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Topic:Thoroughbreds

Thoroughbreds are a breed of horse known for their agility, speed, and spirit, often associated with horse racing and equestrian sports. Originating from crossbreeding native English mares with imported Arabian, Barb, and Turkoman stallions, Thoroughbreds have a well-documented pedigree that traces back to the late 17th and early 18th centuries. This breed is characterized by a refined head, deep chest, and long legs, contributing to their athletic capabilities. Thoroughbreds are primarily bred for their performance in racing but are also utilized in other equestrian disciplines. This page compiles peer-reviewed research studies and scholarly articles that explore the genetics, physiology, and performance characteristics of Thoroughbreds, as well as their management and welfare in various equine activities.
Cardiovascular and respiratory responses to submaximal exercise training in the thoroughbred horse.
Pflugers Archiv : European journal of physiology    March 1, 1988   Volume 411, Issue 3 316-321 doi: 10.1007/BF00585121
Evans DL, Rose RJ.Cardiovascular and respiratory responses to submaximal exercise training were investigated in 6 thoroughbred racehorses. Oxygen uptake, heart rate (HR) and arteriovenous oxygen content difference were measured during incremental treadmill exercise tests, before and after 7 weeks of treadmill training. Cardiac output during exercise was calculated by the direct Fick technique. Maximal oxygen uptake (VO2max) was increased by 23% after training, from 129.7 ml/kg/min to 160.0 ml/kg/min. The treadmill speed at which VO2max was attained increased by 19%. The increased aerobic power after training wa...
Near drowning of a gelding.
Journal of the American Veterinary Medical Association    February 1, 1988   Volume 192, Issue 3 377-378 
Humber KA.After becoming entangled in safety lines and being submerged in a chlorinated swimming pool, a 2-year-old Thoroughbred gelding was evaluated and treated successfully. Treatment included antimicrobial agents, anti-inflammatory drugs, bronchodilators, diuretics, humidified oxygen, and surfactant transplant. The results of follow-up examination of the gelding 120 days after hospitalization were normal.
Scintigraphic appearance of stress-induced trauma of the dorsal cortex of the third metacarpal bone in racing Thoroughbred horses: 121 cases (1978-1986).
Journal of the American Veterinary Medical Association    February 1, 1988   Volume 192, Issue 3 390-395 
Koblik PD, Hornof WJ, Seeherman HJ.Review of 121 bone scintigrams obtained on racing Thoroughbred horses with clinical histories indicative of forelimb lameness revealed 3 scintigraphic patterns of stress-induced trauma to the dorsal cortex of the third metacarpal bone: (1) focal, intense uptake associated with recent stress fracture; (2) regional uptake of varying intensity or a mixed pattern of uptake associated with chronic stress fracture; and (3) diffuse, mild to moderate uptake associated with periostitis (bucked shins). The latter scintigraphic pattern appeared to be an exaggerated manifestation of the normal remodeling ...
Maximum O2 uptake, O2 debt and deficit, and muscle metabolites in Thoroughbred horses.
Journal of applied physiology (Bethesda, Md. : 1985)    February 1, 1988   Volume 64, Issue 2 781-788 doi: 10.1152/jappl.1988.64.2.781
Rose RJ, Hodgson DR, Kelso TB, McCutcheon LJ, Reid TA, Bayly WM, Gollnick PD.This study determined maximal O2 uptake (VO2max), maximal O2 deficit, and O2 debt in the Thoroughbred racehorse exercising on an inclined treadmill. In eight horses the O2 uptake (VO2) vs. speed relationship was linear until 10 m/s and VO2max values ranged from 131 to 153 ml.kg-1.min-1. Six of these horses then exercised at 120% of their VO2max until exhaustion. VO2, CO2 production (VCO2), and plasma lactate (La) were measured before and during exercise and through 60 min of recovery. Muscle biopsies were collected before and at 0.25, 0.5, 1, 1.5, 2, 5, 10, 15, 20, 40, and 60 min after exercis...
Small colon intussusception in a broodmare.
Journal of the American Veterinary Medical Association    February 1, 1988   Volume 192, Issue 3 372-374 
Ross MW, Stephens PR, Reimer JM.A 9-year-old pregnant Standardbred broodmare was evaluated for signs of mild abdominal pain, failure to defecate, and mild abdominal distention. Rectal examination revealed the leading edge of a small colon intussusception, and peritoneal fluid analysis indicated suppurative peritonitis. Surgical management, including reduction of the intussusception and small colon resection with end-to-end anastomosis, resulted in successful outcome (1-year follow-up evaluation). Postoperative complications including dehiscence of the ventral midline surgical incision and simple obstruction at the anastomosi...
Epidemiological studies of musculoskeletal racing and training injuries in Thoroughbred horses, Minnesota, U.S.A.
Acta veterinaria Scandinavica. Supplementum    January 1, 1988   Volume 84 340-343 
Robinson RA, Kobluk C, Clanton C, Martin F, Gordon B, Ames T, Trent M, Ruth G.No abstract available
Cortisol concentrations in blood and urine of horses.
Australian veterinary journal    January 1, 1988   Volume 65, Issue 1 1-5 doi: 10.1111/j.1751-0813.1988.tb14919.x
Ralston JM, Stenhouse AM, Stenhouse NS, Buck GJ, Lucks SF, Reynoldson JA, Bolton JR.A survey of the concentrations of cortisol in blood and urine samples taken from thoroughbred and standardbred horses after racing is presented. Statistical analysis showed the only significant difference between thoroughbred and standardbred horses was a higher cortisol concentration in thoroughbred urine. Urine volume and pH had no significant influence on the urinary cortisol concentration, however 9.5% of the urinary cortisol variation could be explained due to the influence of plasma cortisol concentration. The results of cortisol and ACTH administrations are also shown and compared with ...
The effect of oral L-carnitine supplementation on the muscle and plasma concentrations in the Thoroughbred horse.
Comparative biochemistry and physiology. A, Comparative physiology    January 1, 1988   Volume 91, Issue 4 827-835 doi: 10.1016/0300-9629(88)90971-1
Foster CV, Harris RC, Snow DH.1. L-carnitine was administered orally to thoroughbred horses for 58 days. 2. Acceptability and effects on plasma, muscle and urine concentration were studied. 3. Ten-60 g/day (as 2-3 doses) was acceptable with no deleterious effects. 4. One x 10 g L-carnitine significantly raised the plasma-free carnitine concentration (7 hr post) from 21.2 to 31.8 mumol/l; 2 x 30 g increased the mean to 36.5 mumol/l. 5. Plasma acetylcarnitine increased from approximately 1 to 5.5 mumol/l (7 hr post) on 2 x 30 g/day. 6. Muscle total carnitine was unchanged over 58 days. 7. Urinary output accounted for 3.5-7.5...
Subdivision of equine Tf into H1 and H2.
Animal genetics    January 1, 1988   Volume 19, Issue 2 177-183 doi: 10.1111/j.1365-2052.1988.tb00803.x
Bell K, Pollitt CC, Patterson SD.Subdivision of equine TfH into two variants, designated H1 (faster) and H2 (slower), has been accomplished by high voltage, thin layer polyacrylamide gel electrophoresis at pH 7.9. Transferrin H1 and H2 have been shown to be controlled by codominant alleles and gene frequencies of the Tf alleles have been determined in the Australian Thoroughbred, Standardbred. Quarter Horse and Arabian Horse breeds.
Association of arytenoid chondritis with equine lymphocyte antigens but no association with laryngeal hemiplegia, umbilical hernias and cryptorchidism.
Animal genetics    January 1, 1988   Volume 19, Issue 4 427-433 doi: 10.1111/j.1365-2052.1988.tb00834.x
McClure JJ, Koch C, Powell M, McClure JR.Associations were sought between ELA A1-A10 and W11 antigens and the presence of laryngeal hemiplegia, arytenoid chondritis, umbilical hernias and cryptorchidism in Thoroughbreds and/or Quarter Horses. No significant associations were detected between laryngeal hemiplegia and any ELA antigen in Thoroughbreds. The association between arytenoid chondritis and A9 was significant with a relative risk (RR) of 15.6 and aetiologic fraction (EF) of 0.80 in Thoroughbreds. There were apparent associations based on RR between A4 and A5 in Quarter Horses with umbilical hernias (RR = 7.5 and 6.1 respective...
Body condition scoring and weight estimation of horses.
Equine veterinary journal    January 1, 1988   Volume 20, Issue 1 41-45 doi: 10.1111/j.2042-3306.1988.tb01451.x
Carroll CL, Huntington PJ.Three hundred and seventy two horses of varying breeds, height and fatness were weighed and measured for height at the withers. They were assessed for condition score by adaptation of a previously published method. The heart girth and length of 281 of the horses were also measured. Weight of horses was highly correlated (P less than 0.001) with height (r2 = 0.62), condition score (r2 = 0.22) and girth2 x length (r2 = 0.90). Nomograms were constructed to predict weight from height and condition score, and girth and length measurements. Weight can also be accurately estimated from the formula: (...
Evaluation of breed as a risk factor for sarcoid and uveitis in horses.
Animal genetics    January 1, 1988   Volume 19, Issue 4 417-425 doi: 10.1111/j.1365-2052.1988.tb00833.x
Angelos J, Oppenheim Y, Rebhun W, Mohammed H, Antczak DF.The relationship between breed and the risk of developing sarcoid tumours or uveitis of unknown etiology was evaluated in a retrospective study of 16242 equine cases admitted between 1975 and 1987 to the New York State College of Veterinary Medicine Large Animal Hospital, and 3198 equine tissue samples sent to the New York State Veterinary Diagnostic Laboratory between 1977 and 1987. Of 120 sarcoid cases from the Large Animal Hospital, sarcoids were twice as likely to develop in Quarter Horses (odds ratio, OR = 1.8, P less than 0.05) relative to Thoroughbreds and less than half as likely to de...
Neuroendocrine changes produced by competition stress on the Thoroughbred race horse.
Comparative biochemistry and physiology. A, Comparative physiology    January 1, 1988   Volume 91, Issue 3 599-602 doi: 10.1016/0300-9629(88)90640-8
Martínez R, Godoy A, Naretto E, White A.1. Packed cell volume (PCV) and plasma catecholamines, cortisol and glucose were determined in blood samples obtained from race horses, after competition. 2. All these parameters were higher than basals but catecholamines increased 6-7 times while cortisol was enhanced only by 25%. 3. The increase of glucose and PCV was related to the rise of catecholamines. 4. In samples withdrawn after overnight stress caused by change of horseshoes, it was not possible to find values from basal values significantly different. 5. Influence of nervous temperament was observed only in the higher hematocrit fou...
[Iron and iron-binding capacity in the serum of clinically healthy horses].
Tierarztliche Praxis    January 1, 1988   Volume 16, Issue 2 163-165 
Schorr G.Serum iron concentration and iron-binding capacity were determined in 34 respectively 35 clinically healthy horses of different sex, with the age of 3 to 21 years. In the Warm blooded horse, the Half bred, the Haflinger horse, the Heavy horse and the Arabian Haflinger the mean serum iron concentration amounted to 253 +/- 66 micrograms/dl, 202 +/- 87 micrograms/dl, 166 +/- 67 micrograms/dl, 183 micrograms/dl and 366 micrograms/dl, while the iron-binding capacity in the Warm blooded horse, the Half bred, the Haflinger horse, the Thoroughbred, the Heavy horse and the Arabian Haflinger ran up to 4...
Circulatory, respiratory and metabolic responses in Thoroughbred horses during the first 400 meters of exercise.
European journal of applied physiology and occupational physiology    January 1, 1988   Volume 58, Issue 3 307-314 doi: 10.1007/BF00417268
Littlejohn A, Snow DH.These studies investigated circulatory, respiratory and metabolic responses in four Thoroughbred geldings during the first 400 metres of galloping (mean speed 14.4 +/- 0.38 m.s-1), cantering (mean speed 10.0 +/- 0.61 m.s-1) and walking (mean speed 1.58 +/- 0.05 m.s-1) from a standing start. A radio-controlled device which collected blood samples anaerobically during each 100 m section of the exercise track allowed analyses of changes in and functional relationships of the variables measured. During the 400 m gallop, the mean heart rate (HR) increased from 125 to 201 beats.min-1 and the haemato...
[The progress of a fibrinolytic therapy with streptokinase, urokinase and warfarin in a thoroughbred with intermittent lameness with special reference to resonance thrombography].
Tierarztliche Praxis    January 1, 1988   Volume 16, Issue 4 377-383 
Pause B, Nolte I, Geiss V, Mayer H, Lasch HG.A thoroughbred horse, suffering from intermittent lameness was treated with streptokinase, urokinase and warfarin. The appearing fibrinolytic changes in coagulation were exhibited in a resonance thrombogram. In attendant coagulation studies fibrinogen- and fibrin-degradation products were demonstrated. The stallion does not show any lameness since the end of the treatment and is standing in a breeding station since March 1988.
The detection, pharmacokinetics and behavioral effects of diisopropylamine dichloroacetate (DADA) in the horse: a preliminary report.
General pharmacology    January 1, 1988   Volume 19, Issue 5 683-688 doi: 10.1016/0306-3623(88)90129-2
Yang JM, Woods WE, Weckman TJ, Wood TW, Chang SL, Blake JW, Tobin T.1. Drug administration studies using diisopropylamine dichloroacetate (DADA) and diisopropylamine (DIPA) were conducted in Thoroughbred and Standardbred horses to assess physiological effects and develop detection methods. 2. Four horses received 0.08 mg DADA/kg body wt and showed no changes in heart and respiratory rates or body temperature as measured over a 1-hr period after administration. A transient diuretic effect was found to occur in 2 mares dosed with 0.80 mg DADA/kg body wt. 3. A qualitative detection method using thin-layer chromatography was developed to detect DIPA, the major met...
Cardiovascular and respiratory responses in Thoroughbred horses during treadmill exercise.
The Journal of experimental biology    January 1, 1988   Volume 134 397-408 doi: 10.1242/jeb.134.1.397
Evans DL, Rose RJ.Six detrained Thoroughbred horses performed incremental treadmill tests. Maximal oxygen uptake (VO2max) was measured during exercise by analysis of expired gas. The relationships between oxygen consumption (VO2) and work rate, heart rate (HR), cardiac output (Q), stroke volume (SV) and arteriovenous oxygen content difference [C(a-v)O2] were examined during submaximal and maximal exercise. The relative contributions of blood flow and extraction of oxygen from muscle capillaries were assessed during exercise at VO2max. Mean VO2max was 129.7 +/- 2.9 (mean +/- S.E.M.) ml kg-1 min-1, which occurred...
Esophageal phytobezoar in a horse.
Journal of the American Veterinary Medical Association    December 1, 1987   Volume 191, Issue 11 1455-1456 
MacDonald MH, Richardson DW, Morse CC.A 23-year-old Thoroughbred stallion was admitted to the hospital for treatment of acute esophageal obstruction. Clinical examination and contrast radiography confirmed the presence of an esophageal obstruction. The horse was euthanatized, and examination revealed a bolus of feed material occluding the esophageal lumen 6 cm caudal to the thoracic inlet, with underlying necrosis of the esophageal mucosa. A large pulsion diverticulum was identified in the caudocervical portion of the esophagus. Apparently, the phytobezoar was formed within the esophageal diverticulum and subsequently became dislo...
Sero-epizootiological study of racehorses with pyrexia in the training centers of the Japan Racing Association.
Nihon juigaku zasshi. The Japanese journal of veterinary science    December 1, 1987   Volume 49, Issue 6 1087-1096 doi: 10.1292/jvms1939.49.1087
Sugiura T, Matsumura T, Fukunaga Y, Hirasawa K.A sero-epizootiological study was conducted on horses which showed clinical pyrexia at two training centers, each of which maintained 1, 200 to 2, 100 racehorses for training, of the Japan Racing Association. It continued from 1980 to 1985 to clarify the cause of pyrexia, so that measures might be considered for the prevention of infectious disease. A total of 3, 849 horses were found to be affected with pyrexia for the 6 years. Of them, 2, 852 horses were tested to equine herpesvirus type 1 (EHV-1), equine rhinovirus type 1 (ERhV-1), rotavirus and equine adenovirus (EAdV) by collecting paired...
Cardiac output and oxygen consumption in exercising Thoroughbred horses.
The American journal of physiology    December 1, 1987   Volume 253, Issue 6 Pt 2 R890-R895 doi: 10.1152/ajpregu.1987.253.6.R890
Weber JM, Dobson GP, Parkhouse WS, Wheeldon D, Harman JC, Snow DH, Hochachka PW.This study characterizes the effects of exercise on the cardiac output (Q) and the metabolic rate (VO2) of trained Thoroughbred racehorses. Heart rate, Q, and arteriovenous (a-v)O2 difference were measured at rest and at three levels of submaximal treadmill exercise (1.6 m/s walk and 3-4 m/s trot at 6% incline, and 6.5 m/s horizontal canter). Heart rate and (a-v)O2 difference were also measured during maximal exercise (12.5 m/s gallop, 5% incline) to obtain an estimate of maximum O2 uptake (VO2max). The walk, trot, and canter represented 25, 45, and 55% VO2max. Mean heart rate went from 48.9 (...
Evaluation of the potential for interference by dimethyl sulfoxide (DMSO) in drug detection in racing animals.
Journal of veterinary pharmacology and therapeutics    December 1, 1987   Volume 10, Issue 4 298-304 doi: 10.1111/j.1365-2885.1987.tb00105.x
Craig AM, Blythe LL, Appell LH, Slizeski ML.Dimethyl sulfoxide (DMSO) had been postulated to be a 'masking agent' when used concurrently with therapeutic or prohibited drugs in racing animals. Eight drugs (flunixin, furosemide, caffeine, apomorphine, phenylbutazone, lidocaine, cocaine, and acepromazine maleate) were administered to six horses singly and with concurrent intravenous DMSO. Urine samples were analyzed for the presence of the drugs and/or their metabolites by thin layer chromatography. Direct comparison of thin layer chromatograms of extracts of positive urine samples with and without DMSO verified that DMSO did not interfer...
Lactate kinetics in exercising Thoroughbred horses: regulation of turnover rate in plasma.
The American journal of physiology    December 1, 1987   Volume 253, Issue 6 Pt 2 R896-R903 doi: 10.1152/ajpregu.1987.253.6.R896
Weber JM, Parkhouse WS, Dobson GP, Harman JC, Snow DH, Hochachka PW.Plasma lactate turnover rate of Thoroughbred racehorses was measured by bolus injection of [U-14C]lactate at rest and two levels of submaximal treadmill exercise (3-4 m/s trot, 6% incline, and 6.5 m/s horizontal canter). Our goals were 1) to determine the relative effects of changes in cardiac output and in plasma lactate concentration on turnover rate [using cardiac output data from Weber et al. (28)] and 2) to assess the importance of lactate as a metabolic fuel in a trained animal athlete. Lactate turnover rates were 9.3 mumol.min-1.kg-1 (rest), 75.9 mumol.min-1.kg-1 at the beginning of the...
Observations on the examination of Thoroughbred yearlings for idiopathic laryngeal hemiplegia.
Equine veterinary journal    November 1, 1987   Volume 19, Issue 6 531-536 doi: 10.1111/j.2042-3306.1987.tb02666.x
Lane JG, Ellis DR, Greet TR.No abstract available
The relationship of air hygiene in stables to lower airway disease and pharyngeal lymphoid hyperplasia in two groups of Thoroughbred horses.
Equine veterinary journal    November 1, 1987   Volume 19, Issue 6 524-530 doi: 10.1111/j.2042-3306.1987.tb02665.x
Clarke AF, Madelin TM, Allpress RG.The relationship between air hygiene within two types of identically managed horse housing and the incidence of covert respiratory disease (as revealed by endoscopic examination) of their inhabitants was assessed. The horses were all under the supervision of the same trainer. In one yard the design ensured the boxes were well ventilated in still air conditions. In the other yard the boxes were insulated and there was little provision for natural ventilation in still air conditions. There was heavy fungal and actinomycete contamination of wood shavings in the heavily insulated, poorly ventilate...
Oral administration of ascorbic acid to horses.
Equine veterinary journal    November 1, 1987   Volume 19, Issue 6 520-523 doi: 10.1111/j.2042-3306.1987.tb02664.x
Snow DH, Gash SP, Cornelius J.The effects of oral administration of high doses of ascorbic acid on plasma concentrations were investigated in both experimental Thoroughbred horses and those within racing stables. A single oral dose (20 g) did not result in any increase in plasma concentrations. However, daily administration of either 4.5 g or 20 g doses resulted in significant increases in plasma concentrations. Monthly variations in plasma ascorbate concentrations were found in both supplemented (20 g daily) and unsupplemented stables. It is concluded that oral supplementation with ascorbic acid is a satisfactory route to...
Immunocytochemical localisation of carbonic anhydrase isozyme III in equine skeletal muscle.
Equine veterinary journal    November 1, 1987   Volume 19, Issue 6 509-513 doi: 10.1111/j.2042-3306.1987.tb02660.x
Nishita T, Matsushita H, Kai M.The location of carbonic anhydrase III (CA-III) in frozen sections of biopsies of Thoroughbred horse skeletal muscle was studied. Fibre types were determined by ATP-ase and succinate dehydrogenase staining. CA-III isozyme was detected using a peroxidase conjugated anti-CA-III antibody. CA-III was found to be localised in slow twitch oxidative fibres (ST), but was also present in fast twitch oxidative (FTH) fibres in small amounts. Fast twitch glycolytic (FT) fibres were stained lightly compared with control sections. The concentrations of CA-III in muscle and liver were 70 micrograms/mg protei...
Studies of the pathogenesis of Rhodococcus equi infection in foals.
Australian veterinary journal    November 1, 1987   Volume 64, Issue 11 332-339 doi: 10.1111/j.1751-0813.1987.tb06061.x
Barton MD, Embury DH.Pyogranulomatous pneumonia was induced in Thoroughbred foals by intranasal challenge with freeze-dried cultures of Rhodococcus equi (previously Corynebacterium equi). The incubation period was about 18 days and clinical signs were not seen for a further week. There were marked seasonal and individual foal differences in responses to infection. Elevations in serum caeruloplasmin oxidase activity and copper concentrations appeared to be sensitive indicators of infection. Serum zinc concentrations and serum alpha-mannosidase and alkaline phosphatase activities fell in the more severely infected f...
Auscultatory and phonocardiographic studies on the cardiovascular system of the newborn thoroughbred foal.
The Japanese journal of veterinary research    October 1, 1987   Volume 35, Issue 4 235-250 
Machida N, Yasuda J, Too K.No abstract available
Leptospirosis in horses in Ontario.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire    October 1, 1987   Volume 51, Issue 4 448-451 
Kitson-Piggot AW, Prescott JF.Sera from Thoroughbred and Standardbred horses in southwest Ontario were tested for antibody to seven Leptospira interrogans serovars (autumnalis, bratislava, canicola, grippotyphosa, hardjo, icterohaemorrhagiae, pomona), using the microscopic agglutination test. There was significantly higher seroprevalence of bratislava than of other serovars, in which prevalence was low. Seroprevalence of bratislava increased significantly with age; only 5% of two to three year old horses had titers greater than or equal to 1:80 compared to 52% of horses older than seven years. Eight of 16 foals from two fa...