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Veterinary surgery : VS.

Periodical
General Surgery
Veterinary Medicine
Publisher:
Lippincott.. Malden, MA : John Wiley & Sons
Frequency: Eight issues a year,
Country: United States
Language: English
Author(s):
American College of Veterinary Surgeons., European College of Veterinary Surgeons.
Start Year:1978 -
ISSN:
0161-3499 (Print)
1532-950X (Electronic)
0161-3499 (Linking)
Impact Factor
1.8
2022
NLM ID:8113214
(OCoLC):03905443
(DNLM):V06115000(s)
Coden:VESUD6
Classification:W1 VE938C
Arthroscopic anatomy of the equine temporomandibular joint.
Veterinary surgery : VS    November 13, 2001   Volume 30, Issue 6 564-571 doi: 10.1053/jvet.2001.28438
May KA, Moll HD, Howard RD, Pleasant RS, Gregg JM.To develop an arthroscopic approach to, and describe the arthroscopic anatomy of, the equine temporomandibular joint (TMJ). Methods: Cadaveric study, after which the technique was tested in horses. Methods: Ten cadaveric equine heads and 5 normal horses (age, 5-13 years; weight, 425-545 kg). Methods: Specimens or horses were positioned in right lateral recumbency. After fluid distention of the TMJ, arthroscopic portals were made in the dorsal compartment over the most prominent portion of the joint outpouching (caudodorsal approach) and in rostral and intermediate locations. The joint was expl...
Synovial fluid cytokines and eicosanoids as markers of joint disease in horses.
Veterinary surgery : VS    November 13, 2001   Volume 30, Issue 6 528-538 doi: 10.1053/jvet.2001.28430
Bertone AL, Palmer JL, Jones J.To evaluate the value of various synovial fluid cytokines and eicosanoids to diagnose joint disease or categories of joint disease. Methods: Prospective acquisition of clinicopathologic data. Methods: Client-owned or donated horses: 50 joints with no evidence of disease; 28 joints with acute disease; 32 joints with chronic disease; 9 joints with cartilage damage and no other signs of joint disease. Methods: Concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), prostaglandin E(2) (PGE(2)), thromboxane B(2) (TXB(2)), prostaglandin F1-alpha...
Effects of superior check desmotomy on flexor tendon and suspensory ligament strain in equine cadaver limbs.
Veterinary surgery : VS    November 13, 2001   Volume 30, Issue 6 522-527 doi: 10.1053/jvet.2001.28433
Alexander GR, Gibson KT, Day RE, Robertson ID.To measure the effects of transection of the accessory ligament of the superficial digital flexor (SDF) muscle (superior check desmotomy) on flexor tendon and suspensory ligament (SL) strain in vitro. Methods: In vitro experimental biomechanical investigation. ANIMALS USED: Ten equine cadaver forelimbs. Methods: The effects of superior check desmotomy were determined using equine cadaver forelimbs secured in a servocontrolled hydraulic testing machine. Strain sensors were used to measure strain on the superficial and deep digital flexor tendons and SL, and a goniometer was used to measure join...
Laparoscopic closure of the renosplenic space in standing horses.
Veterinary surgery : VS    November 13, 2001   Volume 30, Issue 6 559-563 doi: 10.1053/jvet.2001.28436
Mariën T, Adriaenssen A, Hoeck FV, Segers L.To report a technique for laparoscopic ablation of the renosplenic space in standing horses. Methods: Development of a technique to perform laparoscopic renosplenic space ablation in standing horses. Methods: Five healthy horses, aged 3 to 13 years, weighing 380 to 520 kg. Methods: Horses were restrained in standing stocks and sedated with detomidine (0.01 mg/kg intravenously [IV]) and butorphanol (0.01 mg/kg IV). Portal sites in the left paralumbar fossa were infiltrated with 2% mepivacaine. A laparoscopic portal was placed between the 17th and the 18th ribs. Two instrument portals were locat...
Laparoscopic ovariectomy using sequential electrocoagulation and sharp transection of the equine mesovarium.
Veterinary surgery : VS    November 13, 2001   Volume 30, Issue 6 572-579 doi: 10.1053/jvet.2001.28435
Rodgerson DH, Belknap JK, Wilson DA.To describe in horses and ponies a laparoscopic ovariectomy technique facilitated by electrosurgical instrumentation. Methods: Elective ovariectomy was performed in 23 mares using laparoscopic electrosurgical instrumentation. Methods: Twenty-three mares (13 horses, 10 ponies), aged from 2 to 21 years and weighing 90 to 545 kg. Methods: Food was withheld for a minimum of 12 hours. Mares were sedated with detomidine hydrochloride (0.02 to 0.03 mg/kg) or xylazine hydrochloride (0.5 to 1.0 mg/kg). Excluding the pony mares, all other mares were restrained in stocks. Portal sites in the paralumbar f...
Podotrochlear bursa endoscopy in the horse: a cadaver study.
Veterinary surgery : VS    November 13, 2001   Volume 30, Issue 6 539-545 doi: 10.1053/jvet.2001.28424
Cruz AM, Pharr JW, Bailey JV, Barber SM, Fretz PB.To evaluate podotrochlear bursa (navicular bursa) endoscopy as a diagnostic technique in horses and to correlate observations to radiographic and pathologic findings. Methods: Descriptive study. Methods: Seventeen equine cadaver forelimbs. Methods: Five standard radiographic views of the navicular region and a bursographic study with lateromedial and caudal tangential radiographic views were taken of each forelimb. Radiographic scoring of the navicular bone (0, excellent; 1, good; 2, fair; 3, poor) was performed using a previously reported technique. Endoscopic examination was performed using ...
Esophagomyotomy and esophagopexy to create a diverticulum for treatment of chronic esophageal stricture in 2 horses.
Veterinary surgery : VS    September 14, 2001   Volume 30, Issue 5 449-453 doi: 10.1053/jvet.2001.25870
Lillich JD, Frees KE, Warrington K, Van Harreveld PD, Gaughan EM, Beard WL.We report use of esophagomyotomy and esophagopexy to create a diverticulum for relief of chronic type I esophageal stricture in 2 horses. After esophagomyotomy, the mucosa was dissected free from the muscularis for approximately 180 degrees around the myotomy. Then, the tunica muscularis of esophagus was sutured to the sternocephalicus muscle ventrally and the periesophageal tissues dorsally to create a diverticulum without disruption of the esophageal mucosa. Clinical signs of esophageal stricture were relieved, and the horses were fed normal diets without further esophageal obstruction.
The effect of recurrent laryngeal neurectomy in conjunction with laryngoplasty and unilateral ventriculocordectomy in thoroughbred racehorses.
Veterinary surgery : VS    September 14, 2001   Volume 30, Issue 5 417-421 doi: 10.1053/jvet.2001.25865
Davenport CL, Tulleners EP, Parente EJ.To investigate the effects of recurrent laryngeal neurectomy (RLN) in combination with laryngoplasty and ventriculocordectomy on the postoperative performance of Thoroughbred racehorses treated for grade III left laryngeal hemiparesis (LLH). Methods: Retrospective study. Methods: Fifty-five Thoroughbred racehorses. Methods: Medical records for Thoroughbred racehorses treated surgically by laryngoplasty and laser ventriculocordectomy with or without RLN between June 1993 and December 1996 were reviewed. Outcome was evaluated subjectively by assessment of performance obtained from telephone inte...
Polymerase chain reaction analysis of the surgical margins of equine sarcoids for bovine papilloma virus DNA.
Veterinary surgery : VS    September 14, 2001   Volume 30, Issue 5 460-467 doi: 10.1053/jvet.2001.25874
Martens A, De Moor A, Demeulemeester J, Peelman L.To examine apparently normal skin around equine sarcoids for evidence of bovine papilloma virus (BPV) DNA, and to relate this finding to the observed recurrence after surgery. Methods: Prospective study. Methods: Forty-one equine sarcoids from 19 horses. Methods: The tumors were surgically excised at a measured distance of 8, 12, or 16 mm. Samples from the tumor and of the entire surrounding skin were taken at 4, 8, 12, and 16 mm from the tumor border and analyzed for the presence of BPV DNA using polymerase chain reaction (PCR) amplification. The samples were grouped per examined sarcoid, and...
Laparoscopic surgical technique for repair of rectal and colonic tears in horses: an experimental study.
Veterinary surgery : VS    September 14, 2001   Volume 30, Issue 5 409-416 doi: 10.1053/jvet.2001.25864
Brugmans F, Deegen E.To determine the efficacy of laparoscopic surgical techniques for repair of rectal lacerations in horses. Methods: Experimental study. Methods: Thirty-two segments of equine bowel placed in an equine pelvitrainer, 8 equine cadavers, and 3 normal horses. Methods: In experiment 1, 3 laparoscopic intestinal-repair techniques were evaluated in an equine pelvitrainer: suturing with needle holders, with an automatic suture device, and stapling with a hernia stapler. In experiment 2, descending colon lacerations were sutured laparoscopically using needle holders in a pelvitrainer and in equine cadave...
Proximal interphalangeal joint arthrodesis in 34 horses using two parallel 5.5-mm cortical bone screws.
Veterinary surgery : VS    September 14, 2001   Volume 30, Issue 5 454-459 doi: 10.1053/jvet.2001.25873
MacLellan KN, Crawford WH, MacDonald DG.To report clinical experience with arthrodesis of the proximal interphalangeal joint in horses using two parallel 5.5-mm cortical bone screws placed in lag fashion. Methods: Retrospective, clinical study. Methods: Thirty-four horses, aged 1 to 19 years. Methods: Medical records for all horses admitted (1991-1997) for pastern arthrodesis using two 5.5-mm ASIF cortical bone screws, in parallel orientation, and placed in lag fashion by use of a combined aiming device to facilitate accuracy were reviewed. Signalment, lameness diagnosis, duration of lameness, limb(s) involved, and outcome were reco...
An in vitro biomechanical investigation of an intramedullary nailing technique for repair of third metacarpal and metatarsal fractures in neonates and foals.
Veterinary surgery : VS    September 14, 2001   Volume 30, Issue 5 422-431 doi: 10.1053/jvet.2001.25866
Fitch GL, Galuppo LD, Stover SM, Willits NH.To evaluate a dorsoproximal extra-articular approach for insertion of 8.25-mm, solid-titanium, intramedullary (IM) interlocking nails into ostectomized foal third metacarpal (MC3) and third metatarsal (MT3) bones; to compare the monotonic mechanical properties of IM nail constructs with paired intact bones; and to determine the effects of age, body weight, fore- or hindlimb, and left or right limb on the mechanical testing variables. Methods: Twenty bone pairs (10 MC3, 10 MT3) collected from 10 foals of various weights and ages. Methods: One bone from each pair was randomly selected to be oste...
Comparison of two methods for presurgical disinfection of the equine hoof.
Veterinary surgery : VS    July 10, 2001   Volume 30, Issue 4 366-373 doi: 10.1053/jvet.2001.24392
Hennig GE, Kraus BH, Fister R, King VL, Steckel RR, Kirker-Head CA.To determine for equine hooves the normal resident aerobic bacterial population and the efficacy of 2 methods of disinfection. Study Design-Measurement of total bacterial, gram-positive bacterial, and gram-negative bacterial surface populations from the frog, sole, and hoof wall after each step of 2 different preoperative surgical disinfection techniques. Methods: Six adult horses. Methods: Hoof wall, sole, and frog samples were collected for quantitative bacteriology before, during, and after 2 multistep antiseptic preparation techniques: Method A-6-minute scrub with povidone-iodine soap, fol...
Penile amputation and sheath ablation in the horse.
Veterinary surgery : VS    July 10, 2001   Volume 30, Issue 4 327-331 doi: 10.1053/jvet.2001.23354
Doles J, Williams JW, Yarbrough TB.To report a surgical technique for penile amputation and sheath ablation in horses. Study Design-Retrospective study. Animals or Sample Population-Twenty-five adult geldings of various breeds with conditions requiring penile amputation and sheath ablation. Methods: The medical records of horses that had penile amputation and sheath ablation were reviewed. Briefly, the technique involved en bloc resection of the skin and subcutaneous tissues of the inner and outer lamina of the prepuce and penile shaft. Resection of the penile shaft, proximal to diseased segments, and spatulation of the urethra...
A biomechanical comparison of headless tapered variable pitch and AO cortical bone screws for fixation of a simulated lateral condylar fracture in equine third metacarpal bones.
Veterinary surgery : VS    July 10, 2001   Volume 30, Issue 4 332-340 doi: 10.1053/jvet.2001.24386
Galuppo LD, Stover SM, Jensen DG, Willits NH.To compare drilling, tapping, and screw-insertion torque, force, and time for the 4.5-mm AO and 6.5-mm Acutrak Plus (AP) bone screws, and to compare the mechanical shear strength and stiffness of a simulated complete lateral condylar fracture of the equine third metacarpal bone (MC3) stabilized with either an AO or AP screw. Methods: In vitro biomechanical assessment of screw-insertion variables, and shear failure tests of a bone-screw-stabilized simulated lateral condylar fracture. Methods: Eight pairs of cadaveric equine MC3s Methods: Metacarpi were placed in a fixture and centered on a biax...
An in vitro biomechanical comparison of two interlocking-nail systems for fixation of ostectomized equine third metacarpal bones.
Veterinary surgery : VS    May 8, 2001   Volume 30, Issue 3 246-252 doi: 10.1053/jvet.2001.23346
Lopez MJ, Wilson DG, Trostle SS, Markel MD.To compare the mechanical properties of 2 interlocking-nail systems for fixation of ostectomized equine third metacarpi (MC3): (1) a standard interlocking nail with 2 parallel screws proximal and distal to a 1-cm ostectomy; and (2) a modified interlocking nail with 2 screws proximal and distal to a 1-cm ostectomy with the screws offset by 30 degrees. Methods: Twelve pairs of adult equine forelimbs intact from the midradius distally. Methods: Twelve pairs of equine MC3 were divided into 2 test groups (6 pairs each): torsion and caudocranial 4-point bending. Standard interlocking nails (6-hole, ...
Effect of venous strangulation obstruction on length of equine jejunum and relevance to small-intestinal resection.
Veterinary surgery : VS    May 8, 2001   Volume 30, Issue 3 218-222 doi: 10.1053/jvet.2001.23349
Freeman DE, Kilgallon EG.To determine if venous strangulation obstruction (VSO) of the distal half of the equine small intestine would increase length of that segment. Methods: Halothane-anesthetized horses were assigned randomly to 3 groups of 5 horses: Group 1 (controls)--the entire small intestine was measured and rubber-shod clamps were applied to mark each end of the most distal 50% of the small intestine; Group 2--same procedure, except that VSO was induced in the distal 50% of the small intestine for 180 minutes; and Group 3--same initial procedure, except that VSO was induced for 90 minutes and followed by rep...
Arthroscopic mosaic arthroplasty in the equine third carpal bone.
Veterinary surgery : VS    May 8, 2001   Volume 30, Issue 3 228-239 doi: 10.1053/jvet.2001.23348
Hurtig M, Pearce S, Warren S, Kalra M, Miniaci A.To investigate survival and function of autogenous heterotopic osteochondral grafts in a site where injuries are common. Methods: Three osteochondral grafts were harvested arthroscopically from the femoropatellar joint and transplanted to the third carpal bone (C(3)). Nine months later, histologic, histomorphometric, and biochemical comparisons were made between the transplanted grafts in C(3) and tissue adjacent to the recipient site, the opposing radial carpal bone (C(r)), the donor site in the femoropatellar joint, and the sham-operated contralateral C(3). Methods: One mixed-breed pony and ...
Arthrodesis of the equine proximal interphalangeal joint: a biomechanical comparison of three 4.5-mm and two 5.5-mm cortical screws.
Veterinary surgery : VS    May 8, 2001   Volume 30, Issue 3 287-294 doi: 10.1053/jvet.2001.23353
Watt BC, Edwards RB, Markel MD, McCabe R, Wilson DG.To compare the biomechanical characteristics and mode of failure of 2 parallel-screw techniques for proximal interphalangeal joint arthrodesis in horses. Methods: Randomized block design, blocking for horse (1-5), method of screw fixation (three 4.5-mm vs two 5.5-mm), side (left limb vs right limb), and end (front limb vs hind limb). Constructs were loaded to failure in 3-point bending in a dorsal-to-palmar (plantar) direction. Methods: Twenty limbs (10 limb pairs) from 5 equine cadavers. Methods: A combined aiming device was used to facilitate consistent screw placement. Three parallel 4.5-mm...
One percent sodium carboxymethylcellulose prevents experimentally induced abdominal adhesions in horses.
Veterinary surgery : VS    May 8, 2001   Volume 30, Issue 3 223-227 doi: 10.1053/jvet.2001.17849
Hay WP, Mueller PO, Harmon B, Amoroso L.To evaluate the efficacy of 1% sodium carboxymethylcellulose (SCMC) for prevention of experimentally induced abdominal adhesions in horses. Methods: Prospective, controlled, experimental study. Methods: Twelve healthy adult horses. Methods: The effect of 1% SCMC on adhesion formation was evaluated in 12 healthy horses by using an established model of serosal trauma to induce intraabdominal adhesions. After ventral median celiotomy, 2 separate areas of the jejunum were abraded, and three 2-0 chromic gut sutures were placed in each abraded area. Jejunal resection and end-to-end anastomosis was p...
Expression of transforming growth factor beta(1), beta(3), and basic fibroblast growth factor in full-thickness skin wounds of equine limbs and thorax.
Veterinary surgery : VS    May 8, 2001   Volume 30, Issue 3 269-277 doi: 10.1053/jvet.2001.23341
Theoret CL, Barber SM, Moyana TN, Gordon JR.To map the expression of transforming growth factor (TGF)-beta(1), TGF-beta(3), and basic fibroblast growth factor (bFGF) in full-thickness skin wounds of the horse. To determine whether their expression differs between limbs and thorax, to understand the pathogenesis of exuberant granulation tissue. Methods: Six wounds were created on one lateral metacarpal area and one midthoracic area of each horse. Sequential wound biopsies allowed comparison of the temporal expression of growth factors between limb and thoracic wounds. Methods: Four 2- to 4-year-old horses. Methods: Wounds were assessed g...
An in vitro biomechanical comparison of interlocking nail constructs and double plating for fixation of diaphyseal femur fractures in immature horses.
Veterinary surgery : VS    March 7, 2001   Volume 30, Issue 2 179-190 doi: 10.1053/jvet.2001.21396
Radcliffe RM, Lopez MJ, Turner TA, Watkins JP, Radcliffe CH, Markel MD.To compare the biomechanical properties of intact immature horse femurs and 3 stabilization methods in ostectomized femurs. Methods: Eighteen pairs of femurs from immature horses aged 1 to 15 months, and weighing 68 to 236 kg. Methods: Thirty-four immature horse femurs were randomly assigned to 1 of 5 test groups: 1) interlocking intramedullary nail (IIN) (n = 6); 2) IIN with a cranial dynamic compression plate (I/DCP) (n = 6); 3) 2 dynamic compression plates (2DCP) (n = 8); 4) intact femurs tested to failure in lateromedial (LM) bending (n = 6); and 5) intact femurs tested to failure in caudo...
The effect of implanting gentamicin-impregnated polymethylmethacrylate beads in the tarsocrural joint of the horse.
Veterinary surgery : VS    March 7, 2001   Volume 30, Issue 2 126-131 doi: 10.1053/jvet.2001.21392
Farnsworth KD, White NA, Robertson J.To determine the effect of intra-articular gentamicin-impregnated polymethylmethacrylate (PMMA) beads inserted in the equine tarsocrural joint on the synovial fluid, synovial lining, and cartilage, and to determine the peak and sustainable gentamicin concentrations in synovial fluid and plasma. Methods: Pharmacokinetic, cytologic, and histologic study of the effect of gentamicin-impregnated PMMA on normal equine tarsocrural joints. Methods: Five healthy adult horses. Methods: Gentamicin-impregnated PMMA bead strands (3 strands each of 40 beads, with each strand containing 100 mg gentamicin) we...
Clinical experiences with axial deviation of the aryepiglottic folds in 52 racehorses.
Veterinary surgery : VS    March 7, 2001   Volume 30, Issue 2 151-160 doi: 10.1053/jvet.2001.21389
King DS, Tulleners E, Martin BB, Parente EJ, Boston R.To describe the clinical findings in 52 racehorses with axial deviation of the aryepiglottic folds (ADAF) and to report outcome in 33 of these horses after either rest or transendoscopic laser excision of aryepiglottic fold tissue. Methods: Retrospective study. Methods: Racehorses admitted for high-speed treadmill (HST) evaluation of poor performance. Methods: Medical records and videotapes of resting and exercising videoendoscopic examinations were reviewed. Racing performance records and owner or trainer interviews, at least 1 year after HST examination, were used to compare results after ei...
Thoracoscopic-assisted diaphragmatic hernia repair using a thoracic rib resection.
Veterinary surgery : VS    March 7, 2001   Volume 30, Issue 2 175-178 doi: 10.1053/jvet.2001.21395
Malone ED, Farnsworth K, Lennox T, Tomlinson J, Sage AM.To describe the surgical treatment of a dorsal diaphragmatic hernia in an adult horse using thoracic rib resection aided by thoracoscopy and a flank incision. Methods: Case report. Methods: One client-owned horse. Results: A six-year-old Dutch warmblood gelding was admitted for colic-associated colonic incarceration in a diaphragmatic hernia. Seven weeks after the initial colic surgery, the gelding underwent surgery to repair the defect. Thoracoscopy and a flank incision were used to identify the location of the hernia and the subsequent site of rib resection. The stomach was adhered to the ed...
Strangulating obstruction caused by intestinal herniation through the proximal aspect of the cecocolic fold in 9 horses.
Veterinary surgery : VS    February 15, 2001   Volume 30, Issue 1 40-43 doi: 10.1053/jvet.2001.20342
Gayle JM, Macharg MA, Smallwood JE.To report the clinical and surgical findings and outcome for horses with strangulating obstruction caused by herniation through the proximal aspect of the cecocolic fold. Methods: Retrospective study. Methods: Nine horses. Methods: Medical records were reviewed for clinical signs, surgical findings and technique, and outcome. Cadaver ponies and necropsy specimens were also used to study the regional anatomy of the cecocolic fold. Results: The ileum and distal jejunum were strangulated in 8 horses, whereas in 1 horse the small intestine and the left ascending colons were incarcerated in a rent ...
Screw fixation in lag fashion of equine cadaveric metacarpal and metatarsal condylar bone specimens: a biomechanical comparison of shaft and cortex screws.
Veterinary surgery : VS    December 1, 2000   Volume 29, Issue 6 564-571 doi: 10.1053/jvet.2000.17839
Rahm C, Ito K, Auer J.To compare acute fixation stability and insertion effort of cortex bone screws with and without a shaft inserted in lag fashion in equine metacarpal (metatarsal, MC(T)III) bone. Methods: Screw types with independent variables of screw diameter (4.5 or 5.5 mm) and shaft type (without shaft, with 20-mm shaft, or with 25-mm shaft) were studied. Bone specimens cut from distal equine MC(T)III condyles were used. After screw insertion in lag fashion into 2 bone blocks with an instrumented device, shear tests were conducted in a mechanical testing machine. Outcome variables of peak insertion torque, ...
Fertility of mares after unilateral laparoscopic tubal ligation.
Veterinary surgery : VS    December 1, 2000   Volume 29, Issue 6 543-545 doi: 10.1053/jvet.2000.17860
McCue PM, Hendrickson DA, Hess MB.To develop a technique for laparoscopic tubal (oviductal) ligation and to evaluate pregnancy rates for mares that ovulated ipsilateral or contralateral to the ligated oviduct. Methods: Randomized prospective clinical trial comparing pregnancy rates after unilateral laparoscopic tubal ligation. Methods: Twelve mares of light horse breeds. Methods: One oviduct in each of 6 mares was surgically ligated with a laparoscopic technique; 6 other mares served as nonligated controls. Mares with unilateral tubal ligations (UTL) were inseminated with 500 million progressively motile sperm during 1 cycle w...
Use of pelvic flexure biopsies to predict survival after large colon torsion in horses.
Veterinary surgery : VS    December 1, 2000   Volume 29, Issue 6 572-577 doi: 10.1053/jvet.2000.17836
Van Hoogmoed L, Snyder JR, Pascoe JR, Olander H.To determine if morphologic evaluation of intraoperative biopsies of the large colon could be used to accurately predict outcome in horses with large colon torsion. Methods: Clinical study. Methods: Fifty-four horses with large colon torsion. Methods: A full-thickness biopsy was collected from the pelvic flexure of the ascending colon after correction of naturally occurring colonic torsion. Morphologic changes were evaluated and graded for interstitial tissue to crypt ratio (I:C ratio), percentage loss of superficial and glandular epithelium, and the degree of hemorrhage and edema. These varia...
The effects of methylprednisolone on normal and monocyte-conditioned medium-treated articular cartilage from dogs and horses.
Veterinary surgery : VS    December 1, 2000   Volume 29, Issue 6 546-557 doi: 10.1053/jvet.2000.17854
Murphy DJ, Todhunter RJ, Fubini SL, Vernier-Singer M, Straubinger RK, Lust G.To study in vitro (1) the dose-response relationships between proteoglycan metabolism in normal and corticosteroid-treated articular cartilage; (2) long-term proteoglycan metabolism after treatment of articular cartilage with corticosteroids; and (3) the effect of corticosteroids on proteoglycan metabolism in articular cartilage treated with monocyte-conditioned medium (MCM). Methods: Equine and canine articular cartilage explants were treated with corticosteroids and MCM. Proteoglycan synthesis and degradation were measured by radioactive labeling in short-term culture, and the long-term effe...
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