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Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
Enteroliths and other foreign bodies. This article focuses on obstructive diseases of the large intestine (large and small colons) caused by intraluminal bodies. Large intestinal obstructions from intraluminal bodies can be divided into the following categories: enteroliths or mineral concretions, bezoars (hair or plant material), and ingested foreign objects. Clinical presentation and treatment of obstructive diseases are presented in this article and are similar regardless of the cause.
Prognosticating equine colic. Prognosticating survival in horses with colic is challenging because of the number of diseases and pathophysiologic processes that can cause the behavior. Although the treatment of horses with colic has improved dramatically over the years, case fatality can still be high because of the delay in recognizing the problem, the time delay inherent in receiving veterinary care, and the lack of effective treatment for the more severe diseases. Intensive case management and surgery for these horses may be expensive and emotionally draining for owners; therefore, providing an accurate prognosis is key...
Update on treatments for endotoxemia. Endotoxemia is a major cause of morbidity and mortality in horses affected by colic. This article briefly reviews the pathogenesis of endotoxemia in horses with colic, reviews current established treatments, and describes new advances in the treatment of endotoxemia.
New perspectives in equine gastric ulcer syndrome. Equine gastric ulcer syndrome (EGUS) is common in horses. A history of mild intermitted recurrent colic signs after eating is noted in many horses. Management of horses with abdominal pain caused by gastric ulcers is especially difficult, because non-steroidal anti-inflammatory agents, typically used to control abdominal pain, may exacerbate this condition. Effective pharmacologic agents are available to treat EGUS and eliminate abdominal pain, but more comprehensive measures of environmental and dietary management are needed to manage horses with EGUS and prevent recurrence. This article focu...
Impactions of the small and large intestines. Impactions of the small and large intestines are frequently diagnosed as the cause of colic in horses. An impaction is an accumulation of dehydrated ingesta in a portion of the digestive tract, typically at sites where the intestinal diameter decreases. The specific pathogenesis for impactions is not fully understood, although risk factors have been identified for several types of impactions. Treatment for impactions includes withholding feed until the impaction passes, rehydrating the ingesta, and, if necessary, administering analgesic agents. In severe cases, surgery may be necessary to reli...
Inflammatory bowel disease in horses. This article discusses types of inflammatory bowel disease in horses, including pathologic findings and proposed causes. The diagnosis of inflammatory bowel disease is presented in detail, including minimum database, rectal palpation, abdominal ultrasound, abdominocentesis, biopsy procedures, and absorption tests. Treatment recommendations and prognosis are also discussed.
Comparison of analyses of respiratory gases made with the K4b2 portable and Quark laboratory analysers in horses. Measurements of minute ventilation (VE) and expired oxygen and carbon dioxide fractions (FeO2 and FeCO2) were measured at rest and during exercise in seven warmblood horses performing two consecutive standardised incremental treadmill exercise tests at submaximal speed, using the portable K4b2 telemetric unit and the laboratory Quark metabolic cart in random order. Oxygen consumption (VO2) and carbon dioxide production (VCO2) were estimated using the Haldane equation. There were no significant differences between the measurements made with the two devices. However, VE was overestimated when th...
Changes in dynamic trunk/head stability and functional reach after hippotherapy. To determine if hippotherapy (therapy using a horse) improves head/trunk stability and upper extremity (UE) reaching/targeting in children with spastic diplegia cerebral palsy (SDCP). Methods: Pre-postoperative follow-up with a 12-week intervention and 12-week washout period after intervention. Methods: A human performance laboratory with 6 camera video motion capture systems for testing. Methods: Eleven children (age 5-13y, average 8y) with SDCP, 8 children (age 5-13y, average 8y) without disabilities. Methods: Hippotherapy intervention performed at 3 therapeutic horseback riding centers. Met...
Treatment of a periarticular tibial fracture in a foal with a hybrid external fixator. To report repair of a right proximal tibial Salter-Harris type II fracture in a foal with a hybrid external fixator (HEF). Methods: Case report. Methods: A 5-month-old male foal. Methods: After open surgical reduction, an HEF built with wires, 2 half-rings, 3 half-threaded connecting rods, and Schanz pins was used to stabilize the fracture. Results: Immediately after surgery, the foal had relatively good weight bearing. The HEF was removed at 60 days after radiographic confirmation of healing. Conclusions: HEF can be used to stabilize a proximal tibial Salter-Harris type II fracture in a 5-mon...
Arthroscopic removal of metallic foreign body from the talocrural joint using a magnetic retriever in a horse. To report use of a magnetic retriever for arthroscopic removal of a metallic foreign body from the equine talocrural joint. Methods: Clinical report. Methods: A 2-year-old Warmblood stallion. Methods: A metallic foreign body was removed from a talocrural joint using a 10-mm magnetic retriever under arthroscopic guidance. Preoperative radiographs were used to locate the intra-articular position of the foreign body. Results: Six months after surgery, the horse was no longer lame. Conclusions: A magnetic retriever can be used for arthroscopic removal of metallic foreign bodies from the equine tal...
Use of computed tomography in standing position to identify guidelines for screw insertion in the distal phalanx of horses: an ex vivo study. To compare the precision of radiography and computed tomography (CT) preoperatively in the standing position for identification of guidelines for screw insertion in the distal phalanx, and to identify whether standing CT might improve operative time compared with preoperative radiographic planning. Methods: Experimental ex vivo study. Methods: Cadaveric equine thoracic limb pairs (n=10). Methods: Insertion of a 4.5 mm cortex screw in lag fashion into an intact distal phalanx was evaluated in 2 groups (n=10) of cadaveric equine thoracic limbs. In 1 group, the site, direction, and length of the ...
Laparoscopic mesh incisional hernioplasty in five horses. To report a technique for incisional hernioplasty in horses using laparoscopic placement of a prosthetic mesh. Methods: Case series. Methods: Horses (n=5) with ventral median abdominal incisional hernia. Methods: A telescope and 2 instrument portals were established bilaterally, lateral to and distant from the hernia margins. After exposure of the internal rectus sheath by removal of retroperitoneal fat with endoscopic scissors and monopolar cautery, a prosthetic mesh was introduced into the abdomen and secured intraperitoneally using transfascial sutures with or without supplemental endoscopi...
A tangential radiographic projection for investigation of the equine temporomandibular joint. To (1) describe a tangential radiographic projection of the equine temporomandibular joint (TMJ) and (2) optimize the radiographic angle and determine its use in standing sedated horses. Methods: Descriptive study. Methods: Cadaveric equine skulls (n=11); 8 horses with a history of quidding or headshaking. Methods: Tangential radiographic projections were taken of a TMJ of a cadaveric skull before and after intra-articular injection of radiographic contrast. Additional tangential radiographic projections were taken after TMJ dissection and placement of a wire along the articular surface of the...
Surgical treatment of gastric outflow obstruction in 40 foals. To report short- and long-term survival and factors affecting outcome of foals after surgical correction of gastric outflow obstruction. Methods: Case series. Methods: Foals (n=40) aged 5-180 days. Methods: Clinical signs, laboratory data, diagnostic imaging, surgical findings, surgical procedures, medical treatment, and necropsy findings were retrieved from medical records. Outcome was obtained by reviewing performance, sales, and produce records or by telephone conversations with the owners. Results: Gastric outflow obstruction was treated by gastroduodenostomy or by gastrojejunostomy with o...
Freezing equine semen: the effect of combinations of semen extenders and glycerol on post-thaw motility. We evaluated combinations of two commercial semen extenders and three concentrations of glycerol to determine the combination that yielded the highest post-thaw sperm motility. Methods: A randomised 2 x 3 block design was used. Methods: Semen was collected from four stallions (6 collections per stallion). The sample was diluted with either a dried skim-milk glucose extender (EZ Mixin Original Formula) or a chemically defined, milk-free diluent (INRA 96), and each was used in combination with 2%, 3% or 4% glycerol in standard commercial freezing medium. Sperm motility was assessed by microscopy...
Comparison of the diagnostic value of ultrasonography and standing radiography for pelvic-femoral disorders in horses. To assess agreement between ultrasonography (transcutaneous and transrectal) and standing radiography in horses with fractures in the pelvic region and disorders of the coxofemoral joint. Methods: Case series. Methods: Warmblood horses (n=23) and 2 ponies. Methods: Medical records (1999-2008) of equids with pelvic or coxofemoral disorders that had pelvic radiography and ultrasonography were retrieved and results of both techniques compared. Results: Radiography and ultrasonography each identified equal numbers of fractures of the tuber coxa (n=4), ilial shaft (2), ischium (3), femoral neck (2)...
Prevalence of and risk factors for postoperative ileus after small intestinal surgery in two hundred and thirty-three horses. To determine the incidence of postoperative ileus (POI) in a population of horses after small intestinal surgery and the effect of multiple variables on development of POI. Methods: Case series. Methods: Horses (n=233) aged > or =1 year that had exploratory celiotomy for small intestinal disease that recovered from surgery from 1995 to 2005. Methods: Sixty-eight variables were collected from medical records (1995-2005) for each horse. POI was defined as nasogastric reflux volume >20 L over 24 hours or >8 L at any single time after surgery. Results: Twenty-seven percent (64/233) of hor...
Comparison of sinoscopic techniques for examining the rostral maxillary and ventral conchal sinuses of horses. To develop a reliable technique for sinoscopic examination of the ventral conchal (VCS) and rostral maxillary sinuses (RMS) of horses Methods: Descriptive study Methods: Cadaveric equine heads (n=40) Methods: The VCS and RMS were examined endoscopically using: (1) rostral trephination of the RMS (rostral RMS approach); (2) caudal trephination of the RMS (caudal RMS approach); (3) conchofrontal sinus (CFS) trephination followed by RMS trephination at a site identified by endoscopic transillumination of the maxillary bone at the most rostral aspect of the caudal maxillary sinus (CMS) (light-indi...
Stereoselective pharmacokinetics of ketamine and norketamine after constant rate infusion of a subanesthetic dose of racemic ketamine or S-ketamine in Shetland ponies. To evaluate pharmacokinetics of ketamine and norketamine enantiomers after constant rate infusion (CRI) of a subanesthetic dose of racemic ketamine or S-ketamine in ponies. Methods: Five 6-year-old Shetland pony geldings that weighed between 101 and 152 kg. Methods: In a crossover study, each pony received a CRI of racemic ketamine (loading dose, 0.6 mg/kg; CRI, 0.02 mg/kg/min) and S-ketamine (loading dose, 0.3 mg/kg; CRI, 0.01 mg/kg/min), with a 1-month interval between treatments. Arterial blood samples were collected before and at 5, 15, 30, 45, and 60 minutes during drug administration and...
Use of epidurally derived evoked potentials for quantification of caudal nociception in ponies. To determine whether epidurally derived evoked potentials (EPs) can be used to reliably assess nociception and antinociception in ponies. Methods: 7 ponies. Methods: EPs and electromyograms (EMGs) from the quadriceps femoris muscles were recorded simultaneously, following electrical stimulation applied to the distal portion of the hind limb. The effect of increasing stimulus intensity, conduction velocities of the stimulated nerves, effect of epidurally applied methadone, and effect of systemically administered propofol were evaluated. Results: In the EP and EMG waveforms, 2 distinct complexes...
Peritoneal D-dimer concentration for assessing peritoneal fibrinolytic activity in horses with colic. Plasma D-dimer concentration is a useful marker to assess systemic coagulation and fibrinolytic activities in humans, dogs, and horses. Peritoneal fibrinolytic activity increases in horses with colic, especially in horses with endotoxin in the peritoneal fluid. Objective: Peritoneal D-dimer concentration can be used to assess peritoneal fibrinolytic activity in horses with severe gastrointestinal (GI) disorders and altered peritoneal fluid. Methods: Two hundred and twenty-one colic horses and 15 control horses. Methods: Prospective observational clinical study. Blood and peritoneal fluid were ...
Efficacy of furosemide for prevention of exercise-induced pulmonary hemorrhage in Thoroughbred racehorses. To evaluate the efficacy of furosemide for prevention of exercise-induced pulmonary hemorrhage (EIPH) in Thoroughbred racehorses under typical racing conditions. Methods: Randomized, placebo-controlled, blinded, crossover field trial. Methods: 167 Thoroughbred racehorses. Methods: Horses were allocated to race fields of 9 to 16 horses each and raced twice, 1 week apart, with each of the 2 races consisting of the same race field and distance. Each horse received furosemide (500 mg, IV) before one race and a placebo (saline solution) before the other, with the order of treatments randomly determ...
Comparison of ultrasonography versus radiography for the diagnosis of dorsal fragmentation of the metacarpophalangeal or metatarsophalangeal joint in horses. To compare clinical usefulness of ultrasonography versus radiography for detection of fragmentation of the dorsal aspect of the metacarpophalangeal (MCP) and metatarsophalangeal (MTP) joints in horses. Methods: Cross-sectional study. Methods: 36 horses with fragmentation of the MCP (n = 19) and MTP (29) joints. Methods: In all joints, radiography (4 standard projections) and ultrasonography were performed prior to arthroscopic examination and fragment removal. Number and location of fragments identified radiographically and ultrasonographically were compared with arthroscopic findings. Results...
Evaluation of pain and inflammation associated with hot iron branding and microchip transponder injection in horses. To compare effects of hot iron branding and microchip transponder injection regarding aversive behavioral reactions indicative of pain and inflammation in horses. Methods: 7 adult horses. Methods: In a randomized controlled clinical crossover study, behavioral reactions to hot iron branding and microchip transponder injection were scored by 4 observers. Local and systemic inflammation including allodynia were assessed and compared by use of physiologic and biochemical responses obtained repeatedly for the 168-hour study period. Serum cortisol concentration was measured repeatedly throughout th...
