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Topic:Prognosis

Prognosis in horses refers to the prediction of the likely outcome or course of a disease or injury in equine patients. It involves assessing various factors such as the nature and severity of the condition, the horse's overall health, and response to treatment. Prognostic evaluations help veterinarians and horse owners make informed decisions regarding treatment options, management strategies, and potential recovery. The process often incorporates clinical assessments, diagnostic tools, and historical data to estimate the chances of recovery or progression. This page compiles peer-reviewed research studies and scholarly articles that explore methodologies, factors influencing prognostic outcomes, and the implications of prognostic evaluations in equine veterinary practice.
Association of admission plasma D-dimer concentration with diagnosis and outcome in horses with colic.
Journal of veterinary internal medicine    October 14, 2010   Volume 24, Issue 6 1490-1497 doi: 10.1111/j.1939-1676.2010.0618.x
Cesarini C, Monreal L, Armengou L, Delgado MÁ, Ríos J, Jose-Cunilleras E.Coagulopathies detected in horses with gastrointestinal problems seem to be associated with poor outcome. Plasma D-Dimer concentration is a sensitive test for assessing coagulopathies. Objective: Plasma D-Dimer concentration tested on admission is related to diagnosis and outcome in horses with colic. Methods: Four hundred and ninety three horses referred for evaluation of abdominal pain. Methods: Prospective observational clinical study. Horses were grouped according to diagnosis (medical and surgical intestinal obstructions, ischemic disorders with and without intestinal resection, enteritis...
Expression of genes associated with inflammation induced by ex vivo exposure to lipopolysaccharide in peripheral blood leukocytes from horses with gastrointestinal disease.
American journal of veterinary research    October 6, 2010   Volume 71, Issue 10 1162-1169 doi: 10.2460/ajvr.71.10.1162
Lopes MA, Salter CE, Vandenplas ML, Berghaus R, Hurley DJ, Moore JN.To investigate the effect of ex vivo exposure to lipopolysaccharide (LPS) on the expression of inflammatory genes in leukocytes from horses with gastrointestinal (Gl) disease and determine whether the pattern or magnitude of the response to LPS correlated with the type of disease and outcome. Methods: 49 horses with Gl disease and 10 healthy horses Methods: Leukocytes were isolated from blood samples and submitted to 3 protocols: immediate freezing, freezing after 4-hour incubation in medium, and freezing after 4-hour incubation in medium containing LPS. Expression of 14 genes associated with ...
European outbreak of atypical myopathy in the autumn 2009.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)    September 21, 2010   Volume 20, Issue 5 528-532 doi: 10.1111/j.1476-4431.2010.00574.x
Van Galen G, Amory H, Busschers E, Cassart D, De Bruijn M, Gerber V, Keen J, Lefere L, Pitel CM, Marr C, Müller JM, Pineau X, Saegerman C....Atypical myopathy is an acute, severe rhabdomyolysis occurring in grazing horses. In the beginning of October 2009, a new outbreak occurred in several European countries. Geographic, demographic and clinical data of the reported cases in the month October 2009 are described. Results: The survival rate in this outbreak was 25%. The most frequently observed clinical signs were congested mucous membranes, dyspnea, tachycardia, depression, weakness, stiffness, recumbency, trembling, sweating, and myoglobinuria. Nonsurvivors were significantly more likely to be recumbent than survivors. Prognostic ...
What is the outlook for equine practice?
The Veterinary record    September 8, 2010   Volume 167, Issue 10 361-363 doi: 10.1136/vr.c4720
Greet T.No abstract available
Prognostic indicators of poor outcome in horses with laminitis at a tertiary care hospital.
The Canadian veterinary journal = La revue veterinaire canadienne    September 3, 2010   Volume 51, Issue 6 623-628 
Orsini JA, Parsons CS, Capewell L, Smith G.This retrospective study investigated the factors associated with a poor outcome (death by euthanasia or from other causes) in horses treated for laminitis at a tertiary care hospital. Cases (n = 247) were defined as patients with laminitis that were euthanized or that died of other causes during hospitalization. Controls (n = 344) were patients with laminitis that survived to be discharged from the hospital. In the final multivariate analysis, the factors significantly associated with an increased risk for death and their respective odds ratios (OR) were as follows: Thoroughbred (OR = 1.57); ...
Arthroscopic treatment of fractures of the lateral malleolus of the tibia: 26 cases.
Equine veterinary journal    August 26, 2010   Volume 43, Issue 3 280-287 doi: 10.1111/j.2042-3306.2010.00183.x
Smith MR, Wright IM.A minimally invasive arthroscopic technique for removal of fractures of the lateral malleolus of the tibia is considered to be beneficial but data to this effect are required. Objective: Arthroscopic removal of fractures of the lateral malleolus of the tibia is technically feasible, provides a comprehensive evaluation of the tarsocrural joint and enables removal of remote comminuted fragments and disrupted short collateral ligaments. The technique is associated with low patient morbidity, requires only short periods of hospitalisation and affords a good prognosis to affected horses. Methods: T...
Extraction of cheek teeth using a lateral buccotomy approach in 114 horses (1999-2009).
Equine veterinary journal    August 26, 2010   Volume 43, Issue 3 348-353 doi: 10.1111/j.2042-3306.2010.00169.x
O'Neill HD, Boussauw B, Bladon BM, Fraser BS.There are few published data regarding the success rates of cheek tooth (CT) removal by lateral buccotomy in the horse. Objective: A retrospective study of 114 horses admitted to 2 private equine referral hospitals over a 10 year period (1999-2009), which underwent CT removal via a lateral buccotomy. Methods: Hospital records were analysed and details including case details, presenting complaint and results of all diagnostic tests and surgical reports were documented. Information obtained during post operative reassessment was also available for analysis. Long-term follow-up information (>2 mo...
The use of small (2.7 mm) screws for arthroscopically guided repair of carpal chip fractures.
Equine veterinary journal    August 26, 2010   Volume 43, Issue 3 270-279 doi: 10.1111/j.2042-3306.2010.00178.x
Wright IM, Smith MR.Removal of large chip fractures of the carpal bones and the osteochondral deficits that result, have been associated with a worse prognosis than removal of small fragments in similar locations. Objective: Reducing the articular defects by repair of large osteochondral fragments may have advantages over removal. Methods: Horses with osteochondral chip fractures that were of sufficient size and infrastructure to be repaired with small (2.7 mm diameter) AO/ASIF cortex screws were identified and repair effected by arthroscopically guided internal fixation. Results: Thirty-three horses underwent su...
Colic in geriatric compared to mature nongeriatric horses. Part 2: Treatment, diagnosis and short-term survival.
Equine veterinary journal    August 19, 2010   Volume 42, Issue 7 628-635 doi: 10.1111/j.2042-3306.2010.00085.x
Southwood LL, Gassert T, Lindborg S.Owners and veterinarians are often concerned about mortality of geriatric horses following colic surgery. Objective: To compare treatment, diagnosis and short-term survival for geriatric compared to mature nongeriatric horses with colic. Methods: Medical records of horses admitted with a presenting complaint of colic between 2000 and 2006 were reviewed. Geriatric horses were aged ≥16 years (n = 300) and subcategorised as age ≥20 years (n = 134). Mature nongeriatric horses were age 4-15 years (n = 300). Information obtained included medical (included horses subjected to euthanasia without s...
Quantitative evaluation of subchondral bone injury of the plantaro-lateral condyles of the third metatarsal bone in Thoroughbred horses identified using nuclear scintigraphy: 48 cases.
Equine veterinary journal    August 19, 2010   Volume 42, Issue 6 552-557 doi: 10.1111/j.2042-3306.2010.00088.x
Parker RA, Bladon BM, Parkin TD, Fraser BS.Increased radio-isotope uptake (IRU) in the subchondral bone of the plantaro-lateral condyle of the third metatarsus (MTIII) is a commonly reported scintigraphic finding and potential cause of lameness in UK Thoroughbred racehorses in training and has not been fully documented. Objective: To characterise lameness attributable to IRU of the subchondral bone of MTIII, compare the scintigraphic findings of these horses with a normal population and evaluate the use of scintigraphy as an indicator of prognosis. Objective: IRU will be in significantly higher in horses with subchondral bone injury an...
Arthroscopic removal of fractures of the lateral malleolus of the tibia in the tarsocrural joint: a retrospective study of 13 cases.
Equine veterinary journal    August 19, 2010   Volume 42, Issue 6 558-562 doi: 10.1111/j.2042-3306.2010.00103.x
O'Neill HD, Bladon BM.There is limited information on the treatment of lateral malleolus (LM) fractures in the horse, with no previously published case series for the outcome following arthroscopic removal of such fractures. This report reviews and evaluates findings of a retrospective study of 13 horses admitted to a private equine referral hospital over a 10 year period (1999-2009) that underwent arthroscopic removal of fractures of the LM. Hospital records were reviewed and details including patient history, aetiology of the fracture and limb affected, results of all diagnostic tests and surgical reports were do...
Outcome of medical treatment for horses with foot pain: 56 cases.
Equine veterinary journal    August 19, 2010   Volume 42, Issue 8 680-685 doi: 10.1111/j.2042-3306.2010.00081.x
Gutierrez-Nibeyro SD, White Ii NA, Werpy NM.Currently, there are limited data regarding the long-term outcome of horses with foot pain treated with corrective shoeing, rest and rehabilitation, and intrasynovial anti-inflammatory medication to target lesions detected with MRI. Objective: To report the long-term (≥12 months) outcome of horses with foot lesions following medical therapy. Objective: 1) There is no association between clinical parameters considered and a poor response to therapy. 2) Horses with a deep digital flexor tendinopathy are less likely to respond to medical therapy than horses without a deep digital flexor tendino...
Cutaneous schwannomas in 22 horses.
Veterinary pathology    August 17, 2010   Volume 48, Issue 2 433-442 doi: 10.1177/0300985810377072
Schöniger S, Valentine BA, Fernandez CJ, Summers BA.Schwannomas are uncommonly recognized in horses. This study describes cutaneous schwannomas in 22 horses aged 8 to 25 years: 12 male, 7 female, and 3 of unknown sex. The horses had solitary cutaneous masses: 9 on the head, 3 on the neck, and the others on the shoulder, hip, thorax, abdomen, rump, extremities, or tail. The location of 1 tumor was unknown. The dermal tumors were well demarcated and expansile. Twelve had a multinodular pattern, whereas 10 formed a single nodule. Antoni A areas were observed in all tumors, and 10 tumors contained Antoni B areas. In Antoni A areas, the densely pack...
Extraluminal, C shaped polyethylene prostheses in two ponies with tracheal collapse.
Veterinary surgery : VS    August 14, 2010   Volume 39, Issue 6 776-783 doi: 10.1111/j.1532-950X.2010.00715.x
Busschers E, Epstein KL, Holt DE, Parente EJ.To describe the surgical technique, complications, and outcome after use of extraluminal prostheses in 2 ponies with severe tracheal collapse. Methods: Clinical report. Methods: Ponies (n=2) with severe tracheal collapse. Methods: A ventral median approach was used to expose the trachea from the larynx to the manubrium. Extraluminal, high-density polyethylene, C-shaped prostheses were sutured to the dorsal tracheal membrane and tracheal rings to provide external tracheal support. Results: The surgical approach provided good tracheal access and placement of the rings was uncomplicated. Initial ...
Clinical presentation, diagnosis, and prognosis of chronic laminitis in Europe.
The Veterinary clinics of North America. Equine practice    August 12, 2010   Volume 26, Issue 2 391-405 doi: 10.1016/j.cveq.2010.06.005
Eustace RA.The terminology relating to laminitis is confusing. This article describes how equine veterinarians, by using their eyes and fingers alone, can diagnose and evaluate a case of chronic laminitis. This evaluation will enable veterinarians to give a statistically significant prognosis that can be further refined by measurements taken from plain, weight-bearing lateromedial radiographs of the affected hooves. Should invasive techniques such as digital venography also be used, the results of both techniques are complementary.
Removal of 11 incompletely erupted, impacted cheek teeth in 10 horses using a dental alveolar transcortical osteotomy and buccotomy approach.
Veterinary surgery : VS    August 12, 2010   Volume 39, Issue 7 884-890 doi: 10.1111/j.1532-950X.2010.00724.x
Tremaine WH, McCluskie LK.To describe surgical technique and outcome in 10 horses with impacted cheek teeth that were removed by a transcortical osteotomy and buccotomy technique. Methods: Case series. Methods: Horses (n=10) with impacted cheek teeth. Methods: Medical records (2002-2008) of horses with impacted cheek teeth requiring removal were reviewed; surgical technique and outcome were determined. Results: Exodontia of 11 cheek teeth was performed surgically in 10 horses; 3 horses had complications (residual swelling of the mandible) that resolved and all horses returned to their previous use. Conclusions: Transco...
Clinical features and prognostic variables in 109 horses with esophageal obstruction (1992-2009).
Journal of veterinary internal medicine    August 12, 2010   Volume 24, Issue 5 1147-1152 doi: 10.1111/j.1939-1676.2010.0573.x
Chiavaccini L, Hassel DM.Esophageal obstruction is common in horses and can result in life-threatening complications. Previous studies have described clinical findings in horses with esophageal obstruction, but there are no reports that attempt to make correlations of clinical findings with outcome. Objective: Specific clinical features of horses with esophageal obstruction are associated with increased likelihood of complications. Methods: One hundred and nine horses with esophageal obstruction. Methods: Retrospective cross-sectional study. All clinical records of horses admitted between April 1992 and February 2009 ...
Standing lateral thoracotomy in horses: indications, complications, and outcomes.
Veterinary surgery : VS    August 3, 2010   Volume 39, Issue 7 847-855 doi: 10.1111/j.1532-950X.2010.00713.x
Hilton H, Aleman M, Madigan J, Nieto J.To describe the indications for, complications arising from, and outcome of horses that had standing lateral thoracotomy for pleural or pericardial disease. Methods: Case series. Methods: Horses (n=16). Methods: Medical records (January 1990-December 2008) of sedated standing horses that had lateral thoracotomy were reviewed. Clinical and surgical findings, perioperative and short-term complications were recorded. Long-term (>6 months) outcome was determined through telephone conversations with owners and veterinarians. Results: Mean (±SD) horse age was 6.6±5.3 years (range, 1-15 years). ...
Expression of inflammation-associated genes in circulating leukocytes collected from horses with gastrointestinal tract disease.
American journal of veterinary research    August 3, 2010   Volume 71, Issue 8 915-924 doi: 10.2460/ajvr.71.8.915
Lopes MA, Salter CE, Vandenplas ML, Berghaus R, Hurley DJ, Moore JN.To investigate whether expression of inflammation-associated genes in leukocytes from horses with gastrointestinal tract (GIT) diseases correlated with the type of disease and outcome. Methods: 10 healthy horses and 50 horses with GIT disease. Methods: A blood sample was collected from each healthy horse or horse with GIT disease (during admission to the hospital). Leukocytes were isolated, diluted to a standard concentration, and frozen until RNA extraction. Expression of 14 genes associated with inflammation was quantified by use of a real-time quantitative reverse transcription PCR assay. R...
The propagation of induced tendon lesions in the equine superficial digital flexor tendon: an ex vivo study.
Equine veterinary journal    July 20, 2010   Volume 42, Issue 5 407-411 doi: 10.1111/j.2042-3306.2010.00099.x
Bosch G, Lameris MC, van den Belt AJ, Barneveld A, van Weeren PR.Clinical tendon lesions usually enlarge during the first days to weeks after sustaining the injury due to enzymatic and biomechanical influences. Limiting this enlargement would positively influence prognosis related to lesion size. Objective: To investigate the effect of cyclic loading on the propagation of enzymatically and physically induced tendon lesions and to assess the effect of immobilisation thereon in an ex vivo model. Methods: Equine cadaver limbs with either physically or collagenase-induced SDFT lesions were placed in a pneumatic loading device. Groups consisted of unloaded limbs...
Outcome and long-term follow-up of 20 horses undergoing surgery for caecal impaction: a retrospective study (2000-2008).
Equine veterinary journal    July 20, 2010   Volume 42, Issue 5 388-392 doi: 10.1111/j.2042-3306.2010.00087.x
Smith LC, Payne RJ, Boys Smith SJ, Bathe AP, Greet TR.If untreated, caecal impaction may progress to rupture of the caecum and reports of long-term outcome for horses undergoing surgery for caecal impaction are required. Objective: To describe short- and long-term complication rates for horses undergoing surgery for caecal impaction in an otherwise life-threatening gastrointestinal condition. Methods: Case records were reviewed for horses undergoing surgery for caecal impaction. Horses were included in the study if an abnormally large, fluid-distended or feed-impacted caecum was the primary diagnosis at surgery and excluded if the caecum had alre...
Peritoneal concentrations of transforming growth factor beta in horses with colic.
Equine veterinary journal    July 20, 2010   Volume 42, Issue 5 451-455 doi: 10.1111/j.2042-3306.2010.00102.x
Argüelles D, Casteljins G, Carmona JU, Armengou L, Climent F, Prades M.In man, peritoneal transforming growth factor beta (TGF-beta) is associated with peritoneal diseases and subsequent adhesion formation. No studies on plasma and peritoneal TGF-beta concentrations in horses with colic are available. Objective: 1) To determine both plasma and peritoneal TGF-beta(1) and TGF-beta(3) concentrations in horses with different types of colic (not previously subjected to abdominal surgery); 2) to compare these concentrations according to the type of peritoneal fluid (transudate, modified transudate and exudate); and 3) to compare and correlate plasma and peritoneal conc...
Size and geometry of apical sesamoid fracture fragments as a determinant of prognosis in Thoroughbred racehorses.
Equine veterinary journal    July 20, 2010   Volume 43, Issue 4 412-417 doi: 10.1111/j.2042-3306.2010.00134.x
Kamm JL, Bramlage LR, Schnabel LV, Ruggles AJ, Embertson RM, Hopper SA.Analysis was performed to examine a method for refining the preoperative prognosis for horses that had surgery to remove apical fractures of the proximal sesamoid bones (PSBs). Objective: To determine if: 1) there was a difference in size or configuration of apical fractures between the different anatomical locations of the PSBs, which have been shown to affect the prognosis; and 2) the size or configuration could predict the prognosis for racehorses with these fractures. Methods: The study included 110 weanlings and yearlings and 56 training racehorses that underwent surgery to remove apical ...
Muscle strain injuries of the hindlimb in eight horses: diagnostic imaging, management and outcomes.
Australian veterinary journal    July 17, 2010   Volume 88, Issue 8 313-321 doi: 10.1111/j.1751-0813.2010.00597.x
Walmsley EA, Steel CM, Richardson JL, Hesse KL, Whitton RC.To describe the clinical presentation, ultrasound findings, management and outcome in horses with muscle tear injuries of the hindlimbs. Methods: Retrospective case series Procedure Medical records of eight horses were reviewed and information on signalment, history, presenting complaint, physical examination findings and further diagnostic tests were recorded. Diagnosis of muscle injury was determined by the presence of abnormal ultrasound findings, compared with the contralateral limb, and, when required, nuclear scintigraphy. Follow-up information was obtained via telephone interviews with ...
The use of CT and CT arthrography in diagnosing equine stifle injury in a Rheinlander gelding.
Equine veterinary journal    June 9, 2010   Volume 42, Issue 4 367-371 doi: 10.1111/j.2042-3306.2010.00082.x
Crijns CP, Gielen IM, van Bree HJ, Bergman EH.A 5-year-old Rheinlander gelding was evaluated for left hindlimb stifle lameness. The lameness was localised to the stifle, but source of the lameness was not specifically diagnosed from the physical, radiographic and ultrasonographic examinations. Computed tomography (CT) and CT arthrography were therefore used for further investigation since these imaging techniques image bony structures, cartilage and soft tissues. This examination showed multiple lesions in the stifle: an osteochondrosis dissecans like lesion of the medial femoral condyle, bony fragments, cartilage trauma and caudal crucia...
Bacterial culture of septic synovial structures of horses: does a positive bacterial culture influence prognosis?
Equine veterinary journal    May 22, 2010   Volume 42, Issue 3 213-218 doi: 10.2746/042516409X480403
Taylor AH, Mair TS, Smith LJ, Perkins JD.The influence of synovial fluid culture on short- and long-term prognosis of cases with septic synovitis requires study. Objective: Horses with a positive bacterial culture from septic synovial fluid are less likely to survive or return to successful athletic function than those with a negative bacterial culture from septic synovial fluid. Methods: Records of mature horses presented to 2 equine referral hospitals for investigation of suspected septic synovitis were examined. Horses (n=206) were included in the study if synovial fluid was submitted for full laboratory examination, including bac...
Resection and anastomosis of the descending colon in 43 horses.
Veterinary surgery : VS    April 29, 2010   Volume 39, Issue 6 748-753 doi: 10.1111/j.1532-950X.2010.00700.x
Prange T, Holcombe SJ, Brown JA, Dechant JE, Fubini SL, Embertson RM, Peroni J, Rakestraw PC, Hauptman JG.To determine (1) the short- (to hospital discharge) and long- (>6 months) term survival, (2) factors associated with short-term survival, and (3) the perioperative course for horses with resection and anastomosis of the descending colon. Methods: Multicentered case series. Methods: Horses (n=43) that had descending colon resection and anastomosis. Methods: Medical records (January 1995-June 2009) of 7 equine referral hospitals were reviewed for horses that had descending colon resection and anastomosis and were recovered from anesthesia. Retrieved data included history, results of clinical and...
Antimicrobial delivery by intrasynovial catheterisation with systemic administration for equine synovial trauma and sepsis.
Australian veterinary journal    April 21, 2010   Volume 88, Issue 4 115-123 doi: 10.1111/j.1751-0813.2010.00553.x
Stewart AA, Goodrich LR, Byron CR, Evans RB, Stewart MC.To present the technique for intra-articular catheter placement and report the clinical outcomes of 38 cases of equine synovial trauma and/or infection treated with broad-spectrum antimicrobials administered via an intrasynovial catheter (ISC). Methods: Retrospective study. Methods: Medical records of 38 horses treated for synovial trauma and sepsis with frequent antimicrobial administration through an ISC from 1995 to 2008 were reviewed. Follow-up information was obtained via clinical re-evaluation or telephone contact with the owners. Results: The majority of horses (84%) received amikacin a...
Equine venography and its clinical application in North America.
The Veterinary clinics of North America. Equine practice    April 13, 2010   Volume 26, Issue 1 167-177 doi: 10.1016/j.cveq.2009.12.008
Rucker A.The digital venogram uses contrast radiography to evaluate the soft tissues and vasculature of the foot, thus identifying pathology attributable to laminitis. Pathology can be detected before changes appear on plain-film radiographs. When used in conjunction with clinical and radiographic findings, information gained from a venographic study informs and directs treatment. Serial venograms assess the response to treatment and help determine prognosis early in the course of therapy. If the venographic contrast pattern does not improve, either the treatment needs to be altered, or the damage is s...
Clinical presentation, diagnosis, and prognosis of chronic laminitis in North America.
The Veterinary clinics of North America. Equine practice    April 13, 2010   Volume 26, Issue 1 141-153 doi: 10.1016/j.cveq.2009.12.006
Hunt RJ, Wharton RE.Chronic laminitis involves laminar morphologic changes resulting in digital collapse and can vary greatly in its clinical manifestation depending on duration, severity of lameness, and stability of the distal phalanx/hoof wall interface. Accurate assessment of the whole patient is mandatory and consideration must be given to signalment, occupation, and owner expectations, as well as history and etiology, which often predict the broad course of the disease. Diagnosis is made via physical examination with adjunctive serial radiographic evaluation and possibly venography. Eventual functionality o...
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