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Topic:Veterinary Research
Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
Total and free thyroxine and triiodothyronine in blood serum of mammals. 1. Blood samples were obtained from seven species of mammals: horses, cattle, sheep, goats, pigs, guinea pigs and rats for determination of total and free thyroxine and triiodothyronine. Total thyroxine in the order listed above in ng/ml was: 15, 60, 79, 185, 53, 45 and 79. Free thyroxine in pg/ml was: 5.9, 10.0, 19.2, 32.1, 21.7, 6.7 and 51.3. 2. Total triiodothyronine in pg/ml was: 677, 1290, 979, 3170, 760, 317 and 1747. Free triiodothyronine in pg/ml was: 3.22, 4.40, 2.60, 6.74, 2.74, 2.42 and 10.88. 3. Percent free thyroxine was high in rats and low in guinea pigs, while percent free trii...
[Epidemiological study of leptospirosis in New Caledonia]. This epidemiological survey includes the study of human and animal leptospirosis in New Caledonia from clinical cases as well as a systematic serological study about exposed human and animal populations. The results show that this disease is endemic on the whole territory with a few important focuses in agricultural area, especially on the Western coast. Leptospira icterohemorrhagiae is the main serotype and is responsible for serious human leptospirosis. The male farmers constitute the most exposed population, especially from March to May, end of the host season. In order to reduce the import...
[Infection with equine herpesvirus and its manifestation in the central nervous system of the horse]. Infections with EHV1 can lead to manifestation at the CNS of horses followed by encephalomyelitis and "equine stroke". Horse experiments could confirm the clinical picture and gave links to the potential pathogenesis of the disease. We also have been in the position to isolate and characterize an EHV4 virus out of the brain of a horse with CNS disorders. The two viruses carry different biological properties which obviously dominate the pathogenesis. These properties as well as experimental and field cases are described and different diagnostic tests are discussed.
Asinine herpesvirus genomes: comparison with those of the equine herpesviruses. Two previously unknown and distinct herpesviruses were isolated from donkeys. One, with the characteristics of a betaherpesvirus, was isolated from the leukocytes of an apparently healthy donkey, while the second, an alphaherpesvirus, was recovered from the nasal cavity of donkeys given high doses of corticosteroids, and caused rhinitis in two seronegative weanling donkeys when they were intranasally infected. Few, if any, restriction endonuclease fragments were shared by the donkey betaherpesvirus, equine herpesvirus 2 (EHV 2) or EHV 5, a second distinctly different equine betaherpesvirus, no...
Evaluation of breed as a risk factor for sarcoid and uveitis in horses. The relationship between breed and the risk of developing sarcoid tumours or uveitis of unknown etiology was evaluated in a retrospective study of 16242 equine cases admitted between 1975 and 1987 to the New York State College of Veterinary Medicine Large Animal Hospital, and 3198 equine tissue samples sent to the New York State Veterinary Diagnostic Laboratory between 1977 and 1987. Of 120 sarcoid cases from the Large Animal Hospital, sarcoids were twice as likely to develop in Quarter Horses (odds ratio, OR = 1.8, P less than 0.05) relative to Thoroughbreds and less than half as likely to de...
T lymphocyte development and maturation in horses. Monoclonal antibodies specific for equine T lymphocyte subpopulations were produced and procedures for the continuous culture of equine lymphocytes were developed. These reagents and procedures were used to analyse the appearance, maturation and functions of T lymphocytes in normal horses and in T lymphocyte deficient horses with severe combined immunodeficiency (SCID). T lymphocytes appeared as early as the 75th day of fetal development and were normally distributed prior to birth of normal foals. Analysis of thymic T lymphocyte differentiation in SCID foals revealed the presence of both prot...
Morphologic effects of experimental distention of equine small intestine. The morphologic effects of induced intraluminal hydrostatic pressures (IHPs) of 0, 9, and 18 cm H2O were evaluated in 33 isolated equine jejunal segments. Fifteen segments were distended with Tyrode's solution for 1 hour and nine segments for 4 hours. Tyrode's solution was added as needed to maintain the prescribed pressures. Nine other segments were left undisturbed for 4 hours after the initial distention period. On decompression of the intestinal segments, progressive peristaltic contractions resumed in all segments. Evaluation of intestinal sections by light microscopy and transmission ele...
Exploratory celiotomy for suspected urinary tract disruption in neonatal foals: a review of 18 cases. The medical records of 18 neonatal foals, in which exploratory celiotomies were performed for suspected urinary tract lesions, were reviewed. Despite clinical signs and laboratory values indicative of disruption of the urinary tract, three foals did not have a site of urinary tract leakage at surgery. Eight foals had ruptured bladders and seven foals had urachal lesions. Ultrasonography was used as a pre-operative diagnostic procedure in eight foals to evaluate the presence of free peritoneal fluid and urinary tract integrity. Nine foals were alive six months after discharge. Seven of the nine...
Host responses to Borrelia burgdorferi in dogs and horses. By using paired sera the IgM and IgG host responses were analyzed in dogs with ELISA and Western blot techniques. Antibodies in clinical seropositive dogs bound to 4-25 IgM and up to 40 or more IgG antigenic determinants. Early IgM response to the 41-kDa flagellin persisted for at least 9 months and involved as many as seven other peptides. IgG response expanded later in the disease and involved more immunogens than are currently recognized in late human disease. A percentage of asymptomatic dogs that later developed clinical symptoms were seropositive. Immunoblot studies suggested that B. bur...
Effects of halothane anesthesia on the clearance of gentamicin sulfate in horses. Inhalation anesthetics decrease the clearance of some drugs that are eliminated by renal excretion. The purpose of the study reported here was to investigate the effects of halothane anesthesia on the pharmacokinetics and urinary excretion of gentamicin sulfate, using the horse as a model. Using a crossover design, pharmacokinetic values after a single IV dose of gentamicin (4 mg/kg) were compared in halothane-anesthetized and unanesthetized horses. Compared with unanesthetized horses, the anesthetized horses had significant decreases in total body clearance (P less than 0.01) and apparent vol...
Effects of lesion size and location on equine articular cartilage repair. The mechanisms and completeness of equine articular cartilage repair were studied in ten horses over a nine month period. Large (15 mm square) and small (5 mm square) full-thickness lesions were made in weight bearing and nonweight bearing areas of the radiocarpal, middle carpal and femoropatellar joints. The horses were euthanized in groups of two 1, 2.5, 4, 5 and 9 months later. Gross pathology, microradiography, and histopathology were used to evaluate qualitative aspects of articular repair. Computer assisted microdensitometry of safranin-O stained cartilage sections was used to quantitate...
Development of a scoring system for the early diagnosis of equine neonatal sepsis. A sepsis scoring system was developed and tested prospectively in a blind study of 190 neonatal foals admitted to the University of Florida Veterinary Medical Teaching Hospital's neonatal intensive care unit. The system used 14 readily available historical, clinical or laboratory variables and weighted each item to arrive at a sepsis score. The score was found to have a sensitivity of 93 per cent, a specificity of 86 per cent, positive accuracy rate of 89 per cent and negative accuracy rate of 92 per cent. The sepsis score was far more sensitive and specific for infection, even in very early c...
Pulmonary mechanics during treadmill exercise in race ponies. Exercise-induced variations in their ventilatory mechanics were studied in 8 healthy ponies 4.2 +/- 1.4 years old and weighing 282 +/- 11 kg. Airflow (V), tidal volume (VT), esophageal pressure, mask pressure and electrocardiogram were simultaneously recorded before, during and after a treadmill (incline 8.3 degrees) exercise which consisted of 2 min walking (1.5 m.sec-1), 3 min slow trotting (3.0 m.sec-1) and 3 min fast trotting (3.5 m.sec-1). The results of three consecutive daily measurements were averaged for each pony. Heart rate, minute volume (Ve), respiratory frequency (f) and peak ins...
Uterine contractions in nonpregnant and early pregnant mares and jennies as determined by ultrasonography. Uterine contractions in 8 nonpregnant and 13 pregnant mares were studied using ultrasonography. A 1-min video tape recording was made of longitudinal real-time images of the uterine body. An overall uterine contractile activity score (0 = no or minimal activity to 4 = maximal activity) was assigned to each video tape segment. There was a day effect (P less than .01) and an interaction (P less than .01) of reproductive status X day. Uterine activity scores were highest on d 14 to d 18 (d 0 = day of ovulation) for nonpregnant mares and on d 10 to d 14 for pregnant mares. Uterine activity scores ...
The use of H(orse) INDEX: a method of analysing the ground reaction force patterns of lame and normal gaited horses at the walk. The amplitudes, impulses and times of occurrence of a number of selected peaks in the ground reaction force tracings of 17 horses with various clinical histories were compared with those of 20 horses used to establish values for the 'standard' Dutch Warmblood horse. The resulting factors were combined, using different weighting factors, into indices characterising each limb. The symmetry between the loading of the forelimbs and the hindlimbs was used to calculate amplitude and peak-time symmetry indices. Limb and symmetry indices were combined in one H(orse) INDEX. This method of quantifying t...
Effect of sample freezing on the isolation of Mycoplasma spp. from the clitoral fossa of the mare. The growth of Mycoplasma equigenitalium and Mycoplasma subdolum from specimens collected from the clitoral fossa of each of four Standardbred mares was not diminished by freezing of the specimens in liquid nitrogen (-196 degrees C) for up to 30 days when compared to samples cultured immediately.
Ultrastructural description of a new chytrid genus of caecum anaerobe, Caecomyces equi gen. nov., sp. nov., assigned to the Neocallimasticaceae. Vegetative and reproductive stages of Caecomyces equi gen. nov., sp. nov. isolated from the horse caecum were examined by light and electron microscopy. This organism, which is similar to isolates known as Sphaeromonas communis, produces uniflagellate, uninucleate zoospores whose perikinetosomal structures, i.e. circumflagellar ring, spur, struts and scoop, are similar in many respects to those described in species of Neocallimastix. Microtubular roots extend basally from the spur and associate with hydrogenosomes and the nucleus. Another group of microtubules radiates laterally in a fan-shape...
Human recombinant interleukin-2(125) induced in vitro proliferation of equine, caprine, ovine, canine and feline peripheral blood lymphocytes. Equine, caprine, ovine, canine and feline peripheral blood lymphocytes were evaluated in a short term dose-response study for their in vitro blastogenic responsiveness to human recombinant interleukin-2(125) (HrIL-2(125] alone or in combination with phytohemagglutinin-P, concanavalin-A, and pokeweed mitogen. HrIL-2(125) induced lymphocyte proliferation in all of the animals tested. The magnitude of the proliferative response varied among the species of animal tested. In all cases the proliferative response was dependent on the concentration of HrIL-2(125). HrIL-2(125) at a minimum concentratio...
Serologic response of Babesia equi-infected horses as measured by complement-fixation and indirect fluorescent antibody tests. Both the complement-fixation test (CFT) and the indirect fluorescent antibody test (IFAT) were conducted on weekly serum samples from nine Arab geldings for 28 days before and 256 days after their exposure to Babesia equi of European origin. On an average the IFAT became positive 8 days before the CFT and showed higher relative serum titer increases. Both test procedures successfully detected infection and neither showed an appreciable drop in titer during this time frame, with the exception of the CFT, which showed a transient drop immediately following treatment with imidocarb. A test conduc...
Peritoneal fluid analysis in ponies after abdominal surgery. Ten student surgery ponies were subjected to exploratory laparotomy. Abdominal paracentesis was performed preoperatively and daily postoperatively for 6 days, then the ponies were euthanatized and necropsied. Initial baseline peritoneal fluid parameters were within established reference limits. Postoperatively, the total leukocyte count and total protein in the peritoneal fluid rose and remained elevated for the 6 days of the study. Complete blood counts (CBCs) were performed preoperatively and on days 1 and 4 postoperatively. On day 1, a stress leukogram with a mild inflammatory component dev...
Joint Report of the Fifth International Workshop on Lymphocyte Alloantigens of the Horse, Baton Rouge, Louisiana, 31 October-1 November 1987. Six laboratories participated in the Fifth International Workshop on Lymphocyte Alloantigens of the Horse, testing 132 alloantisera against lymphocytes of 880 horses chosen to represent different families and breeds. Most of the alloantisera were produced by lymphocyte immunization between horses matched at the ELA-A locus. All horses were also tested with antisera contributed to the workshop by participating laboratories which identified ELA specificities A1-A10 and W12-W21. Previously identified workshop specificities ELA-W14, W15 and W19 were accepted as products of the ELA-A locus based on...
Epidemiologic studies of Lyme disease in horses and their public health significance. A serologic survey of horses in the New Jersey-Pennsylvania area demonstrated that about 10% (6.2-14.2%) have significant levels of serum antibody to Borrelia burgdorferi. However, in a highly endemic area of central New Jersey, up to 60% of the mares and yearlings samples on one farm were seropositive. In 1983, sera from this same farm exhibited only 12% positives in mares and 35% positives in yearlings. Longitudinal studies of paired sera obtained from individual yearlings over a 6-month period in 1985 showed that 34% of them declined during the period. A new clinical syndrome associated wit...
Calibration of the mercury-in-silastic strain gauge in tendon load experiments. A calibration method is presented by which the signals of mercury-in-silastic strain gauges (MISS), implanted in the tendons of in vitro loaded equine hindlegs, were converted to tendon loads. The relationships between MISS-signals and tendon loads were obtained from tensile-force tests applied to the tendons. Special attention was paid to the correction of the MISS-signals for amplitude-shifts resulting from internal repositioning of the MISS after tendon isolation and temperature differences. Shift corrections equivalent to tendon strains up to 2.8% were necessary in the in vitro experiment....
Effects of cooling rate and storage temperature on equine spermatozoal motility parameters. Two experiments were conducted to examine the effects of cooling rate and storage temperature on motility parameters of stallion spermatozoa. In Experiment 1, specific cooling rates to be used in Experiment 2 were established. In Experiment 2, three ejaculates from each of two stallions were diluted to 25 x 10(6) sperm/ml with 37 degrees C nonfat dry skim milk-glucose-penicillin-streptomycin seminal extender, then assigned to one of five treatments: 1) storage at 37 degrees C, 2) storage at 25 degrees C, 3) slow cooling rate to and storage at 4 degrees C, 4) moderate cooling rate to and storag...
Standardbred stallion gene transmission for twelve protein systems: evidence for selection in trotters. The transmission ratios of alleles at 12 protein marker loci were computed individually for American Standardbred stallions in a genealogy of 5392 phenotyped horses. Over all loci there was significant gene transmission distortion for trotting stallions (p = 0.0019) but not for pacing stallions (p = 0.99). The transmission distortion was due to sire-specific effects (p = 0.0024) and not to increased transmission of one or the other allele of a given heterozygous genotype (p = 0.21). Individual-specific, non-random transmission of homologous chromosomes may provide a mechanism for selection to ...
Use of an immediate, qualitative progesterone assay for determination of day of ovulation in an equine embryo transfer program. An immediate, qualitative enzyme-linked immunosorbent assay (ELISA) for progesterone was evaluated for use in determining the day of ovulation in an equine embryo transfer program. Plasma samples were collected from 27 mares from the third day of estrus to the second day of diestrus for 50 cycles. Ovulation was detected by ultrasound examination per rectum. Plasma progesterone concentrations were estimated using the qualitative assay to detect the time of the rise in progesterone after ovulation. Qualitative scores were compared to progesterone concentrations for the same samples as measured b...
Histology of the post partum equine uterus as determined by endometrial biopsies. Altogether 156 equine endometrial biopsies were carried out during the post partum (p.p.) period: immediately after parturition until 15 days after foaling. The histological changes are described. The rapid restoration of the equine endometrium is remarkable. The destruction of the luminal epithelium is minor and regeneration takes place rapidly. Remnants of the placenta, the microcotyledons and desquamated cells, have disappeared by 5 p.p. The transformation of glands from a pronounced secretory pattern to normal appearance also takes only 5 days. The occurrence of neutrophils and lymphocytes...
[Indirect blood pressure determination in the horse with the Dinamap 1255 research monitor]. In 26 horses measurings of blood pressure, using the Dinamap 1255 research monitor, were performed and compared for accuracy with blood pressure values obtained by direct measurement in the arteria carotis. It was found that oscillometrically ascertained initial blood values in standing horses have a sufficient correlation to initial blood pressure values obtained by direct measurement. But every blood pressure change is registered too late, when using the oscillometric blood pressure apparatus. This temporal delay becomes unacceptable, when a considerable increase in blood pressure occurs. A ...
Evaluation of the presence of a specific histocompatibility protein on equine embryonic cells. An indirect immunofluorescence assay was used to detect the presence of H-Y antigen on equine blastocysts. A total of 33 blastocyst stage horse embryos were collected 6 to 7 days post-ovulation by trans-cervical flush and were immediately evaluated for the presence of H-Y antigen. Additionally, 17 embryos, were collected and cultured for 72 h to the expanded blastocyst stage and similarly evaluated. Embryos were placed in medium containing monoclonal antibodies to H-Y antigen followed by incubation in medium containing 1/10 (v/v) fluorescein isothiocyanate conjugated goat anti-mouse IgM Fc spe...
A monoclonal antibody identifying a T-cell marker in the horse. A cell surface molecule of equine T lymphocytes was identified and characterized using a mouse monoclonal antibody, HT23A. The molecule was detected on all T cells but not on other cells in peripheral blood, with the possible exception of a small subpopulation (about 5%) of B cells, as assessed by indirect immunofluorescence and flow cytometry. HT23A labelled T cell areas of horse lymph nodes and spleen when used in an indirect immunoperoxidase assay on frozen sections. Macrophages and neutrophils were not labelled by the antibody nor were frozen sections of horse liver, kidney, or brain. HT23...
