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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
[The polymerase chain reaction (PCR) for the detection of DNA of equine herpesviruses 1 and 4].
Berliner und Munchener tierarztliche Wochenschrift    February 1, 1992   Volume 105, Issue 2 52-55 
Hardt M, Teifke JP, Weiss E.Formalin-fixed and Paraplast-embedded tissue samples of 42 aborted equine fetuses were examined by polymerase chain reaction for the presence of equine herpesvirus DNA. The used set of primers was located in the glycoprotein 13 open reading frame and allowed the amplification of both EHV 1 und EHV 4. By cleaving pattern analysis after Hinf I digestion EHV 1 could be distinguished from EHV 4. In 9 of the cases investigated EHV 1-DNA was detected. This finding is in absolute context with the results of the virological investigations.
Disposition of ampicillin sodium in horses, ponies and donkeys after intravenous administration.
Equine veterinary journal. Supplement    February 1, 1992   Issue 11 59-61 doi: 10.1111/j.2042-3306.1992.tb04775.x
Horspool LJ, Sarasola P, McKellar QA.No abstract available
The importance of understanding pharmacokinetics for equine veterinarians.
Equine veterinary journal. Supplement    February 1, 1992   Issue 11 3-4 doi: 10.1111/j.2042-3306.1992.tb04761.x
Davis LE.No abstract available
Sequence analysis of the equine H7 influenza virus haemagglutinin gene.
Virus research    February 1, 1992   Volume 22, Issue 2 93-106 doi: 10.1016/0168-1702(92)90037-a
Gibson CA, Daniels RS, Oxford JS, McCauley JW.The nucleotide sequences of ten haemagglutinin genes of representative H7N7 equine influenza viruses isolated between 1956 and 1977 have been determined by primer extension sequencing. Their nucleotide and deduced amino acid sequences demonstrate a high degree of homology. These equine viruses can be divided into two distinct subgroups, the prototype-like, and a group comprising the early American isolates and the remaining equine viruses. The equine H7 haemagglutinins form a quite distinct group compared to H7 haemagglutinins isolated from other species. Each of these equine H7 haemagglutinin...
Follow-up of 28 horses with third metacarpal unicortical stress fractures following treatment with osteostixis.
Equine veterinary journal. Supplement    February 1, 1992   Issue 11 5-9 doi: 10.1111/j.2042-3306.1992.tb04762.x
Hanie EA, Sullins KE, White NA.The results of 31 intracortical dorsal metacarpal stress fractures in 28 horses following unicortical osteostixis were reviewed. The incidence was predominately in the middle third of the lateral aspect of the left metacarpus, and males were affected more commonly. Approximately half of the surgical procedures were performed with the horse in the standing position. The mean times to return to training and racing were 4.25 and 6.9 months respectively. There was no correlation between time taken to return to racing and position of surgery. Complications experienced included lack of suture remova...
Equine anaesthesiology.
Equine veterinary journal. Supplement    February 1, 1992   Issue 11 2-3 doi: 10.1111/j.2042-3306.1992.tb04760.x
Steffey EP.No abstract available
Crystallographic studies of a calcium binding lysozyme from equine milk at 2.5 A resolution.
Journal of biochemistry    February 1, 1992   Volume 111, Issue 2 141-143 doi: 10.1093/oxfordjournals.jbchem.a123727
Tsuge H, Ago H, Noma M, Nitta K, Sugai S, Miyano M.The crystal structure of a calcium binding equine lysozyme has been determined at 2.5 A resolution by means of molecular replacement. The energy minimized equine lysozyme as the starting model, was refined with the molecular dynamics program, X-PLOR, and the R factor of the current model was found to be 24% without any water molecules. The conformation of the calcium binding loop is similar to that of alpha-lactalbumin. The profiles of backbone atomic displacements throughout the lysozyme and alpha-lactalbumin superfamilies are comparable as well as their homologous tertiary structures.
Effect of chronic hypoxia on breathing and EMGs of respiratory muscles in awake ponies.
Journal of applied physiology (Bethesda, Md. : 1985)    February 1, 1992   Volume 72, Issue 2 739-747 doi: 10.1152/jappl.1992.72.2.739
Brown DR, Forster HV, Lowry TF, Forster MA, Forster AL, Gutting SM, Erickson BK, Pan LG.Breathing, diaphragmatic and transversus abdominis electromyograms (EMGdi and EMGta, respectively), and arterial blood gases were studied during normoxia (arterial PO2 = 95 Torr) and 48 h of hypoxia (arterial PO2 = 40-50 Torr) in intact (n = 11) and carotid body-denervated (CBD, n = 9) awake ponies. In intact ponies, arterial PCO2 was 7, 5, 9, and 11 Torr below control (P less than 0.01) at 1 and 10 min and 5 and 24-48 h of hypoxia, respectively. In CBD ponies, arterial PCO2 was 3-4 Torr below control (P less than 0.01) at 4, 5, 6, and 24 h of hypoxia. In intact ponies, pulmonary ventilation, ...
Methylprednisolone acetate induced release of cartilage proteoglycans: determination by high performance liquid chromatography.
Annals of the rheumatic diseases    February 1, 1992   Volume 51, Issue 2 214-219 doi: 10.1136/ard.51.2.214
Saari H, Tulamo RM, Konttinen YT, Sorsa T.A high performance liquid chromatography (HPLC) procedure suitable for the simultaneous determination of the molecular size and concentration of macromolecular hyaluronate and proteoglycans in synovial fluid has been developed. Irrigation of the equine tarsocrural joint with 20 ml physiological saline (PSS) caused a mild inflammation with an increase of proteoglycans in the synovial fluid over the baseline arthrocentesis control sample. Proteoglycan and hyaluronate in the synovial fluid did not interact to form hyaluronate-proteoglycan aggregates, but separated as distinct chromatographic peak...
Pharmacokinetics and metabolism of intravenous doxapram in horses.
Equine veterinary journal. Supplement    February 1, 1992   Issue 11 45-51 doi: 10.1111/j.2042-3306.1992.tb04772.x
Sams RA, Detra RL, Muir WW.The pharmacokinetics and metabolism of doxapram in horses administered intravenous (iv) doses of 0.275, 0.55 and 1.1 mg doxapram/kg bodyweight (bwt) were investigated. Plasma doxapram concentrations decreased rapidly after drug administration and the disappearance of doxapram from plasma was best described by a polyexponential equation. Median values of total body clearance were 10.9, 10.6 and 10.9 ml/min/kg bwt for the three doses and were independent of dose. The steady-state volume of distribution was approximately 1,200 ml/kg bwt and the median biological half-life ranged from 121 to 178 m...
Cardiovascular effects of dopexamine HCl in conscious and halothane-anaesthetised horses.
Equine veterinary journal. Supplement    February 1, 1992   Issue 11 24-29 
Muir WW.The cardiovascular effects of serial increasing infusions of dopexamine HCl were investigated in six conscious (1, 2, 4, 6, 10 micrograms/kg bodyweight [bwt]/min) and eight (0.5, 1, 5, 10, 20 micrograms/kg bwt/min) halothane-anaesthetised horses. Dopexamine produced dose-dependent increases in heart rate, +dP/dtmax' -dP/dtmax and cardiac output, and a decrease in systemic vascular resistance in conscious and halothane-anaesthetised horses. Mean arterial blood pressure did not change in conscious horses but increased to a maximum value at 10 micrograms/kg bwt/min in halothane-anaesthetised hors...
Evidence for two serotype G3 subtypes among equine rotaviruses.
Journal of clinical microbiology    February 1, 1992   Volume 30, Issue 2 485-491 doi: 10.1128/jcm.30.2.485-491.1992
Browning GF, Chalmers RM, Fitzgerald TA, Snodgrass DR.Ten cultivable equine rotavirus isolates, two of North American, six of British, and two of Irish origin, were compared with standard rotavirus strains and with each other by cross neutralization, neutralization with a panel of monoclonal antibodies (MAbs), hybridization to a simian rotavirus (SA-11) VP7 gene probe, and reaction with rotavirus subgrouping and serotyping MAbs in enzyme-linked immunosorbent assays. Six isolates, two of which had previously been serotyped as G3 by other workers, were found to be serotype G3; one was confirmed to be G5, and three were not related to serotypes G1 t...
Anaesthetic problems caused by diaphragmatic hernia in the horse: a review of four cases.
Equine veterinary journal. Supplement    February 1, 1992   Issue 11 30-33 doi: 10.1111/j.2042-3306.1992.tb04768.x
Clutton RE, Boyd C, Richards DL, Welker FW, Modransky P.No abstract available
Species restrictions demonstrated by the stimulation of equine cells with recombinant human interleukin-1.
Veterinary immunology and immunopathology    January 31, 1992   Volume 30, Issue 4 373-384 doi: 10.1016/0165-2427(92)90106-z
May SA, Hooke RE, Lees P.Equine thymocytes, which respond to equine monocyte supernatants, do not respond to stimulation with recombinant human interleukin-1 alpha and beta, and equine synovial fibroblasts show a limited response in the form of prostaglandin E2 production without any evidence of neutral metalloproteinase production. Human interleukin-1 beta was about three to ten times as active on equine synovial cells as human interleukin-1 alpha in terms of prostaglandin E2 production. This preliminary evidence would suggest that there are qualitative and quantitative differences in the way recombinant human interl...
Treatment of tendonitis in horses.
The Veterinary record    January 25, 1992   Volume 130, Issue 4 83 doi: 10.1136/vr.130.4.83
Clayton Jones DG.No abstract available
Treatment of tendonitis in horses.
The Veterinary record    January 18, 1992   Volume 130, Issue 3 58 doi: 10.1136/vr.130.3.58-a
Goodship AE, Silver IA, Wilson AM.No abstract available
Fecalith impaction in four miniature foals.
Journal of the American Veterinary Medical Association    January 15, 1992   Volume 200, Issue 2 205-207 
McClure JT, Kobluk C, Voller K, Geor RJ, Ames TR, Sivula N.Four miniature foals admitted with signs of progressive nonresponsive abdominal pain and no fecal production had fecalith impaction of the small colon. Duration of clinical signs ranged from 10 hours to 5 days. Removal of the fecalith via small colon enterotomy was a successful treatment in all 4 cases. Miniature foals may be predisposed to fecalith impaction of the small colon. If a miniature foal has signs of progressive nonresponsive abdominal pain, fecalith impaction needs to be considered. Surgical correction may be required.
Factors that influence passive transfer of immunoglobulins in foals.
Journal of the American Veterinary Medical Association    January 15, 1992   Volume 200, Issue 2 179-183 
LeBlanc MM, Tran T, Baldwin JL, Pritchard EL.Effects of farm management, breed, mare age, gestation duration, and climatologic factors on colostral specific gravity, colostral IgG concentration, and foal serum IgG concentration were evaluated. Climatologic variables measured were daily maximal, minimal, and mean air temperature, precipitation, average relative humidity, and total solar radiation. Presuckle, postpartum colostrum samples were collected from 140 Standardbred, 94 Thoroughbred, and 59 Arabian mares from January through June during 1985 and 1986. Thoroughbred (farm A, n = 61; farm B, n = 33) and Arabian (farm C, n = 45; farm D...
Volvulus of the cecum and large colon caused by multiple mesenteric defects in a horse.
Journal of the American Veterinary Medical Association    January 15, 1992   Volume 200, Issue 2 203-204 
Ross MW, Bayha R.A 2-year-old Standardbred colt was examined because of signs of abdominal pain of 12 hours' duration. Clinical signs of disease, including tachycardia and abdominal distention, and rectal palpation findings of distention and thickening of the ventral colon, were consistent with displacement or early strangulation obstruction of the large colon. Surgical exploration revealed volvulus of the large colon around an axis formed by the dorsal mesenteric attachment of the transverse colon. The cecum could be completely exteriorized and lacked the cecocolic ligament and dorsal mesenteric attachments. ...
Influence of endophyte-infected tall fescue on serum prolactin and progesterone in gravid mares.
Journal of animal science    January 11, 1992   Volume 70, Issue 1 217-223 doi: 10.2527/1992.701217x
McCann JS, Caudle AB, Thompson FN, Stuedemann JA, Heusner GL, Thompson DL.Thirty mares in late gestation were used in a 3-yr study to assess effects of the tall fescue endophyte Acremonium coenophialum on serum prolactin (PRL) and progesterone. Two paddocks of each treatment, 0 or 100% infected 'Kentucky 31' tall fescue, were grazed by the mares for 21 d. Blood was collected three times per week until parturition. At 7-d intervals, mares were challenged with thyrotropin-releasing hormone (TRH) while grazing and blood was collected postinjection. Mares grazing 100% infected tall fescue (E+) had decreased serum PRL compared with mares grazing the 0% infected tall fesc...
PGE2-independent immunosuppressive activity of horse trophoblast tissue.
Journal of reproductive immunology    January 11, 1992   Volume 21, Issue 1 87-95 doi: 10.1016/0165-0378(92)90042-3
Roth TL, White KL, Thompson DL, Horohov DW.It has been proposed that PGE2 is an important immunosuppressant acting at the fetal-maternal interface during pregnancy. We have previously shown that horse conceptus-conditioned medium suppresses lymphocyte proliferation. This experiment was designed to determine if horse conceptus-derived immunosuppressive activity could be attributed to PGE2 production by the trophoblast tissue. Trophoblast tissue from 21-day-old conceptuses was cut into equal sections and cultured in the presence or absence of the prostaglandin inhibitor, indomethacin. Following culture, immunosuppressive activity and the...
Solid-phase extraction techniques for the determination of glycopyrrolate from equine urine by liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry.
Journal of chromatography    January 3, 1992   Volume 573, Issue 1 43-48 doi: 10.1016/0378-4347(92)80472-3
Matassa LC, Woodard D, Leavitt RK, Firby P, Beaumier P.Glycopyrrolate (Robinul) is a quaternary ammonium salt which serves as a respiratory enhancing drug. It is reportedly used in horse racing to improve breathing. Extraction of glycopyrrolate from equine urine employing unique solid-phase extraction techniques gave a residue suitable for liquid chromatography-tandem mass spectrometry (LC-MS-MS) and gas chromatography-mass spectrometry (GC-MS). LC-MS-MS analysis employed an extract derived from 5 ml of urine subjected to cation-exchange chromatography. The daughter ion of m/z 318 monitored in the positive-ion mode was m/z 116. Recovery of glycopy...
Identification of a tolfenamic acid metabolite in the horse by gas chromatography-mass spectrometry.
Journal of chromatography    January 3, 1992   Volume 573, Issue 1 136-140 doi: 10.1016/0378-4347(92)80486-a
Jaussaud P, Guieu D, Courtot D, Barbier B, Bonnaire Y.A tolfenamic acid metabolite, a hydroxylated product, has been identified in equine plasma and urine samples using gas chromatography-mass spectrometry in the electron-impact and chemical-ionization modes. The method also allows the qualitative monitoring of the elimination of the drug and its metabolites from plasma. The two compounds are detected up to 48 and 24 h, respectively, after a single oral administration of a 30 mg/kg dose. The simultaneous detection of the two products increases the reliability of anti-doping control analysis.
Are tick-borne diseases also horse-borne?
The New England journal of medicine    January 2, 1992   Volume 326, Issue 1 72 doi: 10.1056/NEJM199201023260122
Jerace CK.No abstract available
Organic structures of the hypercalcified peritubular matrix in horse dentine.
Acta anatomica    January 1, 1992   Volume 145, Issue 3 181-188 doi: 10.1159/000147363
Kodaka T, Hirayama A, Abe M, Miake K.EDTA-insoluble organic structures of the hypercalcified peritubular matrix (PM) in horse dentine were observed by scanning electron microscopy. The PM was enveloped in double cylindrical structures composed of fibrillar sheaths in the inner and outer peripheries. Between the outer fibrillar sheath and intrinsic fibrils of the intertubular matrix, a calcified cementing membrane existed. Within the PM, warped cone-shaped structures of fibrillar sheaths, overlapping at intervals of 4-6 microns and semiconcentrically surrounding the dentinal tubule, extended from the inner fibrillar towards the ou...
Polysaccharide storage myopathy associated with recurrent exertional rhabdomyolysis in horses.
Neuromuscular disorders : NMD    January 1, 1992   Volume 2, Issue 5-6 351-359 doi: 10.1016/s0960-8966(06)80006-4
Valberg SJ, Cardinet GH, Carlson GP, DiMauro S.A polysaccharide storage myopathy is described in nine Quarterhorses, Quarterhorse crossbreds, American Paints and Appaloosa horses which had a history of recurrent exertional rhabdomyolysis. Muscle biopsies were characterized by high muscle glycogen concentrations with up to 5% of type 2 muscle fibers containing inclusions which stained positively with the periodic acid Schiff (PAS) stain. The inclusions were classified as an acid mucopolysaccharide, based on their histochemical staining characteristics. Ultrastructural studies revealed that the inclusions were composed of beta glycogen parti...
Follicle aspiration in the mare using a transvaginal ultrasound-guided technique.
Equine veterinary journal    January 1, 1992   Volume 24, Issue 1 58-59 doi: 10.1111/j.2042-3306.1992.tb02780.x
Brück I, Raun K, Synnestvedt B, Greve T.No abstract available
Current practical use of a glasswool/Sephadex filtration technique of frozen stallion semen.
Acta veterinaria Scandinavica. Supplementum    January 1, 1992   Volume 88 67-70 
Hellander JC.No abstract available
Alkaloids of Stipa robusta (sleepygrass) infected with an Acremonium endophyte.
Natural toxins    January 1, 1992   Volume 1, Issue 2 84-88 doi: 10.1002/nt.2620010205
Petroski RJ, Powell RG, Clay K.Stipa robusta (= Stipa vaseyi) is a perennial grass found in certain areas of the southwestern United States. It is commonly known as sleepygrass, as horses that ingest this grass may become profoundly somnolent or stuporous for periods of time lasting up to several days. In an attempt to determine the active principle(s), fractionation of a methanolic extract of sleepygrass infected with an Acremonium endophyte has yielded lysergic acid amide (20 micrograms/g dry wt), isolysergic amide (8), 8-hydroxylsergic acid amide (0.3), ergonovine (7), chanoclavine-I (15), and N-formylloline (18). Relate...
Modelling exercise-induced pulmonary hemorrhage in racing thoroughbreds. Johnson AT, Soma LR, Ferouz C.Exercise-induced pulmonary hemorrhage (EIPH) affects a large portion of racing thoroughbred horses. Sites of hemorrhage and causal mechanisms remain unestablished. Our mathematical model was constructed to test the hypothesis that EIPH could be caused by a combination of respiratory and circulatory mechanical factors occurring during exercise. Various physiological data for respiration, blood circulation and exercise were incorporated into the model. Results show that inhalation pressure drops across airway resistances become great enough during exercise to cause rupture of capillaries for bot...