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Topic:Clinical Pathology
Clinical pathology in horses involves the study and analysis of biological samples to diagnose and monitor diseases and health conditions. This discipline encompasses various laboratory tests and procedures that assess the physiological and biochemical status of equines. Common analyses include hematology, biochemistry, urinalysis, and cytology, each providing insights into different aspects of equine health. Hematology evaluates blood components, such as red and white blood cells and platelets, to identify conditions like anemia or infection. Biochemistry tests measure enzymes, electrolytes, and metabolites to assess organ function and metabolic status. Urinalysis examines urine samples for indicators of renal function and systemic diseases. Cytology involves the microscopic examination of cells from tissues or fluids to detect abnormalities. This page aggregates peer-reviewed research studies and scholarly articles that explore the methodologies, applications, and diagnostic value of clinical pathology in equine medicine.
Hematologic responses to exercise and training. Hematology has been widely used in attempts to provide information about disease states, performance problems, and fitness in performance horses. However, owing to factors such as the temperament of the horse and time of collection and feeding, considerable variation in the hemograms can be found. This article reviews some of the hematologic responses to exercise and training.
[Frontal sinusitis in a horse with a neurological complication]. The case of a horse affected with frontal sinusitis, in which neurological complications occurred following trepanation, is reported. The previous history of the animal as well as the clinical, radiological and pathological findings are discussed.
Preliminary studies on the measurement of conjunctival oxygen tension in the foal. The capability of a transconjunctival oxygen monitoring system to provide an accurate and reliable means of observing arterial oxygenation trends was evaluated in 12 horse and pony foals between 5 and 20 days of age. Ten of the foals were anesthetized with isoflurane in oxygen and nitrous oxide, and 2 foals were conscious. Inspired oxygen concentration was manipulated by differing proportions of oxygen and nitrous oxide in the fresh gas supplied to the breathing circuit. With arterial oxygen tension values ranging from less than 20 to greater than 400 mm of Hg, all foals had significant positi...
Flunixin meglumine given in small doses: pharmacokinetics and prostaglandin inhibition in healthy horses. The pharmacokinetics and inhibition of prostaglandin synthesis in conscious horses given various dosages of flunixin meglumine were studied. Plasma concentrations of flunixin were measured by high-performance liquid chromatography, and serum thromboxane B2 and 6-keto prostaglandin F1 alpha were quantitated by radioimmunoassay. Within the dosage range studied, linear pharmacokinetics were achieved. After IV administration of flunixin (1.1 mg/kg, 0.25 mg/kg, 0.1 mg/kg), significant suppression of serum thromboxane generation persisted for 12, 4, and 3 hours, respectively. Repeated administration...
Quantitative methodology for corticosteroids based on chemical oxidation to electrophilic products for electron capture-negative chemical ionization using capillary gas chromatography-mass spectrometry. I. Assessment of feasibility in the analysis of horse urine for dexamethasone. Sensitive and specific methodology based on capillary column gas chromatography-electron capture-negative chemical ionization-mass spectrometry has been developed for the quantitative analysis of corticosteroids from biological fluids. The feasibility of this method is demonstrated in the quantitative analysis of dexamethasone in horse urine following administration of the drug. A structurally similar compound, 6 alpha-methylprednisolone, is added to the urine as an internal standard. The free dexamethasone and the internal standard are extracted and oxidized to high-electron-affinity 1,4-andr...
Physical and clinical pathological findings associated with experimentally induced rupture of the equine urinary bladder. Two mature horses were examined for changes in laboratory and physical findings after experimentally induced bladder rupture. The postrupture laboratory diagnostic changes, which provide valuable information for a correct diagnosis are described. Hematology, serum and peritoneal fluid sodium, potassium, calcium, phosphorous, creatinine, urea nitrogen, albumin and peritoneal fluid components were measured and evaluated versus time. Hyponatremia and hyperkalemia occurred, as well as increased concentrations of peritoneal fluid potassium and inorganic phosphorus. In addition, peritoneal fluid cre...
Paralysis and lipofuscin-like pigmentation of farm stock caused by the plant, Trachyandra laxa var. laxa. A paralytic condition of farm stock in South West Africa, characterized by prominent neuronal and some mild extraneuronal pigmentation, is described. The distribution of the pigment, which was mainly located in the larger neurones of the brain and spinal cord, is given. Experimental evidence, obtained by feeding the plant, is presented that the condition is caused by Trachyandra laxa var. laxa. The histochemical features of the pigment proved to be compatible with a lipofuscin.
Effects of plasma sample storage on blood ammonia, bilirubin, and urea nitrogen concentrations: cats and horses. Ten horses, a pony, and 13 cats were used to evaluate base-line blood ammonia, bilirubin, and urea nitrogen concentrations and to determine The effects of prolonged cold storage (-20 degrees C) before assay. Base-line plasma ammonia concentrations in cats (0.992 +/- 0.083 [SE] micrograms/ml) did not change significantly after 48 hours of storage (0.871 +/- 0.073 micrograms/ml); however, they were increased 4.2- and 13-fold after 168 and 216 hours of storage, respectively. In contrast to base-line plasma-ammonia values in cats, those of horses were significantly (0.265 +/- 0.044 micrograms/ml) ...
Scapular notch resection for suprascapular nerve decompression in 12 horses. Supraspinatus and infraspinatus muscle paralysis with atrophy was treated by partial osteotomy of the scapula, deep to the suprascapular nerve. The horses had various gait abnormalities, which were corrected by the surgery, but regeneration of the muscles varied from partial to complete, depending on the duration of the condition and the degree of atrophy before surgery.
Work intolerance in a horse with thyroid carcinoma. A thyroid carcinoma was diagnosed in a 14-year-old competitive trail horse with a 3-month history of work intolerance. Abnormal findings included low base-line triiodothyronine (T3) and thyroxine (T4) values, a large thyroid gland and decreased work tolerance. Nuclear medicine scanning revealed displacement of the right thyroid gland by a mass. Needle biopsy of the mass revealed neoplastic changes compatible with thyroid carcinoma. After removing the tumor surgically, T3 and T4 values returned to normal. Subsequently, the horse was able to compete successfully. Horses with work intolerance com...
Comparison of the bacterial and fungal flora in the pharynx of normal horses and horses affected with pharyngitis. A total of 43 horses were used for the study of the pharyngeal bacterial flora. The median value of the number of bacteria in the group of 19 normal horses was 3.8 x 10(4) cfu/g of secretions. This value was 6.4 x 10(4)cfu/g in horses with grade I pharyngitis, 1.3 x 10(5) cfu/g in horses with grade II pharyngitis and 3.5 x 10(6) cfu/g in horses affected with grades III and IV pharyngitis. Corynebacterium spp, coagulase-negative staphylococci, Nocardia spp, Moraxella spp and Enterobacter spp were the most frequently encountered bacteria in the normal animals as well as in horses affected with p...
Erythrogram and red cell distribution width of Equidae with experimentally induced anemia. The erythrogram (erythrocyte histogram) and red cell distribution width (RDW) were evaluated in 5 purebred horses and 1 pony of mixed breeding with experimentally induced anemia. Four horses were studied for 6 weeks after 20% of their estimated blood volume was removed on each of 2 consecutive days (40% total blood loss; acute blood-loss group). Two horses were given acetylphenyl hydrazine IV daily, until acute Heinz body hemolytic anemia was induced; the 2 horses were then evaluated for 6 weeks. One horse and the pony had 20% of their estimated blood volume removed via phlebotomy once each we...
Methods of assigning accurate values to reference serum. Part 2. The use of definitive methods, reference laboratories, transferred values and consensus values. Eight analytes (Ca, Cl, cholesterol, glucose, Mg, K, Na and urate) have been determined in one horse serum masterlot by up to six different procedures: (i) by so-called definitive methods; (ii) by a group of reference laboratories using a variety of analytical methods; (iii) using the results of two independent external quality assessment schemes; (iv) by transferring values from a human serum standard reference material analysed by definitive methods; (v) by similar transfer of values from several batches of horse reference serum previously analysed by definitive methods; and (vi) as in (v) b...
Mononuclear phagocytes of transport-stressed horses with viral respiratory tract infection. Twelve horses comprised 3 treatment groups; all horses in 2 of the groups had recently been transported and had clinical and laboratory evidence of respiratory tract infection, with equine influenza type 2 virus being the principal pathogen. Mononuclear phagocytes and other leukocytes from blood, lung, and peritoneal cavity were studied in phagocytosis and erythrocyte-antibody (EA) rosette assays. Total numbers of pulmonary alveolar macrophages were increased over control values in bronchoalveolar lavage (BAL) fluid of group 3 horses after recovery from influenza (P less than 0.02), whereas th...
