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Topic:Biological Half-Life

Biological half-life refers to the time required for a substance to decrease by half in its concentration within the body. In horses, understanding the biological half-life of various substances, such as medications, nutrients, or toxins, is important for determining dosing schedules, withdrawal times, and potential effects on equine health. The biological half-life can vary significantly depending on the substance in question, as well as factors such as the horse's metabolism, age, and health status. This page compiles peer-reviewed research studies and scholarly articles that explore the biological half-life of different substances in horses, examining factors that influence these rates and their implications for veterinary medicine and equine management.
Tissue distribution of sulfadimethoxine and sulfamonomethoxine in horses after intravenous injection.
Nihon juigaku zasshi. The Japanese journal of veterinary science    February 1, 1968   Volume 30, Issue 1 21-23 doi: 10.1292/jvms1939.30.21
Oishi S.The author has already reported on the time course of blood level of sulfonamides in horses at various dose schedules3). The present paper is concerned with the tissue distri-bution of sulfadimethoxine and sulfamonomethoxine in horses. The distribution of sulfonamides has been reported by KoNDol) in experimental animals, in which the concentrations of these drugs in the kidney, liver, lung and spleen were found to be close to the blood level. Many investigators ascribed the low concen-tration of sulfonamides in the spinal fluid to the existence of a blood-brain barrier, and also observed that ...
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The blood and saliva clearances of phenobarbitone and pentobarbitone in the horse.
Biochemical pharmacology    February 1, 1968   Volume 17, Issue 2 203-210 doi: 10.1016/0006-2952(68)90324-9
Alexander F, Nicholson JD.No abstract available
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Blood concentration of chloramphenicol in horses after intramuscular or oral administration.
Nihon juigaku zasshi. The Japanese journal of veterinary science    February 1, 1968   Volume 30, Issue 1 25-28 doi: 10.1292/jvms1939.30.25
Oishi S.No abstract available
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The urinary excretion of phenobarbitone and pentobarbitone in the horse.
Biochemical pharmacology    January 1, 1968   Volume 17, Issue 1 1-8 doi: 10.1016/0006-2952(68)90150-0
Nicholson JD.No abstract available
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Estimation of the stability of dry horse serum cholinesterase by means of an accelerated storage test.
The Journal of pharmacy and pharmacology    January 1, 1968   Volume 20, Issue 1 48-53 doi: 10.1111/j.2042-7158.1968.tb09617.x
Cole BR, Leadbeater L.No abstract available
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Polyethylene glycols. Studies of absorption, excretion, retention, and identification.
Journal of forensic sciences    January 1, 1968   Volume 13, Issue 1 90-113 
Principe AH.No abstract available
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Biological half-life of endogenous PMS following hysterectomy and studies on losses in urine and milk.
Endocrinology    October 1, 1967   Volume 81, Issue 4 927-930 doi: 10.1210/endo-81-4-927
Cole HH, Bigelow M, Finkel J, Rupp GR.No abstract available
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The salivary secretion and clearance in the horse of chloral hydrate and its metabolites.
Biochemical pharmacology    July 7, 1967   Volume 16, Issue 7 1305-1311 doi: 10.1016/0006-2952(67)90161-x
Alexander F, Horner MW, Moss MS.No abstract available
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Activity of carbonic anhydrase in mammalian blood in relation to body size.
Comparative biochemistry and physiology    May 1, 1967   Volume 21, Issue 2 357-360 doi: 10.1016/0010-406x(67)90797-9
Magid E.No abstract available
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A thin-layer chromatography study on the metabolism of prednisolone in the horse.
The Journal of endocrinology    February 1, 1967   Volume 37, Issue 2 129-137 doi: 10.1677/joe.0.0370129
Moss MS, Rylance HJ.No abstract available
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Compartmentalization and turnover of 131-I-labeled albumin and gamma globulin in horses.
American journal of veterinary research    May 1, 1966   Volume 27, Issue 118 699-705 
Matteeuws DR, Kaneko JJ, Loy RG, Cornelius CE, Wheat JD.No abstract available
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[Biogenesis of estrogens in the horse placenta].
Die Naturwissenschaften    October 1, 1965   Volume 52, Issue 19 540-541 doi: 10.1007/BF00645829
Stsrka L, Breuer J, Breuer H.No abstract available
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Pregnant mare serum gonadotrophin potency: effect of single and multiple injections.
Nature    July 24, 1965   Volume 207, Issue 995 412-413 doi: 10.1038/207412c0
Connell GM.No abstract available
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Microstructure of the Peritubular Matrix in Horse Dentin.
The Bulletin of Tokyo Dental College    March 1, 1965   Volume 35 1-14 
EDA S, TAKUMA S.No abstract available
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The plasma protein concentration in horses following the infusion of different amounts of intradex.
Acta veterinaria Academiae Scientiarum Hungaricae    January 1, 1965   Volume 15, Issue 3 297-300 
Lami G.No abstract available
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Photoperiodic Control of Gonadal and Hypophyseal Activity in Domestic Mammals.
Annals of the New York Academy of Sciences    September 10, 1964   Volume 117 157-193 doi: 10.1111/j.1749-6632.1964.tb48171.x
ORTAVANT R, MAULEON P, THIBAULT C.No abstract available
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Acetylcholinesterase Activity in the Atrio-Ventricular Connections in Some Domestic Mammals.
Rivista di biologia    January 1, 1964   Volume 57 31-51 
CIAMPOLI A, PALMIERI G, ASOLE A.No abstract available
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The Submolar Quantities of N-Terminals in Proteins: Effect of Sodium Dodecyl Sulfate on the N-Terminals of Egg Albumin and Bovine, Equine, and Porcine Gamma-Globulins.
Archives of biochemistry and biophysics    January 1, 1964   Volume 104 27-31 doi: 10.1016/s0003-9861(64)80030-8
COLACICCO G.No abstract available
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Longevity of Red Blood Cells in Interspecies Transfusion.
Journal of the American Veterinary Medical Association    August 15, 1963   Volume 143 400-401 
CLARK CH, KIESEL GK.No abstract available
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Protein denaturation by high pressure. Measurements of turbidity of isoelectric ovalbumin and horse serum albumin under high pressure.
Archives of biochemistry and biophysics    May 1, 1963   Volume 101 225-228 doi: 10.1016/s0003-9861(63)80006-5
SUZUKI K, MIYOSAWA Y, SUZUKI C.No abstract available
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Phenylbutazone: short-term versus long-term administration to thoroughbred and standardbred horses.
Journal of the American Veterinary Medical Association    February 15, 1962   Volume 140 337-341 
GABRIEL KL, MARTIN JE.No abstract available
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Studies on the pharmacodynamics of succinylcholine chloride in the horse.
Journal of the American Veterinary Medical Association    January 1, 1955   Volume 126, Issue 934 37-42 
BELLING TH, BOOTH NH.No abstract available
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Equine serum penicillin levels following injection of depo-penicillin.
Journal of the American Veterinary Medical Association    March 1, 1951   Volume 118, Issue 888 161-163 
STOCKING GG, DAVIDSON JL, TROOST MA, NOOK MA, HENSHAW C.No abstract available
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Serum levels of aureomycin in foals.
Veterinary medicine    March 1, 1951   Volume 46, Issue 3 84-86 
McCOLLUM WH, DOLL ER.No abstract available
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The decidual reaction in the mare’s placenta.
The Journal of physiology    March 1, 1951   Volume 113, Issue 1 3p-4p 
AMOROSO EC.No abstract available
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Serum levels of horses following intramuscular injection of aqueous suspension of procaine penicillin.
Veterinary medicine    August 1, 1950   Volume 45, Issue 8 309 
DOLL ER, WALLACE ME, McCOLLUM WH.No abstract available
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Serum level response of horses to procaine penicillin in oil and penicillin in oil and wax.
Veterinary medicine    December 1, 1948   Volume 43, Issue 12 512-517 
DOLL ER, WALLACE ME, NEWTON AC.No abstract available
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Dosage and serum level of streptomycin in horses.
Veterinary medicine    October 1, 1948   Volume 43, Issue 10 410-413 
DOLL ER, WALLACE ME.No abstract available
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The blood level response of horses to administration of penicillin in oil and wax.
Journal of the American Veterinary Medical Association    September 1, 1948   Volume 113, Issue 858 240-244 
DOLL ER, WALLACE ME.No abstract available
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Sulfamethazine blood concentrations in horses.
Journal of the American Veterinary Medical Association    May 1, 1948   Volume 112, Issue 854 381-385 
SCHROEDER CR, WELSH M.No abstract available
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