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Topic:Pain Management

Pain management in horses involves various strategies and interventions designed to alleviate discomfort and improve the well-being of equine patients. It encompasses pharmacological approaches, such as the use of non-steroidal anti-inflammatory drugs (NSAIDs), opioids, and other analgesics, as well as non-pharmacological methods like physical therapy, acupuncture, and environmental modifications. Effective pain management aims to address both acute and chronic pain conditions, which can result from injuries, surgeries, or diseases such as laminitis and arthritis. This page aggregates peer-reviewed research studies and scholarly articles that explore the mechanisms, efficacy, and safety of different pain management techniques in horses, contributing to the understanding and advancement of equine veterinary care.
Intra-abdominal hyaluronan concentration in peritoneal fluid of horses with sudden signs of severe abdominal pain.
American journal of veterinary research    December 1, 2011   Volume 72, Issue 12 1666-1673 doi: 10.2460/ajvr.72.12.1666
Lillich JD, Ray-Miller W, Silver KS, Davis EG, Schultz BD.To determine hyaluronan concentrations in peritoneal fluid from healthy horses and horses with sudden signs of severe abdominal pain and to identify the cellular sources of hyaluronan within the peritoneal cavity. Methods: 7 client-owned horses that were evaluated for sudden signs of severe abdominal pain, 6 healthy teaching horses, and 13 euthanized horses (11 with no abdominal disease and 2 that had undergone abdominal surgery 2 weeks previously for a different study). Methods: Abdominal fluid was collected from the client-owned and teaching horses. Hyaluronan concentrations were determined ...
Lesions of the equine neck resulting in lameness or poor performance.
The Veterinary clinics of North America. Equine practice    November 22, 2011   Volume 27, Issue 3 417-437 doi: 10.1016/j.cveq.2011.08.005
Dyson SJ.Lesions of the neck are an uncommon primary cause of pain resulting in either lameness or poor performance but should be considered if local analgesic techniques of the limbs fail to abolish lameness or if there are clinical signs directly referable to the neck such as pain, abnormal neck posture, stiffness, or patchy sweating. Accurate diagnosis requires careful clinical examination, exclusion of other causes of lameness or poor performance, and accurate interpretation of diagnostic imaging findings.
Pain recognition and treatment in the horse: a survey of equine veterinarians in The Netherlands and Belgium.
Tijdschrift voor diergeneeskunde    October 27, 2011   Volume 136, Issue 10 715-724 
Dujardin CL, van Loon JP.This survey investigated the attitudes of equine veterinarians in The Netherlands and the Flemish region of Belgium towards pain management in the horse. Questionnaires were sent out to 771 equine veterinarians, all members of the Dutch or Flemish equine practitioners society. The return rate of completed questionnaires was 16.6%. The survey provided information about the use of analgesic drugs, factors influencing their prescription, pain scoring, analgesic therapy for specific clinical conditions, use of epidural analgesia, and appraisal of personal knowledge of pain management. The pain sco...
Clinical snapshot: acute colic in a paint horse.
Compendium (Yardley, PA)    October 1, 2011   Volume 33, Issue 10 E1-E2 
Stern A.No abstract available
Comparison of transvaginal natural orifice transluminal endoscopic surgery (NOTES®) and laparoscopy for elective bilateral ovariectomy in standing mares.
Veterinary surgery : VS    September 23, 2011   Volume 40, Issue 8 998-1008 doi: 10.1111/j.1532-950X.2011.00877.x
Pader K, Freeman LJ, Constable PD, Wu CC, Snyder PW, Lescun TB.To compare surgical trauma, perioperative pain, surgical time, and complication rate in mares undergoing standing bilateral ovariectomy by natural orifice transluminal endoscopic surgery (NOTES) or laparoscopy. Methods: Experimental study. Methods: Healthy mares (n = 12). Methods: Ovariectomy was performed with a vessel-sealing device by transvaginal NOTES (n = 6) using a flexible endoscope and specialized instruments or by bilateral flank laparoscopy (n = 6). Preoperative and postoperative complete blood count (CBC), plasma fibrinogen concentration, serum amyloid A concentration, peritoneal n...
Physiological and behavioural responses of young horses to hot iron branding and microchip implantation.
Veterinary journal (London, England : 1997)    September 13, 2011   Volume 191, Issue 2 171-175 doi: 10.1016/j.tvjl.2011.08.008
Erber R, Wulf M, Becker-Birck M, Kaps S, Aurich JE, Möstl E, Aurich C.Branding is the traditional and well-established method used to mark horses, but recently microchip transponders for implantation have become available. In this study, behaviour, physiological stress variables and skin temperature in foals were determined in response to hot-iron branding (n=7) and microchip implantation (n=7). Salivary cortisol concentrations increased in response to branding (1.8 ± 0.2 ng/mL) and microchip implantation (1.4 ± 0.1ng/mL), but cortisol release over time did not differ. In response to both manipulations there was a transient increase in heart rate (P<0.001) ...
Comparison of xylazine-butorphanol and xylazine-morphine-ketamine infusions in horses undergoing a standing surgery.
The Veterinary record    September 6, 2011   Volume 169, Issue 14 364 doi: 10.1136/vr.d5333
Benredouane K, Ringer SK, Fourel I, Lepage OM, Portier KG, Bettschart-Wolfensberger R.No abstract available
Treating navicular syndrome in equine patients.
Compendium (Yardley, PA)    September 2, 2011   Volume 33, Issue 1 E2 
Waguespack RW, Hanson RR.Navicular syndrome is a chronic, progressive condition affecting the navicular bone and bursa, deep digital flexor tendon (DDFT), and associated soft tissue structures composing the navicular apparatus. The treatment options for navicular syndrome are as varied as the proposed causes of the condition. The severity of clinical signs, intended use and workload of the horse, and owner compliance with therapy are important considerations in developing a treatment plan. Nonsurgical treatment of navicular syndrome consists of rest, hoof balance and corrective trimming/shoeing, and medical therapy, i...
Close, impinging and overriding spinous processes in the thoracolumbar spine: the relationship between radiological and scintigraphic findings and clinical signs.
Equine veterinary journal    September 1, 2011   Volume 44, Issue 2 178-184 doi: 10.1111/j.2042-3306.2011.00373.x
Zimmerman M, Dyson S, Murray R.There has been no objective study comparing radiological features of spinous processes (SPs) in the thoracolumbar region and/or scintigraphic findings with clinical signs. Objective: To investigate the relationship between the presence or absence of clinical signs of back pain and: 1) radiological findings of close, impinging or overriding SPs; 2) increased radiopharmaceutical uptake (IRU) in the SPs; and 3) the combination of radiological findings and IRU. Also to determine the prevalence of concurrent osseous pathology. Methods: Five-hundred and eighty-two horses, presented for perceived bac...
A randomised, double-blinded, placebo-controlled study on the efficacy of a unique extract of green-lipped mussel (Perna canaliculus) in horses with chronic fetlock lameness attributed to osteoarthritis.
Equine veterinary journal    September 1, 2011   Volume 44, Issue 4 393-398 doi: 10.1111/j.2042-3306.2011.00455.x
Cayzer J, Hedderley D, Gray S.Lyophilised products from green-lipped mussel (Perna canaliculus[LPPC]) are used to orally treat horses with osteoarthritis (OA). However, no randomised, controlled or double-blinded studies on the efficacy of this treatment in horses have been reported to date. Objective: To investigate the effects of a unique LPPC (Biolane)(1) in improving clinical signs of OA in the fetlock. Methods: Data were analysed from 26 horses with primary fetlock lameness in a controlled, randomised and double-blinded, multi-centre clinical trial. The study design was a partial crossover with a washout period and co...
Equine recurrent uveitis: treatment.
Compendium (Yardley, PA)    August 27, 2011   Volume 33, Issue 6 E1 
Curling A.Equine recurrent uveitis has traditionally been treated with medical management to reduce ocular inflammation and control pain during a single episode. Newer management methods include surgical options such as cyclosporine implantation and vitrectomy. These methods were developed not only to control inflammation but also to eliminate the underlying cause of uveitis in order to prevent recurrence.
Use of acetaminophen (paracetamol) as a short-term adjunctive analgesic in a laminitic pony.
Veterinary anaesthesia and analgesia    August 13, 2011   Volume 38, Issue 5 521-522 doi: 10.1111/j.1467-2995.2011.00639.x
West E, Bardell D, Morgan R, Senior M.No abstract available
Amputation of finger by horse bite with complete avulsion of both flexor tendons.
Orthopedics    August 8, 2011   Volume 34, Issue 8 e421-e423 doi: 10.3928/01477447-20110627-26
Koren L, Stahl S, Rovitsky A, Peled E.Amputation of fingers with tendon avulsion occurs through a traction injury, and most occur through a ring avulsion mechanism. Usually the flexor digitorum profundus is torn out with the amputated finger. Replantation usually is recommended only when the amputation is distal to the flexor digitorum superficialis insertion. Animal bites are relatively common, with a decreasing order of frequency of dogs, cats, and humans. Horse bites are relatively infrequent but are associated with crush injuries and tissue loss when they occur. This article describes a 23-year-old man with amputation of his m...
Are matrix and vascular changes involved in the pathogenesis of deep digital flexor tendon injury in the horse?
Veterinary journal (London, England : 1997)    August 6, 2011   Volume 189, Issue 3 289-295 doi: 10.1016/j.tvjl.2010.07.015
Beck S, Blunden T, Dyson S, Murray R.It was hypothesised that there is increased blood vessel frequency and proteoglycan staining intensity within the distal aspect of the deep digital flexor tendon (DDFT) in horses with chronic foot pain. Samples of the DDFT from three standardised sites from 10 age-matched mature horses, with chronic foot pain (Group L) or with no history of forelimb lameness (Group N), were collected for this study. A histological analysis of haematoxylin and eosin-stained sections focussed on the frequency and location of blood vessels, while safranin 0 fast green staining was used for semi-quantitative asses...
Nephrosplenic entrapment of the large colon in 142 horses (2000-2009): analysis of factors associated with decision of treatment and short-term survival.
Equine veterinary journal. Supplement    August 4, 2011   Issue 39 63-68 doi: 10.1111/j.2042-3306.2011.00376.x
Lindegaard C, Ekstrøm CT, Wulf SB, Vendelbo JM, Andersen PH.Previous studies indicate similar overall survival of horses with nephrosplenic entrapment of the large colon (NSE), regardless of treatment strategy. Short-term survival of a primarily conservative treatment strategy without rolling under general anaesthesia (GA) and a low proportion of surgical intervention as well as indicators of short-term nonsurvival has not been documented. Objective: To document short-term survival of horses with NSE treated in a university referral hospital with a low rate of surgical interventions and to determine factors associated with the decision of treatment and...
The effect of nonsteroidal anti-inflammatory drugs on the equine intestine.
Equine veterinary journal. Supplement    August 4, 2011   Issue 39 140-144 doi: 10.1111/j.2042-3306.2011.00398.x
Marshall JF, Blikslager AT.Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in the management of pain and endotoxaemia associated with colic in the horse. While NSAIDs effectively treat the symptoms of colic, there is evidence to suggest that their administration is associated with adverse gastrointestinal effects including right dorsal colitis and inhibition of mucosal barrier healing. Several studies have examined the pathophysiology of NSAID associated effects on the large and small intestine in an effort to avoid these complications and identify effective alternative medications. Differences in the re...
Incomplete longitudinal fractures and fatigue injury of the proximopalmar medial aspect of the third metacarpal bone in 55 horses.
Equine veterinary journal    August 4, 2011   Volume 44, Issue 1 64-70 doi: 10.1111/j.2042-3306.2011.00371.x
Morgan R, Dyson S.Previous descriptions of incomplete longitudinal fractures and fatigue injury of the proximopalmar aspect of the third metacarpal bone (McIII) have focused on diagnostic imaging findings, especially in racehorses. Objective: To document the case details, clinical features, response to diagnostic analgesia, diagnostic imaging findings and follow-up data in a large group of horses with an incomplete longitudinal fracture or fatigue injury of the proximopalmar medial aspect of the McIII. Methods: Horses were included in the study if pain was localised to the proximopalmar aspect of the metacarpal...
Epidural analgesia with morphine or buprenorphine in ponies with lipopolysaccharide (LPS)-induced carpal synovitis. Freitas GC, Carregaro AB, Gehrcke MI, De La Côrte FD, Lara VM, Pozzobon R, Brass KE.This study evaluated the analgesia effects of the epidural administration of 0.1 mg/kg bodyweight (BW) of morphine or 5 μg/kg BW of buprenorphine in ponies with radiocarpal joint synovitis. Six ponies were submitted to 3 epidural treatments: the control group (C) received 0.15 mL/kg BW of a 0.9% sodium chloride (NaCl) solution; group M was administered 0.1 mg/kg BW of morphine; and group B was administered 5 μg/kg BW of buprenorphine, both diluted in 0.9% NaCl to a total volume of 0.15 mL/kg BW administered epidurally at 10 s/mL. The synovitis model was induced by injecting 0.5 ng of lipopol...
Lumbar ligamentum flavum hematoma treated with endoscopy.
Orthopedics    July 7, 2011   Volume 34, Issue 7 e324-e327 doi: 10.3928/01477447-20110526-27
Ohba T, Ebata S, Ando T, Ichikawa J, Clinton D, Haro H.Hematoma of the ligamentum flavum is a rare cause of neural compression, for which treatment has consisted of excising the hematoma via open surgical approaches, including total laminectomy or bilateral partial laminectomy. This article presents the first report of a microscope-assisted endoscopic decompression to resect a hematoma of the ligamentum flavum.A 52-year-old man presented with back and leg pain, as well as difficulty initiating micturation. Magnetic resonance imaging demonstrated an epidural mass at L5/S1 that was continuous with the facet joint. Visualization was obtained via an e...
Factors associated with mortality of geriatric horses in the United Kingdom.
Preventive veterinary medicine    July 5, 2011   Volume 101, Issue 3-4 204-218 doi: 10.1016/j.prevetmed.2011.06.002
Ireland JL, Clegg PD, McGowan CM, Platt L, Pinchbeck GL.Geriatric horses (aged≥15 years) now represent a substantial proportion of the equine population, yet mortality rates for aged horses in the UK have not previously been described. Although post-mortem studies have provided some data regarding specific causes of death, "old age" is a common owner-reported reason for euthanasia of adult horses, indicating further elucidation of reasons for death or euthanasia is required for the geriatric equine population. The objective of this cohort study was to describe mortality rates, causes of death or euthanasia and factors associated with mortality in...
Effects of acepromazine, butorphanol and buprenorphine on thermal and mechanical nociceptive thresholds in horses.
Equine veterinary journal    June 23, 2011   Volume 44, Issue 2 221-225 doi: 10.1111/j.2042-3306.2011.00412.x
Love EJ, Taylor PM, Murrell J, Whay HR.To investigate the antinociceptive effects of buprenorphine administered in combination with acepromazine in horses and to establish an effective dose for use in a clinical environment. Objective: To evaluate the responses to thermal and mechanical stimulation following administration of 3 doses of buprenorphine compared to positive (butorphanol) and negative (glucose) controls. Methods: Observer blinded, randomised, crossover design using 6 Thoroughbred geldings (3-10 years, 500-560 kg). Thermal and mechanical nociceptive thresholds were measured 3 times at 15 min intervals. Horses then rec...
Evaluation of sedation and analgesia in standing horses after administration of xylazine, butorphanol, and subanesthetic doses of ketamine.
Journal of the American Veterinary Medical Association    June 16, 2011   Volume 238, Issue 12 1629-1633 doi: 10.2460/javma.238.12.1629
Wagner AE, Mama KR, Contino EK, Ferris DJ, Kawcak CE.To evaluate the sedative and analgesic effects of subanesthetic doses of ketamine in horses sedated with xylazine, with or without butorphanol. Methods: Prospective, randomized, controlled study. Methods: 10 adult horses. Methods: Each horse was sedated multiple times by administration of xylazine (treatment X), xylazine and butorphanol (treatment XB), xylazine with 1 of 2 dosages of ketamine (treatment XK1 or XK2), or xylazine and butorphanol with 1 of 2 dosages of ketamine (treatment XBK1 or XBK2). Head height and various behaviors, including responses to noise, insertion of a dental float, ...
Nociceptive trigeminal reflexes in non-sedated horses.
Veterinary journal (London, England : 1997)    June 12, 2011   Volume 191, Issue 1 101-107 doi: 10.1016/j.tvjl.2011.03.022
Veres-Nyéki KO, Leandri M, Spadavecchia C.Electrically induced reflexes can be used to investigate the physiology and pathophysiology of the trigeminal system in humans. Similarly, the assessment of the trigemino-cervical (TCR) and blink reflexes (BR) may provide a new diagnostic tool in horses. The aim of this study was to evoke nociceptive trigeminal reflexes and describe the electrophysiological characteristics in non-sedated horses. The infraorbital (ION) and supraorbital nerves (SON) were stimulated transcutaneously in 10 adult Warmblood horses in separate sessions using train-of-five electrical pulses. The current was increased ...
Effect of topical vapocoolant spray on response to arthrocentesis and intravenous catheterization in unsedated horses.
American journal of veterinary research    June 2, 2011   Volume 72, Issue 6 746-750 doi: 10.2460/ajvr.72.6.746
Fjordbakk CT, Haga HA.To assess the efficacy of a commercially available topical vapocoolant spray in reducing responses to arthrocentesis of the middle carpal (MC) and metacarpophalangeal (MCP) joints and jugular vein catheterization in unsedated horses. Methods: 8 healthy research horses. Methods: Arthrocentesis of both MC and MCP joints and bilateral jugular vein catheterization were performed in each horse. Immediately prior to skin penetration, 1 randomly selected MC joint, MCP joint, and jugular vein were sprayed with a vapocoolant liquid (intervention product), and the contralateral MC joint, MCP joint, and ...
Efficacy of single-dose intravenous phenylbutazone and flunixin meglumine before, during and after exercise in an experimental reversible model of foot lameness in horses.
Equine veterinary journal. Supplement    May 27, 2011   Issue 38 601-605 doi: 10.1111/j.2042-3306.2010.00232.x
Foreman JH, Grubb TL, Inoue OJ, Banner SE, Ball KT.Objective blinded efficacy data during exercise are lacking on the use of single-dose i.v. nonsteroidal anti-inflammatory drugs (NSAIDs) before, during and after exercise. Objective: Single i.v. doses of either phenylbutazone (PBZ) or flunixin meglumine (FM) would prove more efficacious than negative saline control (SAL) before, during and after exercise in a reversible model of foot lameness. Methods: Six Quarter Horse mares had lameness induced by tightening a set screw against a heart bar shoe 1 h prior to treatment. Randomised blinded treatments included PBZ (4.4 mg/kg bwt i.v.), FM (1.1 m...
Relationship between saddle pressure measurements and clinical signs of saddle soreness at the withers.
Equine veterinary journal. Supplement    May 27, 2011   Issue 38 650-653 doi: 10.1111/j.2042-3306.2010.00191.x
von Peinen K, Wiestner T, von Rechenberg B, Weishaupt MA.Similar to human decubitus ulcers, local high pressure points from ill-fitting saddles induce perfusion disturbances of different degrees resulting in tissue hypoxia and alteration in sweat production. Objective: To relate the different clinical manifestations of saddle sores to the magnitude of saddle pressures at the location of the withers. Methods: Sixteen horses with dry spots after exercise (Group A) and 7 cases presented with acute clinical signs of saddle pressure in the withers area (Group B) were compared with a control group of 16 sound horses with well fitting saddles (Group C). Al...
Acupuncture and Chinese herbal medicine for treating horses.
Compendium (Yardley, PA)    May 1, 2011   Volume 33, Issue 5 E1-E11 
Shmalberg J, Xie H.Acupuncture exerts diffuse analgesic effects through the release of endogenous opioids and other locally and centrally acting mediators. Successful therapeutic interventions for various musculoskeletal conditions in horses are well documented, and acupuncture may significantly enhance performance. The use of acupuncture is specifically supported in treating nonsurgical gastrointestinal disorders, in which specific techniques can alter motility and contribute to visceral analgesia. This article describes the use of acupuncture and Chinese herbal medicine for equine reproductive management and f...
Mortierella wolfii keratomycosis in a horse.
Veterinary ophthalmology    April 19, 2011   Volume 14, Issue 4 267-270 doi: 10.1111/j.1463-5224.2011.00891.x
Wada S, Ode H, Hobo S, Niwa H, Katayama Y, Takatori K.To describe a case of superficial keratomycosis caused by Mortierella wolfii (M. wolfii) in a horse. Methods: A thoroughbred filly was presented with painful right eye of 2 days' duration. A superficial corneal ulcer was observed ventrally together with multifocal punctuate opacities axially. Samples were collected by swabbing and scraping the ulcerated lesion and submitted for microbiologic and cytologic examination. Results: Microscopic evaluation of debrided corneal tissue revealed the presence of nonseptate fungal hyphae, and culture of a corneal swab yielded fungal growth. Medical treat...
Continuous peripheral neural blockade to alleviate signs of experimentally induced severe forelimb pain in horses.
Journal of the American Veterinary Medical Association    April 16, 2011   Volume 238, Issue 8 1032-1039 doi: 10.2460/javma.238.8.1032
Watts AE, Nixon AJ, Reesink HL, Cheetham J, Fubini SL, Looney AL.To investigate the efficacy and safety of a low-volume, single-catheter, continuous peripheral neural blockade (CPNB) technique to locally deliver bupivacaine to alleviate signs of severe forelimb pain resulting from experimentally induced tendonitis in horses. Methods: Randomized controlled experimental trial. Methods: 14 horses and 5 forelimbs from equine cadavers. Methods: Horses underwent collagenase-induced superficial digital flexor tendonitis in the midmetacarpal region of 1 forelimb. To deliver analgesia, a closed-tip catheter was placed from lateral to medial, approximately 12 cm dist...
High-field magnetic resonance imaging investigation of distal border fragments of the navicular bone in horses with foot pain.
Equine veterinary journal    April 16, 2011   Volume 43, Issue 3 302-308 doi: 10.1111/j.2042-3306.2010.00159.x
Biggi M, Dyson S.Distal border fragments of the navicular bone can be seen in lame and nonlame horses and their clinical significance remains open to debate. Objective: To describe the magnetic resonance imaging (MRI) appearance of distal border fragments and the adjacent navicular bone. To investigate the relationship between fragments and other abnormalities of the navicular bone and the distal sesamoidean impar ligament (DSIL). Methods: Horses were included if pain causing forelimb lameness was localised to the foot and high-field MR images were acquired. The size and location of distal border fragments wer...
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