Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
Application of thermography in the assessment of physical effort on body surface temperature distribution in racehorses. The aim of this study was to evaluate the efficacy of thermography in assessing the impact of regular physical effort on changes in the body surface temperature of the upper body parts of young racehorses. The study involved monitoring 33 racehorses aged 3 years in 3 imaging sessions over a period of 3 months. Temperature measurements of the neck and upper part of the forelimbs and hindlimbs from both sides were taken just before and after training. Three regions of interest (ROIs) located at the base of the neck, elbow and quarter on both sides of the body were analysed. Before physical effor...
Pharmacodynamics and pharmacokinetics of rocuronium in sevoflurane-anesthetized Thoroughbred horses. To investigate the pharmacodynamics and pharmacokinetics of rocuronium administered by bolus injection to sevoflurane-anesthetized horses. Methods: Prospective, experimental, crossover study. Methods: Five healthy adult Thoroughbred horses (body mass 368-470 kg, three females and two males). Methods: Each horse was anesthetized twice with sevoflurane and assigned to be administered rocuronium bromide intravenously: 0.2 mg kg (R02) or 0.4 mg kg (R04). There was a minimum 2 week washout period between experiments. During anesthesia, the peroneal nerve was stimulated (train-of-four) and neuromusc...
Foals born alive from mares with ultrasonographically assessed placental abnormalities: Neonatal health and development up to weaning compared to foals from healthy mares. Little is known about the health status of foals born alive from mares treated for placental disease. The aims of the present study were (1) to compare the neonatal health status and health development during the rearing period of foals born from mares treated for ultrasonographically assessed placental abnormalities (UPA) to age-matched healthy foals from the same warmblood stud and (2) analyze the influence of mare's placental health on colostrum quality. Foals (n = 127) born from mares with UPA (UPA group; P) in 2017-2019 were compared to 127 foals born from healthy mares (control group; ...
Impact of musical rhythm on blood, physiological and welfare parameters in stabled horses. The aim of this study was to evaluate the effects of two styles of classical music, based on different tempos (BPM), on the physiological and blood parameters of horses during social isolation and restriction of movements. First experiment was carried out using nine horses of no defined breed, distributed in Control, Slow-tempo music and Moderate-tempo music .For social isolation and restriction of movement, the animals were housed daily in individual stalls for two hours and exposed to the stimuli for 60 min, and eye temperature, heart rate, and respiratory rate were assessed. The second exp...
Phosphorylation of SNW1 protein associated with equine melanocytic neoplasm identified in serum and feces. Equine melanocytic neoplasm (EMN) represents a form of skin tumor observed predominantly in grey horses aged over 15 years. Despite its prevalence, current therapeutic and preventive strategies for EMN have been subject to limited investigation. This study endeavors to shed light on potential phosphoproteins present in equine serum and fecal samples, potentially linked to EMN, with a specific focus on functional interactions in EMN pathogenesis. We examined 50 samples (25 serum, 25 feces), divided into three groups based on EMN severity: normal (n = 16), mild (n = 18), and severe EMN (...
Evaluation of Theileria equi vertical transmission rate and routes in a cohort of asymptomatic mares and their foals. Equine piroplasmosis is a tick-borne disease mainly caused by Theileria equi and Babesia caballi. The objectives of this study were to analyse the frequency and routes of vertical transmission of these blood parasites from 179 asymptomatic mares to their foals. Foals were sampled within 72 h post-partum. The seroprevalences determined by Indirect Immunofluorescent Antibody Test (IFAT) and based on a subset sample of 107 couples, were 59.8% and 42.1% for T. equi and B. caballi, respectively in the mare population, and 54.2% and 40.2% in the foal population. A species-specific nested PCR was per...
Emotional and Motor Improvements in Children With ADHD Following Equine-Assisted Occupational Therapy. Attention deficit/hyperactivity disorder (ADHD) is characterized by inattention, hyperactivity, and impulsivity, as children may present developmental and chronic impairments in cognitive-emotional and sensory-motor aspects. This study examined the changes in self-efficacy, muscle tone, and mood following a single session of Equine-Assisted Occupational Therapy (EAOT) within Attention Skills Therapy (ASTride) intervention, designed to improve emotional and cognitive functions. Notably, 31 children diagnosed with ADHD aged 6-12 (mean age 10.06) years. A preliminary study of pre- and post-single...
Effect of refrigeration, room temperature, and processing time on serum immunofluorescent antibody titers for Sarcocystis neurona. Evaluating antibody titers for Sarcocystis neurona for the diagnosis of equine protozoal myeloencephalitis from serum samples is a common practice. However, ensuring timely and proper refrigeration is not always possible. Objective: To evaluate immunofluorescent antibody (IFA) titers for S. neurona from serum samples stored at room temperature and 4°C. Methods: Twenty-two serum samples. Methods: Prospective longitudinal study. Two serum aliquots of 1 mL each were stored at room temperature (20-23.3°C) and 4°C. The unrefrigerated aliquot was immediately tested for IFA titers. Both aliquots...
Facial pressure beneath a cavesson noseband adjusted to different tightness levels during standing and chewing. Noseband adjustment should avoid discomfort and allow some jaw movement. Objective: To determine pressure beneath a cavesson noseband at five tightness levels during standing and chewing. It was hypothesised that increased noseband tightness is associated with increases in nasal and mandibular pressures while standing and chewing, accompanied by increases in eye temperature and blink rate. Methods: Experimental. Methods: Eight highly-trained dressage horses wore a snaffle bridle with their own bit. Pressure mats over the nasal bones and beneath the mandibular rami recorded sub-noseband pressur...
Effects of orally administered clioquinol on the fecal microbiome of horses. Whereas restoration of fecal consistency after treatment with clioquinol for chronic diarrhea and free fecal water syndrome has been attributed to its antiprotozoal properties, actions of clioquinol on the colonic bacterial microbiota have not been investigated. Objective: Characterize the dynamics of fecal microbial diversity before, during, and after PO administration of clioquinol to healthy horses. Methods: Experimental prospective cohort study using a single horse group. Methods: Eight healthy adult horses received PO clioquinol (10 g, daily) for 7 days. Feces were obtained daily for ...
Development of an ultrasound-guided proximo-medial approach for injection of the carpal flexor tendon sheath in horses and comparison with the conventional proximo-lateral ´blind` technique. The aim of this prospective case-control study was to describe and implement a reliable, accurate, and straightforward ultrasound-guided proximo-medial approach technique for injecting the carpal flexor tendon sheath in horses. The proximo-medial ultrasound-guided approach for intrathecal access to the carpal canal, as described in this study, was firstly developed on ten cadaveric limbs using an undiluted ionic iodinated contrast medium. Landmarks were identified, and the access point was established. Subsequently, the technique was validated in ten horses, and its efficacy was compared with ...
Comparison of end-to-side versus side-to-side jejunocecostomy in horses. To compare end-to-side (ES) and side-to-side (SS) jejunocecostomy (JC) in healthy horses. Methods: Experimental study in vivo. Methods: A total of 14 healthy adult horses underwent ventral midline celiotomy, a resection, and either an ES (n = 7) or stapled SS (n = 7) JC. Methods: Surgical times and the external lengths of completed anastomoses were measured. Physical examinations and pain scoring were performed every 6 h for 5 days, then once daily until euthanasia and necropsy 28 days postoperatively. Results: The anastomosis was completed more rapidly (p < .002) with the SS...
Alcohol-based antisepsis without the use of chlorhexidine for arthroscopy in horses. Alcohol-based antisepsis has shown experimentally to be as effective as 4% chlorhexidine gluconate (CHG) at reducing bacterial counts (colony forming units; CFU) on equine skin. Our objectives were to determine the immediate and post-surgical reduction in CFU/mL on equine skin prepared with CHG-based or 70% isopropyl alcohol (IPA)-based (without CHG) protocols in a clinical setting with arthroscopic surgery. Our hypotheses were that the logCFU/mL reduction would not significantly differ between protocols immediately after preparation or at the end of surgery. Six horses underwent a 40 min bila...
Prevalence of Lower Back Pain and Risk Factors in Equestrians: A Systematic Review. This systematic review aimed to determine the prevalence of lower back pain (LBP) in equestrian athletes (EAs) and identify associated risk factors. Following the PRISMA guidelines, observational studies published between 2004 and 2024 in English, Portuguese, Spanish, and German were included. The review identified relevant studies through the Web of Science, EBSCO, MEDLINE, and SCOPUS (last search performed on 30 October 2024), yielding 14 studies with a total of 4527 participants. The question format for the included studies specified the population as equestrian athletes, the exposure as eq...
A Prioritized List of Veterinary Clinical Presentations in Dogs, Cats, and Horses to Guide Curricular Content, Design, and Assessment. The Association of American Veterinary Medical Colleges competency-based veterinary education (CBVE) framework can be used to guide curriculum and assessment design and is intended to prepare veterinary graduates for Day One of clinical practice. However, while the framework defines curricular outcomes in terms of demonstrable competencies, it does not define the specific knowledge, skills, and attitudes required to achieve those outcomes. In some human medical curricula, prioritized lists of clinical presentations guide curricular content, design, and assessment. These lists are based, in par...
Retrospective cohort study on diseases and risk factors associated with death in hospitalized neonatal foals. The care of sick neonatal foals is labor-intensive and costly. Prediction of risk of death upon admission is often difficult but might support decision-making. Objective: To determine diseases and risk factors associated with death in neonatal hospitalized foals. Methods: Two hundred twenty-two hospitalized foals, ≤7 days old. Methods: Retrospective cohort study. Clinical and laboratory variables were evaluated for their association with death by means of Cox survival analysis and by classification and regression tree (CART) analysis. Results: Most prevalent diseases were sepsis (43.9%), e...
Factors affecting survival of foals with pneumonia in a referral hospital. Pneumonia is a common condition in ailing neonatal foals, and it remains an important cause of morbidity and mortality in this veterinary patient group. Factors affecting the survival of young foals with pneumonia have not been thoroughly investigated. The aim of this study was to explore the potential prognostic factors associated with survival of these foals. Fifty foals under one month of age with pneumonia were included in this retrospective clinical study. The foals were divided into groups based on survival (survived to discharge or died/euthanised during hospitalisation). Multiple clini...
Effect of Bio-Electro-Magnetic-Energy-Regulation (BEMER) Horse Therapy on Cardiopulmonary Function and Recovery Quality After Isoflurane Anesthesia in 100 Horses Subjected to Pars-Plana Vitrectomy: An Investigator-Blinded Clinical Study. The use of Bio-Electro-Magnetic-Energy-Regulation (BEMER) therapy during general anesthesia has not previously been reported in horses. This randomized, investigator-blinded, placebo-controlled trial evaluates equine cardiopulmonary function and recovery quality after BEMER therapy application for 15 min in 100 horses during general anesthesia using isoflurane for pars-plana vitrectomy surgery as treatment for recurrent uveitis. Visually identical blankets were used in the two groups (1:1 ratio), one with a functional BEMER module and the other with a placebo module. Arterial blood pressure, b...
Temporal kinetics of serum amyloid A (SAA) concentration and identification of SAA isoforms in blood and synovial fluid of horses with experimentally induced septic arthritis, non-septic synovitis, and systemic inflammation. Prompt diagnosis of equine septic arthritis is crucial for successful treatment. Serum amyloid A (SAA) has been suggested as a reliable biomarker. However, we previously found that synovial fluid SAA increases in nonaffected joints of horses with septic arthritis. We hypothesized that systemic SAA may leak into the nonaffected joints. If this is the case, we also hypothesized that locally produced joint SAA isoforms may be better candidates for septic arthritis biomarkers. Thus, our objectives were 1) to evaluate the temporal kinetics of systemic and synovial fluid SAA in horses with septic ar...
Clinical application and prognostic value of computed tomography examination in foals diagnosed with osteomyelitis: Forty-four cases. Computed tomography (CT) is increasingly recognized as superior to conventional imaging methods for diagnosing osteomyelitis in foals. However, comprehensive studies in this area are limited. This study aims to report on clinical cases of osteomyelitis in foals, establishing a relationship between CT findings and survival outcomes. Additionally, it compares CT imaging with conventional methods such as radiography and ultrasound. We hypothesized that CT variables would more accurately predict survival than other clinical factors and provide more detailed information about osteomyelitis lesions....
Clinical application and prognostic value of computed tomography examination in foals diagnosed with osteomyelitis: Forty-four cases. Computed tomography (CT) is increasingly recognized as superior to conventional imaging methods for diagnosing osteomyelitis in foals. However, comprehensive studies in this area are limited. This study aims to report on clinical cases of osteomyelitis in foals, establishing a relationship between CT findings and survival outcomes. Additionally, it compares CT imaging with conventional methods such as radiography and ultrasound. We hypothesized that CT variables would more accurately predict survival than other clinical factors and provide more detailed information about osteomyelitis lesions....
Electrochemotherapy with bleomycin for bilateral ocular squamous cell carcinoma in a horse. To describe the procedure and outcome of electrochemotherapy (ECT) with bleomycin as a first-line treatment for bilateral ocular surface squamous neoplasia (OSSN) in the eye of a horse. Methods: A client-owned 5-year-old Haflinger gelding with limbal-conjunctival squamous cell carcinoma. Methods: During general and local anesthesia, injection of bleomycin in the ocular tumor was followed by electroporation, applied with a 15 mm needle electrode, needles held parallel to the ocular surface. Results: Treatment with ECT resulted in therapeutic electric pulses and complete tumor response with no...
Electrochemotherapy with bleomycin for bilateral ocular squamous cell carcinoma in a horse. To describe the procedure and outcome of electrochemotherapy (ECT) with bleomycin as a first-line treatment for bilateral ocular surface squamous neoplasia (OSSN) in the eye of a horse. Methods: A client-owned 5-year-old Haflinger gelding with limbal-conjunctival squamous cell carcinoma. Methods: During general and local anesthesia, injection of bleomycin in the ocular tumor was followed by electroporation, applied with a 15 mm needle electrode, needles held parallel to the ocular surface. Results: Treatment with ECT resulted in therapeutic electric pulses and complete tumor response with no...
An ongoing concern: 20 years of research on equine atypical myopathy. Anne-Christine François, Benoît Renaud, Caroline-Julia Kruse, Christel Marcillaud-Pitel and Dominique-Marie Votion of the Atypical Myopathy Alert Group discuss insights from 20 years of research and surveillance on equine atypical myopathy.
Pilot study characterizing a single pooled preparation of equine platelet lysate for nebulization in the horse. Platelet lysate (PL) demonstrates antimicrobial and anti-inflammatory properties offering potential for treatment of bacterial pneumonia in horses. It remains unknown whether nebulization is suitable for PL administration in horses. This pilot study characterized particle size and flow rate of pooled equine PL (single preparation) nebulized using an equine-specific nebulizer (Flexivent®). Unassigned: Protein composition and antimicrobial activity were compared before and after nebulization. Protein composition was evaluated according to growth factor, antimicrobial peptide and cytokine concen...
Role of cannabidiolic acid or the combination of cannabigerol/cannabidiol in pain modulation and welfare improvement in horses with chronic osteoarthritis. Cannabidiol (CBD) is a non-psychotropic cannabinoid obtained from hemp (Cannabis sativa L.) used for pain management in companion animals including horses. The present study aimed to evaluate the efficacy of cannabidiolic acid (CBDA) and cannabigerol/cannabidiol oil (CBG/CBD) oral administration in alleviating pain in adult horses affected by chronic osteoarthritis (OA). Twenty-four horses (10 geldings and 14 mares), aged between 11 and 18 years old, were equally divided into two groups. One group received CBDA 15% oil and the other group received CBG/CBD oil (CBG20%-CBD10%) for 14 consecuti...
Effects of Porcine Zona Pellucida Immunocontraception on Mare Body Condition and Foaling Season Length in Two Western Wild Horse Populations. Wildlife managers and the public have expressed considerable interest in the use of contraception to help manage the populations of wild horses and burros (Equus caballus and E. asinus). Field testing has shown that two preparations of the porcine zona pellucida (PZP) vaccine, a simple emulsion (ZonaStat-H) and PZP-22 (which supplements ZonaStat-H with a controlled-release component) effectively prevent pregnancy in individual mares and can substantially reduce population foaling rates. To determine whether some PZP preparations might have secondary effects that harm treated mares or their foa...
Promoting mental health in military veterans. Methodology and evaluation tools in a pilot study involving an Equine-Assisted Intervention. Military veterans exposed to stressful or traumatic events may experience adjustment difficulties in the post-deployment period, developing a high risk of mental health-related issues. Promising complementary practices such as Equine-Assisted Therapy (EAT) are now widely used, although standardized protocols are missing. The present study aimed to develop an EAT standardized intervention. Methods: A total of 16 veterans were enrolled for the study (11 veterans for the EAT group and 5 veterans for the control group). The EAT lasted 9 months and both a quantitative (State-Trait Anxiety Inventory...
Efficacy of 0.2% povidone-iodine and 0.1% polyhexamethylene biguanide as preoperative antiseptics in equine ophthalmic procedures. This retrospective study evaluates the efficacy of povidone-iodine (PI) and polyhexamethylene biguanide (PHMB) as preoperative antiseptics in equine ophthalmic procedures. Methods: Horses that underwent routine ophthalmic surgery and procedures. Methods: Data were collected retrospectively from the medical records of equine patients undergoing ophthalmic procedures. Inclusion criteria were sampling for aerobic microbial culture at three different time points (T0: pre-irrigation, T1: post-irrigation, and T2: postoperatively) and T0 showing bacterial growth. Microbiological outcomes were assesse...
Effectiveness of Equine-Assisted Activities and Therapies for Children with Autism Spectrum Disorder: An Update. Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition requiring personalised therapeutic approaches. This study evaluated the effectiveness of Equine-Assisted Activities and Therapies (EAATs) in 86 children with varying ASD severity levels (levels 1-3). Methods: Vineland Adaptive Behaviour Scales and the Parenting Stress Index were used. Between May 2022 and October 2023, participants completed 20 weekly sessions of 45 min each, tailored to their individual needs. Results: Children with level 3 ASD demonstrated greater challenges in communication (level 1: 67.1 ± 29.0 vs. l...
