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Topic:Disease Prevention
Disease prevention in horses encompasses strategies and practices aimed at minimizing the occurrence and spread of infectious and non-infectious diseases within equine populations. These practices include vaccination programs, biosecurity measures, and regular health monitoring. Vaccination helps to stimulate the horse's immune system to protect against specific pathogens, while biosecurity measures, such as quarantine and sanitation, reduce the risk of disease transmission. Regular health monitoring, including physical examinations and diagnostic testing, aids in early detection and management of potential health issues. This page compiles peer-reviewed research studies and scholarly articles that explore various methods and their effectiveness in preventing diseases in horses, as well as the development and implementation of prevention programs in different equine settings.
Role of antibody to extracellular proteins of Rhodococcus equi in protection against R. equi pneumonia in foals. Rhodococcus equi produces two exoenzymes (REE), a cholesterol oxidase in large amounts and a phospholipase C, which cause lysis of sheep red blood cells (SRBC) sensitized with Staphylococcus aureus beta toxin. Two immunization studies were done in foals to determine the role of antibody to REE in protection against R. equi pneumonia. In the first study, three foals (mean age 10 days) were vaccinated four times at 2-week intervals with over 1 million units of partially purified exoenzymes (PREE). In the second study, three foals (mean age 19 days) were administered plasma from an adult horse va...
[Studies in riding arenas and on different riding path surfaces with respect to respiratory tract contamination in horses. Air hygiene studies in riding arenas]. Using the direct sedimentation method, the air pollution with fungal spores was measured in indoor riding arenas and compared to horse stables, outside riding arenas and covered sport courts. Depending on the location of indoor arenas and stables, the presence of "dust-nests", the number of horses ridden, and the moisture of the tread layer, an air pollution was measured which was equivalent to that in stables except at times of feeding and straw-giving. Outside and in sport arenas a low air pollution was found. Recommendations are given, regarding optimum air hygiene especially for horses wit...
Investigation of antigenic structure of attenuated and virulent Venezuelan equine encephalomyelitis virus by means of monoclonal antibodies. A comparative study of the antigenic structure of virulent strains and attenuated vaccine strains of Venezuelan equine encephalomyelitis virus (VEEV) by means of monoclonal antibodies has made it possible to investigate the antigenic structure of the envelope glycoproteins E1 and E2, and to specify their role in the development of antiviral immunity. On the E1 glycoprotein there are five nonoverlapping antigenic sites consisting of eight epitopes that are recognized by monoclonal antibodies; six sites consisting of twenty epitopes were found on the E2 glycoprotein. The monoclonal antibodies ag...
Immunization of horses with Crotalus durissus terrificus (South American rattlesnake) venom. A comparison of four different procedures. 1. A comparative study was carried out on horses immunized with Crotalus durissus terrificus venom using four different inoculation procedures, which included the use of Freund's adjuvant, A1(OH)3 and liposomes as adjuvants. The antibody titer was assessed by enzyme linked immunosorbent assay (ELISA) and the neutralizing potency by the neutralizing median effective dose (ED50). 2. The inoculation schedule used in horses to obtain antivenom serum consisted of sc injections of a 7.5 mg venom starting dose in 5.0 ml sterile saline emulsified with an equal volume of Freund's complete adjuvant. One...
Protection against naturally acquired Rhodococcus equi pneumonia in foals by administration of hyperimmune plasma. A 2-year field study was performed to determine the capability of increasing Rhodococcus equi specific antibody in foals via plasma transfusion or mare vaccination, to determine the kinetics of R. equi (ELISA) antibody decay and to assess the protective effects of these procedures in foals on a farm endemic for R. equi. Plasma donors were vaccinated with a killed R. equi bacterin and produced high levels of anti-R. equi antibodies, which were harvested by plasmapheresis. In Experiment 1, 68 foals were given 1 litre of hyperimmune plasma intravenously (i.v.) between 1-60 days of age. Foal plasm...
Antigen recognition in feral mares previously immunized with porcine zonae pellucidae. Twenty-six free-roaming feral mares were immunized against porcine zonae pellucidae (PZP) between February and May, 1988. Eight sexually mature mares received 2 inoculations 2 weeks apart, and 18 mares received 3 inoculations at intervals of 2 and 4 weeks. Analysis of urinary oestrone conjugates (E1C) and non-specific progesterone metabolites (iPdG) in samples collected in October, 1988, revealed that none of the 18 mares that received 3 and only 1 of the 6 mares that received two inoculations were pregnant, whereas 3 of 6 sham-injected control mares and 5 of 11 untreated mares were pregnant. ...
Resistance to benzimidazole anthelmintics in small strongyles (Cyathostominae) of horses in Denmark. This study was undertaken to establish whether anthelmintic resistance was present in nematode parasites of horses in Denmark. Sixteen horse farms were selected for faecal egg count reduction (FECR) tests to measure the efficacy of the anthelmintic used. Resistance to benzimidazole anthelmintics was found on 13 of the 16 farms, with FECR values ranging from 80.0% to -101.3%. On the remaining 3 farms FECR was 100.0%, 99.3% and 97.2%. Results of a questionnaire study on anthelmintic usage, parasite control measures and management practices showed that horses in this study were treated on average...
A rare GC mutant in horses disclosed by isoelectric focusing and subsequent immunoprinting. An apparent incompatibility in the GC/DBP system in a mare and her colt was found after classification by polyacrylamide gel electrophoresis. Because of this observation an analysis of the equine GC/DBP system by isoelectric focusing and subsequent immunoprinting was initiated. Further GC subtypes, however, were not encountered: the three phenotypes GC F, FS and S were also delineated by this method. The GC types in the case of disputed descent were dissolved: GC S was found in the mare and GC FS in her colt as well as in another of her male offspring. It is proposed that a rare GC mutant is r...
[Immunotherapy of squamous cell carcinoma of the bovine eye and of equine sarcoid]. Squamous cell carcinomas of the bovine eye and equine sarcoids are briefly reviewed. A single injection of BCG into the tumour results in permanent regression of the lesion in 37 per cent of the cattle, regression followed by recurrence of the tumour in 26 per cent and in progressive growth of the tumour in 37 per cent of the cases. Recurrence may be prevented by repeated injection into the lesion. From 50 to 60 per cent of the cows will remain free from tumours. Equine sarcoids show a complete regression in 70-80 per cent of the cases. Tumours on the limbs show a less satisfactory response (l...
Strangles in horse studs: incidence, risk factors and effect of vaccination. A questionnaire survey of 179 horse studs in New South Wales was conducted to estimate the incidence of strangles during 1985 to 1988, to identify risk factors for strangles outbreaks and to assess the effect of strangles vaccination. Forty-nine of the studs (27.4%) had at least one strangles outbreak during this period and 62 studs (34.6%) had at least one case of strangles. The average incidence of strangles was 2.1 cases per 100 horses per year. The risk of strangles increased progressively with the total horse population and rose markedly when more than 100 mares had been served in the 198...
[Epidemiology, chemotherapy, anthelmintics-resistance and prevention of Strongylidae infections in horses]. The epidemiology, chemotherapy and control of strongylus infections in the horse are discussed. The annual cycle of various species are stated. In addition the anthelmintics available for treatment and control and the occurrence of anthelmintic resistance are referred to. Finally the options for control under various management conditions (little if any grazing; extensive grazing; intensive grazing) are discussed.
Molds, mycotoxins, and mycotoxicosis. Interest in mycotoxins and mycotoxicosis in humans and animals has greatly increased in recent years. Horses have long been considered very susceptible to molds. The signs, treatment, and prevention of several conditions, such as leukoencephalomalacia, aflatoxicosis, ergotism, fescue toxicity, slobbering disease, ryegrass staggers, and moldy sweet clover disease, are discussed.
Serum IgG antibody concentrations against environmental microbes in mares and foals during different seasons and effect of stabling practices. Over periods of 22 and 14 months, IgG antibody concentrations in serum samples obtained monthly from 14 mares and 19 foals, respectively, were measured by use of ELISA against antigens of the following environmental microbes: Aspergillus umbrosus, Penicillium brevicompactum, Rhodotorula glutinis, Absidia corymbifera, Aspergillus fumigatus, Humicola grisea, Micropolyspora faeni, and Thermoactinomyces vulgaris. The mares and foals were on pasture from early June until early October, then were stabled during the winter season until the following June. In the mares, increased antibody concentratio...
Viraemia and abortions are not prevented by two commercial equine herpesvirus-1 vaccines after experimental challenge of horses. Eighteen horses, vaccinated on a number of occasions over a period of 12 to 20 months with either a live equine herpesvirus-1 (EHV-1) or an inactivated EHV-1 vaccine, were challenged by the intranasal instillation of the subtype 1 virus isolated from the 1983 outbreak of abortion and paralytic disease at the Lipizzan Stud, Piber, Austria. The prechallenge serum titres of all vaccinated horses were remarkably low, although most horses had received their last vaccine dose only 3 weeks before test-infection. Higher titres were obtained with the inactivated product than with the live virus vaccine...
[Veterinary examinations of horses during purchase transactions]. Veterinary examinations of horses on the occasion of sale or purchase take place on the basis of contracts for work and services. Three types may be distinguished: Examinations for sale (by order of the seller before the sales contract is concluded) Guarantee examination (by order of the buyer after conclusion of the sales contract) (Real) purchase examination (under a conditional contract of purchase). In the latter case the veterinarian acts as trustee for both seller and buyer and is equally obliged to both parties morally and at law. The deficiencies of the law of warranties for contracts ...
Safety and efficacy of a thymidine kinase negative equine herpesvirus-1 vaccine in young horses. A drug induced equine herpesvirus-1 (EHV-1) mutant lacking thymidine kinase inducing activity was developed and evaluated as a vaccine. The safety and effectiveness of the vaccine to protect against experimentally induced EHV-1 respiratory disease were evaluated in weanling horses free of EHV-1 neutralizing antibody. The vaccine was safe when administered either intramuscularly or intravenously, and EHV-1 was not shed intranasally during the 12 days following administration. Intranasal challenge with virulent EHV-1 was used to evaluate vaccine efficacy. Following challenge, there was a signifi...
A survey of equine parasite control practices in Tennessee. A weighted, random sample of 130 horse owners in Tennessee was selected from subscribers to an equine newsletter published by the Agricultural Extension Service. Data about the participants' farms, horses, parasite control practices, and sources of information regarding equine parasite control were obtained through a telephone survey. The response rate was 98%. The typical respondent kept 4 horses on 2 pastures totaling 15 acres, and did not rotate pastures as a parasite control measure. The majority (83%) of horse owners indicated that they administered anthelmintics according to a regular sc...
Induction of immune response and protection from equine viral arteritis (EVA) by formalin inactivated-virus vaccine for EVA in horses. Thirty-nine horses included 3 pregnant mares were examined by inoculating with formalin inactivated-virus vaccine for EVA. Antibody response of horses after one dose vaccination was somewhat poor and 50% effective inoculum dose of the vaccine should be included 10(8.4) pfu of virus before inactivation. After 2 doses given at an interval of 4 weeks, the horses developed such high titer of SN antibody as up to 1:5,120. The SN titer declined rather rapidly, but supplemental administration of the vaccine at an interval of more than 2 months elicited a prompt antibody response and SN titers persist...
