The study of diseases in horses encompasses a wide range of conditions affecting equine health, including infectious diseases, metabolic disorders, and genetic abnormalities. These diseases can impact various systems within the horse, such as respiratory, gastrointestinal, and musculoskeletal systems, and can lead to significant health challenges. Research in this area focuses on understanding the pathophysiology, diagnosis, prevention, and treatment of equine diseases. Common diseases studied include equine influenza, equine herpesvirus, and laminitis. This page provides access to peer-reviewed research studies and scholarly articles that explore the etiology, clinical presentation, and management strategies of diseases in horses, contributing to the advancement of equine veterinary medicine.
Cain JL, Norris JK, Swan MP, Nielsen MK.The microbiome plays an important role in health, where changes in microbiota composition can have significant downstream effects within the host, and host-microbiota relationships can be exploited to affect health outcomes. Parasitic helminths affect animals globally, but an exploration of their microbiota has been limited, despite the development of anti-Wolbachia drugs to help control infections with some filarial nematodes. The equine ascarids, Parascaris spp., are considered the most pathogenic nematodes affecting juvenile horses and are also the only ascarid parasite to have developed wi...
Sousa JA, Miranda LM, Coutinho DJB, Costa TF, Costa SP, Freitas ÚS, Costa FB, Machado RZ, Nogueira RMS, Costa APD.The hemoprotozoan Trypanosoma evansi is a parasite that infects mammals, causing an infection known as trypanosomiasis. There is no report of T. evansi in horses in the State of Maranhão, highlighting the need to assess exposure and infection by the parasite and generate data for its monitoring. The objectives of this study were to identify T. evansi in blood samples from horses, investigate its occurrence in horses in this region, and analyze the associated risk factors. Three hundred blood samples were collected for parasitological (blood smear), serological (indirect enzyme-linked immunoso...
Pinho APVB, Ferreira F, Fuck JJ, de Oliveira JP, Dias RA, Grisi-Filho JHH, Heinemann MB, Telles EO, Amaku M, Ferreira Neto JS.Considering that control strategies for Equine Infectious Anemia, based on the serological diagnosis of equids and the removal of positive animals, may not be optimal for developing countries with an absolute predominance of grade working animals, this study aimed to address this issue based on the epidemiological situation of the disease in Pará, a state in the Brazilian Amazon. Pará was divided into five regions, and within each region a pre-established number of farms were randomly selected. Within each farm, a pre-set number of animals were randomly selected and submitted to Agar Gel Imm...
Kloster H, Stormo C, Haaland AH, Stuen S, Kjelland V. ticks play a crucial role as carriers of diseases, transmitting pathogens to vertebrate hosts, including horses. This study aimed to investigate the seroprevalence of IgG antibodies against sensu lato (s. l.), , and tick-borne encephalitis virus (TBE-virus) in equine sera collected in southern Norway. In total, sera from 331 horses stabled in four counties (Agder, Vestfold and Telemark, Vestland, and Viken) were analyzed by immunoblot. In total, 66% of the horses were IgG-seropositive for antibodies against one or multiple tick-borne pathogens. The highest seroprevalence was detected against...
Hellige M, Geburek F.A number of indications exist that necessitate radiologic examination of the equine cervical spine. Different neurologic and pain-associated clinical signs within the scope of lameness or poor performance may be associated to pathologies of the cervical spine. Moreover, the number of requests for radiographic examinations of the cervical spine, for example as part of the pre-purchase examination, has increased significantly in recent years. However, the interpretation of radiographs represents a challenge, particularly in the case of clinically sound horses, as it often necessitates the resolu...
Charbonnel A, Lavoie JP, Juette T, St-Sauveur VG, Denis S, Gagnon CA, Leclère M.The control of equine respiratory infections is a biosecurity challenge. Respiratory viruses are often rapidly detected using quantitative polymerase chain reaction (qPCR) on nasal swabs. In the past, some laboratories developed handmade techniques to increase the amount of nasal secretions collected, without comparing them with nasal swabs when qPCR replaced the use of viral culture. The objectives of this study were to compare nasal swabs and handmade foam cubes for i) the detection of a common equine herpesvirus (EHV-5) by qPCR, and ii) their tolerability. Forty-five polyester swabs and foa...
Costa Kamura BD, Albertino LG, Cavallari RR, Queiroz de Souza L, Rodrigues LT, Barros de Sousa Pereira I, Rocha NS, Takahira RK, Briscola Pereira WA....Africanized crossbred bees (Apis mellifera) originated in Brazil in 1957, and since then, the number of accidents involving humans and animals has significantly increased. Although they are considered clinical emergencies, there are few reports describing the clinical and pathological aspects of bee envenomation in horses. In this context, this report aims to describe the clinical and pathological features of bee toxicity after massive bee envenomation in three horses. The horses were referred to the veterinary hospital the day following the attack, and after clinical and laboratory examinatio...
Muñoz-Caro T, Gavilán P, Villanueva J, Oberg C, Herrera C, Fonseca-Salamanca F, Hidalgo A.Parasitic infections are among the most important causes of morbidity and mortality in horses worldwide. In the Andean mountainous regions of Chile, horses are a highly valued specie, playing a key role as working animals also providing support in cattle transhumance grazing into high mountainous areas during dry season. The breeding and maintenance of horses in the mountainous region of La Araucanía in Chile is a key issue allowing to the subsistence economy of communities with a strong ethnic component represented by Mapuche-Pehuenche origin families. However, the health status of these ani...
de Albuquerque CV, da Silva Andrade M, de Freitas MS, Paulino PG, Santos HA, de Tarso Landgraf Botteon P.Equine Piroplasmosis (EP) and Equine Granulocytic Anaplasmosis (EGA) are diseases that affect horses, transmitted by ixodid ticks, causing a nonspecific febrile syndrome. Equine Piroplasmosis is endemic in Brazil, and most horses are in enzootic stability. Serological and molecular studies carried out on horses in Brazil have shown the presence of Anaplasma phagocytophilum, however, the clinical relevance of this infection has not yet been established. The present study aims to evaluate the importance of Babesia caballi, Theileria equi, and A. phagocytophilum as etiological agents in horses wi...
Uprety T, Soni S, Sreenivasan C, Hause BM, Naveed A, Ni S, Graves AJ, Morrow JK, Meade N, Mellits KH, Adam E, Kennedy MA, Wang D, Li F.Equine rotavirus species A (ERVA) G3P[12] and G14P[12] are two dominant genotypes that cause foal diarrhoea with a significant economic impact on the global equine industry. ERVA can also serve as a source of novel (equine-like) rotavirus species A (RVA) reassortants with zoonotic potential as those identified previously in 2013-2019 when equine G3-like RVA was responsible for worldwide outbreaks of severe gastroenteritis and hospitalizations in children. One hurdle to ERVA research is that the standard cell culture system optimized for human rotavirus replication is not efficient for isolatin...
Uchida-Fujii E, Kato Y, Ueno T, Numasawa Y, Yusa S, Haga T.Equus caballus papillomavirus 2 (EcPV2) is known to cause genital neoplasms in horses. However, reports on EcPV2 in Japan and Asia are limited. Herein, we present the histopathological and virological findings of the first reported case of an EcPV2-associated penile mass in Japan. The patient was a 22-year-old stallion with a history of breeding in Japan and abroad. Histopathological examination contained RNA in situ hybridization targeting the E6/E7 region and an immunohistochemical approach, and whole-genome sequencing was conducted within the viral examination. Proliferating epidermal cells...
Machado M, Queiroz-Machado CRR, Queiroz F, Gardner DR, Riet-Correa F.A Mimosa pudica var. unijuga-associated toxicity affecting horses occurred in Araguari, Triângulo Mineiro, Southeast Brazil. Affected horses had gradual hair loss of the mane and tail and endocrine dermatosis after grazing for three months during the dry season on a paddock invaded by the plant. The main histological lesions include compact ortho-keratotic hyperkeratosis and numerous flame follicles. Toxicological analysis by HPLC-UV demonstrated 0.8 mg/g of mimosine in the leaves.
Leppänen V, Mykkänen A.Vipera berus berus is the only venomous snake present in the Nordic countries and cases of envenomation in horses are reported during the warmer months. Little is known about the presentation, treatment and survival of horses with common European adder envenomation. Clinical and laboratory findings, treatment and outcome are reported for 28 horses admitted to Helsinki University Equine Hospital in 2008-2023 due to suspicion of snake bite. Eleven of these horses received antivenom treatment. Other common treatments included non-steroidal anti-inflammatories (22/28), antimicrobials (19/28), intr...
Baumgarten CM, Delph Miller KM, Davis EG, Beard LA, Blevins CA, Wottowa M, Hill M, Larson RL.To measure the effect of routine vaccination on serum amyloid A (SAA) concentration in apparently healthy horses. We hypothesized that routine vaccination would increase SAA in healthy horses. Methods: 21 apparently healthy client-owned horses and 15 Kansas State University College of Veterinary Medicine-owned horses. Methods: In experiment 1 (n = 8 horses), a blinded, randomized, prospective, crossover study was performed. Horses were either vaccinated (rabies, tetanus, West Nile, Eastern and Western equine encephalomyelitis, equine herpesvirus-1/-4, influenza) or administered saline, and SAA...
Getahun YA, Tsalke BS, Buzuneh AW, Mejo MM, Habtewold WT.Equines are indispensable in reducing the huge burden on children and women and income generation. On the other hand, minimal attention is given to improving their health and welfare. Objective: This study examined the prevalence and associated risk factors of helminth parasites of equine in the Gamo Gofa Zone. Methods: A cross-sectional study was employed from June 2019 to March 2020. The study districts and were selected purposively based on agroecology whereas selection of study households and animals were performed based on simple random sampling techniques. Identification of nematode, tr...
Kuzmina TA, Königová A, Burcáková L, Babjak M, Syrota Y.This study aimed to examine the species diversity and structure of the strongylid community in domestic horses in Eastern Slovakia. Also, an analysis of the impact of age, sex, and collection location factors on the strongyid communities was performed. Methods: Twenty-seven horses 1.5-21 years old from two farms in eastern Slovakia with different horse-management conditions were studied. Strongylids were collected after horse treatments with Noromectin (0.2 mg ivermectin); 66,170 specimens were collected and identified. Faecal egg count reduction test (FECRT) was performed following fenbendaz...
Soliman R, Yousef M, Gelil SA, Aboul-Ella H.Strangles is a highly contagious disease of the equine upper respiratory tract caused by Streptococcus equi subspecies. Streptococcus equi subsp. equi (S. equi) and Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) was isolated, as local, hot, and field strains, from horses clinically suffering from respiratory distress. The isolated Streptococci were identified using bacteriological and molecular techniques. Four formulations of inactivated S. equi vaccines were developed and evaluated. The first formulation was prepared using the S. equi isolates, adjuvanted with MONTANIDE GEL adjuv...
Linnegar B, Kerlin DH, Eby P, Kemsley P, McCallum H, Peel AJ.To identify the size and distribution of the horse population in the Northern Rivers Region of NSW, including changes from 2007 to 2021, to better understand populations at risk of Hendra virus transmission. Methods: Census data from the 2007 Equine Influenza (EI) outbreak were compared with data collected annually by New South Wales Local Land Services (LLS) (2011-2021), and with field observations via road line transects (2021). Results: The horse populations reported to LLS in 2011 (3000 horses; 0.77 horses/km) was 145% larger than that reported during the EI outbreak in 2007 (1225 horses; ...
Cutarelli A, Buonavoglia A, Fusco G, Pellicanò R, Napoletano M, Brandt S, Roperto S.Sarcoids are benign and locally aggressive skin lesions that commonly affect horses and other equid species. Sarcoids are generally considered to be caused by bovine delta-papillomaviruses (δPVs) types 1 and 2 (BPV1 and BPV2, respectively). Moreover, while bovine δPV types 13 and 14 (BPV13 and BPV14, respectively) are also suspected to induce sarcoids, information regarding this possibility and the occurrence of multiple bovine δPV infections in sarcoids is scarce. This study aimed, for the first time, to assess BPV1, BPV2, BPV13, and BPV14 infections and co-infections in equine sarcoid sam...
Dahlgren AR, Careddu F, Norris JW, Adili R, Kropp EM, Li Q, Holinstat M, Biunno I, Balduini A, Tablin F, Shavit JA, Finno CJ.SEL1L is a well-known protein in the endoplasmic reticulum associated degradation (ERAD) pathway. While it is known to be expressed in platelets, SEL1L has never been shown to play an active role. Here we find evidence that SEL1L regulates platelet function. We first identified SEL1L through the study of Atypical Equine Thrombasthenia (AET), an autosomal recessive platelet disorder found in Thoroughbred horses. A missense variant in (c.1810A>G p.Ile604Val) was found in AET-affected horses, which we show is associated with decreased protein expression. SEL1L is intracellular in equine platelet...
Christofi E, Hoopes J, El-Hage C, Coffin J, Riley T, Cumming B.Since their arrival in the 1700s, horses have played a significant role in shaping the identity of rural and remote communities. However, Indigenous perspectives on the historical role of horses in communities have been largely underrepresented. In remote regions, where access to veterinary and medical services is limited, interactions between people and free-roaming horses present a potential risk for zoonotic disease transmission. This review identifies potential pathways for the transmission of equine zoonoses in rural and remote Aboriginal and Torres Strait Islander communities, aiming to ...
Bazan L, Argibay HD, Borges-Silva W, Pita Gondim LF, Dos Santos Mattos TA, Santana JO, da Silva EM, Begon M, Khalil H, Costa F, de Oliveira Carneiro I.Toxoplasma gondii is a globally neglected zoonotic parasite, particularly prevalent in socioeconomically vulnerable areas. Various animal species serve as reservoirs for T. gondii across different regions, including domestic cats, livestock, and a variety of wild and synanthropic animals. In urban areas, especially informal settlements, the close coexistence of humans, domestic animals, and wildlife may influence local transmission dynamics. This study evaluated the seroprevalence and associated risk factors for T. gondii infection in domestic and synanthropic animals from two low-income neigh...
Hananeh W, Al Rukibat R, Hammad H, Mukbel R.Leishmaniosis is an endemic parasitic infection in Jordan and the Middle East. Despite the endemicity of leishmaniosis in Jordan and frequently reported humancases, no singleclinical case has been documented in animals throughout the country. This report documents the first two animal Leishmania cases in two different animal species with a current literature review. Cutaneous leishmaniosis was diagnosed in an adult horse that presented with multiple variably sized skin nodules, some of which ulcerated. Visceral leishmaniosis was diagnosed in a stray dog. Cytological, histopathological, and mol...
Pineda V, Calzada JE, Montilla S, Rodríguez I, Howard E, Torres AI, Vasquez V, Reina A, Saldaña A, González K. (CL) is a vector-borne zoonotic disease affecting the skin and mucous membranes of animals and humans. While CL is commonly diagnosed and studied in humans in Panama, limited information exists on its occurrence in domestic animals and their potential role as reservoirs. In this study, samples from twelve domestic animals (ten dogs and two horses) with suspected CL lesions were collected between 2021 and 2025 in endemic regions of Panama and evaluated using multiple diagnostic methods. infection was confirmed in six of them (50%): five dogs and one horse. Three dogs were infected with () , ...
Alsakini KAMH, Al-Ammiri HH, Touma MM.A prevalent contagious pathogenic parasite that can lead to major health issues is . Unassigned: The present study aimed to detect the parasitic immune response and the existence of genomic DNA in the blood of a -positive equine. Unassigned: Thirty serum samples from horses suspected of having toxoplasmosis were collected from the Al-Rusafa neighborhood in Baghdad. To quantitatively investigate toxoplasma antibody levels in horse serum, an ELISA was used to evaluate immunoglobulin G (IgG) levels. Conventional (PCR) was used to identify DNA. Unassigned: The blood levels of IgG immunoglobulin i...
Ribeiro MG, Barbosa AN, Pereira JG, Possebon FS, Pinto JPAN, Portilho FVR, Bello TS, Paz PJL, Arabe Filho MF, Panegossi LC, Reznik AU, Zeferino LO....Rhodococcus equi, a versatile and adapted opportunistic in nature bacterium, infects animals and humans. This soil-borne microorganism widely occurs in farms. Its dissemination occurs by feces from domestic animals (particularly horses, cattle, and pigs). In the last decades, bacterial virulence has been strongly attributed to plasmid-encoded virulence-associated proteins (VAPs). To date, three virulence plasmid types have been recognized: pVAPA, pVAPB, and pVAPN, which are considered host- or livestock-adapted. The pVAPA type is related to equine isolates (horse-type), the pVAPB type is assoc...
Uzal FA, Navarro MA, Asin J, Henderson E.Clostridioides difficile affects humans, and several other animal species, such as horses, pigs, gerbils, guinea pigs, hamsters, and rabbits. This microorganism has also been isolated from the gastrointestinal tract of healthy individuals of a wide variety of animal species in which its association with disease is not known. Traditionally, in most domestic animal species, C. difficile-infection disease (CDI) was antibiotic-associated, although in the past few years more cases in which no antibiotic association was known have been described. In addition, no antibiotic association has been descr...
Kern-Allely C, Scott D, Magzamen S, Duncan C.Air pollution is a major global health threat that is expected to worsen, yet its effects on domestic animals remain poorly understood. The objective of this scoping review was to synthesize existing evidence on associations between ambient air pollutants and health outcomes in domestic animals and to identify gaps to guide future research. Unassigned: A scoping review was conducted following the Arksey and O'Malley framework and Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines with 2 search databases (PubMed and Web of Science) using ...
Basso RM, Cerri FM, Braga PRC, Silva ROS, de Araújo Júnior JP, Oliveira-Filho JP, Pantoja JCF, Ribeiro MG, Arroyo LG, Borges AS.Diarrhea is a significant cause of morbidity and mortality in foals. Our hypothesis is that foals with diarrhea have a greater prevalence of ≥2 organisms causing coinfections. We investigated the major microorganisms associated with diarrhea in 200 foals up to 1-y-old (100 diarrheic and 100 non-diarrheic). Fecal samples were analyzed by real-time PCR (rtPCR) for the detection of and toxin genes and , (genotyping for toxin-encoding genes), spp., , , , , , and spp. Rotavirus A and coronavirus were detected using reverse-transcription rtPCR. Fecal bacterial culture was also performed for ...
Nakayama T.In Mongolia, the traditional pastoral system has changed by the overuse and degradation of water resources. However, there is a research gap between the socio-economic transition and ecosystem degradation on the existing knowledge. In the present study, a process-based eco-hydrology model, National Integrated Catchment-based Eco-hydrology (NICE), was coupled with inverse method (NICE-INVERSE) and applied to the total of 29 river basins in the entire country to quantify the heterogeneous distribution of livestock water use and its relation to pasture degradation there. The result showed that th...
