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Topic:Disease
The study of diseases in horses encompasses a wide range of conditions affecting equine health, including infectious diseases, metabolic disorders, and genetic abnormalities. These diseases can impact various systems within the horse, such as respiratory, gastrointestinal, and musculoskeletal systems, and can lead to significant health challenges. Research in this area focuses on understanding the pathophysiology, diagnosis, prevention, and treatment of equine diseases. Common diseases studied include equine influenza, equine herpesvirus, and laminitis. This page provides access to peer-reviewed research studies and scholarly articles that explore the etiology, clinical presentation, and management strategies of diseases in horses, contributing to the advancement of equine veterinary medicine.
Equine adenocarcinomas of the large intestine with osseous metaplasia. Large intestinal adenocarcinoma with osseous metaplasia was diagnosed in two horses, a 15-year-old standard bred gelding and a 9-year-old Haflinger mare. Clinically, both animals had displayed weight loss and anaemia. A presumptive diagnosis of abdominal neoplasia was made and the horses were humanely killed. At necropsy, the gelding and the mare were found to have ulcerated tumours growing into the lumen of the caecum and colon, respectively. In the mare, the mass extended through the mesocolon and was evident in the left dorsal and ventral colon. Histopathologically, the tumours consisted of...
Open peritoneal drainage in horses with experimentally induced peritonitis. Peritonitis was induced in 12 horses by median celiotomy and 1 hour of small intestinal ischemia. Six horses had primary closure of the incision, whereas six horses had a plastic mesh sutured to the ventral abdominal wall leaving the abdomen open for ventral drainage. The mesh was removed after 5 days and the abdominal wall was closed by apposition of the linea alba and subcutaneous tissues and approximation ef the skin edges. Peritoneal fluid was collected and analyzed for nucleated cell count and total protein concentration on days 0 and 5. Serum biochemical profiles, serum electrolyte conce...
Influence of chronic degenerative endometritis (endometrosis) on placental development in the mare. Placentation between 80 and 220 days of gestation was studied by measurement of fetal dimensions and gross, light and transmission and scanning electron microscopic examinations of the allantochorion and endometrium from 4 fertile mares with no, or very mild, endometrial histopathology and 6 subfertile Thoroughbred mares suffering varying degrees of age-related chronic degenerative endometritis (endometrosis). Spontaneously occurring twin gestation was observed in 3 animals. Several of the subfertile mares had endometrial cysts which showed 2 distinct features during pregnancy: those located n...
Ultrasonographic assessment of fetal well-being during late gestation: development of an equine biophysical profile. Mares with complicated pregnancies (illness, problems at parturition or delivery of an abnormal foal, n = 30) were scanned transabdominally from 298 days gestation to term in order to measure fetal size, evaluate fetal well-being and characterise the intrauterine environment. The results of the last scan obtained prior to parturition were compared to normal data obtained from fetuses of comparable gestational age to develop a biophysical profile specific for the equine fetus. Twelve mares produced a normal foal (positive outcome) and 18 mares delivered 19 abnormal foals (negative outcome). Bot...
Seasonal variation in the vector competence of Culex tarsalis (Diptera:Culicidae) from the Coachella Valley of California for western equine encephalomyelitis and St. Louis encephalitis viruses. The vector competence of Culex tarsalis Coquillett from the Coachella Valley of California for western equine encephalomyelitis (WEE) and St. Louis encephalitis (SLE) viruses was monitored monthly from February to November 1993. The concentration of WEE virus required to infect 50% of the females increased during summer coincidentally with ambient temperature and was highest during July. Transmission rates of WEE virus were high during March, low during May-June, and high again during July-September. Females expressed both mesenteronal escape and salivary gland barriers limiting WEE virus diss...
Evaluation of a one-step test for rapid, in practice detection of rotavirus in farm animals. An immunochromatographic test for the detection of group A rotavirus was evaluated against a reference group A rotavirus ELISA, by using a panel of 161 bovine, porcine and equine faecal samples submitted for routine examination. The sensitivity of the test was 89 per cent and the specificity 99 per cent compared with the ELISA. Its reproducibility was 100 per cent. The simplicity and rapidity of the test procedure make it suitable for use in practice.
Prognosis for return to racing after recovery from infectious pleuropneumonia in thoroughbred racehorses: 70 cases (1984-1989). To determine the percentage of Thoroughbred racehorses that would be capable of racing performance after recovery from infectious pleuropneumonia. Methods: Retrospective case series. Methods: 70 Thoroughbred horses that had recovered from pleuropneumonia. Only horses 5 years old known to be in race training at the time of illness were included in the study. Results: Forty-three of the 70 (61%) horses raced after recovery, and 24 of the 43 (56%) won at least 1 race. Horses that required placement of an indwelling thoracic drain apparently did not have a worse prognosis than did horses that did...
Clinical and pathological features of Nigerian equine encephalitis. Thirteen cases of a disease with a low morbidity and very high mortality in horses in Nigeria are described; the disease is characterised by fever (rectal temperature > or = 40 degrees C), generalised muscle spasms, ataxia, increased respiratory and heart rates and terminal lateral recumbency. The illness generally lasts three to five days but durations of 12 to 30 hours have been observed. Laboratory investigations, including histopathology and serology suggest a viral aetiology, possibly an alphavirus of the equine encephalitis group.
Unequivocal identification of the equine Dcfmqr phenogroup. An alloimmune reagent has been produced that distinguishes the equine factor Df in the D phenogroup, cfmqr, from that occurring in cefmqr and dfklr. Using this reagent it has been possible to correctly genotype Dc, d, f, k, l, m, q and r positive cells without recourse to family data.
Mycobacterium avium complex abortion in a mare. No abstract available
Adverse drug reactions: report of the Australian Veterinary Association Adverse Drug Reaction Subcommittee, 1994. Seventy-seven reports of suspected adverse drug reactions (ADRs) were received by the Adverse Drug Reaction Subcommittee (ADRSc) of the Australian Veterinary Association from April 1993 to December 1994 inclusive. The number of reports received/number of animals involved per species were: dogs (32/44), cats (18/31), horses (17/48), and cattle (10/21). Of these, 49 (64%) were classified as definite ADRs and 9 (12%) as probable ADRs. In 11 (14%) reports an ADR could not be substantiated or there was insufficient information available to make a decision. Eight reports were not classified because ...
Proliferative enteropathy in a foal caused by Lawsonia intracellularis-like bacterium. No abstract available
Ctenocephalides felis flea infestation in horses. The horses were in two stables: in the first stable they were kept together with sheep and in the second stable they were kept together with goats. All horses in both stables were diagnosed as being infested with the cat flea Ctenocephalides felis felis. Foals were severely infested, whereas adult horses were only moderately infested.
Evaluation of plasma alpha-2-macroglobulin and interactions with tumour necrosis factor-alpha in horses with endotoxemic signs. The electrophoretic position and behavior of the native and activated forms of equine plasma alpha-2-macroglobulin (alpha 2M) were characterized and compared to human alpha 2M by nondenaturing polyacrylamide-gel electrophoresis (PAGE). Plasma alpha 2M was also compared between 6 normal horses and 6 horses with clinical signs of colic and endotoxemia due to volvulus or enteritis. Native and activated forms of alpha 2M were quantified by PAGE and densitometry. Binding of radio-labeled recombinant human tumour necrosis factor-alpha (125I-rhTNF-alpha) to native and activated forms of equine alpha ...
Blastogenic response of lymphocytes from foals infected with Rhodococcus equi. The blastogenic response of lymphocytes from 16 newborn foals naturally infected with Rhodococcus equi was investigated, in order to evaluate the relationship between R. equi infection and depressed host response. Naturally infected foals showed evidence of R. equi infection at 5-6 weeks of age, as determined by clinical, haematological, bacteriological and serological methods. The blastogenic response of lymphocytes against phytohaemagglutinin was significantly depressed (stimulation index < 1.80; P < 0.01, P < 0.05) in R. equi-infected foals at 5-6 weeks of age compared with those o...
Detection of eastern equine encephalomyelitis virus RNA in formalin-fixed, paraffin-embedded tissues using DNA in situ hybridization. Eastern equine encephalomyelitis (F.EE) virus was detected in infected formalin-fixed horse and emu tissues and in infected chicken embryo fibroblasts. Results of in situ hybridization using a digoxigenin-labeled 40-base DNA probe complementary to a conserved region of the EEE virus RNA compared favorably with results of both virus isolation and serum neutralization tests. This technique may be useful for diagnosis of EEE virus infection in various animal species, especially when fresh tissues are not available for analysis, and also will provide a means for studying the involvement of alphavi...
Equine neonatal septicaemia: 24 cases. Equine neonatal septicaemia was confirmed in 24 foals hospitalised at the Rural Veterinary Centre between 1989 and 1992 with suspected septicaemia. Septicaemia was confirmed by culture of bacteria from blood of live foals and tissues obtained at necropsy of foals that died or were euthanased. Pathogenic bacteria isolated were predominantly Enterobacteriaceae (including Escherichia coli and Salmonella serovars) and Actinobacillus equuli. Clinical manifestations of septicaemia included signs of depression, dehydration, abnormalities in body temperature and manifestations of localised infection i...
Medical treatment of horses with ileal impactions: 10 cases (1990-1994). To evaluate clinical and laboratory findings for horses treated medically for ileal impactions. Methods: Retrospective case series. Methods: 10 horses with primary ileal impaction that were treated successfully with medical treatment alone. Methods: Medical records were reviewed for all horses with naturally developing ileal impaction seen at our hospital between 1990 and 1994. Results: Transrectal palpation revealed an impaction in the midabdominal area in all horses. Generalized distention of the small intestine was evident in 6 horses, whereas 4 horses were examined early in the course of t...
Comparison of the reappearance of strongyle eggs on foals, yearlings and adult horses after treatment with ivermectin or pyrantel. The reappearance of strongyle eggs in faeces after treatment with ivermectin or pyrantel embonate was investigated in 22 foals, 36 yearlings, and 45 adult horses on five Dutch horse farms. The results confirmed earlier studies which showed an egg reappearance period of 9 and 6 weeks after ivermectin and pyrantel treatment, respectively. There were no differences between the egg reappearance periods of foals, yearlings, and adult horses. The mean egg counts of the yearlings were, however, consistently higher than the mean egg counts of the adult horses and foals in both ivermectin- and pyrantel...
Anomalous inheritance of a paternally derived trophoblast antigen. Recurrent spontaneous abortion occurs in 1 in 500 random matings and usually results in abortion of all pregnancies. If absence of antibody to a paternally derived antigen caused abortion, the woman would be expected to make antibody to the other paternal antigen and abort only half her pregnancies. Methods: Microvesicles were prepared from equine placentae. Acid-eluted IgG antibody was eluted from the polymorphic R80K antigen and used to type the residual R80K antigen on vesicles or on peripheral blood leucocytes. Results: In several equine sibships all the half-sibs had the same paternal R80...
