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Topic:Epidemiology

Epidemiology in horses involves the study of the distribution and determinants of health-related states and events in equine populations. It encompasses the investigation of patterns, causes, and effects of diseases and health conditions within horse populations. This field of study aims to identify risk factors for disease and targets for preventive healthcare. Key components of equine epidemiology include disease surveillance, outbreak investigation, and the study of disease dynamics within herds or regions. Research in this area often focuses on infectious diseases, zoonotic diseases, and the impact of environmental factors on equine health. This page compiles peer-reviewed research studies and scholarly articles that explore various aspects of epidemiology in horses, including disease prevalence, transmission pathways, and strategies for disease prevention and control.
Hendra virus: what do we know?
New South Wales public health bulletin    July 26, 2011   Volume 22, Issue 5-6 118-122 doi: 10.1071/NB10077
Hess IM, Massey PD, Walker B, Middleton DJ, Wright TM.Hendra virus infection is an emerging infectious disease that is not well understood. Most cases of Hendra virus infection have occurred in Queensland, with one case in a horse in NSW. Hendra virus infection has a high mortality rate in horses and humans and as cases could occur anywhere in Australia it is important to be ready for prompt action should an outbreak occur in NSW. This paper: reviews the current knowledge on Hendra virus infection including methods for preventing the disease; explains the animal health and human health response for an outbreak within NSW; and discusses possible f...
The mosquito Aedes (Aedimorphus) vexans arabiensis as a probable vector bridging the West Nile virus between birds and horses in Barkedji (Ferlo, Senegal).
Medical and veterinary entomology    July 25, 2011   Volume 26, Issue 1 106-111 doi: 10.1111/j.1365-2915.2011.00974.x
Fall AG, Diaïté A, Etter E, Bouyer J, Ndiaye TD, Konaté L.Active catches of adult females of Aedes vexans arabiensis Patton, (Diptera: Culicidae) Patton by nets or aspirator, were conducted in 2003 and 2004 in the vegetation at the edge of temporary ponds in Barkedji, Senegalese Ferlo area. Two hundred and forty-one engorged females were captured, dissected and the gut content adsorbed on a Whatman filter paper and analysed using the enzyme-linked immunosorbent assay (ELISA) technique to determinate the bloodmeal origin. Results indicated that Ae v. arabiensis fed primarily on mammals, including horses (35.7% of the bloodmeals), but also on birds (10...
Comparison of helminth and hard tick infestation between riding and work horses in Ahwaz, Iran.
Comparative clinical pathology    July 21, 2011   Volume 21, Issue 3 333-336 doi: 10.1007/s00580-011-1280-x
Khosravi M, Kavosh F, Taghavi-Moghadam A, Ghaem-Maghami S, Pirali-Kheirabadi K, Rahimi-Feyli P, Navid-Pour S, Amin-Pour A, Arbabi F.No abstract available
Antibody profiling of Borrelia burgdorferi infection in horses.
Clinical and vaccine immunology : CVI    July 20, 2011   Volume 18, Issue 9 1562-1567 doi: 10.1128/CVI.05123-11
Burbelo PD, Bren KE, Ching KH, Coleman A, Yang X, Kariu T, Iadarola MJ, Pal U.Infection with Borrelia burgdorferi is common in horses and ponies from the New England and mid-Atlantic regions of the United States. Here, we evaluated luciferase immunoprecipitation systems (LIPS) for profiling antibody responses against three different antigenic targets for the diagnosis of equine B. burgdorferi infection. LIPS testing of horse serum samples suspected of Lyme infection revealed that approximately 75% of the horse samples (114/159) were seropositive against the synthetic VOVO antigen, comprising repeated immunodominant C6 epitopes as well as OspC immunodominant epitopes. A ...
Natural Burkholderia mallei infection in Dromedary, Bahrain.
Emerging infectious diseases    July 19, 2011   Volume 17, Issue 7 1277-1279 doi: 10.3201/eid1707.110222
Wernery U, Wernery R, Joseph M, Al-Salloom F, Johnson B, Kinne J, Jose S, Jose S, Tappendorf B, Hornstra H, Scholz HC.We confirm a natural infection of dromedaries with glanders. Multilocus variable number tandem repeat analysis of a Burkholderia mallei strain isolated from a diseased dromedary in Bahrain revealed close genetic proximity to strain Dubai 7, which caused an outbreak of glanders in horses in the United Arab Emirates in 2004.
Equine babesiosis: seroprevalence, risk factors and comparison of different diagnostic methods in Jordan.
Transboundary and emerging diseases    July 19, 2011   Volume 59, Issue 1 72-78 doi: 10.1111/j.1865-1682.2011.01244.x
Abutarbush SM, Alqawasmeh DM, Mukbel RM, Al-Majali AM.The purposes of this study were to estimate the seroprevalence and distribution of horse piroplasmosis, to evaluate risk factors associated with the occurrence of the disease and to compare the different diagnostic methods used for this disease. A total of 253 clinically normal horses were sampled, and a collection form was completed for each horse from five of six different climatic zones of Jordan. The sixth zone was not sampled because it did not include horse population. Competitive enzyme-linked immunosorbent assay (cELISA) revealed 37 horses (14.6%) positive for Theileria equi, and none ...
Suspected horse-to-human transmission of MRSA ST398.
Emerging infectious diseases    July 14, 2011   Volume 17, Issue 6 1137-1139 doi: 10.3201/eid/1706.101330
van Duijkeren E, Ten Horn L, Wagenaar JA, de Bruijn M, Laarhoven L, Verstappen K, de Weerd W, Meessen N, Duim B.No abstract available
Streptococcus equi: a pathogen restricted to one host.
Journal of medical microbiology    July 14, 2011   Volume 60, Issue Pt 9 1231-1240 doi: 10.1099/jmm.0.028233-0
Waller AS, Paillot R, Timoney JF.Strangles caused by the host adapted Lancefield group C Streptococcus equi subspecies equi (S. equi) is a frequently diagnosed infectious disease of horses worldwide. Critical to the global success of S. equi is its ability to establish persistent infections within the guttural pouches of recovered apparently healthy horses that can result in transmission to in-contact animals. Recent research has identified key events in the S. equi genome, which occurred during its evolution from an ancestral strain of S. equi subspecies zooepidemicus, that may enhance its ability to evade host innate immune...
Phylogenetic and molecular characterization of equine H3N8 influenza viruses from Greece (2003 and 2007): evidence for reassortment between evolutionary lineages.
Virology journal    July 14, 2011   Volume 8 350 doi: 10.1186/1743-422X-8-350
Bountouri M, Fragkiadaki E, Ntafis V, Kanellos T, Xylouri E.For first time in Greece equine influenza virus infection was confirmed, by isolation and molecular analysis, as the cause of clinical respiratory disease among unvaccinated horses during 2003 and 2007 outbreaks. Methods: Equine influenza virus (EIV) H3N8 was isolated in MDCK cells from 30 nasal swabs from horses with acute respiratory disease, which were tested positive by Directigen Flu A. Isolation was confirmed by haemagglutination assay and RT-PCR assay of the M, HA and NA gene. Results: HA sequences of the Greek isolates appeared to be more closely related to viruses isolated in early 19...
Faecal shedding of CTX-M-producing Escherichia coli in horses receiving broad-spectrum antimicrobial prophylaxis after hospital admission.
Veterinary microbiology    July 14, 2011   Volume 154, Issue 3-4 298-304 doi: 10.1016/j.vetmic.2011.07.005
Damborg P, Marskar P, Baptiste KE, Guardabassi L.The objective of this longitudinal study was to investigate the occurrence and genetic background of faecal Escherichia coli resistant to cefotaxime (CTX) in horses receiving broad-spectrum antimicrobial prophylaxis after admission to a veterinary teaching hospital. The ten horses enrolled in the study were treated with cefquinome either alone (n=4) or in combination with metronidazole (n=3) or other antimicrobial agents (n=3). CTX-resistant coliforms in faeces collected before, during and after treatment were quantified on selective MacConkey agar supplemented with CTX, and a colony isolated ...
Decreased infectivity of a neutralization-resistant equine infectious anemia virus variant can be overcome by efficient cell-to-cell spread.
Journal of virology    July 13, 2011   Volume 85, Issue 19 10421-10424 doi: 10.1128/JVI.05349-11
Wu W, Blythe DC, Loyd H, Mealey RH, Tallmadge RL, Dorman KS, Carpenter S.Two variants of equine infectious anemia virus (EIAV) that differed in sensitivity to broadly neutralizing antibody were tested in direct competition assays. No differences were observed in the growth curves and relative fitness scores of EIAVs of principal neutralizing domain variants of groups 1 (EIAV(PND-1)) and 5 (EIAV(PND-5)), respectively; however, the neutralization-resistant EIAV(PND-5) variant was less infectious in single-round replication assays. Infectious center assays indicated similar rates of cell-to-cell spread, which was approximately 1,000-fold more efficient than cell-free ...
The effect of geographic location, breed, and pituitary dysfunction on seasonal adrenocorticotropin and α-melanocyte-stimulating hormone plasma concentrations in horses.
Journal of veterinary internal medicine    July 11, 2011   Volume 25, Issue 4 872-881 doi: 10.1111/j.1939-1676.2011.0745.x
McFarlane D, Paradis MR, Zimmel D, Sykes B, Brorsen BW, Sanchez A, Vainio K.Plasma α-melanocyte-stimulating hormone (α-MSH) and adrenocorticotropin (ACTH) concentrations in horses vary with season, confounding diagnostic testing for pituitary pars intermedia dysfunction (PPID). Objective: The goals of this study were to determine whether seasonal variation in plasma α-MSH and ACTH concentrations in horses is influenced by geographic location, breed, or PPID. Methods: Healthy light breed horses residing in Florida, Massachusetts, and Finland (n = 12 per group); healthy Morgan horses (n = 13); healthy ponies (n = 9) and horses with PPID (n = 8). Methods: Monthly plas...
Neutralising antibodies for West Nile virus in horses from Brazilian Pantanal.
Memorias do Instituto Oswaldo Cruz    July 9, 2011   Volume 106, Issue 4 467-474 doi: 10.1590/s0074-02762011000400014
Pauvolid-Corrêa A, Morales MA, Levis S, Figueiredo LT, Couto-Lima D, Campos Z, Nogueira MF, da Silva EE, Nogueira RM, Schatzmayr HG.Despite evidence of West Nile virus (WNV) activity in Colombia, Venezuela and Argentina, this virus has not been reported in most South American countries. In February 2009, we commenced an investigation for WNV in mosquitoes, horses and caimans from the Pantanal, Central-West Brazil. The sera of 168 horses and 30 caimans were initially tested using a flaviviruses-specific epitope-blocking enzyme-linked immunosorbent assay (blocking ELISA) for the detection of flavivirus-reactive antibodies. The seropositive samples were further tested using a plaque-reduction neutralisation test (PRNT90) for ...
Seasonal abundance of stable flies and filth fly pupal parasitoids (Hymenoptera: Pteromalidae) at Florida equine facilities.
Journal of economic entomology    July 9, 2011   Volume 104, Issue 3 1108-1115 doi: 10.1603/ec10227
Pitzer JB, Kaufman PE, Hogsette JA, Geden CJ, Tenbroeck SH.Beginning in November 2007 and continuing until December 2009, weekly stable fly, Stomoxys calcitrans (L.), surveillance was conducted at four equine facilities near Ocala, FL, by using alsynite sticky traps for adults and by searching immature developmental sites for pupae. Adult stable fly trap captures were highly variable throughout the year, ranging from 0 to 1,400 flies per trap per farm. The greatest adult stable fly activity was observed during the spring months of March and April, with weekly three-trap means of 121 and 136 flies per farm, respectively. The importance of cultural cont...
Exposure of free-ranging wild carnivores, horses and domestic dogs to Leptospira spp in the northern Pantanal, Brazil.
Memorias do Instituto Oswaldo Cruz    July 9, 2011   Volume 106, Issue 4 441-444 doi: 10.1590/s0074-02762011000400009
Jorge RS, Ferreira F, Ferreira Neto JS, Vasconcellos Sde A, Lima Ede S, Morais ZM, Souza GO.Leptospirosis is a zoonotic disease affecting most mammals and is distributed throughout the world. Several species of domestic and wild animals may act as reservoirs for this disease. The purpose of this study was to assess the exposure of free-ranging wild carnivores, horses and domestic dogs on a private reserve located in the northern Pantanal (Brazil) and the surrounding areas to Leptospira spp from 2002-2006, 75 free-ranging wild carnivores were captured in the Pantanal and serum samples were collected. In addition, samples from 103 domestic dogs and 23 horses in the region were collecte...
Assessment of the proportion of under-reporting during the 2007 equine influenza outbreak in New South Wales, Australia.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 73-74 doi: 10.1111/j.1751-0813.2011.00754.x
Dhand NK, Sergeant ES.During the 2007 equine influenza (EI) outbreak in Australia, there was no objective information about the possible under-reporting of cases by horse owners either so that they would avoid movement restrictions or because of their inability to detect infection. This investigation aimed to estimate the proportion of under-reporting during the outbreak based on the results of surveillance undertaken in conjunction with vaccination. The results provided improved estimates of morbidity during the outbreak and indicated the level of under-reporting likely to occur in future outbreaks of other infect...
Clinical signs of equine influenza in a closed population of horses at a 3-day event in southern Queensland, Australia.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 17-18 doi: 10.1111/j.1751-0813.2011.00729.x
Dups JN, Morton JM, Anthony ND, Dwyer JF.This report describes the clinical signs of equine influenza (EI) during an epidemic in a closed, predominantly immunologically naïve population of horses. It included 254 study horses, few of which exhibited all three signs of pyrexia, nasal discharge and cough simultaneously. We conclude that although the majority of affected horses exhibit temperature patterns resembling those most often described in the published literature, clinicians should be aware that other profiles are quite common.
Quantitative analysis of the risk of spread of equine influenza associated with movements of vaccinated horses from infected areas during the Australian outbreak.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 103-108 doi: 10.1111/j.1751-0813.2011.00761.x
Sergeant ES, Stone M, Moloney BJ, Arthur R.Simulation models were developed to quantify the likelihood of equine influenza virus infection entering pre-movement isolation, persisting through pre- and post-movement isolation periods without being detected by scheduled laboratory testing, and escaping to infect susceptible horses at a destination. The mean probability of escape ranged from 1 in 1,200,000 to 1 in 600,000 depending on lot size. For 95% of iterations the probability of escape was less than 1 in 200,000, regardless of lot size. For a large group of 600 horses processed as multiple separate lots, the mean probability of escap...
Clinical impression of equine influenza at Morgan Park and the western region of Brisbane, Queensland, Australia.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 16-17 doi: 10.1111/j.1751-0813.2011.00727.x
Anthony ND.The clinical signs of horses infected with equine influenza in two Queensland locations, Morgan Park Recreational Grounds at Warwick, and the western region of Brisbane, are described and compared. Clinical signs were observed to be more severe, and treatment more intensive, in horses in stressful settings.
In this issue: Equine influenza in Australia in 2007–the definitive story.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 1-2 doi: 10.1111/j.1751-0813.2011.00783.x
Jackson AE.No abstract available
Pathological changes in horses dying with equine influenza in Australia, 2007.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 19-22 doi: 10.1111/j.1751-0813.2011.00731.x
Begg AP, Reece RL, Hum S, Townsend W, Gordon A, Carrick J.Analysis of pathology results from the 2007 equine influenza (EI) outbreak in Australia indicate that young foals in naïve horse populations are prone to developing broncho-interstitial pneumonia, and that this can be a rare manifestation of EI virus infection in mature horses. All horses may develop secondary bacterial bronchopneumonia, with mature horses more likely to die. EI outbreaks among heavily pregnant mares can result in increased neonatal losses because of premature placental separation and dystocia causing fetal hypoxia.
Equine influenza immunity in the Special Restricted Area (Purple Zone) of New South Wales, Australia.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 116-120 doi: 10.1111/j.1751-0813.2011.00762.x
Wilson G, Cooper K, Williams J, Eastwood S, Peake C.The 2007 equine influenza (EI) outbreak in New South Wales (NSW) consisted of a central infected area that extended south from the lower New England Tableland, across the Hunter Valley, Central Coast and the Sydney basin, and a series of isolated clusters outside this area across rural NSW. The central area was assigned the status of a Purple Zone (Special Restricted Area, SRA) approximately 1 month after the outbreak commenced. Within this SRA, the eradication program's focus was to increase the proportion of horses immune to EI via vaccination, thus reducing the susceptible proportion to a l...
Real-time RT-PCR for detection of equine influenza and its evaluation using samples from horses infected with A/equine/Sydney/2007 (H3N8).
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 37-38 doi: 10.1111/j.1751-0813.2011.00739.x
Foord AJ, Selleck P, Colling A, Klippel J, Middleton D, Heine HG.No abstract available
Special issue: Equine influenza in Australia in 2007. Foreword.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 2 doi: 10.1111/j.1751-0813.2011.00723.x
Glanville R.No abstract available
Factors associated with high psychological distress in horse industry participants during the 2007 Australian equine influenza outbreak and evidence of recovery after 1 year.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 158-159 doi: 10.1111/j.1751-0813.2011.00772.x
Taylor M, Agho K, Stevens G, Raphael B.This short report summarises data on the prevalence of high psychological distress in horse industry participants during the 2007 Australian equine influenza (EI) outbreak and the statistical analysis undertaken to identify the factors associated with this high psychological distress. In addition, follow-up data collected 1 year later are reported briefly.
Risk of an equine influenza virus reservoir establishing in wild horses in New South Wales during the Australian epidemic.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 75-78 doi: 10.1111/j.1751-0813.2011.00752.x
Gilchrist P, Sergeant ES.Australia has the world's largest population of wild equids and equine influenza (EI) was confirmed on several properties in New South Wales (NSW) close to uncontrolled areas of land during the 2007 outbreak. Likelihood and risk management assessments were carried out to determine the risk of EI infection of the wild horse populations. The likelihood of spread to the wild horse population was determined to be extremely low, but the likelihood of spread from an established wild horse reservoir back to domestic horses was considered high. The most effective mechanism of control was determined to...
Demonstrating freedom from equine influenza in New South Wales, Australia, following the 2007 outbreak.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 164-169 doi: 10.1111/j.1751-0813.2011.00779.x
Sergeant ES, Wilson G.To quantify the probability of freedom from equine influenza (EI) in New South Wales (NSW), Australia, based on analysis of polymerase chain reaction (PCR) testing. Methods: Testing in the infected areas of NSW during the period 1 January to 30 April 2008. Results: Data from the random survey were collated and analysed to provide estimates of the probability of detecting EI if it was present at a prevalence ranging from 0.01% to 0.5%. The sensitivity estimates were then combined with a prior estimate of the probability of freedom in a simulation model, to estimate the posterior probability of ...
The August 2007 equine influenza response management framework.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 92-97 doi: 10.1111/j.1751-0813.2011.00758.x
Webster WR.This section outlines the most important issues addressed in the management of the response in the two infected states, New South Wales and Queensland. There were differences in the management of the response between the states for logistic, geographic and organisation structural reasons. Issues included the use of control centres, information centres, the problems associated with the lack of trained staff to undertake all the roles, legislative issues, controls of horse movements, the availability of resources for adequate surveillance, the challenges of communication between disparate groups...
Application of high-throughput systems for the rapid detection of DNA and RNA viruses during the Australian equine influenza outbreak.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 38-39 doi: 10.1111/j.1751-0813.2011.00744.x
Kirkland PD, Davis RJ, Gu X, Frost M.No abstract available
Diagnosis of equine influenza virus infections in quarantine stations in Australia, 2007.
Australian veterinary journal    July 8, 2011   Volume 89 Suppl 1 4-6 doi: 10.1111/j.1751-0813.2011.00722.x
Watson J, Selleck P, Axell A, Bruce K, Taylor T, Heine H, Daniels P, Jeggo M.In August 2007, several horses showed pyrexia and respiratory signs while in post-arrival quarantine in Australia. Subsequent investigations diagnosed equine influenza by serology and PCR in two quarantine stations. A common origin in a shipment of horses from Japan was indicated.