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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Culicoides antigen extract stimulates equine blood mononuclear (BMN) cell proliferation and the release of eosinophil adherence-inducing factor(s).
Research in veterinary science    May 18, 2001   Volume 70, Issue 2 115-122 doi: 10.1053/rvsc.2000.0452
Mckelvie J, Foster AP, Hamblin AS, Cunningham FM.Intradermal injection of a Culicoides antigen extract (CAgX) induces T lymphocyte and eosinophil accumulation in the skin of horses with sweet itch. Blood mononuclear (BMN) cells from normal ponies proliferate when stimulated by mitogen (phytohaemagglutinin, PHA) or antigen (tetanus toxoid, TT) and, as shown here, release soluble factor(s) that induce eosinophil adherence. CAgX also caused concentration dependent proliferation of BMN cells from sweet itch and normal ponies [stimulation index: 29 (13) and 17 (7) for BMN cells from sweet itch and normal ponies, respectively during the active pha...
Surface mucus in the non-glandular region of the equine stomach.
Research in veterinary science    May 18, 2001   Volume 70, Issue 2 149-155 doi: 10.1053/rvsc.2001.0455
Bullimore SR, Corfield AP, Hicks SJ, Goodall C, Carrington SD.In horses, ulceration of the non-glandular region of the stomach is common and has been attributed to the lack of a protective mucus covering. This study aimed to determine whether the non-glandular region is covered by a mucus layer. A mixture of antibodies raised against human gastric mucin (MUC 5 AC) showed a tissue distribution in the glandular region of the equine stomach similar to that seen in humans. Dot blots of mucus from the glandular and non-glandular regions showed cross-reactivity with these antibodies. Various histological fixation and processing techniques were compared for the...
Immunity to Rhodococcus equi: antigen-specific recall responses in the lungs of adult horses.
Veterinary immunology and immunopathology    May 18, 2001   Volume 79, Issue 1-2 101-114 doi: 10.1016/s0165-2427(01)00258-6
Hines MT, Paasch KM, Alperin DC, Palmer GH, Westhoff NC, Hines SA.Rhodococcal pneumonia is an important disease of young horses that is not seen in immunocompetent adults. Since all foals are normally exposed to Rhodococcus equi in their environment, we hypothesized that most develop protective immune responses. Furthermore, these antigen-specific responses were hypothesized to operate throughout adult life to prevent rhodococcal pneumonia. A better understanding of the mechanisms of immune clearance in adult horses would help define the requirements for an effective vaccine in foals. Adult horses were challenged with virulent R. equi by intrabronchial inocu...
Cardiorespiratory and endocrine effects of endogenous opioid antagonism by naloxone in ponies anaesthetised with halothane.
Research in veterinary science    May 18, 2001   Volume 70, Issue 2 95-100 doi: 10.1053/rvsc.2000.0444
Luna SP, Taylor PM.Halothane depresses cardiorespiratory function and activates the pituitary-adrenal axis, increasing beta endorphin. In horses, beta endorphin may enhance the anaesthetic-associated cardiorespiratory depression and mortality risk. The authors studied endogenous opioid effects on cardiorespiratory function and pituitary-adrenal activity in halothane-anaesthetised ponies by investigating opioid antagonism by naloxone. Six ponies were anaesthetised three times (crossover design). Anaesthesia was induced with thiopentone and maintained with 1.2 per cent halothane for 2 hours. Immediately after indu...
Nasal strips do not affect pulmonary gas exchange, anaerobic metabolism, or EIPH in exercising Thoroughbreds.
Journal of applied physiology (Bethesda, Md. : 1985)    May 18, 2001   Volume 90, Issue 6 2378-2385 doi: 10.1152/jappl.2001.90.6.2378
Goetz TE, Manohar M, Hassan AS, Baker GJ.The present study was carried out to examine whether nasal strip application would improve the exercise-induced arterial hypoxemia and hypercapnia, diminish anaerobic metabolism, and modify the incidence of exercise-induced pulmonary hemorrhage (EIPH) in horses. Two sets of experiments, control and nasal strip experiments, were carried out on seven healthy, sound, exercise-trained Thoroughbred horses in random order, 7 days apart. Simultaneous measurements of core temperature, arterial and mixed venous blood gases/pH, and blood lactate and ammonia concentrations were made at rest, during subma...
Effect of prior high-intensity exercise on exercise-induced arterial hypoxemia in Thoroughbred horses.
Journal of applied physiology (Bethesda, Md. : 1985)    May 18, 2001   Volume 90, Issue 6 2371-2377 doi: 10.1152/jappl.2001.90.6.2371
Manohar M, Goetz TE, Hassan AS.Strenuously exercising horses exhibit arterial hypoxemia and exercise-induced pulmonary hemorrhage (EIPH), the latter resulting from stress failure of pulmonary capillaries. The present study was carried out to examine whether the structural changes in the blood-gas barrier caused by a prior bout of high-intensity short-term exercise capable of inducing EIPH would affect the arterial hypoxemia induced during a successive bout of exercise performed at the same workload. Two sets of experiments, double- and single-exercise-bout experiments, were carried out on seven healthy, sound Thoroughbred h...
Application of fluorescent in situ hybridization for specific diagnosis of Pneumocystis carinii pneumonia in foals and pigs.
Veterinary pathology    May 18, 2001   Volume 38, Issue 3 269-274 doi: 10.1354/vp.38-3-269
Jensen TK, Boye M, Bille-Hansen V.Fluorescent in situ hybridization, immunohistochemistry, and Grocott's methenamine-silver nitrate staining were compared as diagnostic methods for Pneumocystis carinii pneumonia in formalin-fixed lung tissue from foals and pigs. An oligonucleotide probe targeting 18S ribosomal RNA of P. carinii was designed for in situ hybridization, and a commercially available monoclonal antibody was used for immunohistochemistry. Samples from six foals and 10 pigs with P. carinii pneumonia, as verified by Grocott's methenamine-silver nitrate staining, were examined concurrently with samples from seven anima...
Electromyography under caudal epidural anaesthesia as an aid to the diagnosis of equine motor neuron disease.
The Veterinary record    May 17, 2001   Volume 148, Issue 17 536-538 doi: 10.1136/vr.148.17.536
Kyles KW, McGorum BC, Fintl C, Hahn CN, Mauchline S, Mayhew IG.Electromyography was used as an aid to the diagnosis of equine motor neuron disease in a conscious horse while it was under caudal epidural anaesthesia. A muscle biopsy was taken to confirm the diagnosis which was then supported by a postmortem examination.
Confocal microscopy of germinal vesicle-stage equine oocytes.
Theriogenology    May 17, 2001   Volume 55, Issue 7 1417-1430 doi: 10.1016/s0093-691x(01)00491-5
Gable TL, Woods GL.The objectives were to compare cumulus type with nucleus form in equine cumulus oocyte complexes (COCs), to define the percentage of germinal vesicle (GV)-stage oocytes within a population of mares, and to further define GV nucleus shapes of equine oocytes. Cumulus types were as follows: 1) compact (56/208, 26.9%), 2) slightly expanded (37/208, 17.8%), 3) moderately expanded (27/208, 13.0%), 4) greatly expanded (15/208, 7.2%), or 5) denuded (73/208, 35.1%). One hundred thirty of 208 COCs (62.5%) were GV-stage, 21/208 (10.1%) were condensed chromatin-stage, 8/208 (3.8%) were polar body-stage, 4...
The role of the horse in Europe. Proceedings of the WALTHAM Symposium.
Equine veterinary journal. Supplement    May 17, 2001   Issue 28 1-72 
No abstract available
Increasing culture time from 48 to 96 or 144 hours increases the proportions of equine cumulus oocyte complexes with negative or fragmented nucleus morphology.
Theriogenology    May 17, 2001   Volume 55, Issue 7 1549-1560 doi: 10.1016/s0093-691x(01)00501-5
Gable TL, Woods GL.The objective was to test the hypothesis that increasing equine oocyte culture time from 48 to 96 or 144 h increases nucleus maturation of equine oocytes. The hypothesis was not supported because condensed chromatin-stage oocytes decreased (P<0.01) from 33/126 (26.2%) at 48 h or 34/95 (35.8%) at 96 h to 11/117 (9.4%) at 144 h, and polar body-stage oocytes decreased (P<0.01) from 65/126 (51.6%) at 48 h to 25/95 (26.3%) at 96 h and (P<0.01) to 1/117 (0.9%) at 144 h. Negative (non-staining) oocytes increased (P<0.01) from 16/126 (12.7%) at 48 h or 15/95 (15.8%) at 96 h to 39/117 (33.3%) at 144 h....
Effects of inhalation of albuterol sulphate, ipratroprium bromide and frusemide on breathing mechanics and gas exchange in healthy exercising horses.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 302-310 doi: 10.2746/042516401776249741
Bayly WM, Slocombe RF, Schott HC, Hines MT, Sides RH, Hakala JE.The possibility that pre-exercise inhalation of a bronchodilator by healthy horses could improve their mechanics of breathing and enhance performance was investigated. Ipratropium bromide (0.35 microg/kg bwt; n = 7) was administered by nebulisation 30 min before exercise and frusemide (1 mg/kg bwt; n = 6) was given in the same manner 2 h before exercise. Albuterol sulphate (360 and 720 microg; n = 7) were administered with a metered dose inhaler 2 h before exercise. Each drug was investigated independently of the others using cross-over protocols. Horses completed incremental exercise tests an...
Equine thoracoscopy: normal anatomy and surgical technique.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 231-237 doi: 10.2746/042516401776249688
Peroni JF, Horner NT, Robinson NE, Stick JA.Six normal, healthy horses age 3-10 years underwent left and right thoracoscopic examination using a rigid telescope. A minimum of 30 days was allowed between procedures. Horses were restrained in stocks and sedated with a continuous detomidine infusion. After surgical preparation of the hemithorax elected for surgery, and administration of local or regional anaesthesia of the surgery sites, thoracoscopy was completed during two 15 min pneumothorax periods. During the procedures, the thoracic structures were viewed using a 57 cm, 10 mm diameter, 30 degrees rigid telescope connected to a digita...
Molecular surveillance of the incidence of Taylorella equigenitalis and Pseudomonas aeruginosa from horses in Ireland by sequence-specific PCR.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 319-322 doi: 10.2746/042516401776249750
Moore JE, Buckley TC, Millar BC, Gibson P, Cannon G, Egan C, Cosgrove H, Stanbridge S, Anzai T, Matsuda M, Murphy PG.No abstract available
A case-control study of respiratory disease in Thoroughbred racehorses in Sydney, Australia.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 256-264 doi: 10.2746/042516401776249796
Christley RM, Hodgson DR, Rose RJ, Wood JL, Reids SW, Whitear KG, Hodgson JL.In order to investigate the role of infectious agents in the aetiology of lower respiratory tract disease in Thoroughbred racehorses, a matched case-control study was conducted. Cases were identified by the presence of coughing, and were compared to a control population matched on time of sample collection and location within the same training establishment. Tracheal wash samples were collected from 100 cases and 148 controls. Case horses were more likely than controls to have endoscopic and cytological evidence of airway inflammation. There was no significant association between serological e...
Pulmonary and systemic effects of inhaled endotoxin in control and heaves horses.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 311-318 doi: 10.2746/042516401776249732
Pirie RS, Dixon PM, Collie DD, McGorum BC.To investigate whether inhaled endotoxin contributes to airway inflammation and dysfunction in stabled horses, control (n = 6) and asymptomatic heaves (previously termed chronic obstructive pulmonary disease)-susceptible (n = 7) horses were given inhalation challenges with 20, 200 and 2,000 microg of soluble Salmonella typhimurium Ra60 lipopolysaccharide (LPS). LPS inhalation induced a dose-dependent neutrophilic airway inflammatory response in both groups. Inhalation with 2,000 microg of LPS also induced detectable lung dysfunction in the heaves group. LPS inhalation did not alter clinical sc...
Preliminary evaluation of diagnostic tests using horses experimentally infected with trypanosoma evansi.
Veterinary journal (London, England : 1997)    May 16, 2001   Volume 161, Issue 3 287-300 doi: 10.1053/tvjl.2000.0560
Wernery U, Zachariah R, Mumford JA, Luckins T.Seven surra negative horses were intravenously inoculated with 3 x 10(6)Trypanosoma evansi parasites derived from a camel. One horse was maintained as an uninfected negative control. Three antigen and three antibody detection tests were evaluated for diagnosis of infection in horses. The microhaematocrit centrifugation test (MHCT) was the most sensitive, first detecting parasites between one and three days (x 2.4) post infection (p.i.). The antigen (ag)-ELISA detected antigen between three and ten days (x 6.6) p.i. The latex agglutination test (LAT) first gave positive results on day 3 (x 3.0)...
Intraluminal leiomyoma colon polyp in a mare.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 326-328 doi: 10.2746/042516401776249769
Watt BC, Trostle SS, Cooley AJ.No abstract available
A long-term study of 277 cases of equine sinonasal disease. Part 1: details of horses, historical, clinical and ancillary diagnostic findings.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 274-282 doi: 10.2746/042516401776249615
Tremaine WH, Dixon PM.The clinical and ancillary diagnostic findings in equine sinnasal disease were studied. The diagnoses in 277 referred (1984-1996) cases of equine sinonasal disease included the following (% all cases): 67 cases (24.2%) primary sinusitis, 61 (22.0%) dental sinusitis, 37 (13.4%) sinus cysts, 22 (7.9%) sinonasal neoplasia, 21 (7.6%) progressive ethmoid haematoma, 17 (6.1%) sinonasal trauma, 13 (4.7%) sinonasal mycosis, 11 (4.0%) rostral maxillary cheek tooth infection, 7 (2.5%) sinonasal polyps, 7 (2.5%) cases of nasal epidermal inclusion cysts and 14 (5.1%) miscellaneous sinonasal disorders. Man...
A positive step forwards in the diagnosis of equine sarcoid.
Veterinary journal (London, England : 1997)    May 16, 2001   Volume 161, Issue 3 224-226 doi: 10.1053/tvjl.2000.0555
Knottenbelt DC, Matthews JB.No abstract available
Temporary transvenous atrial pacing in horses: threshold determination.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 290-295 doi: 10.2746/042516401776249633
van Loon G, Laevens H, Deprez P.The purpose of this study was to perform temporary atrial pacing and to determine the atrial strength-duration (S-D) curve which displays the minimal pulse intensity necessary to achieve atrial capture. In 7 horses, atrial pacing was applied using a temporary pacing catheter and a pacemaker as electrical pulse generator. Using the stimulus reduction method, 3 approaches for atrial threshold determination were used. With the fixed pulse width method, at several pulse widths, the corresponding minimal amplitudes to achieve capture were determined, describing an S-D curve. With the fixed amplitud...
Postprandial arterial vasodilation in the equine distal thoracic limb.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 269-273 doi: 10.2746/042516401776249642
Hoffmann KL, Wood AK, Griffiths KA, Evans DL, Gill RW, Kirby AC.The effects of feeding on blood flow to the equine foot are poorly understood. In a temperature-controlled room, duplex Doppler ultrasonographic observations were made pre- and postprandially of the lateral proper palmar digital artery of 5 horses, randomly assigned to twice and 4 times daily feeding in an unbalanced 2 period crossover design. Arterial diameter and blood velocity were measured over 4 h and additional observations made of heart rate, blood pressure, total plasma protein, packed cell volume, plasma glucose and insulin. There was no effect of the feeding regimen on any variable. ...
A long-term study of 277 cases of equine sinonasal disease. Part 2: treatments and results of treatments.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 283-289 doi: 10.2746/042516401776249787
Tremaine WH, Dixon PM.The treatments of 277 horses with equine sinonasal disease (1984-1996), described by Tremaine and Dixon (2001), are reported here. Long-term (median duration 24 months) outcomes of treatment of the more common disorders were good, with 92% of horses with sinonasal mycosis, 84% with primary sinusitis, 82% with sinus cysts, 78% with dental sinusitis and 75% with sinonasal trauma reported to have complete remission of clinical signs. However, only 33% of horses with progressive ethmoidal haematoma (PEH) and 12% with sinonasal neoplasia reported long term remission of clinical signs.
A comparison of the effects of two volumes of local analgesic solution in the distal interphalangeal joint of horses with lameness caused by solar toe or solar heel pain.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 265-268 doi: 10.2746/042516401776249778
Schumacher J, Schumacher J, de Graves F, Steiger R, Schramme M, Smith R, Coker M.The response of horses, with solar pain in the dorsal or palmar aspect of the foot, to 6 or 10 ml local analgesic solution administered into the distal interphalangeal (DIP) joint was examined. Lameness was induced in 7 horses by creating solar pain in the dorsal aspect of one forefoot and, at another time, the palmar aspect of the other forefoot with set-screws inserted into a custom-made shoe. Horses were videotaped trotting before and after application of set-screws and, in separate trials, after 6 or 10 ml local analgesic solution was administered into the DIP joint. Lameness scores were a...
Coughing: a source of irritation?
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 221-223 doi: 10.2746/042516401776249723
Head MJ, Wood JL.No abstract available
Arthroscopic laser extirpation of metacarpophalangeal synovial pad proliferation in eleven horses.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 296-301 doi: 10.2746/042516401776249679
Murphy DJ, Nixon AJ.A new surgical technique for treatment of chronic metacarpophalangeal synovial pad proliferation in the horse and the findings and long-term follow-up from 11 clinical cases are described. The medical records of all equine lameness cases attributed to metacarpophalangeal synovial pad proliferation admitted to the College of Veterinary Medicine at Cornell University (1991-1996) were reviewed and all those treated surgically by laser extirpation were included in this study. Retrieved data included subject details, preoperative lameness, ultrasonography, radiography and synovial fluid evaluations...
Pharyngeal lymphoid tissue: gatekeeper or showstopper?
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 218-220 doi: 10.2746/042516401776249660
Lunn DP.No abstract available
Organisation of uterine innervation in the mare: distribution of immunoreactivities for the general neuronal markers protein gene product 9.5 and PAN-N.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 323-325 doi: 10.2746/042516401776249624
Bae SE, Corcoran BM, Watson ED.No abstract available
PCR detection of bovine papilloma virus DNA in superficial swabs and scrapings from equine sarcoids.
Veterinary journal (London, England : 1997)    May 16, 2001   Volume 161, Issue 3 280-286 doi: 10.1053/tvjl.2000.0524
Martens A, De Moor A, Ducatelle R.The purpose of this study was to examine if bovine papilloma virus (BPV) DNA can be detected in superficial swabs or scrapings from equine sarcoids. Samples were obtained from 92 sarcoids and 20 non-sarcoidal control lesions. The polymerase chain reaction technique was used with a first primer set to check whether DNA extraction was successful, and with a second primer set specific for BPV-DNA. DNA isolation was successful in 88% of the swabs and 93% of the scrapings. All control lesions were negative for BPV-DNA.
M cells and associated lymphoid tissue of the equine nasopharyngeal tonsil.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 224-230 doi: 10.2746/042516401776249697
Kumar P, Timoney JF, Sheoran AS.The aim of this study was to characterise the morphological and histochemical features of equine nasopharyngeal tonsillar tissue. Nasal and oropharyngeal tonsillar tissue has been described as the gatekeeper to mucosal immunity because of its strategic location at the entrance to the respiratory and alimentary tracts. A combination of light, scanning and transmission electron microscopy has revealed the presence of follicle-associated epithelium (FAE) overlying lymphoid tissue of the equine nasopharyngeal tonsil caudal to the pharyngeal opening of the guttural pouch. Membranous microvillus (M)...