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Topic:Veterinary Medicine
Veterinary medicine for horses encompasses the study and application of medical practices to diagnose, treat, and prevent diseases in equine species. This field involves a comprehensive understanding of equine anatomy, physiology, pathology, and pharmacology. Veterinary practitioners employ a range of diagnostic tools and therapeutic interventions to address health issues in horses, including lameness, gastrointestinal disorders, respiratory conditions, and infectious diseases. Preventative care, such as vaccination and deworming programs, is also a significant aspect of equine veterinary medicine. This page gathers peer-reviewed research studies and scholarly articles that explore various aspects of veterinary medicine as it pertains to horses, including advancements in diagnostic techniques, treatment protocols, and preventive health strategies.
Skeletal myosin heavy chain composition and carriage training. Three different myosin heavy chain (MHC) isoforms have been identified in the equine gluteus medius muscle: the slow or MHC-I and the 2 fast MHC-IIA and MHC-IIX isoforms. They are distributed in 3 fibre types containing a single MHC (I, IIA, IIX) and 2 hybrid types co-expressing 2 isoforms (I + IIA, IIA + IIX). The aim of this study was to determine if heavy carriage training alters skeletal MHC composition in horses. Fourteen Andalusian mares age 42-46 months were used. Seven horses were used as controls to estimate the effects of growth on muscle. The remaining 7 horses underwent a training ...
Frusemide and weight carriage alter the acid:base responses of horses to incremental and to brief intense exertion. We speculated that frusemide would attenuate the acidosis associated with intense exertion, and that weight carriage would mitigate this effect. Therefore, in each of 2 experiments we measured pulmonary artery and systemic arterial blood pH, PCO2, PO2 and pulmonary artery temperature in 9 horses during exertion on a treadmill after each of 3 treatments. The treatments were: 1) injection of saline solution (C), 2) injection of frusemide (1 mg/kg bwt, i.v. 4 h before running) (FU) and 3) injection of frusemide (F) as for FU and the horses carried weight equal to that lost in the 4 h after frusem...
Changes in left ventricular dynamics during graded exercise. Three mature Thoroughbred horses were prepared surgically with ultrasonic sonomicrometer crystals affixed to their ventricular pericardia. Signals from crystals recorded dimensions of axes across the left ventricle. Cubic algorithms were fitted to dimensional data to generate volume estimates that matched stroke volumes simultaneously measured using the Fick principle. As horses stood at rest or exercised at various intensities (approx 7, 12, 24, 47 and 100% maximal rate of O2 consumption VO2max[), left ventricular dimensions were recorded and 20 consecutive diastolic and systolic volumes calc...
Environmental stress and 3-day eventing: effects of altitude. Three-day event horses are subject to various external environmental stresses including changes in ambient temperature, humidity, altitude, and test severity. Considerable research on the adverse effects of increased heat and humidity preceded the 1996 Olympic Summer Games in Atlanta, Georgia USA, but no research has been done previously on the effects of altitude on 3-day eventing. Physical and venous blood gas data were collected on horses (n = 24) competing in the High Prairie Preliminary (CCN*) and Intermediate (CCN**) 3-day events and Preliminary Horse Trials in Parker, Colorado (1900 m a...
Effect of inhaled beta 2 adrenoceptor agonist, albuterol sulphate, on performance of horses. This study was designed to test the hypothesis that a specific beta 2 adrenergic receptor agonist, albuterol sulphate, when delivered by metered-dose inhaler (MDI) would affect the performance of Thoroughbred horses during incremental exercise testing. Six conditioned Thoroughbred horses were randomly assigned to one of 2 treatment groups: Group 1 horses received placebo and Group 2 received albuterol. Each horse received both treatments in a crossover design with a 3 week interval between trials. Horses inspired albuterol (900 micrograms) or placebo over a 5 min period followed by an incremen...
Effect of exercise and COPD crisis on isoprostane concentration in plasma and bronchoalveolar lavage fluid in horses. To test whether isoprostanes could be used as markers of oxidative stress in horses, their concentration was determined in plasma and in pulmonary epithelial lining fluid (PELF) in 3 models of oxidative stress: (1) strenuous exercise, (2) acute COPD crisis and (3) exercise combined with COPD crisis. Four horses were investigated twice, once in crisis and once in remission. The animals underwent a standardised treadmill exercise test. Isoprostane assessment was performed in plasma and bronchoalveolar lavage fluid 24 h before and 1 h after exercise and in plasma also immediately after exercise. ...
An MRI study of the effect of treadmill training on bone morphology of the central and third tarsal bones of young thoroughbred horses. Training results in marked modelling of the subchondral bone of the carpus, but the effect of training on the subchondral bone of the distal tarsal joints is unknown. The aim of this study was to determine whether training influenced modelling of the third and central tarsal bones in Thoroughbred horses. Twelve untrained Thoroughbred horses were divided into 2 groups. Group 1 underwent a 19 week progressive training regimen on a high speed treadmill. Group 2 were walked for 40 min daily. Images of left tarsi were obtained by magnetic resonance imaging (MRI) with a 0.5 Tesla superconducting mag...
Haematological and biochemical responses to training and overtraining. We sought a physiological marker of overtraining in horses, using commonly practised field and laboratory tests to allow early prediction and treatment of the syndrome. Thirteen Standardbred horses were trained as follows: phase 1 (endurance, 7 weeks), phase 2 (high intensity, 9 weeks) and phase 3 (overload, 18 weeks). In phase 3 the horses were divided into 2 groups: overload training (OLT) and control (C). The OLT group exercised at greater intensities, frequencies and durations than the C group. Overtraining occurred after 31 weeks and was defined as a significant decrease in treadmill run ...
The effects of a rider’s mass on ground reaction forces and fetlock kinematics at the trot. Ground reaction force (GRF) measurements are often normalised to body mass to facilitate inter-individual comparisons. The objective of this study was to explore the effect of a rider on the GRFs and fetlock joint kinematics of trotting horses. The subjects were 5 dressage-trained horses and 3 experienced dressage riders. Ground reaction force measurements and sagittal view videotapes were recorded as the horses trotted at the same velocity in hand (3.49 +/- 0.52 m/s) and with a rider (3.49 +/- 0.46 m/s). Data were time-normalised to stance duration. Ground reaction force measurements were exp...
A preliminary study of the effect of inhaled nitric oxide on lung mechanics in the standing horse with histamine-induced bronchoconstriction. The effect of inhaled nitric oxide on pulmonary mechanics was studied in normal standing horses with histamine-induced bronchoconstriction. The respiratory health status of 6 normal horses was established on the basis of history, clinical and bronchoalveolar lavage examination. Intrathoracic pressures were estimated using distal oesophageal pressures. Respiratory gas flows were measured using a heated pneumotachograph. Pulmonary mechanics variables were determined from these measurements on a breath by breath basis. Bronchoconstriction was induced by nebulizing a 0.75% w/v solution of histamin...
Contributions of equine exercise physiology research to the success of the 1996 Equestrian Olympic Games: a review. Following public concern about the weather conditions for the 1996 Olympic Games in Atlanta an international research programme was initiated. The primary objective of this effort was to identify strategies for ensuring welfare of horses competing in the heat. Field observations of horses during the endurance test of 3-day events in Europe, Canada, and the USA characterised the work effort of this form of competition; laboratory treadmill studies assessed limitations to performance of heat and humidity, explored the relationships of thermoregulatory demands to the phases of the competition and...
Pulmonary vascular resistance of horses decreases with moderate exercise and remains unchanged as workload is increased to maximal exercise. This study was carried out to examine changes in pulmonary vascular resistance (PVR) induced by moderate and strenuous exercise; the objective being to understand why pulmonary artery blood pressure of exercising horses increases progressively as work intensity increases. Pulmonary arterial and wedge pressures (referenced at the point of the left shoulder) were determined simultaneously with cardiac output in 2 groups of healthy, sound, exercise-trained horses. Horses in Group 1 (n = 8) were studied at rest and during exercise performed at 8 and 13 m/s; the latter workload eliciting maximal he...
The effect of training on the calcified zone of equine middle carpal articular cartilage. Carpal osteochondral injury is frequently observed in strenuously trained horses. It is clear that the integrity of articular cartilage and subchondral bone are intimately related, although there is controversy about which component is the most important. Calcified cartilage provides the mechanical link between soft hyaline cartilage and stiff subchondral bone so it is essential to understand the tissue's response to exercise. Middle carpal calcified and uncalcified (hyaline) cartilage thickness was investigated in horses undergoing high- and low-intensity exercise. Twelve untrained horses (18...
A comparison of grain, oil and beet pulp as energy sources for the exercised horse. High-grain diets for the exercising horse were compared with diets which provided 15% of the total caloric intake from either vegetable oil or a highly fermentable fibre source (beet pulp). Six Thoroughbreds age 3 years were fed one of 3 diets or 5 weeks in a replicated 3 x 3 Latin square. The CONTROL diet was 3.65 kg of sweet feed (SF), 0.9 kg of a protein/vitamin/mineral pellet and 5.45 kg of hay cubes. The FAT diet replaced 1.15 kg of SF with 0.45 kg of soybean oil and the FIBRE diet replaced 1.15 kg of SF with 1.36 kg of beet pulp. Horses were exercised 3 times per week on a high-speed tre...
Relationship of body condition score to completion rate during 160 km endurance races. Three-hundred and sixty horses, primarily of Arabian breeding, age 5-22 years and body conditions scores 1.5-5.5 (on 1 to 9 scale as described by Henneke 1985), participated in one of two 160 km endurance races over the same course in August 1995 and July 1996. Condition score, cannon bone circumference, combined rider and tack weight, heart girth and body length were measured 11-18 h prior to the start of the event and bodyweight estimated according to the formula by Carroll and Huntington (1988). A rider weight ratio was calculated as rider weight divided by horse bodyweight. Rider weight an...
Evaluation of a bioresorbable hyaluronate-carboxymethylcellulose membrane for prevention of experimentally induced abdominal adhesions in horses. To evaluate the efficacy of a bioresorbable hyaluronate-carboxymethylcellulose membrane (HA-membrane) for prevention of experimentally induced abdominal adhesions in horses. Methods: Experimental study. Methods: Twelve healthy adult horses. Methods: The effect of an HA-membrane on adhesion formation was evaluated in 12 healthy horses using an established model of serosal trauma to induce adhesions. A ventral median celiotomy and two jejunal resections and end-to-end anastomoses were performed. Two separate jejunal areas were abraded, and three 2-0 chromic gut sutures placed in the abraded area...
[Functional morphology of the large intestinal mucosa of horses (Equus przewalskii f. caballus) with special regard to the epithelium]. The mucous membrane of the caecum and colon ascendens of adult horses was first studied using light and transmission electron microscopy. In the surface epithelium there was an inconspicuous constellation of organelles, otherwise there was a lot of mitochondria as a source of energy for absorptive performances. Moreover, enlarged intercellular spaces exist as an indication of an increased uptake of water and electrolytes. In the basal region of Lieberkühn's crypts there were single enteroendocrine cells and numerous granules in the apical epithelial cytoplasm. The functional meaning of these ...
The teeth of the horse: evolution and anatomo-morphological and radiographic study of their development in the foetus. The aim of this work was to study the ontogenetic process in teeth from their early appearance in the ossifying matrix of the mandible and maxilla, in different foetuses of scalar ages. Radiographic examinations of the skull and mandible hemisections were performed and the latero-medial (LM) and dorsoventral (DV) projections for the skull and mandible were analysed. A high-definition film-screen combination was used for this study. The exposure values ranged from 35 kV/6 mAs to 58 kV/10 mAs, according to the size of the skulls and their degree of ossification. The first dental germ observed wa...
Sonographic observations of the peripheral vasculature of the equine thoracic limb. Investigations of the equine peripheral vascular system have been constrained by the lack of a non-invasive method of examining the arteries and veins of the limbs of the conscious horse. Precise correlations were established between the gross anatomical features of the peripheral vessels and their B-mode sonographic appearance in each thoracic limb of 35 horses. A sonographic imaging protocol was established. Additional Doppler sonographic recordings defined the arterial waveforms and demonstrated that blood flow to the foot could be evaluated in the lateral proper digital artery, distal to t...
An in vitro biomechanical investigation of an equine interlocking nail. To determine the mechanical properties of Equine Interlocking Nail (EIN; JD Wheat Veterinary Orthopedic Research Laboratory, University of California, Davis) stabilized osteotomized tibiae and compare these variables with estimated in vivo loads. Methods: In vitro biomechanical investigation. Methods: Twelve adult equine cadaveric tibiae. Methods: EIN-stabilized tibiae were tested monotonically under compression, 3- and 4-point bending, and torsion. Mechanical properties were compared with estimated in vivo loads. Results: EIN-tibial composite mean compressive yield load (11 kN) and bending mo...
Growth characteristics of fibroblasts isolated from the trunk and distal aspect of the limb of horses and ponies. To determine if there is a difference in in vitro growth of fibroblasts isolated from the trunk and distal aspect of the limb of horses and ponies. To determine the effects of a corticosteroid and monokine on in vitro growth of fibroblasts isolated from the trunk and distal aspect of the limb of horses and ponies. Methods: Growth of fibroblasts from tissues harvested from the trunk and limb were compared from horse and pony samples grown in control media and control media with triamcinolone or monokine added. Methods: Dermal and subcutaneous tissue from 22 horses and 17 ponies of various ages ...
The effect of compacted cancellous bone grafting on the healing of subchondral bone defects of the medial femoral condyle in horses. To compare the quality of second-intention healing and that of compacting sternally harvested cancellous bone into subchondral bone defects of the medial femoral condyle in horses. Methods: A controlled experiment using a surgical technique that minimizes soft tissue trauma, customized for consistency among horses. Methods: Ten horses, aged 2 to 5 years, free of hindlimb lameness and with radiographically normal stifles. Methods: After a 12.7-mm-diameter x 19-mm-deep defect was created into randomly selected medial femoral condyles, bone and cartilage healing was evaluated over a 6-month perio...
Effects of analgesia of the distal interphalangeal joint or palmar digital nerves on lameness caused by solar pain in horses. To determine if pain of the dorsal margin of the sole in horses can be attenuated by anesthesia of either the distal interphalangeal (DIP) joint or the palmar digital (PD) nerves. Methods: A unilateral forelimb lameness was induced by creating solar pain. Response to administration of local anesthetic or saline solution into the DIP joint and to administration of local anesthetic around the PD nerves was evaluated. Methods: Six horses. Methods: Lameness was induced by creating pressure on the dorsal margin of the sole by screwing set-screws into a nut welded to the inside of each branch of a s...
Diclazuril in the horse: its identification and detection and preliminary pharmacokinetics. Diclazuril (4-chlorophenyl [2,6-dichloro-4-(4,5-dihydro-3H-3,5-dioxo-1,2,4-triazin-2-yl)pheny l] acetonitrile), is a benzeneacetonitrile antiprotozoal agent (Janssen Research Compound R 64433) marketed as Clinacox . Diclazuril may have clinical application in the treatment of Equine Protozoal Myeloencephalitis (EPM). To evaluate its bioavailability and preliminary pharmacokinetics in the horse we developed a sensitive quantitative high-pressure liquid chromatography (HPLC) method for diclazuril in equine biological fluids. MS/MS analysis of diclazuril in our HPLC solvent yielded mass spectral ...
Plasma cortisol and beta-endorphin concentrations in trained and over-trained standardbred racehorses. The effects of training and over-training on plasma cortisol and beta-endorphin (betaEP) concentrations at rest and after standardised exercise tests and the cortisol responses to adrenocorticotropin (ACTH) administration were investigated in standardbred horses. Twelve horses were divided randomly into control and over-trained (OT) groups after 17 weeks slow- and moderate-intensity treadmill training. The standardised treadmill exercise test consisted of 2 min at velocities corresponding to 30, 50, 70 and 100% of maximum O2 consumption. Over-training, defined as a significant decrease in body...
Zymographic analysis of equine laminitis. To investigate the role of matrix metalloproteinase (MMP) activity in the pathophysiology of equine laminitis, the techniques of in situ zymography and quantitative SDS-PAGE zymography were used to analyse the lamellae and plasma and serum of horses with carbohydrate overload-induced laminitis. The gelatinase activity localised within the epidermal lamellae of laminitic hooves did not differ significantly from normal hooves. In laminitis sections there was an increase in vascular gelatinase activity, possibly associated with the perivascular cuffing of polymorphonucleocytes. Both plasma and se...
Thoughts on the source of tissue on subsequent cell culture success. This paper describes attempts to initiate equine adipocyte cultures from necropsy cases with varying intervals from time of death to isolation and culture. Equine adipocytes were isolated from 21 necropsy cases, regardless of the interval from time after death to establishment in primary ceiling cultures. However, while all cultures produced adipocytes, only 2 attempts to produce long-term equine adipocyte cultures from the subcutaneous rump fat depots were successful and not contaminated. Findings from these experiments indicate that it is possible to collect and culture equine adipocytes fro...
Development of a PCR test for rapid diagnosis of contagious equine metritis. In order to establish a rapid diagnostic method for contagious equine metritis (CEM), we developed and evaluated a polymerase chain reaction (PCR) test. Species-specific PCR primer sets were derived from the DNA sequence of a cloned DNA fragment of Taylorella equigenitalis that did not hybridize with the genome of a taxomonically related species, Oligella urethralis. Single step PCR with primer set P1-N2 and two-step semi-nested PCR with primer sets P1-N2 and P2-N2 detected as low as 100 and 10 CFU of the bacteria, respectively. Single-step PCR detected T. equigenitalis from genital swabs of e...
Veterinary vaccinology. Veterinary vaccinology is a very interesting and rapidly developing field. In fact veterinary vaccines are not only used for the prevention of infectious diseases in the animal health sector, but also help to solve problems of public health, to reduce detrimental environmental impact of the use of some veterinary drugs and prevent the emergence of resistance of micro-organisms or parasites. After a short introduction, this paper will deal with the use of vaccines for animal health and welfare, including new developments in the veterinary field such as marker vaccines and vectored vaccines, the...
