar: lookup
  3. Cisneros B, García-Aguirre I, Unzueta J, Arrieta-Cruz I, González-Morales O, Domínguez-Larrieta JM, Tamez-González A, Leyva-Gómez G, Magaña JJ. Immune system modulation in aging: Molecular mechanisms and therapeutic targets. Front Immunol 2022;13:1059173.
    doi: 10.3389/fimmu.2022.1059173pubmed: 36591275google scholar: lookup
  4. Stucchi L, Lo Feudo CM, Stancari G, Conturba B, Ferrucci F. Effect of the Administration of a Nutraceutical Supplement in Racehorses with Lower Airway Inflammation. Animals (Basel) 2022 Sep 19;12(18).
    doi: 10.3390/ani12182479pubmed: 36139339google scholar: lookup
  5. Hamilton JAG, Henry CJ. Aging and immunotherapies: New horizons for the golden ages. Aging Cancer 2020 Dec;1(1-4):30-44.
    doi: 10.1002/aac2.12014pubmed: 35874875google scholar: lookup
  6. Simões J, Batista M, Tilley P. The Immune Mechanisms of Severe Equine Asthma-Current Understanding and What Is Missing. Animals (Basel) 2022 Mar 16;12(6).
    doi: 10.3390/ani12060744pubmed: 35327141google scholar: lookup
  7. Estrada McDermott J, Pezzanite L, Goodrich L, Santangelo K, Chow L, Dow S, Wheat W. Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses. Animals (Basel) 2021 Nov 13;11(11).
    doi: 10.3390/ani11113247pubmed: 34827979google scholar: lookup
  8. Yang Y, Yuan L, Yang M, Du X, Qin L, Wang L, Zhou K, Wu M, He R, Feng J, Xiang Y, Qu X, Liu H, Qin X, Liu C. Aberrant Methylation of Aging-Related Genes in Asthma. Front Mol Biosci 2021;8:655285.
    doi: 10.3389/fmolb.2021.655285pubmed: 34136532google scholar: lookup
  9. Li YS, Kawasaki Y, Watanabe S, Ootsuyama Y, Kasai H, Kawai K. Diurnal and day-to-day variation of urinary oxidative stress marker 8-hydroxy-2'-deoxyguanosine. J Clin Biochem Nutr 2021 Jan;68(1):18-22.
    doi: 10.3164/jcbn.19-105pubmed: 33536708google scholar: lookup
  10. Li Z, Zhang Z, Ren Y, Wang Y, Fang J, Yue H, Ma S, Guan F. Aging and age-related diseases: from mechanisms to therapeutic strategies. Biogerontology 2021 Apr;22(2):165-187.
    doi: 10.1007/s10522-021-09910-5pubmed: 33502634google scholar: lookup
  11. Battelli MG, Bortolotti M, Bolognesi A, Polito L. Pro-Aging Effects of Xanthine Oxidoreductase Products. Antioxidants (Basel) 2020 Sep 8;9(9).
    doi: 10.3390/antiox9090839pubmed: 32911634google scholar: lookup
  12. Bazzano M, Laghi L, Zhu C, Magi GE, Tesei B, Laus F. Respiratory metabolites in bronchoalveolar lavage fluid (BALF) and exhaled breath condensate (EBC) can differentiate horses affected by severe equine asthma from healthy horses. BMC Vet Res 2020 Jul 8;16(1):233.
    doi: 10.1186/s12917-020-02446-9pubmed: 32641035google scholar: lookup
  13. Keshavarz-Bahaghighat H, Darwesh AM, Sosnowski DK, Seubert JM. Mitochondrial Dysfunction and Inflammaging in Heart Failure: Novel Roles of CYP-Derived Epoxylipids. Cells 2020 Jun 27;9(7).
    doi: 10.3390/cells9071565pubmed: 32604981google scholar: lookup
  14. Shim HJ, Park SY, Kwon HS, Song WJ, Kim TB, Moon KA, Choi JP, Kim SJ, Cho YS. Oxidative Stress Modulates the Expression Pattern of Peroxiredoxin-6 in Peripheral Blood Mononuclear Cells of Asthmatic Patients and Bronchial Epithelial Cells. Allergy Asthma Immunol Res 2020 May;12(3):523-536.
    doi: 10.4168/aair.2020.12.3.523pubmed: 32141264google scholar: lookup
  15. Wang ZN, Su RN, Yang BY, Yang KX, Yang LF, Yan Y, Chen ZG. Potential Role of Cellular Senescence in Asthma. Front Cell Dev Biol 2020;8:59.
    doi: 10.3389/fcell.2020.00059pubmed: 32117985google scholar: lookup
  16. Estébanez B, Rodriguez AL, Visavadiya NP, Whitehurst M, Cuevas MJ, González-Gallego J, Huang CJ. Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects. Antioxidants (Basel) 2020 Jan 27;9(2).
    doi: 10.3390/antiox9020110pubmed: 32012711google scholar: lookup
  17. Pan Y, Li W, Feng Y, Xu J, Cao H. Edaravone attenuates experimental asthma in mice through induction of HO-1 and the Keap1/Nrf2 pathway. Exp Ther Med 2020 Feb;19(2):1407-1416.
    doi: 10.3892/etm.2019.8351pubmed: 32010316google scholar: lookup
  18. Jung TY, Lee AY, Song JH, Lee MY, Lim JO, Lee SJ, Ko JW, Shin NR, Kim JC, Shin IS, Kim JS. Scrophularia koraiensis Nakai Attenuates Allergic Airway Inflammation via Suppression of NF-κB and Enhancement of Nrf2/HO-1 Signaling. Antioxidants (Basel) 2020 Jan 24;9(2).
    doi: 10.3390/antiox9020099pubmed: 31991647google scholar: lookup
  19. Guo D, Shen Y, Li W, Li Q, Miao Y, Zhong Y. Upregulation of flavin-containing monooxygenase 3 mimics calorie restriction to retard liver aging by inducing autophagy. Aging (Albany NY) 2020 Jan 11;12(1):931-944.
    doi: 10.18632/aging.102666pubmed: 31927537google scholar: lookup
  20. Raudsepp T, Finno CJ, Bellone RR, Petersen JL. Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era. Anim Genet 2019 Dec;50(6):569-597.
    doi: 10.1111/age.12857pubmed: 31568563google scholar: lookup
  21. Yancey KL, Lowery AS, Chandra RK, Chowdhury NI, Turner JH. Advanced age adversely affects chronic rhinosinusitis surgical outcomes. Int Forum Allergy Rhinol 2019 Oct;9(10):1125-1134.
    doi: 10.1002/alr.22404pubmed: 31454179google scholar: lookup
  22. Kim BK, Lee HS, Sohn KH, Lee SY, Cho SH, Park HW. Different Biological Pathways Are Up-regulated in the Elderly With Asthma: Sputum Transcriptomic Analysis. Allergy Asthma Immunol Res 2019 Jan;11(1):104-115.
    doi: 10.4168/aair.2019.11.1.104pubmed: 30479081google scholar: lookup
  23. Bond S, Léguillette R, Richard EA, Couetil L, Lavoie JP, Martin JG, Pirie RS. Equine asthma: Integrative biologic relevance of a recently proposed nomenclature. J Vet Intern Med 2018 Nov;32(6):2088-2098.
    doi: 10.1111/jvim.15302pubmed: 30294851google scholar: lookup
  24. Jia T, Yuan C, Hu S, Xie L, Liu A, Qin F, He Y, Zhang C. MKRN1 as a prioritized drug target for postpartum depression: evidence from druggable proteome profiling and multi-layer validation. Transl Psychiatry 2026 Feb 10;16(1):75.
    doi: 10.1038/s41398-026-03886-xpubmed: 41667429google scholar: lookup
  25. Conley HE, Davis KU, Adler KB, Lavoie JP, Sheats MK. MARCKS protein is a potential target in a naturally occurring equine model of neutrophilic asthma. Respir Res 2025 Apr 2;26(1):126.
    doi: 10.1186/s12931-025-03194-wpubmed: 40176021google scholar: lookup
  26. Chen R, Zou J, Chen J, Wang L, Kang R, Tang D. Immune aging and infectious diseases. Chin Med J (Engl) 2024 Dec 20;137(24):3010-3049.
    doi: 10.1097/CM9.0000000000003410pubmed: 39679477google scholar: lookup
  27. Cocco R, Sechi S, Rizzo M, Arrigo F, Giannetto C, Piccione G, Arfuso F. Assessing the Peripheral Levels of the Neurotransmitters Noradrenaline, Dopamine and Serotonin and the Oxidant/Antioxidant Equilibrium in Circus Horses. Animals (Basel) 2024 Aug 14;14(16).
    doi: 10.3390/ani14162354pubmed: 39199887google scholar: lookup
  28. Liu X, Li B, Liu S, Zong J, Zheng X. To investigate the function of age-related genes in different subtypes of asthma based on bioinformatics analysis. Heliyon 2024 Aug 15;10(15):e34766.
    doi: 10.1016/j.heliyon.2024.e34766pubmed: 39144919google scholar: lookup
  29. Galeana-Cadena D, Gómez-García IA, Lopez-Salinas KG, Irineo-Moreno V, Jiménez-Juárez F, Tapia-García AR, Boyzo-Cortes CA, Matías-Martínez MB, Jiménez-Alvarez L, Zúñiga J, Camarena A. Winds of change a tale of: asthma and microbiome. Front Microbiol 2023;14:1295215.
    doi: 10.3389/fmicb.2023.1295215pubmed: 38146448google scholar: lookup
  30. Kim HJ, Kim H, Lee JH, Hwangbo C. Toll-like receptor 4 (TLR4): new insight immune and aging. Immun Ageing 2023 Nov 24;20(1):67.
    doi: 10.1186/s12979-023-00383-3pubmed: 38001481google scholar: lookup
  31. Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, Fineman JR, Wang T, Black SM. Complex interplay between autophagy and oxidative stress in the development of pulmonary disease. Redox Biol 2020 Sep;36:101679.
    doi: 10.1016/j.redox.2020.101679pubmed: 32818797google scholar: lookup