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Veterinary immunology and immunopathology.
Periodical
Allergy and Immunology
Veterinary Medicine
Publisher:
Elsevier Scientific.
Frequency: Twenty four no. a year, 1992-
Country: Netherlands
Language: English
Start Year:1979 -
ISSN:
0165-2427 (Print)
1873-2534 (Electronic)
0165-2427 (Linking)
1873-2534 (Electronic)
0165-2427 (Linking)
Impact Factor
1.8
2022
| NLM ID: | 8002006 |
| (DNLM): | V05770000(s) |
| (OCoLC): | 05867096 |
| Coden: | VIIMDS |
| Classification: | W1 VE931HJ |
A study on the possible role of chymotrypsin in the aetiology of equine chronic obstructive pulmonary disease (COPD).
Veterinary immunology and immunopathology
April 1, 1983
Volume 4, Issue 3 387-395 doi: 10.1016/0165-2427(83)90048-x
Thomson JR, McPherson EA, Lawson GH, Wooding P, Brown R.The chymotrypsin activity of seven batches of Micropolyspora faeni and of five batches of Aspergillus fumigatus culture extracts, prepared for inhalation challenge in horses, was assayed and was found to range between 0.29 and 1.45 units/mg protein and 0.02 and 0.20 units/mg protein respectively. Horses affected with chronic obstructive pulmonary disease (COPD) were challenged with two batches of each antigen which had different chymotrypsin activities and no significant correlations were found between the degree of response to challenge and the chymotrypsin activity of the antigens. Inhalatio... The genetic control of antibody formation.
Veterinary immunology and immunopathology
March 1, 1983
Volume 4, Issue 1-2 3-42 doi: 10.1016/0165-2427(83)90055-7
Seide RK, Kehoe JM.Studies of the molecular biology of lymphoid cells have markedly increased our understanding of how millions of different antibodies can be synthesized by a single animal. To date, the most detailed understanding has been achieved for the mouse, primarily because of the relatively greater experimental availability of this species. These studies, as well as those involving other species, have shown that the complete genes for antibody polypeptide chains are assembled from disparate genetic elements which are originally widely separated in the genome. The assembly process itself, together with t... Stimulation by phytohaemagglutinin of peripheral blood lymphocytes from horse, pig, sheep and man.
Veterinary immunology and immunopathology
May 1, 1982
Volume 3, Issue 3 295-300 doi: 10.1016/0165-2427(82)90003-4
Peters GJ, Veerkamp JH.Optimal conditions for stimulation by phytohaemagglutinin (PHA) were established for equine, porcine, ovine and human lymphocytes in MEMS medium. Optimal thymidine concentration was determined for assay of cell transformation. With all species tested horse serum gave highest thymidine incorporation. Homologous serum was not more appropriate for lymphocytes of man, pig and sheep. Optimal stimulation was achieved at 20, 0.5-5, 5, and 10-40 micrograms PHA per 10(6) cells for human, equine, porcine and ovine lymphocytes, respectively. Contagious equine metritis: antibody response of experimentally infected pony mares.
Veterinary immunology and immunopathology
June 1, 1981
Volume 2, Issue 3 201-213 doi: 10.1016/0165-2427(81)90023-4
Rommel FA, Sahu SP.Intrauterine inoculation of pony mares with the bacterium that is the causative agent of contagious equine metritis (CEM) resulted in clinical disease. A humoral immune response could be detected by agglutination and complement fixation (CF), and in some cases precipitating antibody was found by immunodiffusion tests. Agglutinating antibody was the most reliable serological indicator of overt infection and was detected in 8 ot 28 mares after initial intrauterine inoculation of 3-4 x 10(5) bacteria. Seventy percent of mares given a second inoculation and all mares given a third inoculation of 3... An evaluation of contribution derived from investigations of equine immunodeficiencies.
Veterinary immunology and immunopathology
April 1, 1981
Volume 2, Issue 2 101-109 doi: 10.1016/0165-2427(81)90042-8
McGuire TC, Perryman LE, Banks KL.Following the descriptions of immunodeficiencies in horses beginning in 1973, there has been considerable effort to develop methods for differential diagnosis and to determine the cause and prevalence of the disorders. In addition, the equine immunodeficiencies, especially combined immunodeficiency, have been studied from a comparative viewpoint with the goal of finding information applicable to similar diseases of children. Coincident with the development of knowledge about the immunodeficiencies per se, considerable information about several aspects of immunology has been obtained. It is the... The effects of sodium cromoglycate on antigen inhalation challenge in two horses affected with chronic obstructive pulmonary disease (COPD).
Veterinary immunology and immunopathology
November 1, 1979
Volume 1, Issue 1 89-95 doi: 10.1016/0165-2427(79)90010-2
Murphy JR, McPherson EA, Lawson GH.80 mg sodium cromoglycate (SCG) was administered by inhalation to two COPD-affected animals known to have respiratory hypersensitivity to Micropolyspora faeni. SCG treatment 20-30 minutes prior to inhalation challenge with M. faeni prevented exacerbation of respiratory disease, usually seen 4-8 hours after challenge. duration of protection against antigen challenge after a single SCG treatment was 4-5 days. The duration of protection was not prolonged by reducing the frequency of antigen challenge. Multiple antigen challenge, using M. faeni and Aspergillus fumigatus, shortened the protective p... Immunophenotype and gene expression profiles of cell surface markers of mesenchymal stem cells derived from equine bone marrow and adipose tissue.
Veterinary immunology and immunopathology
July 2, 2011
Volume 144, Issue 1-2 147-154 doi: 10.1016/j.vetimm.2011.06.033
Ranera B, Lyahyai J, Romero A, Vázquez FJ, Remacha AR, Bernal ML, Zaragoza P, Rodellar C, Martín-Burriel I.Bone marrow and adipose tissue are the two main sources of mesenchymal stem cell (MSC). The aim of this work was to analyse the immunophenotype of 7 surface markers and the expression of a panel of 13 genes coding for cell surface markers in equine bone marrow and adipose tissue-derived MSCs obtained from 9 horses at third passage. The tri-lineage differentiation was confirmed by specific staining. Equine MSCs from both sources were positive for the MSC markers CD29 and CD90, while were negative for CD44, CD73, CD105, CD45 and CD34. The gene expression of these molecules was also evaluated by ... Read More
68
Resolving an inflammatory concept: the importance of inflammation and resolution in tendinopathy.
Veterinary immunology and immunopathology
January 31, 2014
Volume 158, Issue 3-4 121-127 doi: 10.1016/j.vetimm.2014.01.007
Dakin SG, Dudhia J, Smith RK.Injuries to the superficial digital flexor tendon (SDFT) are an important cause of morbidity and mortality in equine athletes, but the healing response is poorly understood. One important drive for the healing of connective tissues is the inflammatory cascade, but the role of inflammation in tendinopathy has been contentious in the literature. This article reviews the processes involved in the healing of tendon injuries in natural disease and experimental models. The importance of inflammatory processes known to be active in tendon disease is discussed with particular focus on recent findings ... Read More
65
Cytokine induction in pulmonary airways of horses with heaves and effect of therapy with inhaled fluticasone propionate.
Veterinary immunology and immunopathology
April 12, 2002
Volume 85, Issue 3-4 147-158 doi: 10.1016/s0165-2427(01)00420-2
Giguère S, Viel L, Lee E, MacKay RJ, Hernandez J, Franchini M.Work in humans and laboratory animals has identified a central role for cytokines and chemokines in development and persistence of lower airway inflammation. The objectives of this study were to determine interleukin (IL)-1 beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha induction in bronchoalveolar lavage (BAL) of control horses and horses with heaves both during remission and exacerbation of the disease, and to determine the effect of therapy with inhaled fluticasone propionate on the cytokine profile of horses with heaves. IL-1 beta an... Read More
56
Development of a bead-based multiplex assay for simultaneous quantification of cytokines in horses.
Veterinary immunology and immunopathology
October 18, 2008
Volume 127, Issue 3-4 242-248 doi: 10.1016/j.vetimm.2008.10.313
Wagner B, Freer H.The detection and quantification of equine cytokines has been hampered by the lack of antibodies for many years. With the development of antibody pairs for equine cytokines during the past years, the quantification of these essential regulators of the immune response became possible. After being successfully tested by enzyme-linked immunosorbent assays (ELISA), three of these anti-cytokine reagents were used here to establish the first cytokine multiplex assay for equine IL-4, IL-10 and IFN-alpha. A fluorescent bead-based system was used as matrix for this assay that allows the simultaneous de... Read More
54
Investigation of the immune response to autologous, allogeneic, and xenogeneic mesenchymal stem cells after intra-articular injection in horses.
Veterinary immunology and immunopathology
September 18, 2013
Volume 156, Issue 1-2 99-106 doi: 10.1016/j.vetimm.2013.09.003
Pigott JH, Ishihara A, Wellman ML, Russell DS, Bertone AL.Mesenchymal stem cells have demonstrated immunomodulatory capabilities as well as modest efficacy in animal models of joint injury, warranting further study as a potential treatment of joint disease. The goal of the study was to investigate the blood and synovial immune and histologic response to intra-articular injection of autologous, allogeneic, and xenogeneic bone marrow-derived mesenchymal stem cells (MSC) in horses. The study group consisted of 6 five-year-old Thoroughbred mares that had been injected previously with 15 million, genetically modified autologous, allogeneic, or xenogeneic ... Read More
46
A West Nile virus (WNV) recombinant canarypox virus vaccine elicits WNV-specific neutralizing antibodies and cell-mediated immune responses in the horse.
Veterinary immunology and immunopathology
February 16, 2008
Volume 123, Issue 3-4 230-239 doi: 10.1016/j.vetimm.2008.02.002
El Garch H, Minke JM, Rehder J, Richard S, Edlund Toulemonde C, Dinic S, Andreoni C, Audonnet JC, Nordgren R, Juillard V.Successful vaccination against West Nile virus (WNV) requires induction of both neutralizing antibodies and cell-mediated immune responses. In this study, we have assessed the ability of a recombinant ALVAC-WNV vaccine (RECOMBITEK WNV) to elicit neutralizing antibodies and virus-specific cell-mediated immune responses in horses. In addition, we examined whether prior exposure to ALVAC-WNV vaccine would inhibit B and cell-mediated immune responses against the transgene product upon subsequent booster immunizations with the same vaccine. The results demonstrated that the recombinant ALVAC-WNV va... Read More
44
Equine insect bite hypersensitivity: what do we know?
Veterinary immunology and immunopathology
April 3, 2012
Volume 147, Issue 3-4 113-126 doi: 10.1016/j.vetimm.2012.03.017
Schaffartzik A, Hamza E, Janda J, Crameri R, Marti E, Rhyner C.Insect bite hypersensitivity (IBH) is an allergic dermatitis of the horse caused by bites of insects of the genus Culicoides and is currently the best characterized allergic disease of horses. This article reviews knowledge of the immunopathogenesis of IBH, with a particular focus on the causative allergens. Whereas so far hardly any research has been done on the role of antigen presenting cells in the pathogenesis of IBH, recent studies suggest that IBH is characterized by an imbalance between a T helper 2 (Th2) and regulatory T cell (T(reg)) immune response, as shown both locally in the skin... Read More
43
Isolation and immunophenotypic characterization of mesenchymal stem cells derived from equine species adipose tissue.
Veterinary immunology and immunopathology
June 30, 2009
Volume 132, Issue 2-4 303-306 doi: 10.1016/j.vetimm.2009.06.014
de Mattos Carvalho A, Alves AL, Golim MA, Moroz A, Hussni CA, de Oliveira PG, Deffune E.The purpose of this work was to isolate and cultivate mesenchymal stem cells (MSC) derived from equine adipose tissue and conduct cellular characterization with the following markers: CD90, CD44 and CD13. Adipose tissue collection was performed at the base of the horses' tails, followed by immediate isolation and cultivation of the MSC and posterior characterization by flow cytometry for the interspecies reaction test using mouse anti-rat CD90 monoclonal antibody (mAb), fluorescein isothiocyanate (FITC), and tests with specific mAb mouse anti-horse CD13 and mouse anti-horse CD44. The technique... Read More
41
Report of the Second Equine Leucocyte Antigen Workshop, Squaw valley, California, July 1995.
Veterinary immunology and immunopathology
June 25, 1998
Volume 62, Issue 2 101-143 doi: 10.1016/s0165-2427(97)00160-8
Lunn DP, Holmes MA, Antczak DF, Agerwal N, Baker J, Bendali-Ahcene S, Blanchard-Channell M, Byrne KM, Cannizzo K, Davis W, Hamilton MJ, Hannant D....The final assignment of antibody clusters for leucocyte antigens and immunoglobulins, as described in detail in Sections 3 and 4, is summarized in Table 4. Together with other mAbs developed outside of ELAW II (Table 9) this pool of reagents represent a powerful array of tools for the study of equine immunity. The Second Equine Leucocyte Antigen Workshop made considerable advances in pursuing the objectives of establishing the specificities of mAbs and achieving consensus on the nomenclature for equine leucocyte and immunoglobulin molecules. Of equal importance, several productive collaboratio... Read More
40
Recurrent airway obstruction (RAO) in horses is characterized by IFN-gamma and IL-8 production in bronchoalveolar lavage cells.
Veterinary immunology and immunopathology
October 3, 2003
Volume 96, Issue 1-2 83-91 doi: 10.1016/s0165-2427(03)00142-9
Ainsworth DM, Grünig G, Matychak MB, Young J, Wagner B, Erb HN, Antczak DF.In horses prone to developing recurrent airway obstruction (RAO), we tested the hypotheses that the cytokine profile in the bronchoalveolar lavage (BAL) cells of affected horses would reflect a polarized Th-2 response; that cytokine and chemokine alterations would occur within 24 h of allergen exposure; and that allergen exposure would induce alterations in the expression of the transcription factor t-bet (t-box-expressed in T-cells). The expression levels of interleukin-4 (IL-4), IL-13, Interferon-gamma (IFN-gamma), t-bet, IL-8 and granulocyte-macrophage colony stimulating factor (GM-CSF) wer... Read More
38
Elevated extrahepatic expression and secretion of mammary-associated serum amyloid A 3 (M-SAA3) into colostrum.
Veterinary immunology and immunopathology
December 4, 2001
Volume 83, Issue 3-4 203-211 doi: 10.1016/s0165-2427(01)00380-4
McDonald TL, Larson MA, Mack DR, Weber A.Mammary-associated serum amyloid A 3 (M-SAA3) was secreted at highly elevated levels in bovine, equine and ovine colostrum and found at lower levels in milk 4 days postparturition. N-terminal sequencing of the mature M-SAA3 protein from all the three species revealed a conserved four amino acid motif (TFLK) within the first eight residues. This motif has not been reported to be present in any of the hepatically-produced acute phase SAA (A-SAA) isoforms. Cloning of the bovine M-Saa3 cDNA from mammary gland epithelial cells revealed an open reading frame that encoded a precursor protein of 131 a... Read More
38
Foals are interferon gamma-deficient at birth.
Veterinary immunology and immunopathology
April 18, 2006
Volume 112, Issue 3-4 199-209 doi: 10.1016/j.vetimm.2006.02.010
Breathnach CC, Sturgill-Wright T, Stiltner JL, Adams AA, Lunn DP, Horohov DW.The increased vulnerability of foals to specific pathogens such as Rhodococcus equi is believed to reflect an innate immunodeficiency, the nature of which remains poorly understood. Previous studies have demonstrated that neonates of many species fail to mount potent Th1 responses. The current research investigates the ability of circulating and pulmonary lymphocytes of developing foals to produce interferon gamma (IFNgamma). Peripheral blood mononuclear cells (PBMC) were prepared from up to 10 horse foals at regular intervals throughout the first 6 months of life. Bronchoalveolar lavage (BAL)... Read More
36
The equine immune response to equine herpesvirus-1: the virus and its vaccines.
Veterinary immunology and immunopathology
February 14, 2006
Volume 111, Issue 1-2 15-30 doi: 10.1016/j.vetimm.2006.01.005
Kydd JH, Townsend HG, Hannant D.Equine herpesvirus-1 (EHV-1) is an alphaherpesvirus which infects horses, causing respiratory and neurological disease and abortion in pregnant mares. Latency is established in trigeminal ganglia and lymphocytes. Immunity to EHV-1 lasts between 3 and 6 months. Current vaccines, many of which contain inactivated virus, have reduced the incidence of abortion storms in pregnant mares but individual animals, which may be of high commercial value, remain susceptible to infection. The development of effective vaccines which stimulate both humoral and cellular immune responses remains a priority. Uti... Read More
35
Effect of inflammatory environment on equine bone marrow derived mesenchymal stem cells immunogenicity and immunomodulatory properties.
Veterinary immunology and immunopathology
February 12, 2016
Volume 171 57-65 doi: 10.1016/j.vetimm.2016.02.007
Barrachina L, Remacha AR, Romero A, Vázquez FJ, Albareda J, Prades M, Ranera B, Zaragoza P, Martín-Burriel I, Rodellar C.Mesenchymal stem cells (MSCs) are being investigated for the treatment of equine joint diseases because of their regenerative potential. Recently, the focus mainly has addressed to their immunomodulatory capacities. Inflammation plays a central role in joint pathologies, since the release of proinflammatory mediators to the synovial fluid (SF) leads to the activation of enzymatic degradation of the cartilage. MSCs can modulate the local immune environment through direct or paracrine interaction with immune cells, suppressing their proliferation and re-addressing their functions. Proinflammator... Read More
35
Serum amyloid A isoforms in serum and synovial fluid in horses with lipopolysaccharide-induced arthritis.
Veterinary immunology and immunopathology
December 5, 2005
Volume 110, Issue 3-4 325-330 doi: 10.1016/j.vetimm.2005.10.012
Jacobsen S, Niewold TA, Halling-Thomsen M, Nanni S, Olsen E, Lindegaard C, Andersen PH.The aim of the study was to determine the intraarticular serum amyloid A (SAA) response pattern in horses with inflammatory arthritis. Inflammatory arthritis was induced by injection of lipopolysaccharide (LPS) into the radiocarpal joint of four horses. Serum and synovial fluid (SF) samples were collected before and at 4, 8, 12, 24, 48, 72, 96, and 144 h after injection. Concentrations of SAA were measured by immunoturbidometry, and expression of SAA isoforms was visualized by denaturing isoelectric focusing and Western blotting. The LPS injection caused systemic and local clinical signs of in... Read More
34
IL-4, IL-5 and IFN-gamma mRNA expression in pulmonary lymphocytes in equine heaves.
Veterinary immunology and immunopathology
January 1, 2004
Volume 97, Issue 1-2 87-96 doi: 10.1016/j.vetimm.2003.08.013
Cordeau ME, Joubert P, Dewachi O, Hamid Q, Lavoie JP.Heaves is a common condition of horses of cold climate that is characterized by small airway inflammation and obstruction following exposure of susceptible horses to moldy hay and straw. It has been shown that helper T lymphocytes (Th) orchestrate the inflammatory response in asthma and in various animal models of allergic lung diseases by the release of Th2-type cytokines. Results of previous studies indicate that a predominant expression of Th2-type response by airway cells may also be present in heaves. To evaluate the temporal mRNA expression of Th1 (IFN-gamma) and Th2 (IL-4, IL-5) type cy... Read More
33
The immune response to equine arteritis virus: potential lessons for other arteriviruses.
Veterinary immunology and immunopathology
October 28, 2004
Volume 102, Issue 3 107-129 doi: 10.1016/j.vetimm.2004.09.003
Balasuriya UB, MacLachlan NJ.The members of the family Arteriviridae, genus Arterivirus, include equine arteritis virus (EAV), porcine reproductive and respiratory syndrome virus (PRRSV), lactate dehydrogenase-elevating virus (LDV) of mice, and simian hemorrhagic fever virus (SHFV). PRRSV is the newest member of the family (first isolated in North America and Europe in the early 1990s), whereas the other three viruses were recognized earlier (EAV in 1953, LDV in 1960, and SHFV in 1964). Although arterivirus infections are strictly species-specific, the causative agents share many biological and molecular properties, inclu... Read More
30
Monoclonal anti-equine IgE antibodies with specificity for different epitopes on the immunoglobulin heavy chain of native IgE.
Veterinary immunology and immunopathology
March 12, 2003
Volume 92, Issue 1-2 45-60 doi: 10.1016/s0165-2427(03)00007-2
Wagner B, Radbruch A, Rohwer J, Leibold W.In this study we describe the generation of monoclonal antibodies (mAbs), which recognize different epitopes of the equine IgE constant heavy chain. Equi-murine recombinant IgE (rIgE), composed of the murine V(H)186.2 heavy chain variable region, linked to the equine IgE constant heavy chain and expressed together with the murine lambda(1) chain in J558L cells was used to immunize BALB/C mice. A total of 17 different mAbs were obtained, which recognized the rIgE heavy chain constant region. None of the mAbs reacted with monoclonal equine isotypes IgM, IgG1 (IgGa), IgG3 (IgG(T)), IgG4 (IgGb) or... Read More
30
Chronic exacerbation of equine heaves is associated with an increased expression of interleukin-17 mRNA in bronchoalveolar lavage cells.
Veterinary immunology and immunopathology
March 31, 2005
Volume 105, Issue 1-2 25-31 doi: 10.1016/j.vetimm.2004.12.013
Debrue M, Hamilton E, Joubert P, Lajoie-Kadoch S, Lavoie JP.Recent finding suggests that T-cells may be involved in the pathogenesis of heaves in horses. However, little is known concerning their possible contribution to pulmonary neutrophilia, a characteristic finding in heaves. Interleukin (IL)-17 is a cytokine secreted by activated T-cells that indirectly promotes the maturation, chemotaxis and activation of neutrophils. We therefore hypothesized that IL-17 may be involved in the recruitment of neutrophils into the airways and that its mRNA expression would be increased in bronchoalveolar lavage (BAL) cells of horses with heaves. Heaves susceptible ... Read More
30
Report of the First International Workshop on Equine Leucocyte Antigens, Cambridge, UK, July 1991.
Veterinary immunology and immunopathology
July 1, 1994
Volume 42, Issue 1 3-60 doi: 10.1016/0165-2427(94)90088-4
Kydd J, Antczak DF, Allen WR, Barbis D, Butcher G, Davis W, Duffus WP, Edington N, Grünig G, Holmes MA.The First International Workshop on Equine Leucocyte Antigens was organized and convened for the purposes of identifying immunologically relevant cell surface molecules of equine leucocytes and establishing a system of nomenclature for those molecules. Participating members of the workshop represented the majority of laboratories world-wide engaged in the tasks of production and characterization of equine leucocyte and lymphocyte markers using monoclonal antibodies. The workshop confirmed the identification of several equine CD molecules described previously by individual laboratories, and in ... Read More
29
Replication of West Nile virus in equine peripheral blood mononuclear cells.
Veterinary immunology and immunopathology
November 28, 2005
Volume 110, Issue 3-4 229-244 doi: 10.1016/j.vetimm.2005.10.003
Garcia-Tapia D, Loiacono CM, Kleiboeker SB.A cell model of primary monocytes and other mononuclear cells isolated from equine blood was used to study the kinetics of West Nile virus (WNV) replication in a natural host. West Nile virus has emerged on the North American continent as a significant cause of morbidity and mortality in a wide range of avian and mammalian species. While other flaviviruses are known to infect monocytes and lymphocytes, the ability of WNV to productively replicate in specific immune cells of peripheral blood has not been assessed. In this study, enriched populations of monocytes and lymphocytes as well as purif... Read More
29
Allergen-specific IgE levels against crude mould and storage mite extracts and recombinant mould allergens in sera from horses affected with chronic bronchitis.
Veterinary immunology and immunopathology
March 14, 2000
Volume 73, Issue 3-4 241-253 doi: 10.1016/s0165-2427(00)00154-9
Eder C, Crameri R, Mayer C, Eicher R, Straub R, Gerber H, Lazary S, Marti E.Immunoglobulin E antibody (IgE) levels against four recombinant (r) mould allergens (r-Aspergillus fumigatus [rAsp f] 7, 8 and 9; r-Alternaria alternata 1 [rAlta1]) and crude mould (Aspergillus fumigatus, Alternaria alternata, Penicillium notatum) and storage mite extracts were determined by ELISA in sera from 24 pulmonary sound control horses and 26 horses suffering from chronic bronchitis/bronchiolitis (CB), also called chronic obstructive pulmonary disease (COPD). Serum IgG and IgA titres were also determined against Aspergillus fumigatus extract and rAsp f 8.IgE against the crude extracts ... Read More
26
Studies on pulmonary and systemic Aspergillus fumigatus-specific IgE and IgG antibodies in horses affected with chronic obstructive pulmonary disease (COPD).
Veterinary immunology and immunopathology
January 8, 1999
Volume 66, Issue 3-4 245-256 doi: 10.1016/s0165-2427(98)00202-5
Schmallenbach KH, Rahman I, Sasse HH, Dixon PM, Halliwell RE, McGorum BC, Crameri R, Miller HR.Inhalant exposure to Aspergillus fumigatus (Asp. f.) antigens induces marked inflammatory and immunological alterations in the lungs of horses affected with chronic obstructive pulmonary disease (COPD). In this study we investigated the role of specific allergen(s) present in Asp. f. on systemic and pulmonary IgE and IgG responses in control and COPD-affected horses, using an enzyme-linked immunosorbent assay (ELISA) and immunoblotting techniques. Compared with controls, horses affected with COPD had significantly higher levels of BALF IgE and IgG to somatic Asp. f. antigens as well as to the ... Read More
25
Role of p38 MAPK in LPS induced pro-inflammatory cytokine and chemokine gene expression in equine leukocytes.
Veterinary immunology and immunopathology
November 7, 2008
Volume 129, Issue 3-4 192-199 doi: 10.1016/j.vetimm.2008.11.006
Neuder LE, Keener JM, Eckert RE, Trujillo JC, Jones SL.Endotoxemia occurs when bacterial lipopolysaccharide (LPS) in the blood induces a dysregulated inflammatory response, resulting in circulatory shock and multi-organ failure. Laminitis is a common complication in endotoxemic horses and is frequently the reason for humane euthanasia of these cases. Blood leukocytes are a principal target of LPS in endotoxemia leading to activation of multiple signal transduction pathways involved in the induction of a number of pro-inflammatory genes. In other animal models, the p38 mitogen activated protein kinase (MAPK) pathway has been associated with induced... Read More
25
Evaluation of the systemic acute phase response and endometrial gene expression of serum amyloid A and pro- and anti-inflammatory cytokines in mares with experimentally induced endometritis.
Veterinary immunology and immunopathology
July 21, 2010
Volume 138, Issue 1-2 95-105 doi: 10.1016/j.vetimm.2010.07.011
Christoffersen M, Baagoe CD, Jacobsen S, Bojesen AM, Petersen MR, Lehn-Jensen H.Infectious infertility in the mare is clinically well described, little is however known about the systemic acute phase reaction (APR) and local immunological responses accompanying equine endometritis. The aim of this study was to monitor selected markers of the APR in the systemic circulation and to correlate them to the local innate immune response in the uterus during infectious endometritis. Six adult standard bred mares received an intrauterine infusion of 10(9)CFU Escherichia coli. Blood samples were obtained before (0 h) and 3, 6, 12, 24, 36, 48, 72, 96 and 120 h post inoculation (pi),... Read More
24
Immunological characterization of the equine airway epithelium and of a primary equine airway epithelial cell culture model.
Veterinary immunology and immunopathology
January 11, 2011
Volume 140, Issue 3-4 226-236 doi: 10.1016/j.vetimm.2010.12.008
Quintana AM, Landolt GA, Annis KM, Hussey GS.Our understanding of innate immunity within the equine respiratory tract is limited despite growing evidence for its key role in both the immediate defense and the shaping of downstream adaptive immune responses to respiratory disease. As the first interface to undergo pathogen invasion, the respiratory epithelium is a key player in these early events and our goal was to examine the innate immune characteristics of equine respiratory epithelia and compare them to an in vitro equine respiratory epithelial cell model cultured at the air-fluid interface (AFI). Respiratory epithelial tissues, isol... Read More
24
Characterization of peripheral blood and pulmonary leukocyte function in healthy foals.
Veterinary immunology and immunopathology
March 14, 2000
Volume 73, Issue 3-4 267-285 doi: 10.1016/s0165-2427(00)00149-5
Flaminio MJ, Rush BR, Davis EG, Hennessy K, Shuman W, Wilkerson MJ.Studies in infants and foals indicate an age-dependent maturation of peripheral lymphocyte subsets. The age-dependent relationship for maturation of cellular immune responses, such as phagocytosis and lymphocyte responses of the peripheral and pulmonary-derived leukocytes, has not been characterized in foals. Lymphocyte subpopulations, mitogen stimulation response of lymphocytes, lymphokine-activated killing cell activity, phagocytosis and oxidative burst activity, and serum immunoglobulin (Ig) classes G and M concentrations were determined in developing foals. This study illustrates age-depen... Read More
23
Monoclonal antibodies to equine CD23 identify the low-affinity receptor for IgE on subpopulations of IgM+ and IgG1+ B-cells in horses.
Veterinary immunology and immunopathology
February 18, 2012
Volume 146, Issue 2 125-134 doi: 10.1016/j.vetimm.2012.02.007
Wagner B, Hillegas JM, Babasyan S.CD23, also called FcεRII, is the low-affinity receptor for IgE and has first been described as a major receptor regulating IgE responses. In addition, CD23 also binds to CD21, integrins and MHC class II molecules and thus has a much wider functional role in immune regulation ranging from involvement in antigen-presentation to multiple cytokine-like functions of soluble CD23. The role of CD23 during immune responses of the horse is less well understood. Here, we expressed equine CD23 in mammalian cells using a novel IL-4 expression system. Expression resulted in high yield of recombinant IL-4/... Read More
23
Flow cytometric characterization of culture expanded multipotent mesenchymal stromal cells (MSCs) from horse adipose tissue: towards the definition of minimal stemness criteria.
Veterinary immunology and immunopathology
July 26, 2011
Volume 144, Issue 3-4 499-506 doi: 10.1016/j.vetimm.2011.07.017
Pascucci L, Curina G, Mercati F, Marini C, Dall'Aglio C, Paternesi B, Ceccarelli P.In the last decades, multipotent mesenchymal progenitor cells have been isolated from many adult tissues of different species. The International Society for Cellular Therapy (ISCT) has recently established that multipotent mesenchymal stromal cells (MSCs) is the currently recommended designation. In this study, we used flow cytometry to evaluate the expression of several molecules related to stemness (CD90, CD44, CD73 and STRO-1) in undifferentiated, early-passaged MSCs isolated from adipose tissue of four donor horses (AdMSCs). The four populations unanimously expressed high levels of CD90 an... Read More
23
Development of a multiplex assay for the detection of antibodies to Borrelia burgdorferi in horses and its validation using Bayesian and conventional statistical methods.
Veterinary immunology and immunopathology
August 17, 2011
Volume 144, Issue 3-4 374-381 doi: 10.1016/j.vetimm.2011.08.005
Wagner B, Freer H, Rollins A, Erb HN, Lu Z, Gröhn Y.Lyme disease is a zoonotic, vector-borne disease and occurs in mammals including horses. The disease is induced by infection with spirochetes of the Borrelia burgdorferi sensu lato group. Infection of mammalian hosts requires transmission of spirochetes by infected ticks during tick bites. Lyme disease diagnosis is based on clinical signs, possible exposure to infected ticks, and antibody testing which is traditionally performed by ELISA and Western blotting (WB). This report describes the development and validation of a new fluorescent bead-based multiplex assay for the detection of antibodie... Read More
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