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Topic:Disease Management

Disease management in horses encompasses the strategies and practices employed to prevent, control, and treat diseases affecting equine populations. This field involves understanding the etiology, transmission, and clinical presentation of various equine diseases, as well as implementing biosecurity measures and therapeutic interventions. Common diseases in horses include equine influenza, strangles, and equine herpesvirus. Effective disease management relies on accurate diagnosis, vaccination protocols, and the use of antimicrobials and other treatments. This page compiles peer-reviewed research studies and scholarly articles that explore the methodologies, challenges, and advancements in managing diseases in equine health.
Evaluation of Strategies to Reduce Equine Strongyle Infective Larvae on Pasture and Study of Larval Migration and Overwintering in a Nordic Climate.
Animals : an open access journal from MDPI    November 10, 2022   Volume 12, Issue 22 3093 doi: 10.3390/ani12223093
Osterman-Lind E, Hedberg Alm Y, Hassler H, Wilderoth H, Thorolfson H, Tydén E.Horses, as grazing animals, are inadvertently exposed to intestinal parasites that, if not controlled, may cause disease. However, the indiscriminate use of anthelmintic drugs has led to drug resistance, highlighting the need for pasture-management practices to reduce the level of parasitic exposure and lessen reliance on drugs. The efficacy of such methods depends both on the epidemiology of the parasites and the prevailing weather conditions. The aim of the study was to investigate the effect of faecal removal and harrowing on reducing the number of parasite larvae in herbage. Moreover, the ...
Clinical predictive models in equine medicine: A systematic review.
Equine veterinary journal    November 8, 2022   Volume 55, Issue 4 573-583 doi: 10.1111/evj.13880
Cummings CO, Krucik DDR, Price E.Clinical predictive models use a patient's baseline demographic and clinical data to make predictions about patient outcomes and have the potential to aid clinical decision making. The extent of equine clinical predictive models is unknown in the literature. Using PubMed and Google Scholar, we systematically reviewed the predictive models currently described for use in equine patients. Models were eligible for inclusion if they were published in a peer-reviewed article as a multivariable model used to predict a clinical/laboratory/imaging outcome in an individual horse or herd. The agreement o...
Exploring human behavior change in equine welfare: Insights from a COM-B analysis of the UK’s equine obesity epidemic.
Frontiers in veterinary science    November 8, 2022   Volume 9 961537 doi: 10.3389/fvets.2022.961537
Furtado T, Perkins E, Pinchbeck G, McGowan C, Watkins F, Christley R.While equine obesity is understood by equine professionals to be a serious and widespread welfare problem, thus far approaches to reducing the prevalence of obesity in the UK's leisure horses have mainly been limited to educating owners about the dangers of obesity in their horses. In human health, approaches to behavior change encourage holistic thinking around human behavior, recognizing the importance of the connection between the individuals' knowledge, attitudes, habits, and the social and physical environments. This study used qualitative data from interviews with horse owners and profes...
Use of serum amyloid A in equine medicine and surgery.
Veterinary clinical pathology    November 6, 2022   Volume 52 Suppl 1 8-18 doi: 10.1111/vcp.13195
Jacobsen S.Serum amyloid A (SAA) has become an indispensable part of the management of equine patients in general practice and specialized hospital settings. Although several proteins possess acute phase properties in horses, the usefulness of SAA exceeds that of other acute phase proteins. This is due to the highly desirable kinetics of the equine SAA response. SAA concentrations exhibit a rapid and pronounced increase in response to inflammation and a rapid decline after the resolution of inflammation. This facilitates the detection of inflammatory disease and real-time monitoring of inflammatory activ...
Interventions for treatment of cutaneous melanoma in horses: a structured literature review.
Veterinary research communications    November 4, 2022   Volume 47, Issue 2 347-360 doi: 10.1007/s11259-022-10023-8
Yi Z, Gao Y, Yu F, Zhu Y, Liu H, Li J, Murua Escobar H.Several therapies have been developed to treat equine cutaneous melanoma, but formal comparisons among different treatment options are currently unavailable. It was our intent to assess the efficacy of different treatment protocols and the quality of the studies based on the original published data, and summarize the knowledge concerning the outcome after equine cutaneous melanoma management. This structured review followed PRISMA procedure to search for treatment protocols on equine cutaneous melanoma published from 1960 until June 2021. Studies were assessed for the risk of bias. A descripti...
Race-Level Reporting of Incidents Using an Online System during Three Seasons (2019/2020-2021/2022) of Thoroughbred Flat Racing in New Zealand.
Animals : an open access journal from MDPI    November 3, 2022   Volume 12, Issue 21 3028 doi: 10.3390/ani12213028
Gibson MJ, Legg KA, Gee EK, Rogers CW.In the 2019/20 Thoroughbred racing season, the paper-based reporting process of stipendiary steward reports was upgraded to an online system ('Infohorse database') to allow for the rapid entry of precise event and injury data. The objectives of this study were to describe the incident and non-incident examinations during the 2019/20, 2020/21, and 2021/22 Thoroughbred flat racing seasons in New Zealand and describe the primary injury and reporting outcomes. The introduction of the online system was associated with fewer miscoding events with horse identification (0.1%). An improvement in the de...
Use of antimicrobials licensed for systemic administration in UK equine practice.
Equine veterinary journal    November 2, 2022   Volume 55, Issue 5 808-819 doi: 10.1111/evj.13878
Allen SE, Verheyen KLP, O'Neill DG, Brodbelt DC.Judicious antimicrobial use (AMU) is important for preserving therapeutic effectiveness. Large-scale studies of antimicrobial prescribing can provide clinical benchmarks and help identify opportunities for improved stewardship. Objective: To describe systemic AMU in UK equine practice and identify factors associated with systemic and Category B (third and fourth generation cephalosporins, quinolones and polymixins) AMU. Methods: Retrospective cohort. Methods: Anonymised electronic patient records (EPRs) for all equids attended by 39 UK veterinary practices between 1 January and 31 December 201...
Multivariable analysis to determine risk factors associated with abortion in mares.
Reproduction & fertility    November 1, 2022   Volume 3, Issue 4 301-312 doi: 10.1530/RAF-22-0087
Roach J, Arango Sabogal JC, Smith K, Foote A, Verheyen K, de Mestre AM.Risk factors associated with equine reproductive efficiency have been identified along with those associated specifically with early pregnancy loss (EPL). In contrast, no studies have reported risk factors associated with abortion (loss between day 70 and 300 post-cover). Given the causes of abortion differ to those of EPL, likely too will the risk factors. A retrospective cohort study was carried out to identify risk factors associated with abortion in UK and Irish based Thoroughbreds, collecting data on 20 exposure variables over a five-year period. A generalized linear mixed model was utili...
Novel equi merozoite antigen (ema-1) gene heterogeneity in a geographically isolated Theileria equi population in Croatia.
Parasites & vectors    October 31, 2022   Volume 15, Issue 1 401 doi: 10.1186/s13071-022-05484-4
Coultous R, Gotić J, McCann M, Sutton D, Beck R, Shiels B.The apicomplexan haemoparasite Theileria equi, a causative agent of equine piroplasmosis, is an established pathogen of significant welfare and economic concern within the Croatian equine population. A previous large surveillance study of T. equi has identified two distinct parasite populations, one in the north and one in the south, geographically separated by the Dinaric Alps, which traverse the country. This study aimed to further investigate the genetic diversity within these two populations, focussing on allelic variability of the equi merozoite antigen gene, ema-1. Methods: Following nes...
Equine shock wave therapy – where are we now?
Equine veterinary journal    October 28, 2022   Volume 55, Issue 4 593-606 doi: 10.1111/evj.13890
Johnson SA, Richards RB, Frisbie DD, Esselman AM, McClure SR.Over the past three decades, electrohydraulic extracorporeal shock wave therapy (ESWT) as a treatment modality for equine orthopaedic disorders has sparked exponential interest among practitioners, but its clinical applications are quickly evolving and a current review highlighting modernised equine clinical use is lacking. The objective of this review is to summarise the most current ESWT technology, evidence for its use, proposed mechanisms of action and clinical applications in horses while also highlighting the areas requiring further investigation. The three ways to generate a shock wave ...
Anthelmintic resistance in equine nematodes: Current status and emerging trends.
International journal for parasitology. Drugs and drug resistance    October 26, 2022   Volume 20 76-88 doi: 10.1016/j.ijpddr.2022.10.005
Nielsen MK.Anthelmintic resistance is reported in equine nematodes with increasing frequency in recent years, and no new anthelmintic classes have been introduced during the past 40 years. This manuscript reviews published literature describing anthelmintic resistance in cyathostomins, Parascaris spp., and Oxyuris equi with special emphasis on larvicidal efficacy against encysted cyathostomin larvae and strongylid egg reappearance periods (ERP). Resistance to benzimidazoles and pyrimidines is highly prevalent in cyathostomin populations around the world, and macrocyclic lactone resistance has been docume...
Enterococcus durans infection and diarrhea in Thoroughbred foals.
Journal of veterinary internal medicine    October 26, 2022   Volume 36, Issue 6 2224-2229 doi: 10.1111/jvim.16568
Williams NJ, Slovis NM, Browne NS, Troedsson MHT, Giguėre S, Hernandez JA.Diarrhea remains an important cause of morbidity and mortality in neonatal foals, and correct identification of etiologic agents is essential for effective disease management. Objective: To examine the association between diarrhea and detection of Enterococcus durans or other enteropathogens in neonatal foals on 1 breeding farm in Kentucky, USA. Methods: Fifty-nine Thoroughbred foals and their broodmares. Methods: Prospective observational study. Study foals and broodmares were sampled and tested for E. durans and other enteropathogens during the first 10 days after foaling. The frequency of...
Race-Level Reporting of Incidents Using the New Online System During Two Seasons (2019/2020-2020/2021) of Harness Racing in New Zealand.
Journal of equine veterinary science    October 20, 2022   Volume 119 104142 doi: 10.1016/j.jevs.2022.104142
Gibson MJ, Legg KA, Gee EK, Rogers CW.After establishing a baseline of stipendiary stewards' reporting using the paper-based system in the 2015/16 and 2016/17 seasons of harness racing, it is important to examine if the implementation of an online system has altered frequency and descriptors used for clinical outcomes. The objective of this study was to describe the race level injury and reporting outcomes, and horse- and race-level variables associated with the rate of the reporting of these outcomes during the 2019/20 and2020/21 harness racing seasons in New Zealand. The introduction of the online system was associated with few ...
Bayesian accuracy estimates and fit for purpose thresholds of cytology and culture of endometrial swab samples for detecting endometritis in mares.
Preventive veterinary medicine    October 20, 2022   Volume 209 105783 doi: 10.1016/j.prevetmed.2022.105783
Scott CJ, de Mestre AM, Verheyen KL, Arango-Sabogal JC.The overall aim of this work was to identify the potential impact of misclassification errors associated with routine screening and diagnostic testing for endometritis in mares. Using Bayesian latent class models (BLCM), specific objectives were to: 1) estimate the diagnostic accuracy of cytology and culture of endometrial swab samples to detect endometritis in mares; 2) assess the impact of different cytology thresholds on test accuracy and misclassification costs; and 3) assess the sensitivity (Se) and specificity (Sp) of a diagnostic strategy including both tests interpreted in series and p...
Scoping review: Occurrence and definitions of postoperative complications in equine colic surgery.
Equine veterinary journal    October 19, 2022   Volume 55, Issue 4 563-572 doi: 10.1111/evj.13881
Gandini M, Cerullo A, Giusto G.Postoperative complications frequently occur following equine colic surgery but there is a lack of consistency in their definitions and reporting. Objective: To perform a scoping review to identify current evidence on the definitions and classifications of postoperative complications in equine colic surgery. Methods: Evidence review. Methods: A scoping review was conducted in CAB, Web of Science, Scopus and PubMed databases using a PCC (Population-equids, Concept-complications, adverse events, sequelae, failure to cure, technical failure, disease progression and Context-postoperative period af...
COP27 Climate Change Conference: Urgent action needed for Africa and the world.
Equine veterinary journal    October 18, 2022   Volume 55, Issue 1 9-11 doi: 10.1111/evj.13882
Atwoli L, Erhabor GE, Gbakima AA, Haileamlak A, Ntumba JK, Kigera J, Laybourn-Langton L, Mash B, Muhia J, Mulaudzi FM, Ofori-Adjei D, Okonofua F....No abstract available
Equine blood cultures: Can we do better?
Equine veterinary journal    October 18, 2022   Volume 55, Issue 4 584-592 doi: 10.1111/evj.13891
Giancola S, Hart KA.Blood culture is considered the gold standard test for documenting bacteraemia in patients with suspected bacterial sepsis in veterinary and human medicine. However, blood culture often fails to yield bacterial growth even though the clinical picture is strongly suggestive of bacterial sepsis, or contaminating organisms can overgrow the true pathogen, making accurate diagnosis and appropriate management of this life-threatening condition very challenging. Methodology for collecting blood cultures in equine medicine, and even in human hospitals, is not standardised, and many variables can affec...
Chromosome Instability in Pony of Esperia Breed Naturally Infected by Intestinal Strongylidae.
Animals : an open access journal from MDPI    October 18, 2022   Volume 12, Issue 20 2817 doi: 10.3390/ani12202817
D'Anza E, Buono F, Albarella S, Castaldo E, Pugliano M, Iannuzzi A, Cascone I, Battista E, Peretti V, Ciotola F.The Pony of Esperia is an Italian autochthonous horse breed reared in the wild on the Aurunci and Ausoni Mountains. Currently, it is considered an endangered breed, as its population consists of 1623 animals. It is therefore essential to identify all aspects that can improve the management and economy of its breeding, favoring its diffusion. In this paper, the effects of intestinal strongyle infection on the chromosome stability of peripheral blood lymphocytes (PBLs) was evaluated through aneuploidy and chromosome aberration (gap, chromatid and chromosome breaks, and the number of abnormal cel...
Seroprevalence and risk factors associated with equine infectious anemia in the state of Goiás, Brazil.
Preventive veterinary medicine    October 18, 2022   Volume 209 105781 doi: 10.1016/j.prevetmed.2022.105781
de Pádua BR, Dias RA, Fioravanti MCS, Borsanelli AC.Equine infectious anemia (EIA) is an infectious disease affecting equine in most countries and represents a notifiable disease with compulsory euthanasia of positive animals. The present study aimed to determine the prevalence of EIAV infected equines in herds of the state of Goiás (Central Brazil) and to evaluate the risk factors associated with the occurrence of the disease. Blood samples were collected from 1170 equids from 332 randomly selected farms divided into three different strata according to their herd characteristics. Also, an epidemiological questionnaire was applied during the v...
Prevalence of the RAPGEF5 c.2624C>A and PLOD1 c.2032G>A variants associated with equine familial isolated hypoparathyroidism and fragile foal syndrome in the US Thoroughbred population (1988-2019).
Equine veterinary journal    October 18, 2022   Volume 55, Issue 4 666-671 doi: 10.1111/evj.13883
Elcombe ME, Bellone RR, Magdesian KG, Finno CJ.Equine familial isolated hypoparathyroidism (EFIH) and fragile foal syndrome (FFS) are both fatal recessive conditions reported in Thoroughbred foals. The causal variants for EFIH (RAPGEF5 c.2624C>A; EquCab3.0. chr4: g.54108297G>T) and FFS (PLOD1 c.2032G>A; EquCab3.0, chr2: g.39927817) were recently reported. Prevalence assessment for these variants in a large cohort of samples is needed to provide evidence-based recommendations for genetic testing. Objective: To estimate the frequency of the EFIH and FFS variant alleles in the United States Thoroughbred population between 1988 and 20...
Nasal transmission of equine parvovirus hepatitis.
Journal of veterinary internal medicine    October 17, 2022   Volume 36, Issue 6 2238-2244 doi: 10.1111/jvim.16569
Tomlinson JE, Van de Walle GR.Equine parvovirus hepatitis (EqPV-H) is highly prevalent and causes subclinical to fatal hepatitis, which can occur in outbreaks. Whereas iatrogenic transmission is well documented, the mode of horizontal transmission is not known. The virus is shed in nasal, oral and fecal secretions, and PO transmission has been reported in a single horse. Objective: Investigate the efficiency of PO and nasal transmission of EqPV-H in a larger cohort. Methods: Prospective experimental transmission study. Eleven EqPV-H-negative horses were inoculated with 5 × 10 genome equivalents EqPV-H. Serum PCR and s...
Survey on the recognition, attitudes, and experience of horse owners during episodes of equine colic in Rio Grande do Norte, Brazil.
Brazilian journal of veterinary medicine    October 14, 2022   Volume 44 e003022 doi: 10.29374/2527-2179.bjvm003022
Costa MHDS, Medeiros PR, Melo UP, de Souza RF, da Silva GEL, Ferreira C, de Assis DB, da Silva LP, de Brito EL.Horse owners are crucial in recognizing colic because they are responsible for identifying the signs of colic and deciding whether to seek veterinary intervention. Common reasons for delayed response to clinical issues include lack of understanding or knowledge of the subject and difficulty in recognizing subtle clinical signs of abdominal pain. Examining horse owners' basic knowledge of colic, their motivations, obstacles in seeking veterinary care, and their responses to the various clinical symptoms manifested during colic will identify current knowledge gaps and decision-making barriers. T...
Equine influenza vaccination catches an autumn cold! But must get over it as soon as it can.
Equine veterinary journal    October 13, 2022   Volume 55, Issue 1 142-146 doi: 10.1111/evj.13885
Newton JR, Rendle DI, Mountford DR, Marr CM.No abstract available
[Immunotherapy with anti-SARS-COV-2 neutralizing F(ab’)2 antibodies from equine serum in the treatment of outpatients with bilateral COVID-19 pneumonia].
Medicina    October 12, 2022   Volume 82, Issue 5 667-672 
Manganiello CF, Basbus L, Callegari MS, Cayol F, Amaral De Sousa CR, Porta RE.Passive immunotherapy is a therapeutic alternative for patients with COVID-19. Methods: The decision was made to create a prospective database of patients diagnosed with SARS-CoV-2 pneumonia, nonhypoxemic, treated on an outpatient basis at the Hospital de Bolívar, Dr. Miguel Capredoni, province of Buenos Aires, Argentina, with the aim of evaluating the efficacy in reducing severe cases and hospitalizations of treatment with hyperimmune equine serum in this subgroup of patients. We performed a retrospective analysis of the period from 05/26/2021 to 08/28/2021, where a total of 151 patients wer...
Equine Anthelmintic Resistance: Horse Owner and Yard Manager Perception of the Barriers Affecting Strategic Control Measures in England.
Veterinary sciences    October 11, 2022   Volume 9, Issue 10 doi: 10.3390/vetsci9100560
McTigue FE, Mansbridge SC, Pyatt AZ.Equine anthelmintic resistance poses a threat to the health and welfare of horses worldwide. With no new imminent anthelmintic classes, it is vital to decrease the resistance rate and preserve available classes. Traditional indiscriminate anthelmintic use is not synonymous with a strategic control ideology; however, many continue to implement outdated practices. In comparison to livestock farmers, there have been few social science studies examining horse owner behaviours. This study aimed to understand the perceived barriers faced by horse owners and yard managers to adopting a strategic appr...
Pituitary Pars Intermedia Dysfunction (PPID) in Horses.
Veterinary sciences    October 10, 2022   Volume 9, Issue 10 556 doi: 10.3390/vetsci9100556
Kirkwood NC, Hughes KJ, Stewart AJ.Substantial morbidity results from pituitary pars intermedia dysfunction (PPID) which is often underestimated by owners and veterinarians. Clinical signs, pathophysiology, diagnostic tests, and treatment protocols of this condition are reviewed. The importance of improved recognition of early clinical signs and diagnosis are highlighted, as initiation of treatment will result in improved quality of life. Future research should be targeted at improving the accuracy of the diagnosis of PPID, as basal adrenocorticotropic hormone (ACTH) concentration can lack sensitivity and thyrotropin releasing ...
Comparative Genome Analysis of All Nine African Horse Sickness Serotypes Isolated From Equine Fatalities in Kenya and South Africa.
Journal of equine veterinary science    October 9, 2022   Volume 119 104137 doi: 10.1016/j.jevs.2022.104137
Hoffmann B, Joseph S, Patteril NAG, Caveney MR, Elizabeth SK, Muhammed R, Wernery R, Wernery U.African horse sickness (AHS) is a viral disease of equids, caused by a virus of the genus Orbivirus, family Reoviridae. The African horse sickness virus (AHSV) genome is made up of ten double-stranded RNA (dsRNA) segments that together code for seven structural and four nonstructural proteins. AHS is endemic in sub-Saharan countries. The efficacy and safety of inactivated AHS vaccines containing all nine serotypes, produced at the Central Veterinary Research Laboratory (CVRL) in Dubai, United Arab Emirates have been proven in the past. All nine AHSV serotypes were isolated from 102 samples col...
Study design synopsis: Evidence syntheses-What are they and why do we need them?
Equine veterinary journal    October 6, 2022   Volume 54, Issue 6 1011-1012 doi: 10.1111/evj.13872
Freeman SL.No abstract available
Biomarkers of Kidney Disease in Horses: A Review of the Current Literature.
Animals : an open access journal from MDPI    October 5, 2022   Volume 12, Issue 19 2678 doi: 10.3390/ani12192678
Galen GV, Olsen E, Siwinska N.Creatinine only allows detection of kidney disease when 60 to 75% of the glomerular function is lost and is therefore not an ideal marker of disease. Additional biomarkers could be beneficial to assess kidney function and disease. The objectives are to describe new equine kidney biomarkers. This systematic review assesses the available literature, including the validation process and reference values, following which the authors suggest recommendations for clinical use. SDMA may have some potential as equine kidney biomarker, but there is currently a lack of evidence that SDMA offers any advan...
Characterization of an outbreak of equine coronavirus infection in adult horses in Switzerland.
Schweizer Archiv fur Tierheilkunde    October 5, 2022   Volume 164, Issue 10 733-739 doi: 10.17236/sat00372
Fouché N, Remy-Wohlfender F, Blau D, Franzen J, Gurtner C, Seuberlich T, Unger L, Gerber V.Outbreaks of equine coronavirus (ECoV) infections have been described in different parts of the world including Europe. The aim of this report was to describe clinical signs, diagnostic work-up and outcome of the first documented outbreak of ECoV in Switzerland in order to raise the awareness for the disease and its various clinical presentations. The outbreak occurred on a farm with 26 horses. Of these, seven horses developed clinical disease ranging from mild signs such as fever and anorexia to severe signs of acute colitis. One horse died due to severe endotoxemia and circulatory shock seco...
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