Topic:Adverse Effects
Adverse effects in horses refer to unintended and potentially harmful outcomes that occur as a result of medical treatment, environmental exposure, or other interventions. These effects can impact various physiological systems and may manifest as behavioral changes, organ dysfunction, or other health-related issues. Monitoring and understanding adverse effects are important for ensuring the safety and well-being of horses, particularly in the context of veterinary medicine and equine management. This page gathers peer-reviewed research studies and scholarly articles that explore the causes, mechanisms, and implications of adverse effects in horses, offering insights into their identification, management, and prevention.
[Effect of tranquilizer doping on the muscular activity of the sport horse. II. — Diazepam (author’s transl)]. The practise of repeated doping of the sport horse led us to examine its effects on the health of the animal, and particularly on muscular activity. The main doping agent used at present (acepromazine) has already been studied (COURTOT et al., 1974). In this paper, we study the secondary effects of diazepam, a derivative of the benzodiazepine series, which is being used more and more frequently on horses. In treated animals as compared to controls, we observe: -- a slight respiratory depression related solely to effort, -- an increase in seric creatine phosphokinase rate with no apparent relat...
Field studies of an attenuated Venezuelan equine encephalomyelitis vaccine (strain TC-83). A series of field studies using strain TC-83 attenuated Venezuelan equine encephalomyelitis vaccine in horses was made to determine the rate of seroconversions, the postvaccination viremia, and the possibility of adverse reactions to the vaccine. The rate of seroconversions varied from 50% in one study to 91 and 100% in two others. The highest level of viremia measured was 7 x 10(3) to 8 x 10(3) plaqueforming units per ml. No adverse reactions to the vaccine were observed in any horses, including 42 pregnant mares and their resulting foals.
Comparative trial of three heterologous anti-tetanus sera. The three heterologous anti-sera currently provided for tetanus prophylaxis have been compared with reference to the production of untoward reactions in 498 patients, and to the blood antitoxin concentrations produced in 76 patients. Equine serum, although giving rise to more reactions, was the only effective agent in terms of the levels and duration of serum antitoxin concentration produced. The local response to a test dose of any of the three sera is not a reliable guide to immediate or late general reactions.
Cross-reactivity studies of horse, goat and rabbit anti-lymphocyte globulin. In the sera of ten normal humans and twenty-eight candidates for organ transplantation, the passive haemagglutination test detected a 50% incidence of preformed antibodies of low titre directed against horse serum. Such antibodies were also found to cross react with goat or rabbit sera in most instances. Seventeen of the organ recipients were later studied after the institution of treatment with horse antihuman-lymphocyte globulin (ALG). The incidence of anti-horse-serum antibodies rose to 100%. At the same time, an increased activity against goat serum developed; cross-reactions against rabbi...