Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
Brumbaugh GW, Thomas WP, Hodge TG.A 4-year-old Quarter Horse gelding with atrial fibrillation, mitral regurgitation, and signs of bilateral congestive heart failure was initially treated IV with digoxin and furosemide. After parenteral digitalization, a daily maintenance dose of digoxin was administered orally at a rate of 21.7 micrograms/kg of body weight. At this dosage, a steady-state serum digoxin concentration of 2.3 ng/ml was achieved without clinical signs of toxicosis. The furosemide dosage was decreased and eventually discontinued as clinical improvement occurred. Clinical signs of congestive heart failure were contro...
Visser S, Jenness R, Mullin RJ.Three groups of casein components were isolated from horse milk. Group I is almost insoluble at acid and neutral pH, and is rather heterogeneous on alkaline gels with or without sodium dodecyl sulphate. Group II shows strong similarity to beta-casein from other species, as concluded from its amino acid composition and its N- and C-terminal sequences. This group consists of five electrophoretically distinguishable forms, all containing ester phosphate groups but no carbohydrate. Group III is composed of C-terminal fragments of the beta-like (group II) fraction and probably arises from the actio...
Benson GJ, Manohar M, Kneller SK, Thurmon JC, Steffey EP.A radiograph technique for identification of diaphragmatic segments and quantitation of their contribution to total diaphragmatic function was developed. five anesthetized ponies were studied on 3 separate occasions. Studies were made of the ponies in left lateral recumbency at 2 anesthetic levels (1 and 2 minimal alveolar anesthetic concentrations; halothane) and under spontaneous and controlled ventilation systems. General pattern of diaphragmatic displacement was unchanged by increased depth of anesthesia. Controlled ventilation altered the pattern of diaphragmatic displacement. Diaphragmat...
Brownlow MA, Hutchins DR.Osmolality is an indication of the osmotic pressure of plasma and depends on the amount of solute and solvent (water) present. The mean (+sd) plasma osmolality of 100 clinically normal animals was 282 (+6) mOsm/kg using lithium heparin as anticoagulant. The equation, osmolality=1.86 (sodium + potassium) +glucose +blood urea nitrogen + 9, was found to predict only crudely plasma osmolality. The plasma sodium: osmolality ratio was 0.49. Water and electrolyte disorders are classified into 3 types based on the measurement of electrolytes and osmolality: (1) Hypertonic dehydration (true dehydration...
Canning JF.Bile flow, during feeding and fasting, was studied in three ponies in which catheters, maintained in the bile duct over 1-2 months, drained all bile continuously. During experiments bile was returned to the small intestine, via a second catheter, by means of a small pump which also measured bile flow rates. The mean +/- S.E. of the mean rate of bile flow in fed ponies with an intact enterohepatic circulation of bile salts was 1.33 +/- 0.10 ml/kg . h, n = 13; mean +/- S.E. of the mean concentration of bilirubin in bile was 10.82 +/- 0.91 mg/dl, n = 13. The effect on bile flow and bilirubin excr...
Derksen FJ, Robinson NE, Slocombe RF, Riebold TW, Brunson DB.Arterial blood gas tensions, pulmonary mechanics, and lung volumes were measured in 4 sedated ponies every hour for 6 hours and in 5 ponies 4 times at 2-month intervals to assess the short- and long-term reproducibility of pulmonary function measurements. Variability in blood gas tensions was small over the short- and long-term measurement periods, whereas the variability in total respiratory resistance and functional residual capacity was small over the short term but larger over the long term. The variability in tidal volume, minute ventilation, respiratory rate, and dynamic and quasistatic ...
Pierrot M, Astier JP, Astier M, Charles M, Drenth J.A detailed study of the crystallization of hog and horse colipases has been undertaken. Several crystallographic varieties have been obtained and a 0.3-nm resolution structure determination is actually in progress. The sequence of the A form of horse colipase (one methionine) is given. From spectrophotometric experiments and sequence comparisons, the involvement of the aromatic residue in position 52 in the micelle binding site has been demonstrated.
Caple IW, Doake PA, Ellis PG.Studied were made to determine if a practical assessment of the calcium and phosphorus nutrition of horses could be obtained from an analysis of urine samples. The concentrations of Ca and P in urine samples changed markedly when groups of 4 mares were fed diets containing from 1.0 to 3.9 g Ca/kg and from 1.5 to 6.1 g P/kg, but serum concentrations of Ca and P remained relatively constant. The concentrations in single urine samples were considered unreliable indicators of excretion of the minerals because of variations in water excretion, and two methods to overcome this problem were examined....
Gibson JA, Eaves LE, O'Sullivan BM.During a 20 month period Enterobacter agglomerans was
isolated from 17 cases of equine abortion. In 8 cases E
agglomerans was isolated in pure culture and in 9 cases it was
isolated in mixed culture from the foetus and/or foetal
membranes. Fifteen cases had histological evidence of foetal
infection and/or placentitis.
The occurrence of E agglomerans in pure culture, associated
with inflammatory lesions in the foetus and foetal membranes,
suggests it to be a cause of abortion in mares.
Quinlan TJ, Goulden BE, Barnes GR, Anderson LJ, Cahill JI.The nerve supply to the intrinsic laryngeal muscles of the horse was studied by gross dissection and by electromyography which was carried out before, during and after section of various intralaryngeal nerve branches. The anatomical relationships and passage of the laryngeal nerves throughout the larynx were defined. Unlike the dog and man there was no evidence of the passage of motor nerve fibres from one side of the larynx to the other.
Shively MA, Banks KL, Greenlee A, Klevjer-Anderson P.Equine infectious anemia is a chronic disease of horses caused by a nononcogenic retrovirus. Studies were undertaken to determine the types of cells involved in the in vitro lymphoproliferative response to viral antigens and the dynamics of this reaction. It was observed that reactive lymphocytes were present at unpredictable times in the peripheral blood of infected horses. This reaction was shown to be specific for the interaction of equine infectious anemia virus and T lymphocytes. Enriched B-lymphocyte populations did not divide when exposed to equine infectious anemia virus. Macrophages w...
Jeffcott LB, Dalin G, Drevemo S, Fredricson I, Björne K, Bergquist A.Back pain was induced in Standardbred horses by multiple intramuscular injections of a concentrated lactic acid solution into the left longissimus dorsi muscle. The investigation was divided into 2 parts. In Stage 1, 2 trotters were exercised on a treadmill and filmed by high speed cinematography before and after the induction of back pain. No signs of hindlimb lameness were evident and no quantitative changes in the components of the gait resulted, but a noticeable reduction was seen in performance capacity. Stage 2 involved a more intensive clinical and cinematic analysis of 3 horses. In the...
Cranley JJ.A survey of 1141 horses and ponies, for the presence of hydatid infection, was carried out at an export meat plant near Bristol. Lesions were attributed carefully by morphological, histological and immunological examinations and assessed by flame cell activity. All available detail concerning the animals was recorded. The surveys in the literature were assessed for the criteria on which their figures were based and were compared with the findings of this present survey. Attention was drawn to the apparent discord between the results of some surveys and others.
Zinkl JG, Brown PD.Horse polymorphonuclear leukocytes (PMN) isolated from horse blood by sedimentation and isotonic lysis and having about 25% accompanying lymphocytes were as effective at chemotaxis as nearly pure PMN isolated by density gradient techniques. N-Formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP), used as a representative of the formylmethionyl peptides (produced by prokaryocytic organisms), was effective as a chemoattractant only at the high concentration of 10(-4) M. When serum was preincubated with FMLP at concentrations as low as 10(-8) M, the serum attracted horse PMN. This activity was not g...
Slone DE, Humburg JM, Jagar JE, Powers RD.Rectal tears were detected in three horses treated for colic. Based on historical, clinical, and postmortem findings, the tears could not be attributed to the attending veterinarian and were therefore not iatrogenic (physician induced). One tear was attributable to an infarction that presumably resulted from thromboembolism; 1 tear occurred without any evidence of external cause and resulted in such severe peritonitis that the cause and resulted in such severe peritonitis that the cause could not be determined, and 1 tear occurred during rectal palpation by the owner, before he called the vete...
Mirck MH, van Meurs GK.Seven foals naturally infected with Strongyloides westeri were injected intramuscularly with ivermectin at a dosage rate of 200 mcg per kg body weight. No adverse effects to treatment were observed. Weekly faecal egg counts showed a greater than 99 per cent reduction of S. westeri egg output compared with 7 untreated foals during the 21 days following treatment.
Laan TT, Spoorenberg JF, van der Kolk JH.Intake of Rumex, a plant genus of the Polygonaceae family, probably led through the assimilation of oxalic acid, to hypocalcaemia in a four-week old foal. This foal was presented with muscle rigidity and a stiff gait. Both the total and ionized calcium concentrations were low, 1.38 mmol/l and 0.54 mmol/l respectively. The foal was treated with a total of 150 ml of a 20% calcium solution IV. The foals neuromuscular signs resolved within a few hours after receiving calcium solution.
Rutgers HC, Stibbe S, van den Ingh TS, Breukink HJ.The case of a 16-year-old mare with multiple dermal lymphosarcoma of the histiolymphocytic type is described. Leukaemic changes were not found to be present in the superficial and internal lymph nodes or in the visceral organs.
Wijnberg ID, Ververs FF.Five adult horses with ventricular extra systoles (VES) and 2 with ventricular tachycardia (VT) refractory to treatment with rest, anti-inflammatory drugs, lidocaine, or procainamide were treated with phenytoin sodium p.o. q12h. The starting dosage of phenytoin was 20 or 22 mg/kg body weight (BW) q12h, and the maintenance dosage varied from 8 to 17 mg/kg BW q12h. The mean +/- standard deviation therapeutic blood concentration of total phenytoin was 8.8 +/- 2.1 mg/L, and the mean concentration of free phenytoin of 2.5 +/- 0.5 mg/L was relatively constant at a range of 24 to 29% of the total phe...
Hawkins JF, Andrews-Jones L.To develop a technique for neodymium:yttrium-aluminum-garnet (Nd:YAG) laser ventriculocordectomy in standing horses and document healing in horses undergoing laser ventriculocordectomy. Methods: 6 horses between 2 and 32 years old. Methods: Under endoscopic guidance, the left laryngeal ventricle was everted with grasping forceps and excised with an Nd:YAG laser, using 60 watts of power in a noncontact fashion (6,403 to 9,197 Joules). Following removal of the ventricle, the vocal cord was photoablated. Horses were examined endoscopically 2, 7, 14, 21, 30, and 47 days after ventriculocordectomy,...
McKinney AR, Ridley DD, Suann CJ.After oral administration to a thoroughbred gelding, the anabolic steroid norethandrolone was converted into a complex mixture of oxygenated metabolites. These metabolites were extracted from the urine, deconjugated by methanolysis and converted to their O-methyloxime trimethylsilyl derivatives. Gas chromatographic/mass spectrometric analysis indicated the major metabolites to be 19-norpregnane-3,16,17-triols, 19-norpregnane-3,17,20-triols and 3,17-dihydroxy-19-norpregnan-21-oic acids. Some minor metabolites were also detected.
Boswinkel M, Neyens IJ, Sloet van Oldruitenborgh-Oosterbaan MM.A 5-year old Tinker gelding was referred to the Department of Equine Sciences with a left eye uveitis and fever. At presentation the horse showed a mild lethargy, fever and decreased vision of the left eye. Rectal examination revealed an enlarged left kidney, with a hard and an irregular surface. The cranial mesentery artery had an enlarged and irregular aspect. Blood analysis showed anaemia, leucocytosis, increased blood urea nitrogen and creatinine and a hyperproteinemia. Urine analysis repeatedly showed a marked proteinuria and an increased gammaGT/creatinine ratio. The amount of abdominal ...
Kirberger RM, Gottschalk RD, Guthrie AJ.Twelve horses were injected intra-articularly into the metacarpophalangeal joint and extra-articularly in the region of the lateral palmar digital nerve with 1 ml air and local anaesthetic to simulate gas accidentally introduced during regional anaesthesia. Half the horses underwent limited exercise after which all horses were radiographed at 15 and 45 min and then every 24 h until all evidence of gas had disappeared. Intra-articular gas appeared as gas capped radiolucencies (GCR) in the proximal aspect of the joint. Extra-articular gas appeared as linear radiolucencies (LR) which initially te...
Grahwit G.A historical review is given on the reasons to use restraint measures in animals, their definitions and classifications as well as their mode of action. An attempt is made to give an assessment of these measures according to animal welfare aspects formerly and today. Special emphasis is put on considerations in conformity with the "reasonable reason", as required in the German Animal Welfare Act.
Albrecht BA, MacLeod JN, Daels PF.In the pregnant mare, luteal estrogen production increases at the onset of equine chorionic gonadotropin (eCG) secretion by endometrial cups. In previous studies, we have demonstrated that eCG stimulates luteal androgen and estrogen production in pregnant mares. To further elucidate the regulation of steroidogenesis within the equine corpus luteum (CL) of pregnancy, we examined the expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD), cytochrome P450 17alpha-hydroxylase/17,20 lyase (P450(17alpha)) and cytochrome P450 aromatase (P450(arom)) in luteal tissue samples collected during dies...
Sullins KE, Stashak TS.Six normal adult horses had large colon resections at the sternal and diaphragmatic flexures. Stainless steel staples were used to close the stumps of the dorsal and ventral colons in all six. Intestinal continuity was restored with a side-to-side anastomosis of the dorsal and ventral colons. Three of these anastomoses were performed with staples, and three with a double inverting suture pattern. After one month, the horses were surgically reevaluated, and the anastomotic sites were examined. There was no significant difference between the stoma sizes in the two groups. No complications were o...
Shipstone , Mueller , Bettenay , Mason , Friend .The macroscopic and microscopic effects following the intradermal injection of the mast cell degranulator compound 48/80 were investigated in horses. It was found that a 1000 μg mL-1 solution of compound 48/80 could be used as an alternative to histamine as a positive control in equine intradermal allergy tests. An inflammatory cell infiltration was noted on histological examination, following compound 48/80 injection. This inflammatory cell pattern was similar to that noted for Type-I hypersensitivity.
Kundu A, Cramer SM.The resolving power of displacement chromatography using low-molecular-weight displacers was investigated using a model mixture containing bovine and horse heart cytochrome c. The linear and nonlinear adsorption behavior of these two proteins was examined in cation-exchange chromatography and shown to be quite similar. Furthermore, an analysis of the dynamic affinity of these proteins indicated extremely similar affinities under displacement conditions. Despite the extreme similarities in the adsorption behavior, displacement chromatography using a protected amino acid displacer resulted in ex...
Eto D, Yamano S, Hiraga A, Miyata H.There is little information about the muscle fibre recruitment pattern during sloped and flat track running in Thoroughbred horses. Objective: To examine the glycogen depletion pattern of each muscle fibre type during running on a flat and sloped treadmill. Methods: Thirteen Thoroughbred horses (3-9 years old) were used. They were initially subjected to incremental exercise tests on a treadmill at 10 and 0% inclines in each horse to determine running speed at 90 and 60% VO2max. Needle biopsy samples were obtained from the middle gluteal muscle immediately after the running at 90% VO2max for 4 ...
Sławomirski J, Głuszak J.The studies performed on spinal cords of two horses revealed that cells of the nucleus of the own dorsal horn are present in all segments of lumbo-sacral part of the spinal cord. The nucleus is composed of two parts: basal and marginal. Basal part is composed of large and medium size cells situated in 2/3 of the lower part of the grey substance of the dorsal horn. The marginal part of the described nucleus is composed of elongated and spindle shaped cells situated along the dorsal margine of the grey substance of the dorsal horn. Continuity of the nucleus in lumbo-sacral part of the spinal cor...
Tumblin DL.There are several options to value a veterinary practice (market approach, asset approach, and income approach) and several methods within these approaches. Examples of an income-based approach include excess earnings, discounted future returns, and single period capitalization of earnings. A qualified valuator will use his or her professional opinion and experience to determine the most appropriate method for one's practice situation. This article outlines the excess earnings method for which where the principal components of value are net assets and goodwill.
