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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Predictors of arterial oxygen tension in anesthetized horses: 1,610 cases (1992-1994).
Journal of the American Veterinary Medical Association    October 8, 1999   Volume 215, Issue 7 978-981 
Whitehair KJ, Willits NH.To identify factors associated with various arterial partial pressures of oxygen (Pao2) in anesthetized horses. Methods: Retrospective study. Methods: 1,450 horses anesthetized a total of 1,610 times with isoflurane or halothane. Methods: Anesthesia records, particularly results of blood gas analyses, were reviewed, and horses were grouped on the basis of lowest Pao2. Results: For horses with lowest Pao2 < 120 mm Hg, those with low pulse pressure, that underwent anesthesia on an emergency basis, or that were males were more likely to have Pao2 < 80 mm Hg. For horses with lowest Pao2 <...
Characterization of equine natural killer and IL-2 stimulated lymphokine activated killer cell populations.
Developmental and comparative immunology    October 8, 1999   Volume 23, Issue 6 521-532 doi: 10.1016/s0145-305x(99)00030-0
Viveiros MM, Antczak DF.Natural killer (NK) cells are an important component of the innate immune system. Though intensively studied in humans and rodents. NK cells remain less well characterized in other species. Studies are often limited by the lack of specific cell markers; however, the mAb NK-5C6 has been suggested to recognize an evolutionarily conserved molecule on NK cells and reacts with cells from several species. This mAb was used in the current investigation to identify and characterize equine NK cells, and was found to label approximately 10% of peripheral blood lymphocytes (PBL). Two-color flow cytometry...
Results of bone scintigraphy in racing standardbred horses: 64 cases (1992-1994).
Journal of the American Veterinary Medical Association    October 8, 1999   Volume 215, Issue 7 982-991 
Ehrlich PJ, Dohoo IR, O'Callaghan MW.To document anatomic patterns of scintigraphic uptake and related orthopedic disease associated with racing activity in Standardbred horses. Methods: Retrospective study. Methods: 64 Standardbred horses evaluated for lameness. Methods: Medical records at the time of discharge were reviewed, and information regarding signalment; history; results of lameness examination, scintigraphy, and radiography; diagnosis; and treatment were obtained. Results: 274 areas of increased radiopharmaceutical uptake were identified. Scintigrams of 218 limbs (106 forelimbs, 112 hind limbs) were available for revie...
Factors associated with prognosis for survival and athletic use in foals with septic arthritis: 93 cases (1987-1994).
Journal of the American Veterinary Medical Association    October 8, 1999   Volume 215, Issue 7 973-977 
Steel CM, Hunt AR, Adams PL, Robertson ID, Chicken C, Yovich JV, Stick JA.To identify factors affecting the prognosis for survival and athletic use in foals with septic arthritis. Methods: Retrospective study. Methods: 93 foals with septic arthritis. Methods: Medical records were reviewed to obtain clinical findings, laboratory test results, radiographic findings, treatment method, and outcome. Race records for Thoroughbreds and Standardbreds were evaluated to determine whether foals subsequently raced and whether they raced successfully. Results: 43 foals had 1 affected joint, 44 foals had multiple affected joints, and number of affected joints was not recorded for...
Serologic prevalence of Sarcocystis neurona, Toxoplasma gondii, and Neospora caninum in horses in Brazil.
Journal of the American Veterinary Medical Association    October 8, 1999   Volume 215, Issue 7 970-972 
Dubey JP, Kerber CE, Granstrom DE.To determine serologic prevalence of Sarcocystis neurona, Toxoplasma gondii, and Neospora caninum in horses in Brazil. Methods: Prevalence survey. Methods: 101 Thoroughbreds in Brazil. Methods: Blood samples were obtained from horses and tested for serum antibodies against S neurona by use of an immunoblot procedure with culture-derived S neurona merozoites as antigen, and for serum antibodies against T gondii and N caninum by use of a modified agglutination test with formalin-preserved tachyzoites and mercaptoethanol. Results: Antibodies against S neurona and T gondii were detected in 36 and ...
A retrospective look at horses exhibiting unusual clinical signs after exercising on L-NAME.
Veterinary and human toxicology    October 6, 1999   Volume 41, Issue 5 339-341 
Gallatin LL.Three of 5 horses exercising on L-NAME (NG-nitro-L-arginine methyl ester) exhibited unusual clinical signs towards the end of exercise bouts and post-exercise. L-NAME is a nitric oxide synthase inhibitor which blocks synthesis of nitric oxide from L-arginine. The induced absence of nitric oxide may have lead to the clinical signs observed.
Salmonella Abortusequi strains of equine origin harbor a 95kb plasmid responsible for virulence in mice.
Veterinary microbiology    October 6, 1999   Volume 68, Issue 3-4 265-272 doi: 10.1016/s0378-1135(99)00078-4
Akiba M, Sameshima T, Anzai T, Wada R, Nakazawa M.Most Salmonella choleraesuis subsp. choleraesuis serovar Abortusequi strains of equine origin harbor a 95kb plasmid, pSA95. Results of PCR and Southern blot analysis suggest that pSA95 contains spv genes. A pSA95-cured strain of S. Abortusequi was 48 times less virulent to mice than its parental strain. Virulence was restored by reintroduction of pSA95. These results provide clear evidence that pSA95 confers virulence on S. Abortusequi in mice. This is the first report describing a virulence plasmid of S. Abortusequi.
Disposition and tolerance of suxibuzone in horses.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 411-416 doi: 10.1111/j.2042-3306.1999.tb03841.x
Jaraiz MV, Rodriguez C, San Andres MD, Gonzalez F, San Andres MI.Suxibuzone (SBZ), a nonsteroidal anti-inflammatory drug, was administered to 6 horses at a dose rate of 7.5 mg/kg bwt by intravenous (i.v.) route. Plasma and synovial fluid concentrations of suxibuzone and its main active metabolites, phenylbutazone (PBZ) and oxyphenbutazone (OPBZ), were measured simultaneously by a sensitive and specific high-performance liquid chromatographic method. The pharmacokinetic parameters were determined by noncompartmental analysis. Plasma SBZ concentrations rapidly decreased and were not detectable beyond 20 min after treatment. The parent drug was not detected in...
Horse vision and an explanation for the visual behaviour originally explained by the ‘ramp retina’.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 384-390 doi: 10.1111/j.2042-3306.1999.tb03837.x
Harman AM, Moore S, Hoskins R, Keller P.Here we provide confirmation that the 'ramp retina' of the horse, once thought to result in head rotating visual behaviour, does not exist. We found a 9% variation in axial length of the eye between the streak region and the dorsal periphery. However, the difference was in the opposite direction to that proposed for the 'ramp retina'. Furthermore, acuity in the narrow, intense visual streak in the inferior retina is 16.5 cycles per degree compared with 2.7 cycles per degree in the periphery. Therefore, it is improbable that the horse rotates its head to focus onto the peripheral retina. Rather...
Cardiovascular demands of competition on low-goal (non-elite) polo ponies.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 378-382 doi: 10.1111/j.2042-3306.1999.tb03836.x
Marlin DJ, Allen JC.Knowledge of the competitive demands of different sports or activities is important for designing appropriate training programmes to ensure that animals reach a sufficient level of fitness to reduce the risk of overexertion and injury or illness and to achieve the best possible performance in relation to an individual's genetic potential. Whilst the physiological demands of many equestrian sports have been described, to the best of our knowledge the cardiovascular demands of polo have not. The aims of the present study were therefore to record heart rate during and after competitive polo games...
Clinical, haematological and biochemical findings in foals with neonatal Equine herpesvirus-1 infection compared with septic and premature foals.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 422-426 doi: 10.1111/j.2042-3306.1999.tb03843.x
Perkins G, Ainsworth DM, Erb HN, Del Piero F, Miller M, Wilkins PA, Palmer J, Frazer M.A retrospective multicentre study comparing historical, clinical, haematological, acid-base and biochemical findings of foals with Equine herpesvirus-1 (EHV-1) infection, septicaemia or prematurity was performed to determine if early diagnosis of EHV-1 foals was possible. Fifty-three foals were studied and were assigned to one of 2 groups: herpes positive (n = 14) or herpes negative (n = 39). The latter group included 20 septic, 11 premature, and 8 premature and septic foals. The presence of herpes antigen was confirmed by immunoperoxidase histochemical staining of tissues from necropsied foal...
Factors involved in the prognosis of equine laminitis in the UK.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 433-442 doi: 10.1111/j.2042-3306.1999.tb03845.x
Cripps PJ, Eustace RA.The significance of clinical and radiological parameters as prognostic indicators for laminitis, 'founder' and 'sinking syndrome' was studied using case records of 216 horses and ponies. Five animals were destroyed without treatment and were not included in the results of the study. One hundred and sixty-two (77%) animals returned to athletic soundness; 7 animals (3%) did not regain full athletic function, 42 animals (20%) died or were destroyed. Cases were assigned to 4 groups on the basis of initial clinical examination alone. These groups were laminitis, acute founder, 'sinker' and chronic ...
Age-related changes to the molecular and cellular components of equine flexor tendons.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 391-396 doi: 10.1111/j.2042-3306.1999.tb03838.x
Birch HL, Bailey JV, Bailey AJ, Goodship AE.Specific tendons show a high incidence of partial central core rupture which is preceded by degeneration. In the performance horse, the superficial digital flexor tendon (SDFT) is most often affected. We have described previously the molecular changes that are associated with degeneration in the central core region of the equine SDFT. The pathophysiological mechanism leading to change in synthetic activity of central zone cells in degenerated tendons is not known. In this study, we test the hypothesis that ageing results in matrix composition changes within the central zone of the SDFT. Extrac...
Equine vision.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 354-355 doi: 10.1111/j.2042-3306.1999.tb03832.x
Farrall H, Handscombe M.No abstract available
Indices of oxidative stress in blood and pulmonary epithelium lining fluid in horses suffering from recurrent airway obstruction.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 397-401 doi: 10.1111/j.2042-3306.1999.tb03839.x
Art T, Kirschvink N, Smith N, Lekeux P.To test the hypothesis that reactive oxygen species could be associated to the lower airway disorders occurring in horses suffering from recurrent airway obstruction (RAO), indices of oxidative stress were studied in blood and pulmonary epithelium lining fluid in 5 RAO horses either in clinical remission or 24 h after the onset of a crisis of bronchospasm and in 5 healthy horses. Venous blood and bronchoalveolar lavage fluid (BALF) samples were collected and analysed for reduced glutathione (GSH), oxidised glutathione (GSSG), total glutathione (TGSH), glutathione redox ratio (GRR) in blood hae...
Comparative aspects of diaphragmatic hernia.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 358-359 doi: 10.1111/j.2042-3306.1999.tb03833.x
Collier DS.No abstract available
Hyperkalaemic periodic paralysis in horses: a review.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 362-367 doi: 10.1111/j.2042-3306.1999.tb03834.x
Meyer TS, Fedde MR, Cox JH, Erickson HH.No abstract available
Cell proliferation patterns in the equine endometrium throughout the non-pregnant reproductive cycle.
Journal of reproduction and fertility    October 3, 1999   Volume 116, Issue 1 167-175 doi: 10.1530/jrf.0.1160167
Gerstenberg C, Allen WR, Stewart F.Immunohistochemical detection of the proliferation marker Ki-67 antigen was used to monitor mitotic activity in the endometrium of mares. The monoclonal antibody MIB1 was validated for use on equine tissues by demonstrating its reaction with activated peripheral blood lymphocytes, and endometrial biopsies were recovered from 26 non-pregnant mares at selected stages during the reproductive cycle. The proportion of positively stained nuclei was counted in five random areas on each histological section to determine the percentage and type of proliferating cells. Multiplication rates in the types ...
Tachypnoea associated with a diaphragmatic tear in a horse.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 443-445 doi: 10.1111/j.2042-3306.1999.tb03846.x
Goehring LS, Goodrich LR, Murray MJ.No abstract available
Equine dental disease part 1: a long-term study of 400 cases: disorders of incisor, canine and first premolar teeth.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 369-377 doi: 10.1111/j.2042-3306.1999.tb03835.x
Dixon PM, Tremaine WH, Pickles K, Kuhns L, Hawe C, McCann J, McGorum B, Railton DI, Brammer S.A review of 400 horses referred because of dental disorders showed 44 cases to suffer from primary disorders of their incisors and 11 from canine or 1st premolar teeth disorders. The remaining 345 horses suffered from primary disorders of the cheek teeth. Disorders of incisors included traumatic damage to teeth and their supporting bones, retained deciduous, displaced and supernumerary incisors; brachygnathia and abnormalities of wear, with most of the latter disorders being secondary to primary disorders of the cheek teeth Only 3 cases of apical infection of incisors were recognised. Most cas...
[Mutations in the US2 and glycoprotein B genes of the equine herpesvirus 1 vaccine strain RacH have no effects on its attenuation].
Berliner und Munchener tierarztliche Wochenschrift    October 3, 1999   Volume 112, Issue 9 351-354 
Neubauer A, Meindl A, Osterrieder N.The equine herpesvirus 1 (EHV-1) modified live vaccine strain RacH is apathogenic for both laboratory animals and the natural host. The apathogenicity of RacH was caused by serial passages of the virus in heterologous cells. When compared to the virulent parental strain RacL11 several changes in the RacH genome occurred. Previous results have shown that the loss of the IR6 gene correlated with the loss of virulence. Additional important mutations were observed within the US2 gene which is directly adjacent to the IR6 gene and within the glycoprotein B (gB) gene. To answer the question whether ...
Determination of equid herpesvirus 1-specific, CD8+, cytotoxic T lymphocyte precursor frequencies in ponies.
Veterinary immunology and immunopathology    October 3, 1999   Volume 70, Issue 1-2 43-54 doi: 10.1016/s0165-2427(99)00037-9
O'Neill T, Kydd JH, Allen GP, Wattrang E, Mumford JA, Hannant D.The frequency of antigen-specific, genetically restricted cytotoxic T lymphocyte precursors (CTLp) was measured in peripheral blood mononuclear cells (PBMC) of ponies before and after infection with equid herpesvirus 1 (EHV1). Split-well limiting dilution analysis (LDA) was developed to measure CTLp frequency using EHV1-infected 51Cr-labelled lymphoblasts as targets. Extensive characterisation showed that recombinant human interleukin-2, autologous antigen presenting cells and equine serum containing virus neutralising antibody were necessary for maturation of CTLp into effector CTL in vitro. ...
Myeloblastic leukaemia in a Morgan horse mare.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 446-448 doi: 10.1111/j.2042-3306.1999.tb03847.x
Clark P, Cornelisse CJ, Schott HC, Swenson CL, Bell TG.No abstract available
Supporting forelimb lameness: clinical judgement vs. computerised symmetry measurement.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 417-421 doi: 10.1111/j.2042-3306.1999.tb03842.x
Peham C, Licka T, Girtler D, Scheidl M.The aim of this study was to compare supporting forelimb lameness determined by a motion analysis system with the subjective grading of a trained equine orthopaedic surgeon. Trotting on a treadmill, 29 individuals with a supporting forelimb lameness were measured with the SELSPOT II system and judged by the clinician. The vertical motion of the head was measured, analysed using Fourier transform, and the percentages of symmetry determined. The veterinarian evaluated the lameness and graded it according to a clinical routine. Veterinarian and system for motion analysis assigned the lameness to ...
Radiological measurements from the feet of normal horses with relevance to laminitis.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 427-432 doi: 10.1111/j.2042-3306.1999.tb03844.x
Cripps PJ, Eustace RA.Lateromedial radiographic projections were made from the feet of 25 normal horses and 3 angles and 3 distances were measured. From these, normal ranges of calculated variables were obtained. The width and length of each foot and the height of the horse at the withers was also measured. In view of its possible importance in clinical laminitis, particular attention was paid to 'founder' distance (D). This is the vertical distance between the proximal limit of the dorsal hoof wall and the proximal limit of the extensor process of the distal phalanx. There were significant differences between bree...
Evaluation of antibody parameters as potential correlates of protection or enhancement by experimental vaccines to equine infectious anemia virus.
Virology    September 30, 1999   Volume 262, Issue 2 416-430 doi: 10.1006/viro.1999.9939
Hammond SA, Raabe ML, Issel CJ, Montelaro RC.We previously demonstrated in trials of a variety of experimental vaccines to equine infectious anemia virus (EIAV) a remarkable spectrum of efficacy ranging from sterilizing protection to severe enhancement of virus replication and disease, depending on the immunization strategy used. This range of vaccine efficacy observed in vivo offers a unique opportunity for evaluating potential in vitro immune correlates of protection and enhancement. We describe here a comprehensive analysis and comparison of EIAV envelope-specific antibody responses elicited by attenuated, inactivated whole virus and ...
In vitro stimulation of equine articular cartilage proteoglycan synthesis by hyaluronan and carprofen.
Research in veterinary science    September 30, 1999   Volume 67, Issue 2 183-190 doi: 10.1053/rvsc.1999.0328
Frean SP, Abraham LA, Lees P.The effects of hyaluronan and carprofen (both racemic mixture and separate R and S enantiomers) on proteoglycan (PG) synthesis by equine cultured chondrocytes and cartilage explants were examined. Hyaluronan stimulated PG synthesis in both cell and explant cultures. The concentration-response curve of the latter was bell-shaped. Racemic carprofen and R and S enantiomers also stimulated PG synthesis, although concentration-response relationships varied for each preparation and high concentrations inhibited synthesis. It was concluded that (a) hyaluronan exerts a stimulatory effect on PG synthes...
Government reviews animal welfare during transport.
The Veterinary record    September 30, 1999   Volume 145, Issue 9 238 
No abstract available
Identification of calcium-activated potassium channels in cultured equine sweat gland epithelial cells.
Experimental physiology    September 30, 1999   Volume 84, Issue 5 881-895 doi: 10.1111/j.1469-445x.1999.01801.x
Huang Y, Ko WH, Chung YW, Wong PY.The patch-clamp recording technique was used to examine the properties of the K+ channels in cultured equine sweat gland epithelial cells. With symmetric K+ solutions (140 mM), a single population of K+ channels was identified with a slope conductance of 187 pS and a reversal potential of around 0 mV. The channel was selective for K+ over Na+. Channel activity was increased by membrane depolarization. A 10-fold increase in [Ca2+]i produced an approximate 60 mV negative shift in the open state probability (Popen)-voltage curve. Externally applied tetraethylammonium ions (TEA+) caused a rapid an...
Poisoning inquiries increase.
The Veterinary record    September 30, 1999   Volume 145, Issue 9 238-239 
No abstract available