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Home / Equine Research Bank / PLoS One / Vascular Dysfunction in Horses with Endocrinopathic Laminiti...
PloS one2016; 11(9); e0163815; doi: 10.1371/journal.pone.0163815

Vascular Dysfunction in Horses with Endocrinopathic Laminitis.

Abstract: Endocrinopathic laminitis (EL) is a vascular condition of the equine hoof resulting in severe lameness with both welfare and economic implications. EL occurs in association with equine metabolic syndrome and equine Cushing's disease. Vascular dysfunction, most commonly due to endothelial dysfunction, is associated with cardiovascular risk in people with metabolic syndrome and Cushing's syndrome. We tested the hypothesis that horses with EL have vascular, specifically endothelial, dysfunction. Healthy horses (n = 6) and horses with EL (n = 6) destined for euthanasia were recruited. We studied vessels from the hooves (laminar artery, laminar vein) and the facial skin (facial skin arteries) by small vessel wire myography. The response to vasoconstrictors phenylephrine (10-9-10-5M) and 5-hydroxytryptamine (5HT; 10-9-10-5M) and the vasodilator acetylcholine (10-9-10-5M) was determined. In comparison with healthy controls, acetylcholine-induced relaxation was dramatically reduced in all intact vessels from horses with EL (% relaxation of healthy laminar arteries 323.5 ± 94.1% v EL 90.8 ± 4.4%, P = 0.01, laminar veins 129.4 ± 14.8% v EL 71.2 ± 4.1%, P = 0.005 and facial skin arteries 182.0 ± 40.7% v EL 91.4 ± 4.5%, P = 0.01). In addition, contractile responses to phenylephrine and 5HT were increased in intact laminar veins from horses with EL compared with healthy horses; these differences were endothelium-independent. Sensitivity to phenylephrine was reduced in intact laminar arteries (P = 0.006) and veins (P = 0.009) from horses with EL. Horses with EL exhibit significant vascular dysfunction in laminar vessels and in facial skin arteries. The systemic nature of the abnormalities suggest this dysfunction is associated with the underlying endocrinopathy and not local changes to the hoof.
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Publication Date: 2016-09-29 PubMed ID: 27684374PubMed Central: PMC5042533DOI: 10.1371/journal.pone.0163815Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about a study conducted to test the hypothesis that horses suffering from Endocrinopathic Laminitis (EL) exhibit vascular dysfunction, particularly in the endothelium. The findings indicate that EL horses indeed show substantial vascular dysfunction.

Introduction

  • The research paper focuses on examining vascular dysfunction in horses suffering from Endocrinopathic Laminitis (EL), a vascular condition causing severe lameness.
  • This condition is usually linked with equine metabolic syndrome and equine Cushing’s disease. Notably, vascular dysfunction has commonly been associated with cardiovascular risk in humans suffering from metabolic syndrome and Cushing’s syndrome.

Study Approach

  • For this study, six healthy horses and six horses suffering from EL and due for euthanasia were used as subjects.
  • The researchers studied vessels from the horses’ hooves and facial skin using a technique known as small vessel wire myography.
  • The response of the aforementioned vessels to vasoconstrictors phenylephrine and 5-hydroxytryptamine (5HT), as well as the vasodilator acetylcholine, was determined.

Findings

  • Compared to the healthy controls, the acetylcholine-induced relaxation was significantly reduced in all intact vessels from horses with EL.
  • In addition, the contractile responses to phenylephrine and 5HT were increased in intact laminar veins from horses suffering from EL, and these reactions were independent of the endothelium.
  • The sensitivity to phenylephrine was recorded to be reduced in intact laminar arteries and veins from EL horses.

Conclusion

  • The study concludes that horses with EL exhibit significant vascular dysfunction in laminar vessels and in facial skin arteries.
  • The systemic nature of these abnormalities suggests that this dysfunction is linked with the underlying endocrine disorder rather than local changes to the hoof.

Cite This Article

APA
Morgan RA, Keen JA, Walker BR, Hadoke PW. (2016). Vascular Dysfunction in Horses with Endocrinopathic Laminitis. PLoS One, 11(9), e0163815. https://doi.org/10.1371/journal.pone.0163815

Publication

PloS one
ISSN: 1932-6203
NlmUniqueID: 101285081
Country: United States
Language: English
Volume: 11
Issue: 9
Pages: e0163815
PII: e0163815

Researcher Affiliations

Morgan, Ruth A
  • University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
  • Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom.
Keen, John A
  • Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom.
Walker, Brian R
  • University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Hadoke, Patrick W F
  • University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.

Conflict of Interest Statement

Author Ruth Morgan’s Ph.D. was partially funded by Zoetis Animal Health. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The other authors have no competing interests.

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Citations

This article has been cited 10 times.
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