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Home / Equine Research Bank / Animals (Basel) / The Usefulness of Mesenchymal Stem Cells beyond the Musculos...
Animals : an open access journal from MDPI2021; 11(4); doi: 10.3390/ani11040931

The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses.

Abstract: The differentiation ability of mesenchymal stem cells (MSCs) initially raised interest for treating musculoskeletal injuries in horses, but MSC paracrine activity has widened their scope for inflammatory and immune-mediated pathologies in both equine and human medicine. Furthermore, the similar etiopathogenesis of some diseases in both species has advanced the concept of "One Medicine, One Health". This article reviews the current knowledge on the use of MSCs for equine pathologies beyond the locomotor system, highlighting the value of the horse as translational model. Ophthalmologic and reproductive disorders are among the most studied for MSC application. Equine asthma, equine metabolic syndrome, and endotoxemia have been less explored but offer an interesting scenario for human translation. The use of MSCs in wounds also provides a potential model for humans because of the healing particularities in both species. High-burden equine-specific pathologies such as laminitis have been suggested to benefit from MSC-therapy, and MSC application in challenging disorders such as neurologic conditions has been proposed. The available data are preliminary, however, and require further development to translate results into the clinic. Nevertheless, current evidence indicates a significant potential of equine MSCs to enlarge their range of application, with particular interest in pathologies analogous to human conditions.
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Publication Date: 2021-03-25 PubMed ID: 33805967PubMed Central: PMC8064371DOI: 10.3390/ani11040931Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the potential use of mesenchymal stem cells (MSCs) in treating disorders beyond the musculoskeletal system in horses, highlighting the interest in applying the treatments to similar human conditions.

Understanding Mesenchymal Stem Cells (MSCs)

  • Mesenchymal stem cells are multipotent stromal cells that can differentiate into a variety of cell types, including: osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells).
  • Initially, interest in MSCs was tied to the treatment of musculoskeletal injuries in horses, thanks to their differentiation ability.
  • However, researchers soon realized that the MSCs had a wider scope than initially thought, showing potential in treating inflammatory and immune-mediated disorders in not just horses but also in human medicine.

One Medicine, One Health Concept

  • The concept of “One Medicine, One Health” is brought up; this refers to a growing international movement that recognizes that human health and animal health are interconnected and that these health and disease issues are coupled with the health of the environment.
  • Given the similar etiopathogenesis of some diseases amongst horses and humans, this concept underscores the value of using the horse as a translational model for testing treatments intended for human use.

MSCs in Treating Horse Pathologies

  • The article explores the current knowledge on MSCs’ potential in treating horse pathologies beyond the locomotor system. It calls out areas such as ophthalmologic and reproductive disorders as being the most studied for MSC application.
  • Equine health issues like asthma, metabolic syndrome, and endotoxemia have garnered less research but show promise for human application.
  • Using MSCs to assist in wound healing could also translate well to human medicine due to similar healing particularities between the two species.
  • While initial data is considered preliminary and needs additional development for clinical application, it demonstrates significant potential for using equine MSCs in a broader range of applications, particularly for disorders similar to humans.

Cite This Article

APA
Cequier A, Sanz C, Rodellar C, Barrachina L. (2021). The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses. Animals (Basel), 11(4). https://doi.org/10.3390/ani11040931

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 4

Researcher Affiliations

Cequier, Alina
  • Laboratorio de Genética Bioquímica LAGENBIO-Instituto de Investigación Sanitaria de Aragón (IIS)-Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, Spain.
Sanz, Carmen
  • Servicio de Cirugía y Medicina Equina, Hospital Veterinario, Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, Spain.
Rodellar, Clementina
  • Laboratorio de Genética Bioquímica LAGENBIO-Instituto de Investigación Sanitaria de Aragón (IIS)-Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, Spain.
Barrachina, Laura
  • Laboratorio de Genética Bioquímica LAGENBIO-Instituto de Investigación Sanitaria de Aragón (IIS)-Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, Spain.
  • Servicio de Cirugía y Medicina Equina, Hospital Veterinario, Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, Spain.

Grant Funding

  • AGL2017-84411-P / Ministerio de Economía, Industria y Competitividad, Gobierno de España
  • Pre-doctoral fellowship / Gobierno de Aragón

Conflict of Interest Statement

The authors declare no conflict of interest.

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