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Topic:Alphavirus
Alphaviruses are a group of viruses transmitted primarily by mosquitoes and are known to cause disease in horses and humans. In equine populations, alphaviruses such as Eastern Equine Encephalitis Virus (EEEV), Western Equine Encephalitis Virus (WEEV), and Venezuelan Equine Encephalitis Virus (VEEV) are of particular concern due to their ability to cause severe neurological disease. Infection in horses can lead to symptoms ranging from fever and lethargy to more severe signs such as ataxia, paralysis, and encephalitis, often resulting in high mortality rates. Understanding the transmission dynamics, pathogenesis, and immune response in horses is crucial for developing effective prevention and control strategies. This page compiles peer-reviewed research studies and scholarly articles that explore the epidemiology, clinical presentation, diagnosis, and management of alphavirus infections in horses, as well as advancements in vaccine development and vector control methods.
Equine viral encephalitis. The most important neurotropic viral infections of the horse are the arthropod-borne encephalitides. These include Venezuelan encephalitis (VE), eastern encephalitis (EE) and western encephalitis (WE), which are found in the Americas, and Japanese B encephalitis which occurs in the Far East. All the viruses cause encephalitis in man. Between 1969 and 1972 an epidemic of VE occurred in Central America. In 1971 the disease was reported in Texas, where it was brought under control by the vaccination of susceptible horses with an attenuated live virus vaccine and by the reduction of the mosquito p...
Comparative analyses of members of the Venezuelan equine encephalomyelitis virus complex. Polyacrylamide gel electrophoretic examination of viruses selected from the Venezuelan equine encephalomyelitis (VEE) complex revealed distinct strain to strain differences in profiles of the two virion envelope proteins. The core protein was identical in all viruses tested. We detected five electrophoretic patterns into which the virus strains could be classified and these were designated alpha (alpha), beta (beta), gamma (gamma), delta (delta), and episolon (episolon). Isolates representing variant E of subtype I exhibited a profile characterized by only one apparent envelope band. The epizo...
Investigations on the presence of antibodies to several alphaviruses in humans and domestic animals of a region with elevated epidemiological potential. The paper reports on serological results obtained by HAI tests against several alphaviruses - eastern equine encephalitis (EEE), western equine encephalitis (WEE), Chikungunya, Midlebourg, Semliki Forest, Sindbis, and Ilheus viruses - carried out in humans and some domestic animals in a region with an intensive circulation of migratory birds. It was possible to detect in human antibodies to EEE, WEE, and Sindbis viruses, but in very low proportions (1.8%, 0.4%, and 0.6%, respectively). Serological results obtained in animals were practically negative: antibodies to EEE virus were found only in...
Hemagglutination-inhibition and serum neutralization response of horses to eastern equine encephalomyelitis virus. Four horses inoculated with EEE virus remained asymptomatic following injection but did develop measurable HI and neutralizing antibodies as a result of infection. HI antibodies were detectable earlier than neutralizing antibodies but the levels tended to drop more rapidly. 2. Of 14 horses and ponies having significant levels of neutralizing antibody, 5 to 9 had measurable HI antibody depending on number of units of antigen employed in the test. 3. Sera from 3 clinical cases of EEE were positive on the HI test while only one of these animals had a significant neutralizing antibody level.
The 1952 outbreak of encephalitis in California; epidemiologic aspects. For the most part, epidemiologic phenomena observed in the outbreak of encephalitis in 1952 accorded with patterns that had been apparent in previous years. Ninety-seven per cent of the 414 laboratory-confirmed cases of western equine and St. Louis encephalitis in humans occurred in the 20 Central Valley counties. The cases of western equine encephalomyelitis in horses were generally scattered over the state. In the Central Valley most of the cases in horses were in animals less than two years of age; elsewhere the incidence was higher in older horses.There were no laboratory-confirmed cases o...
