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Topic:Veterinary Medicine
Veterinary medicine for horses encompasses the study and application of medical practices to diagnose, treat, and prevent diseases in equine species. This field involves a comprehensive understanding of equine anatomy, physiology, pathology, and pharmacology. Veterinary practitioners employ a range of diagnostic tools and therapeutic interventions to address health issues in horses, including lameness, gastrointestinal disorders, respiratory conditions, and infectious diseases. Preventative care, such as vaccination and deworming programs, is also a significant aspect of equine veterinary medicine. This page gathers peer-reviewed research studies and scholarly articles that explore various aspects of veterinary medicine as it pertains to horses, including advancements in diagnostic techniques, treatment protocols, and preventive health strategies.
The amino-acid sequence of beta-lactoglobulin II from horse colostrum (Equus caballus, Perissodactyla): beta-lactoglobulins are retinol-binding proteins. beta-Lactoglobulin isolated from horse colostrum is heterogeneous and contains two components: beta-lactoglobulin I and beta-lactoglobulin II. These two proteins are monomeric and show differences in their electrophoretic mobilities, chain lengths and primary structures. The complete amino-acid sequence of beta-lactoglobulin II was determined by automated Edman degradation of the intact protein and of the peptides derived from these by digestion with trypsin or chymotrypsin and by chemical cleavage with cyanogen bromide. Unlike other beta-lactoglobulins which contain 162 amino acids, horse bet...
Common ventricle with separate pulmonary outflow chamber in a horse. On the basis of clinical and laboratory examinations, a ventricular septal defect or a variant of the tetralogy of Fallot was suspected in a 3-year-old filly with a history of poor growth rate and exercise intolerance. The filly was euthanatized and found to have a 3-chambered heart (cor triloculare biatriatum). The heart had 2 normally formed atria and a large common ventricle into which the right and left atrioventricular orifices opened and from which the aorta arose. There was a small separate chamber from which the pulmonary trunk originated. This chamber communicated with the common vent...
Toxoplasma seroprevalence in animals in northern India. In a serological survey of latent Toxoplasma prevalence on 3761 animals in northern India by the microtitre indirect haemagglutination test, 23.7 per cent were found to have antibody titres ranging from 1:4 to 1:1024. Seropositivity was recorded in 25.3 per cent of 1227 sheep, 30.3 per cent of 961 goats, 11.8 per cent of 603 horses, 19.3 per cent of 243 cattle, 15.7 per cent of 108 water buffaloes, 31.5 per cent of 178 pigs, 30.9 per cent of 175 dogs, 33.7 per cent of 80 cats and in 9.7 per cent of 186 bandicoot rats. Relevant epidemiological data has been furnished. High seropositivity in foo...
Osteochondritis dissecans of the sagittal ridge of the third metacarpal and metatarsal bones in horses. Osteochondritis dissecans of the sagittal ridge of the third metacarpal and metatarsal bones was diagnosed in 8 horses during an 18-month period. Seven of the horses were less than or equal to 2 1/2 years old. Synovial distention of the affected fetlock joints and a pain response to fetlock flexion were typical findings. Lameness predominated in 1 limb at a trot, although fetlock flexion frequently elicited lameness in other affected limbs. Radiography revealed bony lesions (flattening, erosion, or fragmentation) of the sagittal ridge in at least 2 fetlock joints in all horses. The onset of si...
Prevalence of equine onchocerciasis in southeastern and midwestern United States. Of 664 horses reported to have originated in southeastern and midwestern United States, 341 (51.4%) were positive for Onchocerca cervicalis cutaneous microfilariasis. The highest prevalence of 68.8% was recorded for horses from Virginia. Horses with the highest concentrations of microfilariae (as high as 19,770 microfilariae/mg in 1 horse) were from the Southeast (Georgia, Florida, Tennessee, and Alabama). For horses from South Carolina, the prevalence of infection was 57.1%; from the Midwest (Kentucky, Illinois, Ohio, and Indiana), 54.4%; from North Carolina, 45.5%; from Pennsylvania, 7.7%; a...
Comparison of three suture techniques for anastomosis of the small intestine in the horse. Seven horses were used to compare the Gambee, the crushing, and a 2-layer inverting suture pattern composed of a simple continuous layer in the mucosa oversewn with a continuous Lembert pattern in the seromuscular layer. Horses were evaluated at 30 days for adhesion formation, lumen diameter, and quality of healing at the anastomotic sites. One horse was euthanatized 9 days after surgery after 24 hours of ileus and colic; necropsy revealed septic peritonitis and widespread adhesions. One horse had no adhesions. The remaining horses had adhesions associated with 50% of the Gambee and 50% of the...
Antagonism of xylazine-pentobarbital anesthesia by yohimbine in ponies. Effects of yohimbine on xylazine-pentobarbital anesthesia were evaluated in ponies. Five minutes after the IV injection of xylazine (1.1 mg/kg of body weight), pentobarbital sodium (12.7 mg/kg, IV) and additional xylazine (2.2 mg/kg, IM) were given and produced anesthesia in 12 ponies for 64.0 +/- 16.4 minutes (mean +/- SD) as well as immobilization for 89.8 +/- 34.2 minutes. Eleven ponies were given yohimbine (0.1 mg/kg, IV) 50 minutes after pentobarbital dosing. In these 11 ponies, durations of anesthesia and immobilization were shorter, 52.0 +/- 1.4 and 65.5 +/- 14.8 minutes, respectively. ...
Ulcerative keratitis associated with Salmonella arizonae infection in a horse. Salmonella arizonae 61:1,5, was isolated in pure culture from the eye of a horse with unilateral ulcerative keratitis. The eye responded well to treatment with atropine sulfate and polymyxin B-bacitracin-neomycin ophthalmic ointments. In swab specimens taken after the lesion had healed, Salmonella was not found to be a constituent of the bacterial flora of the horse's eyes.
Haemorrhagic necrotising enteritis in foals associated with Clostridium perfringens. Two foals aged 35 and 48 h from 2 Thoroughbred studs died several hours after developing clinical signs of depression, severe haemorrhagic diarrhoea and dehydration. Both foals had an acute haemorrhagic enteritis extending from the anterior jejunum to the terminal ileum which was characterised histologically by villus necrosis. Necrotic villi were surrounded by large numbers of rod-shaped Gram positive bacteria. Clostridium perfringens was recovered from the intestines of both foals and the isolates were considered to be C. perfringens type C. Other cases of diarrhoea were also observed in foa...
Suspected Tyzzer’s disease in two foals. Tyzzer's disease was diagnosed histologically in two foals, a 4-week-old Thoroughbred cross and a 6-week-old Arabian foal. Clinically both foals were in good health prior to a short illness lasting only a few hours. The liver lesions in both foals were characterized microscopically by multiple foci of necrosis. Variable numbers of elongated slender intracytoplasmic bacilli resembling Bacillus piliformis were demonstrated within hepatocytes bordering the necrotic foci.
Alterations in coagulation and hemograms of horses given endotoxins for 24 hours via hepatic portal infusions. This experiment was designed to establish a model for the study of gastrointestinal disturbances as a result of prolonged endotoxin uptake in the horse. The hepatic portal vein of 7 horses was catheterized (through flank incisions) to give chronic hepatic portal infusions of lipopolysaccharide (LPS, endotoxin). Lipopolysaccharide was infused at a rate of 1 microgram/kg of body weight/hr for 24 hours. Two of the horses were infused with saline solution for 12 hours before LPS infusions were given. Lipopolysaccharide was shown to affect behavior and hematologic and coagulation values. The 1st ho...
Pharmacokinetics of gentamicin at steady-state in ponies: serum, urine, and endometrial concentrations. Gentamicin (GT) was administered IM to 6 healthy mature mare ponies at a dosage of 5 mg/kg of body weight every 8 hours for 7 consecutive days (total, 21 doses). Two venous blood samples were collected before (trough) and at 1 hour (peak) after the 5th, 10th, 14th, and 19th doses. An endometrial biopsy was done of each mare on days 4 and 7. On the 7th day, just before the 21st administration of GT, base-line blood samples were collected, and 22 blood samples were collected over a period of 48 hours after GT was given. The mares were catheterized on the 7th day, and urine was collected for 24 h...
Studies on histoplasmosis farciminosi (epizootic lymphangitis) in Egypt. Isolation of Histoplasma farciminosum from cases of histoplasmosis farciminosi in horses and its morphological characteristics. Isolation of Histoplasma farciminosum from five horses, showing typical signs of histoplasmosis farciminosi (epizootic lymphangitis) was successfully attempted. The mycelial form of H. farciminosum was isolated on Sabouraud dextrose agar enriched with 2.5% glycerol, brain heart infusion (BHI) agar enriched with 10% horse blood and PPLO dextrose glycerol agar. The last medium proved to be the most effective, both for primary isolation and subculturing of the fungus. It was found that on primary isolation, the lag phase of the mycelial form of the fungus was relatively long, involving 4-8 weeks ...
A direct technique for the preparation of chromosomes from early equine embryos. A technique is described for the preparation of banded chromosomes from early equine embryos cultured for less than 10 h in a medium containing bromodeoxyuridine. In addition to standard Giemsa staining and C-banding, chromosomes thus prepared can also be R-banded by either the RBA or the RB-FPG methods. This technique is rapid, repeatable, and limits cell loss, making it ideal for the preparation of early embryos.
The effect of prostaglandin E1 on motility of the equine gut. Prostaglandin E1 was infused intravenously (25, 50 and 75 ng/kg/min) in three ponies. Changes in gastrointestinal mechanical and electrical activity were recorded from chronically implanted strain-gauge force transducers and electrodes. Dose-dependent responses were obtained: there were significant decreases in electrical spiking activity in the stomach, left large colon and small colon, with a corresponding decrease of activity in the left dorsal colon mechanogram. The small intestine was also affected, showing a decrease in both contraction rate and amplitude, which was more marked in the pr...
An investigation, in vitro, of the actions of three Western Australian snakes on the blood coagulation of the dog, cat, horse and wallaby. Venoms of the tiger snake and brown snake were procoagulant, in vitro, when tested with cat, dog, horse and wallaby plasma. In the absence of calcium and phospholipid the coagulant activity of tiger snake venom was minimal. In contrast, brown snake venom alone had marked procoagulant activity. This activity, however, was enhanced by the presence of calcium and phospholipid. Death adder venom exerted an anticoagulant effect. Apparent species' differences in susceptibility to the coagulant venoms were noted. However, the probable explanation of these differences was attributed to variation in th...
Photomicrographic evaluation of stallion spermatozoal motility characteristics. A photomicrographic method for evaluation of stallion spermatozoal motility was developed, and spermatozoal image and velocity characteristics were defined. The photomicrographic method was compared with visual estimation of motility in the same semen sample over time. Using photomicrography, velocities and percentages of individual spermatozoal image characteristics were determined. Although there was a high correlation between results of the 2 methods, results of the photomicrographic method were more repeatable than were those of the visual method.
Changes in the synovia after the intra-articular injection of sodium hyaluronate into normal horse joints and after arthrotomy and experimental cartilage damage. Sodium hyaluronate was injected into normal horse joints and joints that had undergone an arthrotomy and experimental cartilage damage. The elimination half-life for hyaluronic acid in normal joints was found to be approximately 96 h. The injection caused a non-significant increase (42%) in synovial fluid protein concentration and a fall in the intrinsic viscosity of the fluid. In the arthrotomy group the synovial fluid hyaluronic acid concentration fell after surgery but it was unaffected by the injection of sodium hyaluronate. An initial rise in the intrinsic viscosity of the synovial fluid ...
Effects of phenylbutazone and oxyphenbutazone on basic drug detection in high performance thin layer chromatographic systems. Interference or 'masking' in thin layer chromatography occurs when the presence of one drug on a thin layer plate physically obscures or interferes with the detection of another drug. We investigated the ability of phenylbutazone and oxyphenbutazone to mask or interfere with the detection by high performance thin layer chromatography (HPTLC) of basic drugs used illegally in horse racing. Of fifty-five basic drugs called 'positive' since 1981 by laboratories affiliated with the Association of Official Racing Chemists (AORC), forty did not comigrate with phenylbutazone or oxyphenbutazone and cou...
Increased daily sperm production in the breeding season of stallions is explained by an elevated population of spermatogonia. Seasonal variation in number of spermatogonia and germ cell degeneration was evaluated to determine which mechanism might explain seasonal differences in daily sperm production per testis (DSP/testis) or per g parenchyma (DSP/g) in stallions. Comparing 28 adult stallions (4 to 20 yr old) in each of the nonbreeding (December-January) and breeding (June-July) seasons, the population of type A spermatogonia was more than two times greater (P less than 0.01) in the breeding season. While the number of type B spermatogonia also was elevated (P less than 0.01) in the breeding season, the number of t...
Immunodeficiency manifested by oral candidiasis and bacterial septicemia in foals. Oral candidiasis and bacterial septicemia were diagnosed in 8 foals that had laboratory and/or pathologic evidence of immunodeficiency. Two foals suffered solely from complete failure of passive transfer of colostal immunoglobulins. Six foals had evidence of immune defects but did not meet the criteria for diagnosis of any of the currently recognized primary equine immunodeficiency syndromes. All six of these foals died or were euthanatized due to bacterial infections. One foal with failure of passive transfer recovered and the other died of a mesenteric torsion before the effect of treatment ...
Successful treatment of traumatic oesophageal rupture with severe cellulitis in a mare. A five-year-old standardbred mare suffered a cervical oesophageal rupture subsequent to a kick. Marked cellulitis and extensive soft tissue damage resulted. Treatment consisted of creating an oesophageal fistula, local debridement and systemic antibiotics. The mare made a long but successful recovery. Treatment of oesophageal rupture in the horse is discussed.
Sex chromosome mosaicism and infertility in mares. From the standpoint that cytogenetic screening in mares is seldom necessary as an aid to diagnosis of the gonadal dysgenesis syndrome, a series of double-blind trials were conducted to test the proposal that present practice failed to explore the potential for cytogenetics in clinical practice. It was demonstrated that diagnoses of infertility might be made where mares were found to be of normal phenotype by clinical examination. Such mares were found to be gonosmic mosaics. One stallion had a polymorphism of the X chromosome and had poor conception rates. It was demonstrated that the true val...
Surgical and medical management of rhinophycomycosis (conidiobolomycosis) in a horse. A horse had severe granulomatous lesions of the upper airways that were attributable to Conidiobolus coronatus. Therapeutic success was documented by clinical examination of the horse 4 years after treatment by surgical extirpation and intralesional and topical use of amphotericin B.
