The lamellar wedge.
Abstract: In horses with chronic laminitis, an abnormal horn structure called the lamellar wedge develops within the lamellar region of the foot. This pathologic structure adversely affects normal foot function, and influences return to previous performance levels. Understanding the pathologic process that leads to the development of this structure is essential for correct supportive foot management of the horse with chronic laminitis. The ability to prevent or reduce the formation of the lamellar wedge may eventually lead to better outcomes in cases of laminitis.
Copyright 2010 Elsevier Inc. All rights reserved.
Publication Date: 2010-04-13 PubMed ID: 20381746DOI: 10.1016/j.cveq.2010.01.004Google Scholar: Lookup
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Summary
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This research article discusses how an abnormal horn growth called the lamellar wedge, appearing in horses with chronic laminitis, negatively impacts foot function and performance levels in affected horses. Furthermore, it underscores the need to understand the the causative processes to improve supportive foot care for these horses and possibly better laminitis outcomes.
Understanding Laminitis and the Lamellar Wedge
- The study is focused on chronic laminitis, a serious and common foot disease affecting horses which results in inflammation of the laminae, tissues that connect the hoof to the underlying bone.
- In cases of chronic laminitis, an abnormal horn structure known as the laminar wedge appears in the lamellar region of the horse’s foot. This formation affects how a horse uses its foot and subsequently impacts the performance ability of the affected animal significantly.
Importance of Studying Pathological Processes
- The main issue examined in the article is the process of formation of the lamella wedge and how it evolves. The authors reinforce the necessity of understanding the mechanism behind the pathological process, as it allows for better foot management strategies to be developed.
- Without awareness of the biological process involved in the formation of these abnormal structures, appropriate preventative steps and direct interventions may be hard to determine, leading to poor outcomes.
Implication of Reducing Lamellar Wedge Formation
- The researchers suggest that by gaining knowledge on the formation of the lamellar wedge and the associated pathophysiological processes, new strategies can be developed to prevent or reduce its formation.
- As a result, it could lead to better outcomes for horses suffering from laminitis. This improvement may be reflected in less discomfort and loss of foot function, enhanced recovery rates, and increased chances of return to previous performance levels.
Cite This Article
APA
Collins SN, van Eps AW, Pollitt CC, Kuwano A.
(2010).
The lamellar wedge.
Vet Clin North Am Equine Pract, 26(1), 179-195.
https://doi.org/10.1016/j.cveq.2010.01.004 Publication
Researcher Affiliations
- Orthopaedic Research Group, Centre for Equine Studies, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, CB8 7UU, UK. SIMON.COLLINS@aht.org.uk
MeSH Terms
- Animals
- Biomechanical Phenomena
- Foot Diseases / complications
- Foot Diseases / pathology
- Foot Diseases / veterinary
- Hoof and Claw / microbiology
- Hoof and Claw / pathology
- Horse Diseases / pathology
- Horses
- Inflammation / complications
- Inflammation / pathology
- Inflammation / veterinary
- Onychomycosis / etiology
- Onychomycosis / veterinary
Citations
This article has been cited 9 times.- Castro-Mesa AF, Resende Faleiros R, Martínez-Aranzales JR. Transmural Ultrasonography in the Evaluation of Horse Hoof Internal Structures: Comparative Quantitative Findings-Part 2.. Animals (Basel) 2023 Jul 11;13(14).
- Akinniyi OO, Sackey AKB, Ochube GE, Mshelia PW, Musa FA, Elijah MO, Jolayemi KO. Occurrence of equine metabolic syndrome, clinical manifestations, and associated risk factors in Nigeria.. J Equine Sci 2023 Jun;34(2):29-35.
- Sundberg JP, Galantino-Homer H, Fairfield H, Ward-Bailey PF, Harris BS, Berry M, Pratt CH, Gott NE, Bechtold LS, Kaplan PR, Durbin-Johnson BP, Rocke DM, Rice RH. Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development.. PLoS One 2022;17(11):e0277284.
- Gehlen H, Schwarz B, Bartmann C, Gernhardt J, Stöckle SD. Pituitary Pars Intermedia Dysfunction and Metabolic Syndrome in Donkeys.. Animals (Basel) 2020 Dec 8;10(12).
- Cassimeris L, Engiles JB, Galantino-Homer H. Interleukin-17A pathway target genes are upregulated in Equus caballus supporting limb laminitis.. PLoS One 2020;15(12):e0232920.
- Armstrong C, Cassimeris L, Da Silva Santos C, Micoogullari Y, Wagner B, Babasyan S, Brooks S, Galantino-Homer H. The expression of equine keratins K42 and K124 is restricted to the hoof epidermal lamellae of Equus caballus.. PLoS One 2019;14(9):e0219234.
- Pollard D, Wylie CE, Verheyen KLP, Newton JR. Identification of modifiable factors associated with owner-reported equine laminitis in Britain using a web-based cohort study approach.. BMC Vet Res 2019 Feb 12;15(1):59.
- Cassimeris L, Engiles JB, Galantino-Homer H. Detection of endoplasmic reticulum stress and the unfolded protein response in naturally-occurring endocrinopathic equine laminitis.. BMC Vet Res 2019 Jan 10;15(1):24.
- Linardi RL, Megee SO, Mainardi SR, Senoo M, Galantino-Homer HL. Expression and localization of epithelial stem cell and differentiation markers in equine skin, eye and hoof.. Vet Dermatol 2015 Aug;26(4):213-e47.
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