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Topic:Equine Diseases
Equine diseases encompass a wide range of health conditions that can affect horses, including infectious diseases, metabolic disorders, and genetic conditions. These diseases can impact the overall health, performance, and well-being of horses. Common equine diseases include equine influenza, equine herpesvirus, laminitis, and equine metabolic syndrome. Diagnosis and management of these diseases often require a combination of clinical evaluation, laboratory testing, and appropriate treatment strategies. This page gathers peer-reviewed research studies and scholarly articles that explore the etiology, pathophysiology, diagnosis, and treatment options for various equine diseases, providing valuable insights for veterinarians and researchers in the field.
A giant congenital pigmented nevus in a horse. Pigmented nevi have not been widely recognized in domesticated animals. We describe, for the first time, a giant congenital pigmented nevus in a horse. Because of a prominent neuroid component within the lesion, neurofibromatosis was the major differential diagnosis.
Inhibition of equine S-adenohomocysteine hydrolase by 2′-deoxyadenosine. 2'-Deoxyadenosine and 9-beta-D-arabinofuranosyladenine (ARA) are apparent suicide inhibitors for equine S-adenosylhomocysteine hydrolase. In initial velocity studies of the synthetic reaction converting adenosine and homocysteine to S-adenosylhomocysteine, adenine, adenosine 5'-triphosphate, and 9-beta-D-arabinofuranosyladenine were found to be competitive inhibitors with Kis of 3.8 microM, 1.1 mM, and 30 microM, respectively. In contrast, linear mixed inhibition was observed for 2'-deoxyadenosine, indicating that 2'-deoxyadenosine must bind in more than one fashion to the enzyme.
In vitro induction of lymphocyte responsiveness by a Strongylus vulgaris-derived mitogen. Proliferation in vitro of peripheral blood lymphocytes both from horses infected with Strongylus vulgaris and from helminth-free ponies was observed in the presence of extracts of the fourth and fifth stage larvae and adults of S. vulgaris. In addition, S. vulgaris extracts induced transformation in cultures of peripheral blood lymphocytes from sheep and dogs and in mouse spleen cell cultures. Nylon wool non-adherent, T cell enriched fractions of lymphocytes from both mice and horses were stimulated by the S. vulgaris larval mitogen while no proliferation was observed in cultures containing ny...
Experiences in diagnostic and surgical arthroscopy in the horse. This paper reviews the current status of diagnostic and surgical arthroscopy in the horse. Arthroscopy has been used as a diagnostic aid since 1974 and is useful for evaluation of abnormalities in synovial membrane and articular cartilage. Surgical arthroscopy is a more recent advance that has replaced conventional arthrotomy in 90 per cent of the author's cases. Clinical conditions currently being treated using arthroscopic techniques rather than arthrotomy include all chip fractures in the carpus, chip fractures of the first phalanx, chronic proliferative synovitis in the fetlock and osteoch...
[Nucleus motorius lateralis in the lumbosacral segment of the spinal cord in horses]. Two medullae oblongatae of horses were cut into 15 microns cross-sections and stained according to the modified method of Nissel. The lateral motor nucleus lies in the lateral and median part of the ventral column of spinal cord grey matter. It adjoins medially nucleus motorius medialis of the spinal ventral column. Cells of this nucleus occur both along the whole lumbar and sacral segment of the spinal cord. In the lateral motor nucleus three cell groups are distinguished-median, basal and lateral. The latter is divided in some segments into subgroups-dorsal and ventral. Along the nucleus qui...
Verminous (Strongylus vulgaris) myelitis in a donkey. A fifth stage Strongylus vulgaris migrated through the spinal cord of a 2-year-old, male donkey resulting in progressive paraparesis and then tetraplegia. A profound neutrophilic pleocytosis was detected on analysis of cerebrospinal fluid. The parasite appeared to have entered the mid-lumbar spinal cord, migrated to the cranial thoracic segments, exited, then re-entered the spinal cord a few segments craniad. It then traveled further cranially and was found in the third cervical spinal cord segment. Some parts of the lesion were remarkably free from tissue necrosis, hemorrhage and inflammation...
Retained cartilage in the distal radial physis of foals. Examination of growth plate defects in the distal radial physis of 13 foals three to 70 days of age revealed lesions in the lateral and medial aspects of the distal radial physis; the lateral defects were more numerous and obvious. Lesions consisted of widening of the zone of hypertrophying cells of the metaphyseal growth plate (retained cartilage), retained cartilage with discontinuity of cartilage and primary spongiosa, and microfracture of the primary spongiosa. In some foals, the cartilage retention was thought to be due to primary spongiosa microfracture, although fracture subsequent to c...
Borna disease of horses. An immunohistological and virological study of naturally infected animals. The brains of eight horses that had suffered from natural Borna disease were examined with virologic, immunohistological, and electron-microscopic methods. All brains harbored infectious virus as shown by inoculation of experimental animals. Regional assessment of the infectivity exhibited the highest titers in the hippocampus and piriform cortex and the lowest in the cerebellum. Conventional histology yielded pathologic alterations very similar to those of the classical description of the disease. Immunohistology demonstrated the highest amounts of Borna disease virus-specific antigen in the ...
Muscle perfusion in the horse. Muscle perfusion was studied in conscious and anaesthetised horses by monitoring the clearance of a locally injected bolus of saline containing radioactive xenon (133Xe). The mean of all the measurements made from the brachiocephalicus and semimembranosus muscles in conscious subjects was 1.29 ml/min/100 g while in anaesthetised subjects it was 0.40 ml/min/100 g. The significance of these results is discussed in relation to the clinical occurrence of post anaesthetic myositis.
[Diagnosis and therapy of guttural pouch diseases in horses]. Using a fibreoptic endoscope ("small gastroscope" with outside diameter of 9.3 mm) a simple and sparing inspection of the guttural pouch is performed. The flap-type tube cover is opened by means of medial leverage with a guidance probe shifted through the work duct of the endoscope. The same procedure is used in diagnostic specimen collection and therapeutical measures such as irrigations. Guttural pouch topography and pathological disorders are illustrated by endoscopic photography. The different diseases such as follicular hyperplasia, ascending pharyngeal catarrh, perforating abscesses of t...
Cervical vertebral interbody fusion in the horse: a comparative study of bovine xenografts and autografts supported by stainless steel baskets. A modified form of the Cloward technique for anterior cervical fusion in human beings was used in the application of different grafts for evaluation of their effectiveness in stabilizing equine cervical vertebrae. Results of bovine xenograft implants in 8 horses were compared with results of stainless steel baskets (SSB) packed with cancellous autogenous bone in 8 horses. Graft material was incorporated in all cases. Evidence of graft rejection was not present. Both forms of implants decreased the mobility of the intervertebral space in which they were implanted. A fibrous connective tissue un...
Effects of environmental control on pulmonary function of horses affected with chronic obstructive pulmonary disease. The effects of environmental control on horses affected with chronic obstructive pulmonary disease was assessed by clinical examination and pulmonary function tests, ie, maximum change in intrathoracic pressure, tidal volume, minute volume, non-elastic work of breathing, dynamic compliance, inspiratory and expiratory flow rates and arterial blood gas analysis. A controlled environment (ie, bedding horses on shredded paper and feeding a complete cubed diet) caused symptomatic COPD affected horses to become asymptomatic within four to 24 days (mean +/- sd 8.4 +/- 4.8 days). When asymptomatic, th...
Lymphocyte alloantigens of the horse. III. ELY-2.1: a lymphocyte alloantigen not coded for by the MHC. A new polymorphic locus of the horse which has several unusual properties is described. The suggested name for the locus is ELY-2. The gene product of one allele at this locus, designated ELY-2.1, has been identified with antisera raised as a result of pregnancy. Antibody to ELY-2.1 was first detected on day 55 after conception in the serum of a mare in first pregnancy. This early onset of antibody is similar to that seen for antibody to ELA antigens, and suggests that the source of the antigenic stimulus may be the tissue of the equine endometrial cups. The antisera identifying ELY-2.1 are cy...
Degradation of annular gap junctions of the equine hoof wall. Annular gap junctions interiorized within cells of the stratum spinosum of the coronary border of the equine hoof were degraded by two methods. Some were autophagocytized and some appeared to fuse with lysosomes to form heterophagosomes. Structural changes of partially degraded annular gap junctions included increased density of the enclosed cytoplasm, formation of filamentous or membrane-like material within the annular gap junction, and disruption of the circular or oval profile of the gap junction. The annular gap junctions are apparently incorporated into the fully keratinized cells of the...
[Intersexuality in the horse. Morphologic, hormone analytic and cytogenetic studies in an Arabohaflinger horse]. A case of intersexuality in an arabo-haflinger horse is described. The external genitalia consisted of mammary gland, vulva and hypertrophic clitoris; the inner genitalia of rudimental testes. The sexual behaviour was typically male-like. The chromosome analysis showed the female karyotype 64,XX. The presence of testes in a genetically female animal is explained by translocation of an Y-chromosome fragment bearing the gene for the H-Y-antigen.
Structural proteins of equine infectious anemia virus and their antigenic activity. Using purified equine infectious anemia (EIA) virus labeled with 3H-glucosamine or 14C-protein hydrolysate, structural proteins were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. As a result, 2 glycoproteins and 10 proteins with molecular weights (mol wt) ranging from 12,000 to 115,000 daltons were demonstrated. Of 12 structural proteins, 3 proteins, namely a glycoprotein with mol wt of 76,000 (gp76) and 2 proteins with mol wt of 25,000 (p25) and 12,000 (p12), respectively, had distinct antigenic activity from one another in immunodiffusion. Development of antibodies a...
Structures of the dienoic lactones of horse sebum. The C34, C36, and C38 dienoic omega-lactones were isolated from sebum of the horse (Equus caballus) and the double bond positions were determined by stepwise chemical dissection and analysis of the fragments. The structures found could be formed by delta 9-desaturation at the C18-stage of fatty acid biosynthesis followed by a second delta 9-desaturation when the chains reached C24, C26, C28, C30, or C32 and then addition of one to seven 2-carbon units. These findings provide insight into the dimensions and organization of the endoplasmic reticulum in cells of the sebaceous glands.
[Monoclonal antibodies directed against equine blood group antigens]. The chief application of blood typing in domestic animals is in the verification of parentage. However, the acquisition of good standardized reagents in sufficient quantity remains an obstacle for the development of this work. The production of monoclonal antibodies directed against blood group determinants offers an attractive means of improving both the quality and quantity of serological reagents, and could facilitate the definition of new specificities. Fusions between a mouse myeloma line and splenocytes from mice immunized with horse red cells have resulted in four hybridomas producing a...
Studies on ticks of veterinary importance in Nigeria. VIII. Differences observed in the biology of ticks which fed on different domestic animal hosts. Ticks of the species Amblyomma variegatum (Fabr.), Boophilus decoloratus (Koch), Boophilus geigyi Aeschl. et Morel, and Hyalomma rufipes Koch were detached from cattle, sheep and horses and the influence of these various hosts on the biology of ticks was investigated. No A. variegatum was found in horses. The parameters studied were preoviposition and oviposition periods, ovipositional capacity, eclosion period, hatching patterns, egg sizes and temperature effect. Although the preoviposition and eclosion periods were similar in each tick species irrespective of the host from which the adults w...
The mechanism of Na+-L-lactate cotransport by brush-border membrane vesicles from horse kidney. Analysis by isotopic exchange kinetics of a sequential model and stoichiometry. The present study determines the characteristics of isotopic Na and lactate exchange under equilibrium conditions in horse kidney brush-border membrane vesicles. The influence of one solute (Na+ or lactate) on the isotopic exchange of the co-transported species (lactate or Na) was analyzed in detail. Analysis of the data suggests that Na and lactate interact sequentially with the carrier. The observed apparent symmetry between the activating effect of low Na concentrations and the inhibiting effect of high Na concentrations on the lactate exchange process suggests that the carrier functions ac...
The use of equine anti-endotoxin hyperimmune serum in the treatment of septic arthritis in foals. Three thoroughbred foals were treated with anti-endotoxin hyperimmune serum. The serum was injected into the affected joint spaces. Two of the foals made a complete recovery.
