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Topic:Toxic plants

Toxic plants are a concern in equine management as they pose health risks to horses when ingested. These plants contain various compounds that can lead to adverse effects ranging from mild discomfort to severe illness or death. Horses may encounter toxic plants in pastures, hay, or during foraging. Common toxic plants include ragwort, yew, and oleander, each containing specific toxins that affect equine physiology differently. Understanding the identification, distribution, and toxicological impact of these plants is important for prevention and management. This page compiles peer-reviewed research studies and scholarly articles that explore the identification, toxic mechanisms, and management strategies of toxic plants in relation to equine health.
Toxicosis in horses after ingestion of hoary alyssum.
Journal of the American Veterinary Medical Association    July 1, 1992   Volume 201, Issue 1 63-67 
Geor RJ, Becker RL, Kanara EW, Hovda LR, Sweeney WH, Winter TF, Rorick JK, Ruth GR, Hope E, Murphy MJ.Fever, limb edema, and laminitis were observed in horses 18 to 36 hours after they consumed hoary alyssum (Berteroa incana) under field and experimental conditions. Clinical signs were not observed in all horses that had ingested the plant. Diagnosis in the field cases was limited to observation of clinical signs and evidence of plant ingestion in hay or on pasture. In most cases, clinical remission was observed 2 to 4 days after empirical treatment, removal of the plant source, or both.
Systemic granulomatous disease in a horse grazing pasture containing vetch (Vicia sp.). Woods LW, Johnson B, Hietala SK, Galey FD, Gillen D.No abstract available
The use of ascorbic acid in the treatment of 2 cases of red maple (Acer rubrum)-poisoned horses.
The Cornell veterinarian    July 1, 1992   Volume 82, Issue 3 293-300 
McConnico RS, Brownie CF.Two horses with red maple (Acer rubrum) toxicity responded to treatment with high doses of vitamin C (ascorbic acid), in addition to blood transfusions, and intravenous fluid therapy. The clinical course included Heinz body anemia, marked methemoglobinemia, depression, and evidence of severe tissue anoxia. Clinical recovery was dramatic with stabilization achieved 36 hours following the initiation of ascorbic acid therapy.
Mutagenic potentials of fumonisin contaminated corn following ammonia decontamination procedure.
Mycopathologia    February 11, 1992   Volume 117, Issue 1-2 105-108 doi: 10.1007/BF00497285
Park DL, Rua SM, Mirocha CJ, Abd-Alla ES, Weng CY.Naturally contaminated corn implicated in an outbreak of equine leukoencephalomalacia (ELEM) in southeastern Arizona was analyzed for mutagenic potential using the Salmonella/microsome mutagenicity assay before and after treatment with the ammonia procedure. Crude acetonitrile: water (1 + 1) extracts of high-pressure/ambient temperature (HP/AT) ammonia decontaminated, HP/AT plus low pressure/high temperature (LP/HT), and non-ammoniated fumonisin contaminated corn were tested for mutagenic potentials. Relatively pure (approx. 90%) fumonisin B1 standard was also tested for comparison purposes. T...
Alkaloids of Stipa robusta (sleepygrass) infected with an Acremonium endophyte.
Natural toxins    January 1, 1992   Volume 1, Issue 2 84-88 doi: 10.1002/nt.2620010205
Petroski RJ, Powell RG, Clay K.Stipa robusta (= Stipa vaseyi) is a perennial grass found in certain areas of the southwestern United States. It is commonly known as sleepygrass, as horses that ingest this grass may become profoundly somnolent or stuporous for periods of time lasting up to several days. In an attempt to determine the active principle(s), fractionation of a methanolic extract of sleepygrass infected with an Acremonium endophyte has yielded lysergic acid amide (20 micrograms/g dry wt), isolysergic amide (8), 8-hydroxylsergic acid amide (0.3), ergonovine (7), chanoclavine-I (15), and N-formylloline (18). Relate...
Hepatic disease in Alberta horses: A retrospective study of ‘alsike clover poisoning’ (1973-1988).
The Canadian veterinary journal = La revue veterinaire canadienne    October 1, 1991   Volume 32, Issue 10 602-607 
Nation PN.Over sixteen years, 49 horses were diagnosed by Alberta Agriculture Animal Health laboratories as having "alsike clover poisoning". There was a distinct northwestern distribution of cases, the majority coming from the Peace River district. This distribution is opposite to that of the Alberta horse population, but coincides with areas of alsike clover cultivation. Cases could be divided into chronic or nervous clinical presentations, as described by Schofield. Tissues from 45 animals were retrieved and examined microscopically. Significant histological lesions were confined to the liver and con...
An equine case of urticaria associated with dry garlic feeding.
The Journal of veterinary medical science    August 1, 1991   Volume 53, Issue 4 747-748 doi: 10.1292/jvms.53.747
Miyazawa K, Ito M, Ohsaki K.No abstract available
The identification of hepatotoxic pyrrolizidine alkaloid exposure in horses by the demonstration of sulphur-bound pyrrolic metabolites on their hemoglobin.
Veterinary and human toxicology    June 1, 1991   Volume 33, Issue 3 286-287 
Seawright AA, Hrdlicka J, Wright JD, Kerr DR, Mattocks AR, Jukes R.No abstract available
[Pilot study of the relationship of free amino acids in serum and in the cerebrospinal fluid of horses].
Tierarztliche Praxis    June 1, 1991   Volume 19, Issue 3 271-275 
Grabner A, Goldberg M.In a blind study serum and cerebrospinal fluid (CSF) of control horses and of horses in hepatic coma after chronic food intoxication with Senecio alpinus were collected simultaneously and the composition of free amino acids was determined. The hepatic encephalopathy index in serum (less than 1.65) and in CSF (less than 1.11) of liver patients was distinctly less than to the control values in serum (greater than 2.42) and in CSF (greater than 1.49). The serum concentrations of glutamic acid in hepatic coma were elevated five-fold in comparison to the controls. An indication of ammonia decontami...
Concentrations of fumonisin B1 in feeds associated with animal health problems.
Mycopathologia    June 1, 1991   Volume 114, Issue 3 129-135 doi: 10.1007/BF00437200
Ross PF, Rice LG, Plattner RD, Osweiler GD, Wilson TM, Owens DL, Nelson HA, Richard JL.Ninety-eight samples of feeds associated with 44 cases of equine leukoencephalomalacia (ELEM) and 83 samples of feed associated with 42 cases of a porcine pulmonary edema syndrome (PPE) were analyzed for fumonisin B1 (FB1). For comparison purposes, 51 feed samples not associated with PPE or ELEM were also analyzed. Feed associated with ELEM contained FB1 ranging from less than 1 microgram/g to 126 micrograms/g with 75% of the cases having at least 1 sample above 10 micrograms/g. Feeds associated with PPE ranged from less than 1 microgram/g to 330 micrograms/g with 71% of the cases having at le...
Liver failure attributable to pyrrolizidine alkaloid toxicosis and associated with inspiratory dyspnea in ponies: three cases (1982-1988).
Journal of the American Veterinary Medical Association    May 1, 1991   Volume 198, Issue 9 1651-1654 
Pearson EG.Of 41 equids referred to a veterinary teaching hospital in the Pacific northwest because of dyspnea and inspiratory noise, 3 ponies were diagnosed as having liver failure, most likely attributable to pyrrolizidine alkaloid toxicosis. Dyspnea appeared to be caused by laryngeal and/or pharyngeal paralysis. It is proposed that this paralysis was a manifestation of hepatic encephalopathy. Although these clinical signs are not common for pyrrolizidine toxicosis, practitioners should be aware of the possibility so that misdiagnosis of other causes of inspiratory dyspnea may not be made.
Detection and identification of loline and its analogues in horse urine.
Chemical & pharmaceutical bulletin    April 1, 1991   Volume 39, Issue 4 964-968 doi: 10.1248/cpb.39.964
Takeda A, Suzuki E, Kamei K, Nakata H.Several kinds of loline-type alkaloids, norloline, loline, N-acetylnorloline, N-acetylloline, N-formylnorloline, N-formylloline and N-methylloline were detected in the urine of race-horses. Furthermore, a new compound of the alkaloids, N-senecioylnorloline, was also found and identified. These compounds were mainly identified by means of gas chromatography-mass spectrometry (GC-MS) and gas chromatography-fourier transform-infrared spectrometry (GC-FT-IR). A certain plant of Gramineae containing four kinds of loline-type alkaloids was found in a bale of hay used for the horse forage. The taxono...
Black walnut (Juglans nigra) toxicosis: a model for equine laminitis.
Journal of comparative pathology    April 1, 1991   Volume 104, Issue 3 313-326 doi: 10.1016/s0021-9975(08)80043-6
Galey FD, Whiteley HE, Goetz TE, Kuenstler AR, Davis CA, Beasley VR.Twelve light horse geldings developed laminitis within 8 to 12 h of being dosed by nasogastric tube with an aqueous extract of black walnut (Juglans nigra). Four of the 12 horses developed the severe signs of grade 3 laminitis (lame at a walk, refused to lift feet). Laminitis was accompanied by mild depression and limb oedema. There was no evidence of shock or colic. The horses developed neutropenia by 4 h after dosing with the extract, which shifted to a relative neutrophilia by 8 to 12 h. Minimal increases in plasma epinephrine and cortisol concentrations were suggested in severely affected ...
Red maple toxicity in a horse.
Veterinary and human toxicology    February 1, 1991   Volume 33, Issue 1 66-67 
Plumlee KH.No abstract available
Avocado (Persea americana) poisoning of horses.
Australian veterinary journal    February 1, 1991   Volume 68, Issue 2 77-78 doi: 10.1111/j.1751-0813.1991.tb03147.x
McKenzie RA, Brown OP.No abstract available
Urinary excretion of theobromine in horses given contaminated pelleted food.
Veterinary research communications    January 1, 1991   Volume 15, Issue 2 107-116 doi: 10.1007/BF00405142
Delbeke FT, Debackere M.A high pressure liquid chromatographic (HPLC) method for measuring the theobromine content in cocoa husks, pelleted food and horse urine is described. Starting with 2 ml of urine, concentrations of 500 ng/ml could easily be detected. When feed containing 38.4 mg of theobromine was given twice daily to horses for 2 1/2 days, two days were needed after the last intake before the theobromine concentrations fell below the threshold value of 2 micrograms/ml. The time at which the peak excretion rate occurred varied from 2 to 12 h after the last administration, while the excretion rate seemed to be ...
‘Magic mushroom’ poisoning in a colt.
The Veterinary record    December 15, 1990   Volume 127, Issue 24 603 
Jones J.No abstract available
Beechmast poisoning.
The Veterinary record    November 17, 1990   Volume 127, Issue 20 508 
Hayes MJ, Turner M.No abstract available
Beechmast poisoning in ponies.
The Veterinary record    October 27, 1990   Volume 127, Issue 17 435 
Wilkens WM, Cranwell MP.No abstract available
Suspected Cryptostegia grandiflora (rubber vine) poisoning in horses.
Australian veterinary journal    September 1, 1990   Volume 67, Issue 9 344 doi: 10.1111/j.1751-0813.1990.tb07825.x
Cook DR, Campbell GW, Meldrum AR.No abstract available
[Meadow saffron (Colchicum autumnale) in hay and colic in horses].
Tierarztliche Praxis    June 1, 1990   Volume 18, Issue 3 273-275 
Kamphues J, Meyer H.Following feeding of a new delivery of hay (bought in Southern Germany) 3 horses out of a unit of 17 developed colic within a few days one horse died. Post-mortem there was an intensive accumulation of serous or serous-haemorrhagic fluid in the thorax and abdomen. The hay was heavily contaminated by autumn crocus (colchicum autumnale)--about 1.48% of total mass. Other feedstuffs were of good quality and following removal of the affected hay no further cases of colic occurred. The pathological findings also indicated a colchicine intoxication.
Secondary gastric impaction associated with ragwort poisoning in three ponies.
The Veterinary record    May 19, 1990   Volume 126, Issue 20 502-504 
Milne EM, Pogson DM, Doxey DL.Poisoning with Senecio jacobaea (ragwort) is a common cause of chronic liver disease in horses in Britain. The major clinical signs are the result of hepatic failure but gastric impaction has recently been associated with the disease. The present paper describes three cases of secondary gastric impaction associated with ragwort poisoning. In each case the impaction was the cause of death or necessitated euthanasia.
Gamma scintigraphic analysis of the distribution of perfusion of blood in the equine foot during black walnut (Juglans nigra)-induced laminitis.
American journal of veterinary research    April 1, 1990   Volume 51, Issue 4 688-695 
Galey FD, Twardock AR, Goetz TE, Schaeffer DJ, Hall JO, Beasley VR.Twelve horses, with acute laminitis (primarily in the forefeet) at 12 hours after intragastric dosing with an aqueous extract of black walnut (Juglans nigra) heart-wood, were studied. The distribution of perfusion of blood to the foot and to outlined regions within the foot was quantified, using gamma scintigraphy of regionally infused 99mTc-labeled macroaggregated albumin, before and 12 hours after extract administration. Horses 1 to 3 were not studied further. Perfusion was quantified again for horses 4 to 12 at 84 hours after extract administration. At the onset of acute laminitis, horses 7...
The toxic factor in white snakeroot: identity, analysis and prevention.
Veterinary and human toxicology    January 1, 1990   Volume 32 Suppl 81-88 
Beier RC, Norman JO.White snakeroot (Eupatorium rugosum Houtt) has been known to cause trembles in animals and milk sickness in humans since the American Revolution. It still continues to poison animals. Horses and goats are particularly sensitive to white snakeroot poisoning. Resurgence of livestock production on small farm units, and utilization of fresh raw milk may result in milk sickness; if the animals have white snakeroot exposure. The goat is the only animal with good toxicity threshold data. In other animals and humans the toxicity thresholds of white snakeroot are not known, and that until responsible t...
Black walnut toxicosis in ten horses.
Journal of the American Veterinary Medical Association    August 1, 1989   Volume 195, Issue 3 343-344 
Uhlinger C.Black walnut toxicosis was diagnosed in 10 horses at one stable. The time from exposure to shavings to development of clinical signs was 8 to 12 hours. Most common clinical signs were moderate to severe laminitis (Obel grade 2 or 3), pitting edema of the distal portion of the limbs, and rapid respiratory rate. Two horses had clinical signs of colic and 2 other horses had anorexia and lethargy. All 10 horses recovered without complications.
Depression and choke in a horse: probable white snakeroot toxicosis.
Veterinary and human toxicology    August 1, 1989   Volume 31, Issue 4 321-322 
Thompson LJ.No abstract available
Tremorgenic syndromes in livestock.
The Veterinary clinics of North America. Food animal practice    July 1, 1989   Volume 5, Issue 2 291-300 doi: 10.1016/s0749-0720(15)30977-4
Nicholson SS.Grasses that are essential components of livestock grazing programs sometimes are the source of tremorgenic toxicants to the animals consuming them. Morbidity can be high but mortality need not be if management closely observes the cattle daily and removes them at first sign of trouble. Specific treatment generally is not available nor needed. Survivors recover completely within a few days or weeks, except in chronic phalaris poisoning, where sheep and cattle may die after prolonged illness--or at least not make an economical recovery. Certain poisonous plants are responsible for tremorgenic s...
Alsike clover poisoning: A review.
The Canadian veterinary journal = La revue veterinaire canadienne    May 1, 1989   Volume 30, Issue 5 410-415 
Nation PN.Trifolium hybridum (alsike clover) has been implicated as the cause of two diseases of the horse. One of these is photosensitivity, of which alsike clover is only one of a number of presumed causal agents. The other is a fatal syndrome which is known as "alsike clover poisoning" and which is manifest by progressive loss of condition, signs of hepatic failure, and varying degrees of neurological impairment. The underlying lesion of alsike clover poisoning is fibrosis and proliferation of the biliary tree. The experimental evidence implicating alsike clover as the cause of this syndrome comes en...
Taxus (yews)–a highly toxic plant.
Veterinary and human toxicology    December 1, 1988   Volume 30, Issue 6 563-564 
Ogden L.No abstract available
Kleingrass-associated hepatotoxicosis in horses.
Journal of the American Veterinary Medical Association    October 15, 1988   Volume 193, Issue 8 932-935 
Cornick JL, Carter GK, Bridges CH.Chronic hepatic disease was diagnosed in 6 horses with history of anorexia and weight loss. These horses consistently had abnormally high serum gamma-glutamyltransferase activities, total and direct bilirubin and blood ammonia values, and sulfobromophthalein clearance times, whereas serum iditol dehydrogenase, aspartate transaminase, and alkaline phosphatase activities were variable. In the 6 horses, histologic examination of the liver revealed lesions of chronic hepatitis with varying degrees of fibrosis. All 6 horses had ingested kleingrass (Panicum coloratum) for variable periods. Three hea...
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