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Topic:Disease Outbreaks

Disease outbreaks in horses refer to the occurrence and spread of infectious diseases within equine populations. These outbreaks can be caused by various pathogens, including bacteria, viruses, and parasites, and can lead to significant health issues in affected horses. Common diseases that may result in outbreaks include equine influenza, equine herpesvirus, strangles, and equine infectious anemia. The transmission of these diseases can occur through direct contact, environmental exposure, or vectors such as insects. Disease outbreaks can have substantial impacts on horse health, welfare, and the equine industry as a whole. This page compiles peer-reviewed research studies and scholarly articles that explore the epidemiology, transmission dynamics, and management strategies associated with disease outbreaks in equine populations.
Diversity of interferon inducible Mx gene in horses and association of variations with susceptibility vis-à-vis resistance against equine influenza infection. Manuja BK, Manuja A, Dahiya R, Singh S, Sharma RC, Gahlot SK.Equine influenza (EI) is primarily an infection of the upper respiratory tract and is one of the major infectious respiratory diseases of economic importance in equines. Re-emergence of the disease, species jumping by H3N8 virus in canines and possible threat of human pandemic due to the unpredictable nature of the virus have necessitated research on devising strategies for preventing the disease. The myxovirus resistance protein (Mx) has been reported to confer resistance to Orthomyxo virus infection by modifying cellular functions needed along the viral replication pathway. Polymorphisms and...
Structural and antigenic features of the synthetic SF23 peptide corresponding to the receptor binding fragment of diphtheria toxin.
Molecular immunology    July 23, 2014   Volume 63, Issue 2 235-244 doi: 10.1016/j.molimm.2014.07.008
Khrustaleva TA, Khrustalev VV, Barkovsky EV, Kolodkina VL, Astapov AA.The SF23 peptide corresponding to the receptor binding fragment of diphtheria toxin (residues 508-530) has been synthesized. This fragment forming a protruding beta hairpin has been chosen because it is the less mutable B-cell epitope. Affine chromatography and ELISA show that antibodies from the sera of persons infected by toxigenic Corynebacterium diphtheriae and those immunized by diphtheria toxoid are able to bind the synthetic SF23 peptide. There are antibodies recognizing the SF23 peptide in the serum of horses hyperimmunized with diphtheria toxoid. Analysis of circular dichroism spectra...
Frequency of Corynebacterium pseudotuberculosis infection in horses across the United States during a 10-year period.
Journal of the American Veterinary Medical Association    July 17, 2014   Volume 245, Issue 3 309-314 doi: 10.2460/javma.245.3.309
Kilcoyne I, Spier SJ, Carter CN, Smith JL, Swinford AK, Cohen ND.To quantify the number of horses with Corynebacterium pseudotuberculosis infection identified in the United States from January 2003 through December 2012. Methods: Cross-sectional study. Methods: State veterinary diagnostic laboratory records of 2,237 C pseudotuberculosis culture-positive samples from horses. Methods: 44 state veterinary diagnostic laboratories throughout the United States were invited by mail to participate in the study. Data requested included the number of C pseudotuberculosis culture-positive samples from horses identified per year, geographic location from which the C ps...
Emergency and critical care.
The Veterinary clinics of North America. Equine practice    July 14, 2014   Volume 30, Issue 2 xiii-xiv doi: 10.1016/j.cveq.2014.06.001
Cook VL, Hassel DM.No abstract available
Serological evidence of West Nile virus infection in the horse population of northern Serbia.
Journal of infection in developing countries    July 14, 2014   Volume 8, Issue 7 914-918 doi: 10.3855/jidc.3885
Medić S, van den Hoven R, Petrović T, Lupulović D, Nowotny N.This study was conducted to evaluate the seroprevalence of West Nile virus (WNV) in the horse population of northern Serbia. Furthermore, it aimed to provide insight and an updated overview on the circulation of this re-emerging pathogen in this part of southeastern Europe. At the time of manuscript preparation, no clinical cases of WNV infection in horses were reported in this area. Methods: Between 2007 and 2011, a total of 252 equine serum samples were collected from seven different locations in northern Serbia. The presence of WNV-reactive IgG antibodies was examined by using commercial an...
Cleavage site and Ectodomain of HA2 sub-unit sequence of three equine influenza virus isolated in Morocco.
BMC research notes    July 12, 2014   Volume 7 448 doi: 10.1186/1756-0500-7-448
Boukharta M, Zakham F, Touil N, Elharrak M, Ennaji MM.The equine influenza (EI) is an infectious and contagious disease of the upper respiratory tract of horses. Two outbreaks were notified in Morocco during 1997 and 2004 respectively in Nador and Essaouira. The aims of the present study concern the amino acids sequences comparison with reference strain A/equine/Miami/1963(H3N8) of the HA2 subunit including the cleavage site of three equine influenza viruses (H3N8) isolated in Morocco: A/equine/Nador/1/1997(H3N8), A/equine/Essaouira/2/2004 (H3N8) and A/equine/Essaouira/3/2004 (H3N8). Results: The obtained results demonstrated that the substitutio...
A severe equine herpesvirus type 1 (EHV-1) abortion outbreak caused by a neuropathogenic strain at a breeding farm in northern Germany.
Veterinary microbiology    July 2, 2014   Volume 172, Issue 3-4 555-562 doi: 10.1016/j.vetmic.2014.06.023
Damiani AM, de Vries M, Reimers G, Winkler S, Osterrieder N.A particularly severe equine herpesvirus type 1 (EHV-1) abortion outbreak occurred at a breeding farm in northern Germany. Sixteen of 25 pregnant mares that had received regular vaccination using an inactivated vaccine aborted and two gave birth to weak non-viable foals in a span of three months, with 89% of cases occurring within 40 days after the initial abortion case. Virological examinations revealed the presence of EHV-1 in all cases of abortion and serological follow-up in mares confirmed recent infection. Molecular studies identified a neuropathogenic variant (Pol/ORF30 A2254 to G2254) ...
Infection control and biosecurity in equine disease control.
Equine veterinary journal    June 20, 2014   Volume 46, Issue 6 654-660 doi: 10.1111/evj.12295
Weese JS.Infectious diseases are an important cause of morbidity and mortality in horses, along with economic costs and broader impacts associated with the loss of members of a species that generates income, acts as a working animal and is a companion. Endemic diseases continue to challenge, emerging diseases are an ever-present threat and outbreaks can be both destructive and disruptive. While infectious diseases can never be completely prevented, measures can be introduced to restrict the entry of pathogens into a population or limit the implications of the presence of a pathogen. Objective research ...
Flying-fox species density–a spatial risk factor for Hendra virus infection in horses in eastern Australia.
PloS one    June 17, 2014   Volume 9, Issue 6 e99965 doi: 10.1371/journal.pone.0099965
Smith C, Skelly C, Kung N, Roberts B, Field H.Hendra virus causes sporadic but typically fatal infection in horses and humans in eastern Australia. Fruit-bats of the genus Pteropus (commonly known as flying-foxes) are the natural host of the virus, and the putative source of infection in horses; infected horses are the source of human infection. Effective treatment is lacking in both horses and humans, and notwithstanding the recent availability of a vaccine for horses, exposure risk mitigation remains an important infection control strategy. This study sought to inform risk mitigation by identifying spatial and environmental risk factors...
Hospital biosecurity–how far have we come in the last 10 years?
Equine veterinary journal    June 10, 2014   Volume 46, Issue 4 402-403 doi: 10.1111/evj.12270
Dallap-Schaer B, Aceto HW.No abstract available
Field triage of the neonatal foal.
The Veterinary clinics of North America. Equine practice    June 10, 2014   Volume 30, Issue 2 283-vii doi: 10.1016/j.cveq.2014.05.001
Carr EA.The purpose of this article is to provide a quick reference for field triage of the sick neonatal foal. Therefore, information is focused toward diagnostics and treatments that can be performed in the field. When evaluating a weak, recumbent, or lethargic foal on a farm, it is often difficult to make a definitive diagnosis. Therefore, the approach should be to treat what is treatable and prevent what is preventable. In many cases, the goal will be to stabilize a foal before referral to a tertiary care facility where more intensive and continuous treatment can be performed.
‘Equine research–our only business’: the Grayson-Jockey Club Research Foundation.
Equine veterinary journal    June 10, 2014   Volume 46, Issue 4 515-516 doi: 10.1111/evj.12292
Lunn DP, Antczak DF, McCue P, Richardson D, Scollaly M.No abstract available
Salmonella enterica serovar Oranienburg outbreak in a veterinary medical teaching hospital with evidence of nosocomial and on-farm transmission.
Vector borne and zoonotic diseases (Larchmont, N.Y.)    June 5, 2014   Volume 14, Issue 7 496-502 doi: 10.1089/vbz.2013.1467
Cummings KJ, Rodriguez-Rivera LD, Mitchell KJ, Hoelzer K, Wiedmann M, McDonough PL, Altier C, Warnick LD, Perkins GA.Nosocomial salmonellosis continues to pose an important threat to veterinary medical teaching hospitals. The objectives of this study were to describe an outbreak of salmonellosis caused by Salmonella enterica serovar Oranienburg within our hospital and to highlight its unique features, which can be used to help mitigate or prevent nosocomial outbreaks in the future. We retrospectively analyzed data from patients that were fecal culture-positive for Salmonella Oranienburg between January 1, 2006, and June 1, 2011, including historical, clinical, and pulsed-field gel electrophoresis (PFGE) data...
Successful control of winter pyrexias caused by equine herpesvirus type 1 in Japanese training centers by achieving high vaccination coverage.
Clinical and vaccine immunology : CVI    May 28, 2014   Volume 21, Issue 8 1070-1076 doi: 10.1128/CVI.00258-14
Bannai H, Mae N, Ode H, Nemoto M, Tsujimura K, Yamanaka T, Kondo T, Matsumura T.Equine herpesvirus type 1 (EHV-1) is a major cause of winter pyrexia in racehorses in two training centers (Ritto and Miho) in Japan. Until the epizootic period of 2008-2009, a vaccination program using a killed EHV-1 vaccine targeted only susceptible 3-year-old horses with low antibody levels to EHV-1 antigens. However, because the protective effect was not satisfactory, in 2009-2010 the vaccination program was altered to target all 3-year-old horses. To evaluate the vaccine's efficacy, we investigated the number of horses with pyrexia due to EHV-1 or equine herpesvirus type 4 (EHV-4) infecti...
Epidemiology and reproductive outcomes of EHV-1 abortion epizootics in unvaccinated Thoroughbred mares in South Africa.
Equine veterinary journal    May 9, 2014   Volume 47, Issue 2 155-159 doi: 10.1111/evj.12264
Schulman ML, Becker A, van der Merwe BD, Guthrie AJ, Stout TA.Equine herpesvirus 1 (EHV-1) is one of the most common causes of infectious abortion in mares. Analysing the demography of outbreaks and detailing subsequent reproductive performance of affected mares will assist in the management of future (threatened) epizootics. Objective: To examine the epidemiology and reproductive outcomes of 2 EHV-1 abortion epizootics with very different patterns of morbidity. Methods: Epidemiological and reproductive data were analysed retrospectively following abortion epizootics associated with EHV-1, but initiated via different routes, among unvaccinated mares on 2...
Continuing evolution of equine influenza virus in Central Asia, 2007-2012.
Archives of virology    April 20, 2014   Volume 159, Issue 9 2321-2327 doi: 10.1007/s00705-014-2078-3
Karamendin K, Kydyrmanov A, Kasymbekov Y, Khan E, Daulbayeva K, Asanova S, Zhumatov K, Seidalina A, Sayatov M, Fereidouni SR.Equine influenza (EI) continues to be an important respiratory pathogen of horses worldwide. Since 2007 several outbreaks of EI have occurred in Central Asian countries, including Kazakhstan, western Mongolia, India and western China. Phylogenetic analysis showed that two H3N8 equine influenza virus (EIV) isolates from Kazakhstan, A/equine/Almaty/26/2007 and A/equine/South Kazakhstan/236/12, were related to Florida sublineage 2, with high similarity to EIVs circulating in the same period in neighbouring countries. New outbreaks of EI during 2011 and 2012 in Kazakhstan and other Central Asian c...
West Nile virus reemergence in Romania: a serologic survey in host species.
Vector borne and zoonotic diseases (Larchmont, N.Y.)    April 18, 2014   Volume 14, Issue 5 330-337 doi: 10.1089/vbz.2013.1405
Ludu Oslobanu EL, Mihu-Pintilie A, Anită D, Anita A, Lecollinet S, Savuta G.The presence of West Nile virus (WNV) in humans has been known in Romania since the 1950s; the 1996 epidemics emphasized the reemergence potential of WNV in Romania. Serological surveys made on susceptible species, known as good sentinels or reservoir hosts, e.g., horses, wild and domestic birds were undertaken from 2006-2011. Our results corroborated incidence data in human patients and other recent seroprevalence studies in animals, and should partially clarify the emergence of WNV in the eastern rural territories of Romania. It also highlighted risk zones for endemic WNV infection in Romani...
Clinical review of Hendra virus infection in 11 horses in New South Wales, Australia.
Australian veterinary journal    April 15, 2014   Volume 92, Issue 6 213-218 doi: 10.1111/avj.12170
Ball MC, Dewberry TD, Freeman PG, Kemsley PD, Poe I.Between 2006 and 2012, there were 11 horses diagnosed with Hendra virus (HeV) on 9 independent premises in New South Wales (NSW). We defined a case of HeV as premises where one or more horses were confirmed to be infected with HeV by PCR. All the cases occurred in the north-eastern region of NSW. In 8 of the 9 cases, infection occurred within 2 months over the winter of 2011. With no exception, the affected horses were kept at pasture on properties visited by flying foxes. Of the 11 horses testing positive for HeV, 5 had an association with a fence, with the horses dead or dying on a fence l...
Science-in-brief: clinical highlights from the American Association of Equine Practitioners 59th Annual Convention and Equine Veterinary Journal Supplement 45.
Equine veterinary journal    April 11, 2014   Volume 46, Issue 3 259-261 doi: 10.1111/evj.12239
Dwyer A.No abstract available
The bicolored white-toothed shrew Crocidura leucodon (HERMANN 1780) is an indigenous host of mammalian Borna disease virus.
PloS one    April 3, 2014   Volume 9, Issue 4 e93659 doi: 10.1371/journal.pone.0093659
Dürrwald R, Kolodziejek J, Weissenböck H, Nowotny N.Borna disease (BD) is a sporadic neurologic disease of horses and sheep caused by mammalian Borna disease virus (BDV). Its unique epidemiological features include: limited occurrence in certain endemic regions of central Europe, yearly varying disease peaks, and a seasonal pattern with higher disease frequencies in spring and a disease nadir in autumn. It is most probably not directly transmitted between horses and sheep. All these features led to the assumption that an indigenous virus reservoir of BDV other than horses and sheep may exist. The search for such a reservoir had been unsuccessfu...
Pulmonary disease potentially associated with Nicoletella semolina in 3 young horses.
Journal of veterinary internal medicine    April 1, 2014   Volume 28, Issue 3 939-943 doi: 10.1111/jvim.12349
McConachie EL, Hart KA, Whelchel DD, Schroeder EL, Schott HC, Sanchez S.No abstract available
Seasonal dynamics of Culicoides (Diptera: Ceratopogonidae) biting midges, potential vectors of African horse sickness and bluetongue viruses in the Niayes area of Senegal.
Parasites & vectors    March 31, 2014   Volume 7 147 doi: 10.1186/1756-3305-7-147
Diarra M, Fall M, Fall AG, Diop A, Seck MT, Garros C, Balenghien T, Allène X, Rakotoarivony I, Lancelot R, Mall I, Bakhoum MT, Dosum AM, Ndao M....The African horse sickness epizootic in Senegal in 2007 caused considerable mortality in the equine population and hence major economic losses. The vectors involved in the transmission of this arbovirus have never been studied specifically in Senegal. This first study of the spatial and temporal dynamics of the Culicoides (Diptera: Ceratopogonidae) species, potential vectors of African horse sickness in Senegal, was conducted at five sites (Mbao, Parc Hann, Niague, Pout and Thies) in the Niayes area, which was affected by the outbreak. Methods: Two Onderstepoort light traps were used at each s...
First detection of equine coronavirus (ECoV) in Europe.
Veterinary microbiology    March 30, 2014   Volume 171, Issue 1-2 206-209 doi: 10.1016/j.vetmic.2014.03.031
Miszczak F, Tesson V, Kin N, Dina J, Balasuriya UB, Pronost S, Vabret A.Equine coronavirus (ECoV) is involved mainly in enteric infections. Following the recent description of ECoV in 2000, this study reports for the first time the presence of ECoV in France and, on a wider scale, in Europe. ECoV was molecularly detected from diarrheic and respiratory specimens. Sequencing and phylogenetic analyses demonstrated that European strains are most closely related to the reference North American strain (ECoV-NC99) than the Asian strain (ECoV-Tokachi09).
In this issue – April 2014: Perceptions of 2007 equine influenza outbreak · Hyperinsulinaemia in ponies · Hydration and perennial ryegrass toxicosis · Travel history needed for possible canine leishmaniosis · Complications of arthroscopy · Metaphyseal osteopathy in Kelpies · Infectious bronchitis virus and egg quality.
Australian veterinary journal    March 29, 2014   Volume 92, Issue 4 89-90 doi: 10.1111/avj.12171
Jackson A.No abstract available
Equine victims of unrest in Egypt.
The Veterinary record    March 29, 2014   Volume 174, Issue 13 317 doi: 10.1136/vr.g2186
No abstract available
Survey of Australian equine veterinarians evaluating their biosecurity training and perceptions and opinions about the management of the 2007 equine influenza outbreak.
Australian veterinary journal    March 29, 2014   Volume 92, Issue 4 93-100 doi: 10.1111/avj.12160
Schemann K, Toribio JA, Taylor MR, Ward MP, Dhand NK.To evaluate the level of biosecurity training among Australian equine veterinarians and to assess their perceptions of biosecurity and infectious disease risk and their opinions about the management of the 2007 equine influenza (EI) outbreak. Methods: Cross-sectional study. Methods: A survey was conducted among equine veterinarians attending the 2010 annual conference of the Equine Veterinarians Australia (EVA) in New South Wales, Australia. Data were collected using a self-completed questionnaire and analysed using Fisher's exact tests to assess veterinarians' levels of biosecurity training, ...
Role of U.S. animal control agencies in equine neglect, cruelty, and abandonment investigations.
Journal of animal science    March 18, 2014   Volume 92, Issue 5 2342-2349 doi: 10.2527/jas.2013-7303
Stull CL, Holcomb KE.Every state in the United States has regulations prohibiting acts of neglect and cruelty against animals. Local law enforcement and animal control agencies are responsible in many communities to enforce these statutes. As society's perception of horses has changed from their origin as livestock to companion animals in modern times, owners have transitioned their care and management. The goal of this study was to identify the role and capacities of local animal control services in the United States that investigate equine neglect, cruelty, and abandonment investigations and to identify challeng...
Clarifying the role of maples in atypical myopathy.
Equine veterinary journal    February 20, 2014   Volume 46, Issue 2 135-136 doi: 10.1111/evj.12176
Gillman JH, Hegeman AD, Sharp RG.No abstract available
Serological evidence of widespread circulation of West Nile virus and other flaviviruses in equines of the Pantanal, Brazil.
PLoS neglected tropical diseases    February 13, 2014   Volume 8, Issue 2 e2706 doi: 10.1371/journal.pntd.0002706
Pauvolid-Corrêa A, Campos Z, Juliano R, Velez J, Nogueira RM, Komar N.A recent study reported neutralizing antibodies to West Nile virus (WNV) in horses from four ranches of southern Pantanal. To extend that study, a serosurvey for WNV and 11 Brazilian flaviviruses was conducted with 760 equines, 238 sheep and 61 caimans from 17 local cattle ranches. Among the tested equines, 32 were collected from a ranch where a neurologic disorder outbreak had been recently reported. The sera were initially screened by using a blocking ELISA and then titrated by 90% plaque-reduction neutralization test (PRNT90) for 12 flaviviruses. Employing the criterion of 4-fold greater ti...
Landscape features and reservoir occurrence affecting the risk for equine infection with Borna disease virus.
Journal of wildlife diseases    February 8, 2014   Volume 49, Issue 4 860-868 doi: 10.7589/2012-10-262
Encarnação JA, Herzog S, Eickmann M, Becker NI, Hermes N, Herden C.Borna disease (BD) is a severe endemic and fatal disorder caused by the neurotropic Borna disease virus (BDV) which mainly occurs in horses and sheep. Borna disease virus belongs to the order Mononegavirales, which includes many reservoir-bound viruses with high zoonotic and pathogenic properties including the filoviruses and lyssaviruses. Clinically manifest BD occurs in endemic areas of Germany, Switzerland, Liechtenstein, and Austria. A seasonal accumulation of cases in spring and summer, incidences that vary from year to year, and the recent detection of BDV in bicolored shrews (Crocidura ...
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