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Topic:Veterinary Medicine

Veterinary medicine for horses encompasses the study and application of medical practices to diagnose, treat, and prevent diseases in equine species. This field involves a comprehensive understanding of equine anatomy, physiology, pathology, and pharmacology. Veterinary practitioners employ a range of diagnostic tools and therapeutic interventions to address health issues in horses, including lameness, gastrointestinal disorders, respiratory conditions, and infectious diseases. Preventative care, such as vaccination and deworming programs, is also a significant aspect of equine veterinary medicine. This page gathers peer-reviewed research studies and scholarly articles that explore various aspects of veterinary medicine as it pertains to horses, including advancements in diagnostic techniques, treatment protocols, and preventive health strategies.
The role of cyclooxygenase inhibitors in repair of ischaemic-injured jejunal mucosa in the horse.
Equine veterinary journal. Supplement    February 24, 2001   Issue 32 59-64 doi: 10.1111/j.2042-3306.2000.tb05335.x
Campbell NB, Blikslager AT.Cyclooxygenase inhibitors are administered to horses to prevent endotoxin-induced elaboration of prostaglandins. However, PGE2 and PGI2 stimulate repair of injured intestine. There are 2 isoforms of cyclooxygenase: COX-1, which constitutively produces prostaglandins and COX-2, which is induced by inflammation. We hypothesised that the nonspecific cyclooxygenase inhibitor flunixin meglumine would retard repair of ischaemic intestinal injury by preventing production of reparative prostaglandins, whereas the selective COX-2 inhibitor, etodolac, would permit repair as a result of continued COX-1 p...
Intermittent hypoglycemia in a horse with anaplastic carcinoma of the kidney.
Journal of the American Veterinary Medical Association    February 24, 2001   Volume 218, Issue 2 235-237 doi: 10.2460/javma.2001.218.235
Baker JL, Aleman M, Madigan J.Clinically apparent hypoglycemia is rare in adult horses. Hypoglycemia is a well-recognized paraneoplastic syndrome in humans and dogs with non-insulin-secreting tumors and may occur in horses as well. Hypoglycemia associated with non-insulin-secreting tumors is believed to result from production of an abnormal form of insulin-like growth factor II. Neoplasia should be considered in the differential diagnosis for adult horses with hypoglycemia.
Segmental eosinophilic colitis: a review of 22 cases.
Equine veterinary journal. Supplement    February 24, 2001   Issue 32 86-93 doi: 10.1111/j.2042-3306.2000.tb05341.x
Edwards GB, Kelly DF, Proudman CJ.Twenty-two horses with colic, referred to the University of Liverpool Equine Hospital (1992-1998), were found at laparotomy to have a partial obstruction of the large colon caused by a segmental mural lesion located in the left dorsal colon. The decision to take the horses to surgery was based on rectal examination findings of secondary impaction and mural oedema of the large colon and turbid peritoneal fluid containing large numbers of neutrophils obtained by paracentesis. The affected segment of colon showed oedema and serosal changes varying from erythema to well-defined necrosis. These pat...
The medical management of eight horses with grade 3 rectal tears.
Equine veterinary journal. Supplement    February 24, 2001   Issue 32 104-107 doi: 10.1111/j.2042-3306.2000.tb05345.x
Mair TS.Eight horses with Grade 3b rectal tears of the peritoneal part of the rectum or small colon were treated by a combination of medical therapy and dietary manipulation. All of the horses developed septic peritonitis during the course of treatment. Medical therapy consisted of a combination of penicillin, gentamicin and flunixin meglumine administered parenterally, metronidazole administered orally and liquid paraffin administered by nasogastric tube. Some horses also received fluid and electrolyte therapy i.v., plasma and heparin i.v. All horses were maintained on a laxative diet. Six of the 8 h...
West Nile encephalitis.
The Veterinary clinics of North America. Equine practice    February 24, 2001   Volume 16, Issue 3 427-441 doi: 10.1016/s0749-0739(17)30087-1
Ostlund EN, Andresen JE, Andresen M.WNV encephalitis in horses, previously reported in Africa, Asia, and Europe, occurred for the first time in the Western Hemisphere in 1999. The causative agent, WNV, is a flavivirus maintained in nature by a bird-mosquito cycle. The disease in horses is manifested primarily by ataxia of variable severity. Outbreaks of encephalitis may have a case fatality rate in excess of 40%, although this virus infection is inapparent in some horses. Early evidence indicates that WNV has overwintered in the northeastern United States and poses a threat for future disease occurrences in horses. No vaccine is...
Evaluation of an in-shoe pressure measurement system in horses.
American journal of veterinary research    February 24, 2001   Volume 62, Issue 1 23-28 doi: 10.2460/ajvr.2001.62.23
Judy CE, Galuppo LD, Snyder JR, Willits NH.To develop an objective, accurate method for quantifying forelimb ground reaction forces in horses by adapting a human in-shoe pressure measurement system and determine the reliability of the system for shod and unshod horses. Methods: 6 adult Thoroughbreds. Methods: Horses were instrumented with a human in-shoe pressure measurement system and evaluated at a trot (3 m/s) on a motorized treadmill. Maximum force, stance time, and peak contact area were evaluated for shod and unshod horses. Three trials were performed for shod and unshod horses, and differences in the measured values were examine...
Prevalence and prognostic importance of hypomagnesemia and hypocalcemia in horses that have colic surgery.
American journal of veterinary research    February 24, 2001   Volume 62, Issue 1 7-12 doi: 10.2460/ajvr.2001.62.7
Garcia-Lopez JM, Provost PJ, Rush JE, Zicker SC, Burmaster H, Freeman LM.To determine the prevalence of hypomagnesemia and hypocalcemia in horses with surgical colic. Methods: 35 horses with surgically managed colic. Methods: Serum concentrations of total magnesium (tMg2+) and calcium (tCa2+), as well as ionized magnesium (iMg2+) and calcium (iCa2+) were analyzed before surgery and 1, 3, 5, and 7 days following surgery. A lead-II ECG and pertinent clinical data were also obtained at each time. Results: Preoperative serum tMg2+ and iMg2+ concentrations were below the reference range in 6 (17%) and 19 (54%) horses, respectively. Serum concentrations of tCa2+ and iCa2...
Improving the predictability of performance by prerace detection of dorsal metacarpal disease in thoroughbred racehorses.
Australian veterinary journal    February 24, 2001   Volume 78, Issue 11 784 doi: 10.1111/j.1751-0813.2000.tb10454.x
Lloyd A.No abstract available
Locomotor characteristics of horses with navicular disease.
American journal of veterinary research    February 24, 2001   Volume 62, Issue 2 206-210 doi: 10.2460/ajvr.2001.62.206
Williams GE.To determine whether force-plate evaluation of horses with navicular disease would reveal an abnormal gait that persists despite loss of sensation to the palmar foot region, which may predispose such horses to navicular disease. Methods: 17 clinically normal Thoroughbreds and 8 Thoroughbreds with navicular disease. Methods: Data on ground reaction forces were obtained in trotting horses, using a force plate. Force-time curve variables for clinically normal horses were derived from 4 points at the beginning and 4 points at the end of the vertical and craniocaudal horizontal plots. Principal com...
In vitro pharmacologic effect of two endothelin-1 antagonists on equine colonic arteries and veins.
American journal of veterinary research    February 24, 2001   Volume 62, Issue 2 154-159 doi: 10.2460/ajvr.2001.62.154
Venugopal CS, Holmes EP, Koch CE, Curtis LA, Holm AS, Moore RM.To evaluate the effectiveness of 2 potential endothelin (ET)-1 antagonists in blocking the contractile responses of equine colonic vessels to increasing concentrations of ET-1. Methods: Mesenteric vessels from 6 clinically healthy horses. Methods: Colonic vessels (arterial and venous rings) were placed in organ baths with oxygenated Tyrode solution at 37 C. Each was attached to a force transducer interfaced with a polygraph, and 2 g of tension was applied and equilibrated for 45 minutes. Then, B-1 (PD 142893) and B-2 (PD 145065) ET-1 antagonists were tested. One ring from each vessel type was ...
Clostridial enterocolitis.
The Veterinary clinics of North America. Equine practice    February 24, 2001   Volume 16, Issue 3 471-485 doi: 10.1016/s0749-0739(17)30090-1
Jones RL.Equine clostridial enterocolitis is being recognized with increasing frequency. It has been identified in foals with diarrhea, antibiotic-associated enterocolitis, or nosocomial enterocolitis. The sporadic occurrence of clostridial enterocolitis, the variety of types of clostridia involved, and the difficulty of experimentally reproducing the disease suggest that it is a poorly defined multifactorial syndrome. The risk factors associated with susceptibility to colonization and progressive infection are largely based on anecdotal observations and extrapolation from human studies. Quantitative s...
Hendra and Nipah virus infections.
The Veterinary clinics of North America. Equine practice    February 24, 2001   Volume 16, Issue 3 597-xi doi: 10.1016/s0749-0739(17)30098-6
Hooper PT, Williamson MM.The most important clinical and pathological manifestation of Hendra virus infection in horses and humans is that of severe interstitial pneumonia caused by viral infection of small blood vessels. The virus is also capable of causing nervous disease. Hendra virus is not contagious in horses and is spread by close contact with body fluids, such as froth from infected lungs. Diagnosis should be based on the laboratory examination of blood, lung, kidney, spleen, and, if nervous signs are present, also of the brain. Evidence of infection with the more recently identified and related Nipah virus wa...
Larval cyathostomiasis.
The Veterinary clinics of North America. Equine practice    February 24, 2001   Volume 16, Issue 3 501-513 doi: 10.1016/s0749-0739(17)30092-5
Lyons ET, Drudge JH, Tolliver SC.Over the past few years, cyathostomiasis has become increasingly recognized as a clinical problem of horses in the United States. Clinical cyathostomiasis has been reported frequently in Europe for a considerable time. This clinical syndrome is usually related to the sudden release of large numbers of the larval stages of small strongyles from the mucosa of the large intestine. Typical clinical signs include diarrhea, ventral abdominal edema, pyrexia, colic, weight loss, and poor body condition. Hypoalbuminemia and the presence of large numbers of small strongyles being passed in the feces are...
Completion of the life cycle of Sarcocystis neurona.
The Journal of parasitology    February 24, 2001   Volume 86, Issue 6 1276-1280 doi: 10.1645/0022-3395(2000)086[1276:COTLCO]2.0.CO;2
Dubey JP, Saville WJ, Lindsay DS, Stich RW, Stanek JF, Speert CA, Rosenthal BM, Njoku CJ, Kwok OC, Shen SK, Reed SM.Sarcocystis neurona is the most important cause of a neurologic disease in horses, equine protozoal myeloencephalitis (EPM). The complete life cycle of S. neurona, including the description of sarcocysts and intermediate hosts, has not been completed until now. Opossums (Didelphis spp.) are definitive hosts, and horses and other mammals are aberrant hosts. In the present study, laboratory-raised domestic cats (Felis domesticus) were fed sporocysts from the intestine of a naturally infected opossum (Didelphis virginiana). Microscopic sarcocysts, with a maximum size of 700 x 50 microm, developed...
Laboratory vector competence of black flies (Diptera:Simuliidae) for the Indiana serotype of vesicular stomatitis virus.
Annals of the New York Academy of Sciences    February 24, 2001   Volume 916 437-443 doi: 10.1111/j.1749-6632.2000.tb05323.x
Mead DG, Ramberg FB, Maré CJ.In previous experiments we have demonstrated that colonized and wild black flies are competent laboratory vectors of different Mexican and Western USA isolates of vesicular stomatitis virus, serotype New Jersey (VSV-NJ). We have recently demonstrated biological VSV-NJ transmission by black flies using animal models. In the study described here, we tested the vector competence of colonized and wild black flies for the vesicular stomatitis virus, serotype Indiana (VSV-IN). A 1998 equine isolate was used. After a 10 day incubation period, saliva from experimentally infected Simulium vittatum and ...
A random amplified polymorphic DNA polymerase chain reaction technique that differentiates between Neospora species.
The Journal of parasitology    February 24, 2001   Volume 86, Issue 6 1366-1368 doi: 10.1645/0022-3395(2000)086[1366:ARAPDP]2.0.CO;2
Spencer JA, Witherow AK, Blagburn BL.Neospora caninum is a recently described coccidial parasite that was first isolated from a dog in 1988 and has subsequently been shown to infect a wide range of mammals. Neospora hughesi, a new species of this genus, has recently been isolated from the spinal cord of horses showing clinical signs of equine protozoal myeloencephalitis. The random amplified polymorphic DNA polymerase chain reaction technique is capable of differentiating between N. caninum and N. hughesi.
Theriogenology question of the month. Endometrial cups.
Journal of the American Veterinary Medical Association    February 24, 2001   Volume 218, Issue 2 205-206 doi: 10.2460/javma.2001.218.205
Kutzler MA.No abstract available
International Workshop on Equine Chronic Airway Disease. Michigan State University 16-18 June 2000.
Equine veterinary journal    February 24, 2001   Volume 33, Issue 1 5-19 doi: 10.2746/042516401776767412
Robinson NE.No abstract available
Prognostic indicators in a Danish hospital-based population of colic horses.
Equine veterinary journal. Supplement    February 24, 2001   Issue 32 11-18 doi: 10.1111/j.2042-3306.2000.tb05328.x
Thoefner MB, Ersbøll AK, Hesselholt M.A prospective survey of 528 colic horses, referred to the Large Animal Hospital at the Royal Veterinary and Agricultural University of Copenhagen, Denmark, during the period August 1994 to December 1998, was undertaken to develop a predictive model for application in the clinical assessment of prognosis. In the multivariate logistic regression analysis, 357 colic cases were used in the elaboration of a simple clinical-practical model consisting of degree of pain, packed cell volume, capillary refill time and rectal temperature. The relationship between rectal temperature and outcome (survival/...
Comparative studies in the promoter and exon 1 regions of tumour suppressor p53 in several mammalian species: absence of mutations in a panel of spontaneous domestic animal tumours.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine    February 24, 2001   Volume 47, Issue 10 593-597 doi: 10.1046/j.1439-0442.2000.00322.x
Mayr B, Resch S, Hepperle S, Brem G, Reifinger M, Schaffner G.Tumour suppressor p53 is critical in a broad panel of tumour types in human, mouse and other mammals. Regions of the promoter and exon 1 play an important role in expression of p53. In the present study, the DNA sequences of promoter and exon 1 regions of four domestic animal species (dog, cat, horse and cattle) are determined and compared with experimental rodents (mouse, rat and hamster) and man. A broad panel of tumour types have been investigated for mutations in this regulatory area in 90 canine, 136 feline, 25 equine and 10 bovine patients. No mutation was detected in any of the tumours ...
Celiotomy closure via permanent implantation of polyamide in horses.
Equine veterinary journal. Supplement    February 24, 2001   Issue 32 101-103 doi: 10.1111/j.2042-3306.2000.tb05344.x
Beroza GA, Perry RW, Cotter DM.Permanent implantation of nonabsorbable materials is appropriate in many surgical circumstances but is not commonly used to close equine celiotomies. This paper describes a simple method of continuous nonabsorbable implantation of polyamide suture used successfully to close 48 equine celiotomies. Forty-eight clean or clean-contaminated celiotomies were successfully performed over 5 years using this technique. The postsurgical survival observation period ranged from 1-6 years (median 3.5 years). There were 45 long-term survivors (93.75%). Only 2 minor implant complications (4.4%) were observed ...
Intestinal motility and impactions.
Equine veterinary journal. Supplement    February 24, 2001   Issue 32 8-10 doi: 10.1111/j.2042-3306.2000.tb05327.x
White NA.No abstract available
Colic surgery in 206 juvenile thoroughbreds: survival and racing results.
Equine veterinary journal. Supplement    February 24, 2001   Issue 32 32-36 doi: 10.1111/j.2042-3306.2000.tb05331.x
Santschi EM, Slone DE, Embertson RM, Clayton MK, Markel MD.The purpose of our study was to determine the types of lesions that cause colic in juvenile Thoroughbreds, factors associated with these lesions and the subsequent survival and athletic performance of the juveniles. The age of juvenile Thoroughbreds requiring surgical exploration for abdominal pain has an influence on the type of lesion causing colic. The short-term survival rate (discharge from the hospital) after colic surgery for foals was 85% and was strongly influenced by the lesion causing colic. Thirteen percent of juveniles recovered from the first surgery experienced another severe co...
Factor analysis of the interrelationships between clinical variables in horses with colic.
Preventive veterinary medicine    February 22, 2001   Volume 48, Issue 3 201-214 doi: 10.1016/s0167-5877(00)00193-8
Thoefner MB, Ersbøll AK, Jensen AL, Hesselholt M.A prospective survey of horses with colic referred to the Large Animal Hospital at the Royal Veterinary and Agricultural University of Copenhagen, Denmark, was undertaken between August 1994 and December 1997. The interrelationships between 17 clinical variables were analysed using factor analysis. Factor analysis uncovers the structure of the variability in data and therefore detects multicollinearity. A total of 528 horses were admitted in the study period. Of these, 16 were excluded from the analysis as a result of miscellaneous conditions. Only 205 horses had observations for all 17 variab...
Geophagia in horses: a short note on 13 cases.
Applied animal behaviour science    February 17, 2001   Volume 71, Issue 2 119-125 doi: 10.1016/s0168-1591(00)00173-8
McGreevy PD, Hawson LA, Habermann TC, Cattle SR.Recorded in several species including humans, geophagia or soil eating has been observed in both wild and domesticated horses and has generally been regarded as an indication of nutritional deficiency or "boredom". Studies of soils consumed by different species have led to several theories as to the identity of soil constituents that stimulate geophagia. In this study, geochemical analysis of 13 equine geophagic sites from different parts of Australia was undertaken. Significantly larger concentrations of iron and copper were found in soil samples from geophagic sites when compared to paired c...
Cross-sectional comparison of synovial fluid biochemical markers in equine osteoarthritis and the correlation of these markers with articular cartilage damage.
Osteoarthritis and cartilage    February 17, 2001   Volume 9, Issue 1 49-55 doi: 10.1053/joca.2000.0349
Fuller CJ, Barr AR, Sharif M, Dieppe PA.To investigate the relationship between biochemical markers in the synovial fluid of osteoarthritic and contralateral equine joints and gross articular cartilage pathology. Methods: Twenty-two horses underwent bilateral arthroscopy of their carpal or metacarpophalangeal joints following recent onset lameness. The degree of cartilage damage in each joint was scored and synovial fluid, from both the clinically affected and the contralateral joint, was collected. Bone specific alkaline phosphatase (BAP), 5D4 epitope of keratan sulphate (KS), total glycosaminoglycans (GAG) and hyaluronan (HA) were...
Administration of ticarcillin in combination with clavulanic acid intravenously and intrauterinely to clinically normal oestrous mares.
Journal of veterinary pharmacology and therapeutics    February 13, 2001   Volume 23, Issue 6 373-378 doi: 10.1046/j.1365-2885.2000.00297.x
Van Camp SD, Papich MG, Whitacre MD.Ticarcillin and clavulanic acid (potassium clavulanate) were administered to normal oestrous mares intravenously (i.v.) at a dose of 50 and 1.67 mg/kg for ticarcillin and clavulanate, respectively. In a crossover design, the same drugs were administered intrauterine (i.u.) at a dose of 12.4 and 0.4 mg/kg for ticarcillin and clavulanate, respectively. The i.u. dose was administered in 100 mL of saline solution. Endometrial tissue biopsies and plasma samples were collected after drug administration for the determination of ticarcillin and clavulanate concentrations by high-pressure liquid chroma...
Equine muscular dystrophy with myotonia.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology    February 13, 2001   Volume 112, Issue 2 294-299 doi: 10.1016/s1388-2457(00)00511-3
Montagna P, Liguori R, Monari L, Strong PN, Riva R, Di Stasi V, Gandini G, Cipone M.To describe a case of equine muscular dystrophy with myotonia. Methods: A 5-year-old horse presented with hypertrophy and delayed relaxation of the muscles of the hindlimbs from age 2 months. Testicular atrophy developed from 2 years of age. Action and percussion myotonia was associated with weakness in these muscles, and EMG showed diffuse myotonic discharges and myopathic features. Biopsy of the gluteal muscle showed adipose and connective tissue infiltration, marked variation in muscle fibre size, and moth-eaten, ring and whorled fibres. Results: Injection of apamin, a peptide blocker of ca...
Pharmacokinetics of gentamicin in mares in late pregnancy and early lactation.
Journal of veterinary pharmacology and therapeutics    February 13, 2001   Volume 23, Issue 6 359-363 doi: 10.1046/j.1365-2885.2000.00298.x
Santschi EM, Papich MG.The disposition of drugs may differ between pregnant and nonpregnant animals, necessitating a change in dosage. We hypothesized that volume of distribution or clearance may be different for aminoglycoside antibiotics in pregnant mares vs. nonpregnant lactating mares. To examine this hypothesis, we administered gentamicin sulfate to seven Thoroughbred and Quarterhorse mares on two occasions, followed by plasma drug gentamicin assay and pharmacokinetic analysis. The first dose was administered 1-4 weeks before parturition (mean weight 578 kg) and the second dose was administered in the period 1-...
Clenbuterol administration does not enhance the efficacy of furosemide in attenuating the exercise-induced pulmonary capillary hypertension in Thoroughbred horses.
Journal of veterinary pharmacology and therapeutics    February 13, 2001   Volume 23, Issue 6 389-395 doi: 10.1046/j.1365-2885.2000.00293.x
Manohar M, Goetz TE, Rothenbaum P, Humphrey S.The stimulation of pulmonary beta2-adrenergic receptors causes a decrease in vascular resistance. Thus, the present study was carried out to examine whether concomitant administration of clenbuterol-a beta2-adrenergic receptor agonist, to horses premedicated with furosemide would attenuate the exercise-induced pulmonary capillary hypertension to a greater extent than furosemide alone, and in turn, affect the occurrence of exercise-induced pulmonary hemorrhage (EIPH). Experiments were carried out on six healthy, sound, exercise-trained Thoroughbred horses. All horses were studied in the control...