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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Tissue sites of persistent infection and active replication of equine infectious anemia virus during acute disease and asymptomatic infection in experimentally infected equids.
Journal of virology    March 9, 2000   Volume 74, Issue 7 3112-3121 doi: 10.1128/jvi.74.7.3112-3121.2000
Harrold SM, Cook SJ, Cook RF, Rushlow KE, Issel CJ, Montelaro RC.Equine infectious anemia virus (EIAV) infection of horses is characterized by recurring cycles of disease and viremia that typically progress to an inapparent infection in which clinical symptoms are absent as host immune responses maintain control of virus replication indefinitely. The dynamics of EIAV viremia and its association with disease cycles have been well characterized, but there has been to date no comprehensive quantitative analyses of the specific tissue sites of EIAV infection and replication in experimentally infected equids during acute disease episodes and during asymptomatic ...
Clinical and pathologic findings in donkeys with hypothermia: 10 cases (1988-1998).
Journal of the American Veterinary Medical Association    March 9, 2000   Volume 216, Issue 5 725-729 doi: 10.2460/javma.2000.216.725
Stephen JO, Baptiste KE, Townsend HG.To describe clinical signs and clinicopathologic findings in donkeys with hypothermia. Methods: Retrospective study. Methods: 10 hypothermic donkeys. Methods: Information on signalment, history, physical examination findings, results of diagnostic tests, treatments, and necropsy findings was extracted from medical records of all donkeys with hypothermia between 1988 and 1998 and compared with information from medical records of all normothermic donkeys and hypothermic horses admitted to the hospital during the same period. Results: Donkeys were more likely to be hypothermic than horses. The me...
Possible mechanisms of mammalian immunocontraception.
Journal of reproductive immunology    March 9, 2000   Volume 46, Issue 2 103-124 doi: 10.1016/s0165-0378(99)00063-7
Barber MR, Fayrer-Hosken RA.Ecological and conservation programs in ecosystems around the world have experienced varied success in population management. One of the greatest problems is that human expansion has led to the shrinking of wildlife habitat and, as a result, the overpopulation of many different species has occurred. The pressures exerted by the increased number of animals has caused environmental damage. The humane and practical control of these populations has solicited the scientific community to arrive at a safe, effective, and cost-efficient means of population control. Immunocontraception using zona pellu...
Isolation and characterization of an arterivirus defective interfering RNA genome.
Journal of virology    March 9, 2000   Volume 74, Issue 7 3156-3165 doi: 10.1128/jvi.74.7.3156-3165.2000
Molenkamp R, Rozier BC, Greve S, Spaan WJ, Snijder EJ.Equine arteritis virus (EAV), the type member of the family Arteriviridae, is a single-stranded RNA virus with a positive-stranded genome of approximately 13 kb. EAV uses a discontinuous transcription mechanism to produce a nested set of six subgenomic mRNAs from which its structural genes are expressed. We have generated the first documented arterivirus defective interfering (DI) RNAs by serial undiluted passaging of a wild-type EAV stock in BHK-21 cells. A cDNA copy of the smallest DI RNA (5.6 kb) was cloned. Upon transfection into EAV-infected BHK-21 cells, transcripts derived from this clo...
ITS-1 ribosomal DNA sequence variants are maintained in different species and strains of Echinococcus.
International journal for parasitology    March 8, 2000   Volume 30, Issue 2 157-169 doi: 10.1016/s0020-7519(00)00002-3
van Herwerden L, Gasser RB, Blair D.This study investigated sequence heterogeneity in the first internal transcribed spacer (ITS-1) of ribosomal DNA within and among species and strains of Echinococcus. Different ITS-1 sequence variants exist in Echinococcus granulosus and Echinococcus multilocularis, which represent at least four evolutionary lineages: (1) a sheep strain-lineage of E. granulosus, (2) a sister lineage of a cervid and camel E. granulosus ITS-1 variants, (3) a lineage including the ITS-1 variants representing horse, bovine and camel strains of E. granulosus, as well as variants from E. multilocularis, Echinococcus...
Pony with skin allergy.
The British homoeopathic journal    March 7, 2000   Volume 89, Issue 1 41-42 doi: 10.1038/sj.bhj.5800381
Davies C.No abstract available
Comparison of the antisecretory effects of omeprazole when administered intravenously, as acid-stable granules and as an oral paste in horses.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 54-58 doi: 10.1111/j.2042-3306.1999.tb05170.x
Haven ML, Dave K, Burrow JA, Merritt AM, Harris D, Zhang D, Hickey GJ.The antisecretory activity of omeprazole on gastric acid when administered i.v., intragastrically or per os, was evaluated in 2 female and 3 castrated male horses. Each horse had been prepared with a chronic indwelling gastric cannula. A single i.v. administration of omeprazole (1.5 mg/kg bwt) was effective in abolishing basal and pentagastrin (PG)-stimulated acid secretion. Once daily, nasogastric administration of omeprazole in acid-stable granules for 5 days inhibited acid secretion in a dose-dependent manner: 57% (1.5 mg/kg bwt) and 98% (5.0 mg/kg bwt) reduction of PG-stimulated acid secre...
Safety, acceptability and endoscopic findings in foals and yearling horses treated with a paste formulation of omeprazole for twenty-eight days.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 67-70 doi: 10.1111/j.2042-3306.1999.tb05173.x
Murray MJ, Eichorn ES, Holste JE, Cox JL, Stanier WB, Cooper WL, Cooper VA.A paste formulation of the H+,K(+)-ATPase inhibitor omeprazole was evaluated in Thoroughbred foals and yearlings for its safety and acceptability. Twenty foals age 11-16 weeks and 20 yearling horses age 15-17 months were included and gastroscopic examinations performed 1-3 days before and at the end of each trial. Lesions were scored on a scale of 0 to 3 and animals allocated based on endoscopic lesion score and sex, with 4 animals in each of 5 replicates. Dosages of 4 mg omeprazole/kg bwt or sham treatment were administered once daily for 28 days, from a syringe graduated in 50 lb (22.68 kg) ...
Cross-sectional study of gastric ulcers of the squamous mucosa in thoroughbred racehorses.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 34-39 doi: 10.1111/j.2042-3306.1999.tb05166.x
Vatistas NJ, Snyder JR, Carlson G, Johnson B, Arthur RM, Thurmond M, Zhou H, Lloyd KL.Although gastric ulcers have been identified relatively frequently in racing Thoroughbreds, there have been no large scale studies to determine their effect on health and performance. Two hundred and two Thoroughbred horses in active race training were selected by the attending veterinarians for gastro-endoscopic examination. Images of the stomach mucosa were stored in a digitised format for subsequent evaluation. The number of ulcers and a score of severity were determined. Gastric ulceration of the squamous mucosa was identified in 82% of horses. Seventy-three (39%) horses displayed clinical...
Comparative pathophysiology of nonglandular ulcer disease: a review of experimental studies.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 19-23 doi: 10.1111/j.2042-3306.1999.tb05163.x
Argenzio RA.Ulceration of the nonglandular, stratified squamous mucosa of the equine and porcine stomach is a common event in both species, although in pigs the fatality rate is significant and it is an economically important disease. Because the barrier function of this mucosa in horses and pigs appears similar, it is probable that similar pathophysiological mechanisms may be responsible for the initiating lesions and reparative events. Recent studies of ulcer pathogenesis in the pig have shown that feed preparation or prolonged fasting can result in disruption of the normal stratification of gastric con...
Induction and maintenance of gastric ulceration in horses in simulated race training.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 40-44 doi: 10.1111/j.2042-3306.1999.tb05167.x
Vatistas NJ, Sifferman RL, Holste J, Cox JL, Pinalto G, Schultz KT.Gastric ulceration is a prevalent condition of racehorses. A number of models of gastric ulceration have been described, but none mimic the conditions of a horse in training. The objectives of this study were to determine whether gastric ulcers could be induced and maintained in a group of horses in simulated race training. In addition, serum cortisol was measured on a weekly basis to investigate the possibility that stress may be important in the pathogenesis of gastric ulceration. Thirty horses used in the trial were fed Bermuda grass hay and 6 kg of a concentrate diet, and exercised 6 days/...
Production and characterisation of two monoclonal antibodies recognising equine IgG Fc receptors.
Veterinary immunology and immunopathology    March 4, 2000   Volume 73, Issue 1 63-71 doi: 10.1016/s0165-2427(99)00153-1
Aggarwal N, Holmes MA.Despite the importance of IgG Fc receptors in the regulation of various immunological mechanisms, these receptors have not been well characterised in the domesticated animals including equines. This paper describes the production of two monoclonal antibodies (CVS 59 and CVS 61) that recognise equine IgG Fc receptors. Fusions were conducted using BALB/c mice hyperimmunised with equine peripheral blood mononuclear cells. Hybridoma supernatants were screened on the basis of their ability to inhibit the rosetting of equine antibody coated sheep erythrocytes with equine peripheral blood mononuclear...
Acceptability of a paste formulation and efficacy of high dose omeprazole in healing gastric ulcers in horses maintained in race training.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 71-76 doi: 10.1111/j.2042-3306.1999.tb05174.x
Vatistas NJ, Snyder JR, Nieto J, Thompson D, Pollmeier M, Holste J.Gastric ulceration has been found to occur in 80-90% of Thoroughbreds in active race training. Previously, variable success has been reported using mucosal surface protectants and H2 receptor antagonist. Omeprazole, a substituted benzimidazole, has been shown to inhibit gastric acid secretion in both man and animals. Fourteen horses, in active race training and with endoscopic evidence of moderated to severe gastric ulceration were divided into 2 groups: Group 1 (7 horses) were given placebo paste orally once daily for 28 days; Group 2 (7 horses) received 1.54 g active omeprazole in the placeb...
Clinical syndromes of gastric ulceration in foals and mature horses.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 30-33 doi: 10.1111/j.2042-3306.1999.tb05165.x
Andrews FM, Nadeau JA.No abstract available
A review of medical treatment for peptic ulcer disease.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 45-49 doi: 10.1111/j.2042-3306.1999.tb05168.x
MacAllister CG.No abstract available
Determination of the activity of diclazuril against Sarcocystis neurona and Sarcocystis falcatula in cell cultures.
The Journal of parasitology    March 4, 2000   Volume 86, Issue 1 164-166 doi: 10.1645/0022-3395(2000)086[0164:DOTAOD]2.0.CO;2
Lindsay DS, Dubey JP.Diclazuril is a benzeneacetonitril anticoccidial that has excellent activity against the extraintestinal stages of Toxoplasma gondii and Neospora caninum. It also is highly active against intestinal coccidia of poultry. The present study examined the efficacy of diclazuril in inhibiting merozoite production of Sarcocystis neurona and Sarcocystis falcatula in bovine turbinate cell cultures. Diclazuril inhibited merozoite production by more than 80% in cultures of S. neurona or S. falcatula treated with 0.1 ng/ml diclazuril and greater than 95% inhibition of merozoite production was observed whe...
Efficacy of omeprazole paste in the treatment and prevention of gastric ulcers in horses.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 81-86 doi: 10.1111/j.2042-3306.1999.tb05176.x
Andrews FM, Sifferman RL, Bernard W, Hughes FE, Holste JE, Daurio CP, Alva R, Cox JL.Equine gastric ulcer syndrome (EGUS) is very common among performance horses, with a reported prevalence of approximately 90% in racehorses, and also > 50% in foals. Omeprazole, an acid pump inhibitor 5 times more potent than ranitidine, has been used with great success to treat EGUS. This multicentre study of Thoroughbred racehorses with endoscopically verified gastric ulcers was designed to demonstrate the efficacy of an equine oral paste formulation of omeprazole in the treatment and prevention of recurrence of EGUS. Of the 100 horses entered into the study, 25 were sham-dosed for the full ...
Treatment of gastric lesions in horses with pectin-lecithin complex.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 91-96 doi: 10.1111/j.2042-3306.1999.tb05178.x
Venner M, Lauffs S, Deegen E.This study compared the study of a pectin-lecithin complex (Pronutrin) on gastric ulcer healing during an 11 day period in 2 groups of 12 horses each. Twenty-four horses suffering from gastric lesions of differing severity were selected from a larger group of clinical cases on the basis of gastroscopic examination. Both gastric mucosal erosions as well as gastric ulcers were found in the 2 mucosal regions (pars nonglandularis and pars glandularis). The gastric mucosal lesions occurred predominantly in the pars nonglandularis in the vicinity of the margo plicatus. The 24 horses were divided equ...
Effect of omeprazole paste on gastric acid secretion in horses.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 59-62 doi: 10.1111/j.2042-3306.1999.tb05171.x
Daurio CP, Holste JE, Andrews FM, Merritt AM, Blackford JT, Dolz F, Thompson DR.In a multicentre trial, 13 cannulated horses were treated orally once daily with a paste that delivered omeprazole at a dose of 4 and 5 mg/kg bwt in a 2-period crossover design to evaluate steady state gastric acid suppression. In each period, basal (unstimulated) and pentagastrin-stimulated gastric output were evaluated at 5-8 h after 5 doses, at 13-16 h after 10 doses, and at 21-24 h after 15 doses. Baseline data for gastric acid secretion were collected once for each horse in the month prior to initiation of omeprazole treatment. The inhibition of gastric acid secretion relative to baseline...
Normal equine gastroduodenal secretion and motility.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 7-13 doi: 10.1111/j.2042-3306.1999.tb05161.x
Merritt AM.This article represents an attempt to provide an overview of the current knowledge of equine gastroduodenal secretory and motor activity, with respect to how these functions are controlled and interact. First, the equine gastric mucosal anatomy is discussed in comparison with other monogastric species, with some attention directed at the large nonglandular portion in relation to its function, or lack thereof. Next, control of gastric acid secretion, as assessed by the collection of gastric contents from a cannula or continuous measurement of their changes in pH, is reviewed, pointing out that ...
Gastric ulceration: response to an unnatural environment.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 5-6 doi: 10.1111/j.2042-3306.1999.tb05160.x
Collier DS.No abstract available
[Clinical symptoms of and diagnostic possibilities for hypophyseal adenoma in horses].
Schweizer Archiv fur Tierheilkunde    March 4, 2000   Volume 142, Issue 2 49-54 
Feige K, Eser MW, Geissbühler U, Balestra E, Metzler K.Hirsutism was the most often observed symptom in horses with a pituitary gland tumor and was present in all 13 examined horses. Other symptoms were atrophy of muscles (n = 10), hyperhidrosis (n = 8), polyuria/polydipsia (n = 5), bulging or supraorbital fat (n = 3), polyphagia (n = 2), apathy (n = 2) and seizures (n = 2). Laminitis was the most frequently observed concurrent disease (n = 8). Hyperglycaemia (mean, 9.9 +/- 3.71 mmol/l) in 13 horses and glucosuria (median, 55 [range, 2-55] mmol/l) in 7 horses were the most important laboratory results. The dexamethasone suppression test was positi...
Effects of intramuscular omeprazole on gastric acid secretion in horses over a twenty-four hour period.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 50-53 doi: 10.1111/j.2042-3306.1999.tb05169.x
Sandin A, Andrews FM, Nadeau JA, Doherty TJ, Nilsson G.The effect of intramuscular (i.m.) omeprazole (0.25 or 1.0 mg/kg bwt; LD and HD), respectively, on volume, total acid output (TAO) and pH of the gastric juice was studied during 24 h in 5 horses with a chronically implanted gastric cannula. Whether secretion in controls was basal or stimulated with pentagastrin (8 micrograms/kg bwt/h), volume (NS) and TAO (P < 0.01, NS) gradually decreased and pH increased (P < 0.05, NS). Omeprazole significantly reduced the average basal TAO by 49 +/- 6% (LD) and 88 +/- 3% (HD) and the stimulated TAO by 64 +/- 2% and 97 +/- 1%. Basal pH in controls was 2.1-4....
Role of duodenal reflux in nonglandular gastric ulcer disease of the mature horse.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 24-29 doi: 10.1111/j.2042-3306.1999.tb05164.x
Berschneider HM, Blikslager AT, Roberts MC.Gastric contents were sampled in horses via nasogastric tube to determine changes in pH and bile salt concentrations during feeding and fasting periods. The horses were rotated through 4 feeding protocols. (1) hay; (2) hay with twice daily grain meals; (3) and (4) fasting preceded by either hay only or hay and grain. Sequential, hourly samples were collected from 3 horses prepared with gastric cannulas. Horses were fed hay twice daily and grain mix either twice daily or in small aliquots dispensed every 90 min. The horses were sampled during normal feeding or after 14 h of feed deprivation. Ga...
Clinical trial to determine the effect of omeprazole given once or twice daily on gastric ulceration.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 87-90 doi: 10.1111/j.2042-3306.1999.tb05177.x
Vatistas NJ, Nieto JE, Snyder JR, Thompson D.No abstract available
Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 77-80 doi: 10.1111/j.2042-3306.1999.tb05175.x
MacAllister CG, Sifferman RL, McClure SR, White GW, Vatistas NJ, Holste JE, Ericcson GF, Cox JL.A multicentre, blinded, randomised complete-block, field trial was conducted with 140 horses and foals age 4 weeks-28 years to determine if omeprazole paste is effective and safe in promoting healing of spontaneous gastric ulcers under a variety of field conditions and in different breeds and ages of horses. Horses in the study had gastric ulceration as determined by gastroscopy and were divided into replicates of 4 or 5 animals. One horse in each replicate was assigned randomly to receive an empty omeprazole syringe (sham-dosed control) and the remaining horses received omeprazole paste once ...
Helminthic transmission and isolation of Ehrlichia risticii, the causative agent of Potomac horse fever, by using trematode stages from freshwater stream snails.
Journal of clinical microbiology    March 4, 2000   Volume 38, Issue 3 1293-1297 doi: 10.1128/JCM.38.3.1293-1297.2000
Pusterla N, Madigan JE, Chae JS, DeRock E, Johnson E, Pusterla JB.We report successful helminthic transmission of Ehrlichia risticii, the causative agent of Potomac horse fever, using trematode stages collected from Juga yrekaensis snails. The ehrlichial agent was isolated from the blood of experimentally infected horses by culture in murine monocytic cells and identified as E. risticii ultrastructurally and by characterization of three different genes.
Safety of omeprazole paste in foals and mature horses.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 63-66 doi: 10.1111/j.2042-3306.1999.tb05172.x
Plue RE, Wall HG, Daurio C, Attebery DK, Cox JL, Wallace DH.Omeprazole has been shown to promote healing of spontaneously occurring gastric ulcers in horses when administered for 28 days at a dose of 4 mg/kg bwt/day and to prevent recurrence of ulcers in almost all horses when treatment is continued at a dose of at least 2 mg/kg bwt/day. The purpose of the 3 studies reported here was to 1) evaluate the evolution of potential effects of omeprazole paste (GastroGard), at a dose of 20 mg/kg bwt/day (5x the recommended dose) for 91 days in mature Thoroughbred horses; 2) evaluate the safety in young horses of omeprazole paste when dosed at 4 mg/kg bwt/day (...
Pathophysiology of peptic disorders in foals and horses: a review.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 14-18 doi: 10.1111/j.2042-3306.1999.tb05162.x
Murray MJ.No abstract available
Use of 99mTc-mercaptoacetyltriglycine to evaluate renal function in horses. Woods PR, Drost WT, Clarke CR, Rodebush CJ.Ten healthy horses were injected intravenously with 99mTc-MAG3 and the disappearance of radioactivity from the blood was measured. The total body clearance (Cl(B)) and elimination half-life (t1/2(beta)) were 7.9 +/- 1.5 ml/kg/minute and 32.8 +/- 4.1 minutes, respectively. The disappearance of 99mTc-MAG3 from the blood of 2 horses with compromised renal function was also measured. The data suggest that 99mTc-MAG3 is a useful and clinically applicable radiopharmaceutical for measurement of effective renal blood flow in the horse.