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Topic:Veterinary Research

Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
Magnetic resonance imaging of the brain of normal neonatal foals. Chaffin MK, Walker MA, McArthur NH, Perris EE, Matthews NS.Magnetic resonance imaging (MRI) was performed on the brain of 5 normal, anesthetized, neonatal (age 3-to-6 days) Quarter Horse foals. The objectives of the study were to develop a technique for imaging the brain of neonatal foals, and to ascertain their normal brain anatomy. Intravenous propofol was administered for induction and maintenance of general anesthesia. Using spin echo MR techniques, T1 weighted sagittal and transverse views, and spin density and T2 weighted transverse views were successfully made of each foal. MR images provided excellent visualization of many anatomic structures ...
Partial cloning of prohibitin cDNA from canine, feline, bovine, equine, and rabbit liver mRNA by RT-PCR.
The Journal of veterinary medical science    March 1, 1997   Volume 59, Issue 3 201-203 doi: 10.1292/jvms.59.201
Matsuyama S, Kubo K, Ohashi F, Takamori Y.Prohibitin is the protein which has an inhibitory function in cell growth, and its gene is suggested to be one of putative tumor suppressor genes. In this report, we described a partial cloning of prohibitin cDNAs from canine, feline, bovine, equine, and rabbit liver mRNAs by RT-PCR, and their homology analysis. The sequences of these RT-PCR products were compared with each other as well as those reported for human and rat. The homology in this region of prohibitin cDNA was approximately 90%, and the amino acid sequence of each RT-PCR product shared more than 95% identity. Therefore, it is con...
Amantadine in man and horse–can we learn from each other?
Equine veterinary journal    March 1, 1997   Volume 29, Issue 2 89-91 doi: 10.1111/j.2042-3306.1997.tb01647.x
Oxford JS.The research examines the impact of administering amantadine to horses and humans to combat influenza A, speculating on potential benefits of dual-field research between human and animal health. The study […]
Anatomy of the distal interphalangeal joint of the mature horse: relationships with navicular suspensory ligaments, sensory nerves and neurovascular bundle.
Equine veterinary journal    March 1, 1997   Volume 29, Issue 2 126-135 doi: 10.1111/j.2042-3306.1997.tb01654.x
Bowker RM, Linder K, Van Wulfen KK, Sonea IM.The anatomy of the distal interphalangeal (DIP) joint in the adult horse is described in relationship to the suspensory ligaments of the navicular bone, the neurovascular bundle and the sensory nerves to these periarticular regions. Using polymer plastic injections, the synovial cavity of the DIP joint was observed to have a complex relationship to the proximal suspensory or collateral sesamoidean ligament (CSL) of the navicular bone with the cavity forming cranial and caudal compartments around the CSL abaxially. Sensory nerves, as identified by peptide immunocytochemistry and silver/gold chl...
Equine epidemiology–still struggling to find a seat at the table.
Equine veterinary journal    March 1, 1997   Volume 29, Issue 2 82-84 doi: 10.1111/j.2042-3306.1997.tb01644.x
Reeves MJ.No abstract available
Tricuspid valve atresia with main pulmonary artery atresia in an Arabian foal.
Equine veterinary journal    March 1, 1997   Volume 29, Issue 2 160-162 doi: 10.1111/j.2042-3306.1997.tb01661.x
Meurs KM, Miller MW, Hanson C, Honnas C.No abstract available
Prevalence of fetal maldispositions in equine referral hospital dystocias.
Equine veterinary journal    March 1, 1997   Volume 29, Issue 2 111-116 doi: 10.1111/j.2042-3306.1997.tb01651.x
Frazer GS, Perkins NR, Blanchard TL, Orsini J, Threlfall WR.A retrospective investigation was performed to determine the population characteristics of horses presented for dystocia at 2 equine referral hospitals and the types of fetal maldispositions among these horses. The study population consisted of a similar number of Thoroughbreds (25%), Standardbreds (24%) and draft horses (22%). Most of the current literature pertaining to equine obstetrics is based on a predominately draft horse population (63%). The latter population appeared to have more transverse presentations (P = 0.06), possibly because of the higher number of draft mares. In our study, ...
More background needed on “idle time” of race horses.
Journal of the American Veterinary Medical Association    March 1, 1997   Volume 210, Issue 5 608-609 
MacNamara B.No abstract available
Genetic markers in standardbred trotters susceptible to the rhabdomyolysis syndrome.
Equine veterinary journal    March 1, 1997   Volume 29, Issue 2 117-120 doi: 10.1111/j.2042-3306.1997.tb01652.x
Collinder E, Lindholm A, Rasmuson M.The equine rhabdomyolysis syndrome (RHA) is believed to be multifactorial in origin; and could be caused by an interaction between genetic and environmental factors. In order to analyse its genetic background an association study was undertaken. Two sample groups of Standardbreds (Stb) which had suffered from RHA were compared to the total population of Swedish Standardbred trotters using recorded polymorphic genetic markers. The results showed that gene frequencies for several markers in the RHA groups differed significantly from those estimated for the total population. A rhabdomyolysis risk...
Sensory epithelium of the vomeronasal organ express TrkA-like and epidermal growth factor receptor in adulthood. An immunohistochemical study in the horse.
The Anatomical record    March 1, 1997   Volume 247, Issue 3 299-306 doi: 10.1002/(SICI)1097-0185(199703)247:3<299::AID-AR1>3.0.CO;2-Q
Garcia-Suarez O, Germanà G, Naves FJ, Ciriaco E, Represa J, Vega JA.The medial wall of the vomeronasal organ (VNO) is lined with a sensory epithelium that is closely related to the olfactory epithelium, which is developed from the olfactory placode. It undergoes continuous replacement during its life span. In other sensory epithelia, cell proliferation is under the control of some trophic factors. Whether these proteins are involved in the continuous turnover of the VNO epithelium is unknown. This study approaches this topic by analyzing the occurrence of signal-transducing receptor proteins for neurotrophins (Trk proteins) and epidermal growth factor (EGFr). ...
Oxidant injury and nitric oxide: a role in exercise-induced pulmonary haemorrhage?
Veterinary journal (London, England : 1997)    March 1, 1997   Volume 153, Issue 2 119-121 doi: 10.1016/s1090-0233(97)80032-9
Derksen FJ.No abstract available
Pregnancies from imipramine and xylazine-induced ex copula ejaculation in a disabled stallion.
The Canadian veterinary journal = La revue veterinaire canadienne    March 1, 1997   Volume 38, Issue 3 171-174 
Card CE, Manning ST, Bowman P, Leibel T.Breeding or semen collection was attempted using: natural cover, manual stimulation, artificial vagina, pharmacologic induction of ejaculation, and electroejaculation. Sperm cells were recovered from the ductus deferens and epididymides post mortem. Only semen collected ex copula by imipramine and xylazine treatment resulted in conceptions (4/5). This is the first report of pregnancies in horses from ex copula semen collection.
[Observations of the development of the equine distal interphalangeal joint cavity concerning the pelvic limb of fetuses, fillies and adult horses].
Anatomia, histologia, embryologia    March 1, 1997   Volume 26, Issue 1 45-48 doi: 10.1111/j.1439-0264.1997.tb00102.x
Breit S.Ten horses, younger than 1 year, were used to investigate the articulatio interphalangea distalis of the pelvic limb. The expansion of the dorsal recess was compared to those of adult horses. The recessus dorsalis always formed a shape like the letter 'm' or like a triangle with oblique angles. Consequently the great proximo-distal expansion on the medial side of the dorsal recess very probably has nothing to do with the age of horses.
Biochemical changes in the equine capsule following prostaglandin-induced pregnancy failure.
Molecular reproduction and development    March 1, 1997   Volume 46, Issue 3 286-295 doi: 10.1002/(SICI)1098-2795(199703)46:3<286::AID-MRD7>3.0.CO;2-L
Chu JW, Sharom FJ, Oriol JG, Betteridge KJ, Cleaver BD, Sharp DC.The equine embryonic capsule, an acellular covering that envelops the conceptus during the second and third weeks of pregnancy, is composed of mucin-like glycoproteins. Its structure is consistent with a dual role during early pregnancy: protection of the conceptus, and communication between the embryo and the mother. Loss of sialic acid from the capsular glycoproteins at day 16 correlates with the time of "fixation," or loss of conceptus mobility throughout the uterine horns. This study investigated how the structure of the capsule is linked to the maintenance of pregnancy. Six pregnancies, c...
Nitric oxide production by equine articular cells in vitro.
Equine veterinary journal    March 1, 1997   Volume 29, Issue 2 98-102 doi: 10.1111/j.2042-3306.1997.tb01649.x
Frean SP, Bryant CE, Fröling IL, Elliott J, Lees P.Recent research in several species has suggested nitric oxide (NO) as a mediator of articular cartilage damage and an inhibitor of cartilage matrix neosynthesis. This study investigated NO production by cultured equine articular chondrocytes in response to 2 arthritogenic molecules, namely lipopolysaccharide (LPS) and interleukin-1 beta (IL-1 beta), and compared NO production by cultured equine synoviocytes stimulated with LPS. Synoviocytes exhibited a low basal level of NO synthesis (measured as nitrite, a NO metabolite) that was neither significantly increased nor decreased by exposure to LP...
Comparison of collagen fibril populations in the superficial digital flexor tendons of exercised and nonexercised thoroughbreds.
Equine veterinary journal    March 1, 1997   Volume 29, Issue 2 121-125 doi: 10.1111/j.2042-3306.1997.tb01653.x
Patterson-Kane JC, Wilson AM, Firth EC, Parry DA, Goodship AE.This study was undertaken to test the hypothesis that collagen fibrils, the submicroscopic units of strength in tendon, would hypertrophy in response to a specific defined training programme. Fibril diameters were measured in central and peripheral regions of superficial digital flexor tendon (SDFT) samples from five 18-month-old horses which underwent a subsequent 18 month training programme and 6 age- and sex-matched controls. Central region fibrils from the trained horses had a mass-average diameter (MAD) of 105.3 nm, which was significantly lower (P < 0.01) than that of 131.7 nm for the...
Equine epidemiology: Horserace Betting Levy Board workshop. London, 24 October 1996.
Equine veterinary journal    March 1, 1997   Volume 29, Issue 2 92-97 
No abstract available
Oxidative energy metabolism in equine tendon cells.
Research in veterinary science    March 1, 1997   Volume 62, Issue 2 93-97 doi: 10.1016/s0034-5288(97)90127-2
Birch HL, Rutter GA, Goodship AE.Hypoxia has been suggested as a possible cause of tissue degeneration and subsequent rupture in equine tendons. To determine whether low oxygen tension is likely to be detrimental to tendon cell function, experiments were designed to investigate oxidative energy metabolism in freshly isolated and cultured equine tendon cells. Freshly isolated tenocytes and cultured fibroblasts possessed activities of the mitochondrial enzyme citrate synthase similar to those of other mammalian cells, with well defined oxidative metabolism. D-[6(-14)C]-glucose oxidation was measurable in both freshly isolated a...
Nested polymerase chain reaction for detection of Ehrlichia risticii genomic DNA in infected horses.
Veterinary parasitology    March 1, 1997   Volume 68, Issue 4 367-373 doi: 10.1016/s0304-4017(96)01083-7
Barlough JE, Rikihisa Y, Madigan JE.A nested polymerase chain reaction was developed for amplifying a 529-bp segment of the 16S ribosomal RNA gene of Ehrlichia risticii from equine buffy coat cells. Confirmation of identity of the amplified bands was accomplished by Southern hybridization and DNA sequencing. The study indicated a detection limit of > 10 copies of the target gene, and specificity for E. risticii as based on a panel of test rickettsiae. Ticks (Ixodes pacificus) collected in an area of northern California enzootic for equine monocytic ehrlichiosis were found to be negative for E. risticii DNA.
Acute paraplegia in a thoroughbred racehorse after general anaesthesia.
Australian veterinary journal    March 1, 1997   Volume 75, Issue 3 178-179 doi: 10.1111/j.1751-0813.1997.tb10060.x
Raidal SR, Raidal SL, Richards RB, Cosgriff AV, Rose KJ.No abstract available
Adrenoceptor-mediated regulation of the contractility in horse penile resistance arteries.
Journal of vascular research    March 1, 1997   Volume 34, Issue 2 90-102 doi: 10.1159/000159206
Simonsen U, Prieto D, Hernández M, Sáenz de Tejada I, García-Sacristán A.The receptors mediating the contractions to both exogenously applied noradrenaline and electrical field stimulation (EFS) were characterized in horse isolated penile resistance arteries. The alpha 1-adrenoceptor-selective antagonist, prazosin, caused competitive rightward shifts of the contractile concentration-response curves (CRC) to phenylephrine. The alpha 2-antagonist, rauwolscine, also displaced to the right the CRC to the alpha 2-adrenoceptor-selective agonist, BHT 920. EFS (0.3 ms, 20-second trains) caused tetrodotoxin-sensitive frequency-dependent contractions which were enhanced in t...
Intrinsic atrioventricular conductive function in horses with a second degree atrioventricular block.
The Journal of veterinary medical science    March 1, 1997   Volume 59, Issue 3 149-151 doi: 10.1292/jvms.59.149
Yamaya Y, Kubo K, Amada A, Sato K.The atrioventricular (AV) conductive functions were investigated before and after the pharmacological autonomic nervous blockade (PAB) through the electrophysiological study on six horses (AV block group) in which the dropped beats occurred more frequently (over 200 beats/24 hr) and on five horses (control group) in which the dropped beats occurred sporadically (under 200 beats/24 hr) or in which the arrhythmias were not recognized at all on the long-term electrocardiogram. As a result, AV conductivity, conduction time and refractoriness in the AV block group were lower, longer and higher, res...
Failure to establish chronic infection of the reproductive tract of the male horse with a South African asinine strain of equine arteritis virus (EAV).
The Onderstepoort journal of veterinary research    March 1, 1997   Volume 64, Issue 1 17-24 
Paweska JT.Eight sexually mature horse stallions were inoculated intranasally with a South African asinine strain of EAV, a strain that was isolated from the semen of a donkey carrier. All horses developed fever, with maximum rectal temperatures of 38.9-39.9 degrees C recorded 3-6 d post challenge. Six horses showed very mild clinical signs of equine viral arteritis and two were asymptomatic. The virus was recovered from the nasopharynxes of six horses 2-7 d after inoculation, and from buffy-coat samples of all horses, 2-11 d after inoculation. Seroconversion to EAV was detected on days 8 and 10 and peak...
Effects of alfentanil on the equine electroencephalogram during anaesthesia with halothane in oxygen.
Research in veterinary science    March 1, 1997   Volume 62, Issue 2 159-163 doi: 10.1016/s0034-5288(97)90139-9
Johnson CB, Taylor PM.Opioids have variable effects on the minimum alveolar concentration of inhaled anaesthetics in the horse. During halothane anaesthesia at an end-tidal halothane concentration between 0.75 and 0.85 percent, the electroencephalogram (EEG) frequency power spectrum and the auditory evoked potential were recorded continuously in eight ponies during an infusion of approximately 40 micrograms kg-1 alfentanil over five minutes, and for a further 55 minutes. The spectral edge and median frequency of the EEG and the mid-latency of the auditory evoked potential at the time of maximum change of these vari...
Primary intraosseous mast cell tumour of the third phalanx in a quarter horse.
Equine veterinary journal    March 1, 1997   Volume 29, Issue 2 151-152 doi: 10.1111/j.2042-3306.1997.tb01658.x
Ritmeester AM, Denicola DB, Blevins WE, Christian JA.No abstract available
Preliminary investigations of pain and analgesia assessment in horses administered phenylbutazone or placebo after arthroscopic surgery.
Veterinary surgery : VS    March 1, 1997   Volume 26, Issue 2 150-155 doi: 10.1111/j.1532-950x.1997.tb01478.x
Raekallio M, Taylor PM, Bennett RC.Twenty-five horses undergoing arthroscopic surgery were studied to develop a scheme for assessing pain in horses while investigating the effects of phenylbutazone (PBZ) analgesia. Fifteen of the 25 horses received PBZ 4 mg/kg intravenously (IV) before surgery and 2 mg/kg (IV) every 12 hours thereafter until 60 hours; the remaining 10 (placebo group) were given a corresponding volume of saline. In both groups, venous blood samples were collected for catecholamine, beta-endorphin, and cortisol assays before premedication and up to 72 hours after surgery. Postoperative pain was evaluated by measu...
Seroprevalence of antibodies to Sarcocystis neurona in horses residing in Ohio.
Journal of the American Veterinary Medical Association    February 15, 1997   Volume 210, Issue 4 519-524 
Saville WJ, Reed SM, Granstrom DE, Hinchcliff KW, Kohn CW, Wittum TE, Stamper S.To determine the seroprevalence of serum antibodies to Sarcocystis neurona in horses residing in Ohio. Methods: Prevalence survey. Methods: Serum from samples from 1,056 horses. Serum was collected on every 36th sample submitted to the Ohio State Diagnostic Laboratory for testing for equine infectious anemia. Methods: Serum was frozen at -80 C and analyzed for antibodies to S neurona, using a western blot. Information regarding blood sample collection, age, breed, sex, and geographic location was recorded for each horse. Data were analyzed, using multivariable logistic regression. Results: Hor...
Seroprevalence of antibodies to Sarcocystis neurona in horses residing in Oregon.
Journal of the American Veterinary Medical Association    February 15, 1997   Volume 210, Issue 4 525-527 
Blythe LL, Granstrom DE, Hansen DE, Walker LL, Bartlett J, Stamper S.To determine seroprevalence of antibodies to Sarcocystis neurona in neurologically normal horses residing in 4 regions of Oregon and to describe the effects of age, gender, breed, and housing on seroprevalence within each region. Methods: Prevalence survey. Methods: Serum samples from 334 horses systematically selected by practicing veterinarians. Methods: Antibodies to S neurona were measured in sera, using a western blot. Information including age, gender, breed, housing, geographic location, and duration of residence was obtained for each horse. Data were analyzed, using descriptive statist...
An infectious arterivirus cDNA clone: identification of a replicase point mutation that abolishes discontinuous mRNA transcription.
Proceedings of the National Academy of Sciences of the United States of America    February 4, 1997   Volume 94, Issue 3 991-996 doi: 10.1073/pnas.94.3.991
van Dinten LC, den Boon JA, Wassenaar AL, Spaan WJ, Snijder EJ.Equine arteritis virus (EAV) is a positive-strand RNA virus that uses a discontinuous transcription mechanism to generate a nested set of six subgenomic mRNAs from which its structural genes are expressed. A stable bacterial plasmid (pEAV030) containing a full-length cDNA copy of the 12.7-kb EAV genome was constructed. After removal of a single point mutation in the replicase gene, RNA transcripts generated in vitro from pEAV030 were shown to be infectious upon electroporation into BHK-21 cells. A genetic marker mutation was introduced at the cDNA level and recovered from the genome of the pro...
Sixteen new polymorphic equine microsatellites.
Animal genetics    February 1, 1997   Volume 28, Issue 1 69-70 
Meyer AH, Valberg SJ, Hillers KR, Schweitzer JK, Mickelson JR.No abstract available