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Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
Effect of third carpal slab fracture and repair on racing performance in Thoroughbred horses: 31 cases (1977-1984). Between 1977 and 1984, 31 Thoroughbred horses (mean age, 2.8 years) were surgically treated for slab fractures of the third carpal bone. All fractures involved the articular surfaces of the intercarpal and the carpometacarpal joints in a frontal plane and had a cuboidal or slab shape. In 20 of the horses, the bone was fractured during racing and in 8 of the horses, the bone was fractured during race training. The right limb was affected more frequently than was the left limb (24 vs 7, P less than 0.05). Twenty-one (67.6%) horses raced at least once after recovery from the surgery. Data were av...
The effects of corticosteroid administration on the migration, phagocytosis and bactericidal capacity of equine neutrophils. Neutrophil function was evaluated in six clinically normal adult horses, immediately before and 3-6 hours after they were given one dose of hydrocortisone sodium succinate (1 mg/kg body weight). Random migration, stimulated migration to zymosan-activated serum, bacterial phagocytosis and bactericidal capacity of neutrophils were determined in vitro. The mean indices of stimulated migration (net migration and migration ratio) were significantly greater after CS administration (net migration = 62 +/- 23 micron; migration ratio = 11.5 +/- 6.7) than before CS administration (net migration = 44 +/-...
Possible resistance of small strongyles from female ponies in The Netherlands against albendazole. To determine resistance of small strongyles to albendazole, 3 female ponies (group 1) were grazed on a pasture from May to November 1985 and were treated with 7.5 mg of albendazole/kg of body weight, PO, 2 days before turnout in May and again in June and in July. Three other female ponies (group 2) grazed on a similar pasture from May to July, were treated with 7.5 mg of albendazole/kg, and were removed to another pasture until November. In December, ponies from both groups were treated with 7.5 mg of albendazole/kg, and 8 days later, they were euthanatized and necropsied for a critical test. ...
Use of iohexol for myelography in the horse. The use of iohexol as a contrast agent for myelography is reported in two groups of horses. Group 1 (n = 6) were used only for myelography and to assess the clinical and pathological effects of intrathecal administration of iohexol. A volume of 20 ml at a concentration of 300 or 350 mg iodine/ml gave satisfactory myelographic detail with no serious clinical or neurological side effects. Only a minimal inflammatory response could be demonstrated in cerebrospinal fluid at four and 14 days after injection. At post mortem examination 14 days after myelography there was no evidence of meningitis no...
The influence of supplemental feed on growth and bone development of nursing foals. Thirty foals of mixed breeding, from two consecutive years, were used in two 120-d experiments to evaluate the effects of supplemental feeding (creep feed) on growth in nursing foals. At 10 d postpartum, foals were randomly assigned either to a creep-fed group (CF) or an unsupplemented group (NCF). Initial measurements of body weight (BW), height at the withers (WH), third metatarsal length (MtIII) and third metacarpal length (McIII) were made at 10 d of age and at 30-d intervals thereafter. Medial and lateral cortical peak values for radiographic bone density, cortical width and cortical area...
Corynebacterium folliculitis in a horse. A 7-year-old Thoroughbred was examined for evaluation of mildly pruritic multiple skin lesions that had progressed from nodules to alopecia and crusts. Folliculitis caused by Corynebacterium pseudotuberculosis was diagnosed by bacterial culture. Oral treatment with a trimethoprimsulfadiazine paste resulted in resolution of all lesions, with normal hair regrowth.
Postanesthetic hind limb adductor myopathy in five horses. Five horses that underwent prolonged anesthesia (greater than 3 hours) in dorsal recumbency for a surgical procedure were unable to stand after recovery and were euthanatized. A provisional diagnosis of postanesthetic myopathy was confirmed at necropsy in all 5 horses. However, distribution of affected muscles in these horses was atypical, because there was bilateral hind limb adductor muscle involvement.
Factors affecting the composition of mare uterine fluid. The influx of protein and polymorphonuclear leucocytes (PMN) into the uterine lumen was examined at different intervals after intrauterine infusion of fluids. The intrauterine infusion of both phosphate buffered saline (PBS) and a solution of lipopolysaccharide (LPS) derived from Escherichia coli resulted in a biphasic influx of protein in the uterine flushings peaking three and six hours after infusion. LPS infusion caused an additional influx of protein at 24 hours. The initial influx of protein preceded a biphasic influx of PMN which peaked six and 24 hours after both infusions. Uterine flu...
Species-dependent binding of disopyramide enantiomers. Serum protein binding of the basic enantiomers of disopyramide were studied in several animal species. (S)-(+)-Disopyramide was more highly bound than the (R)-(-)-enantiomer to serum protein in the man, gorilla, and pig. The reverse was true in cow serum, and in serum and albumin from sheep. Enantioselective differences in binding were due to differences in association constants. No enantioselective differences in binding were observed in serum protein from horse and goat, or in albumin from cow and pig. Disopyramide was highly bound to two sites on horse albumin. The association constant char...
Interstitial pH and pressure in the dependent biceps femoris muscle of laterally recumbent anesthetized horses. Interstitial pressure and pH in the dependent biceps femoris muscle were measured in anesthetized, laterally recumbent horses. The mean (+/- standard deviation) interstitial pressure in 10 horses was 19.70 +/- 0.15 mmHg in the 30 to 180 minute interval after induction of anesthesia. Pressures of this order have been associated with reduction in muscle perfusion. Mean (+/- standard deviation) interstitial pH in six horses decreased from 7.07 +/- 0.30 to 6.73 +/- 0.21 between 45 and 150 minutes of anesthesia. These results indicated the presence of circulatory compromise to intracompartmental st...
Verification of ineffectual activity of ivermectin against adult Onchocerca spp in the ligamentum nuchae of horses. Ivermectin paste formulation (200 micrograms/kg) was administered orally to 27 horses (13 Thoroughbreds and 14 of mixed breeding) to evaluate activity against adult Onchocerca spp in the ligamentum nuchae. Ages, known or estimated, of the horses ranged from 1 to 22 years. Single or multiple doses (1 to 5) of the drug were given to each horse. When multiple doses were administered, the intervals between treatments ranged from 7 to 92 days. At 27 to 171 days after initial treatment (single dose or first of multiple doses), the horses were killed. Some of the horses treated more than once were ki...
Effect of splenectomy on exercise-induced pulmonary and systemic hypertension in ponies. Large increases in systemic and pulmonary arterial pressures of exercising healthy ponies have been observed. Because exercise causes a considerable increase in PCV of ponies, we examined the effect of splenectomy on exercise-induced changes in systemic and pulmonary pressures. These pressures (taken with catheter-tip micromanometers) and indicator dilution cardiac output were determined on 9 healthy ponies that had undergone splenectomy 4 to 9 weeks before the study. Data obtained at rest and during submaximal (10.5 to 11.0 mph) and maximal (14 to 15 mph) exercise from these ponies were compa...
Clinical significance of aerobic bacterial flora of the uterus, vagina, vestibule, and clitoral fossa of clinically normal mares. Swab specimens for bacterial culture were obtained from the uterus, vagina, vestibule, and clitoral fossa of 48 mares that had normal reproductive tracts, no history of reproductive problems, and no inflammation on evaluation of endometrial biopsy. The mares were predominantly Thoroughbred and Standardbred. Swab specimens of the vagina were obtained through a sterile speculum; swab specimens of the uterus were obtained by use of a double-guarded, occluded culture instrument. Fifteen (31%) of the uterine swab specimens and 20 (42%) of the vaginal swab specimens yielded growth on aerobic culture...
Neuromuscular and cardiovascular effects of atracurium administered to healthy horses anesthetized with halothane. Neuromuscular and cardiovascular effects of atracurium, a nondepolarizing neuromuscular blocking agent, were evaluated in 10 halothane-anesthetized adult horses. Hind limb digital extensor tension (hoof twitch) was measured with a strain gauge to quantitate the muscle relaxant effects of atracurium. Response of facial muscles was compared with hoof twitch. Five injections of atracurium were given. Initial mean (+/- SEM) dosage of 0.07 +/- 0.01 mg of atracurium/kg of body weight caused 98.6 +/- 0.8% reduction of the preinjection hoof twitch. Subsequent dosages of 0.04 +/- 0.003 mg/kg induced a ...
Embryo reduction before day 11 in mares with twin conceptuses. Incidence of embryo reduction (natural elimination of one member of a twin set) before d 11 was studied by comparing the number of ultrasonically detected conceptuses per ovulation between single and double ovulators. Effect of unilateral (n = 24) vs bilateral (n = 26) double ovulations on the incidence of embryo reduction also was considered. Each of 50 double-ovulating mares was matched with two single ovulators yielding 100 ovulations, or potential embryos, per group. Frequency with which an ovulation resulted in a conceptus was greater for single ovulators (85%, P less than .01) and for bi...
Some aspects of the epidemiology of equine salmonellosis. A survey of 2 horse populations was done to detect the number of asymptomatic faecal excretors of Salmonella sp. 1201 faecal samples from 250 horses hospitalised at the University of Sydney were cultured. Three serotypes, S. typhimurium (4 horses), S. anatum (2) and S. tennessee (1) were isolated from 7 horses (2.8%). None was detected in 75 mares similarly examined at a thoroughbred stud farm. In retrospect, S. typhimurium was also the most common (70%) of the 19 serotypes recovered from 171 horses with clinical salmonellosis seen at Camden, 1969 to 1986. Forty cases occurring since 1983 were...
Validation of a radioimmunoassay for measurement of gastrin in equine serum. A commercial radioimmunoassay kit designed for measuring gastrin in human serum was validated for use with equine serum. This nonextraction, double-antibody procedure uses an antiserum with broad specificity for molecular forms of gastrin. Synthetic human gastrin (G17-I) was added to pooled equine serum, and the observed assay values were compared with the mass added. Recovery was 99 to 115% in the gastrin concentration range of 40 to 640 pg/ml. Dilutions of postprandial serum with serum from fasted horses were assayed, and the inhibition curves were compared with those of the human gastrin ki...
Respiratory airflow patterns in ponies at rest and during exercise. The exercise-induced changes in the equine breathing pattern were studied by analyzing tidal breathing flow-volume loops recorded in ten ponies both at rest and during a standardized exercise. Airflow, tidal volume, esophageal pressure and mask pressure were simultaneously recorded before, during and after a treadmill exercise. From the collected data, respiratory frequency and total pulmonary resistance were calculated, tidal breathing flow-volume loops were retraced using a computerized method and loop indices were measured for each period of the experimental protocol. For each pony, results...
Nonsystemic causes of the downer cow syndrome. Traditionally, the downer cow has been considered a metabolic problem. This viewpoint cannot account for the pelvic limb predilection of the condition. Whatever the primary cause of recumbency, all recumbent animals are susceptible to pressure damage. The extensive literature on pressure damage in human beings and horses is reviewed. Miscellaneous causes of and contributing factors to bovine recumbency are reviewed. Concepts and details of diagnosis, prevention, management, and therapy are discussed.
Effects of gonadotrophin-releasing hormone and prostaglandin F-2 alpha on corpus luteum function and timing of the subsequent ovulation in the mare. Standard bred mares that were cycling normally were treated beginning on Days 9 or 10 of the oestrous cycle with repeated pulses of GnRH (20 micrograms/h) and/or a single injection of prostaglandin (PG)F-2 alpha (alfaprostol, 3 mg), and were subsequently bled and palpated daily until the next ovulation. GnRH treatment increased serum concentrations of LH and progesterone at 4 days after the start of treatment compared to controls. The combination of PGF-2 alpha + GnRH treatment resulted in an immediate decline in serum progesterone values, and subsequently decreased the interval to next ovulat...
Effect of exercise on the partitioning of equine respiratory resistance. Pleural, tracheal, pharyngeal and mask pressures as well as airflow and tidal volume of five ponies on a treadmill (incline 8.3 degrees) were recorded simultaneously while resting, walking, trotting slowly, trotting fast, after standing for 30 secs and 5 mins after the end of the exercise. The curves obtained were used to calculate total pulmonary resistance (RL), lower airway resistance (RLA) and upper airway resistance (RUA). The latter was also divided into nasal resistance (Rnas) and laryngeal plus extrathoracic tracheal resistance (Retr + lar). Furthermore, the inspiratory and expiratory ...
Efficacy of ivermectin in the oral paste formulation against naturally acquired adult and larval stages of Parascaris equorum in pony foals. The efficacy of ivermectin in oral paste formulation at a dosage of 200 micrograms/kg of body weight was tested against naturally acquired larval and adult stages of Parascaris equorum, in a controlled study. Twenty infected pony foals 18 to 27 weeks of age were randomly allocated to 2 groups of 10 each and were placed in dry lots. Foals in 1 group were given ivermectin on day 0. Necropsies and parasite recoveries from small intestines and lung tissues were performed on 5 foals in each group at 2 weeks after treatment (WAT) and on the remaining foals at 5 WAT. Ivermectin was 100% effective aga...
