Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Hoffman AM, Mazan MR, Ellenberg S.To correlate indices of airway reactivity to bronchoalveolar lavage (BAL) fluid cytologic features in horses with a recent decline in exercise tolerance. Methods: 20 actively working horses from 2 to 24 years old. Methods: Bronchoalveolar lavage fluid samples were obtained and analyzed. Forced oscillatory mechanics (1-7 Hz) technique was used for measurements of total respiratory system resistance (RRS), compliance (CRS), and resonant frequency (fres). Changes in RRS (1 Hz) during histamine challenge were used to generate histamine dose-response curves, from which the provocative concentration...
Ingle-Fehr JE, Baxter GM.To measure blood flow in the palmar digital artery and laminae corium, using ultrasonic and laser Doppler flowmetry, respectively. Methods: 6 healthy horses. Methods: Digital blood flow and laminar perfusion, respectively, were measured by placing a flow probe around the palmar digital artery and a laser Doppler flow probe in a hole in the dorsal aspect of the hoof wall. All horses were given saline (0.9% NaCl) solution (1 L, IV, during a 30-minute period). Seven days later, each horse was given endotoxin (0.1 microgram/kg of body weight, IV, in 1 L of saline solution, during a 30-minute perio...
Nasir L, McFarlane ST, Torrontegui BO, Reid SW.Papillomaviral DNA has been identified in peripheral blood cells of both cattle and humans with and without associated disease and it has been suggested that such cells may act as sites of viral latency. In order to investigate the possibility of latent papillomaviral infection in the aetiopathogenesis of the equine sarcoid, peripheral blood derived DNA samples from 20 healthy and 34 sarcoid-affected donkeys were subject to polymerase chain reaction (PCR) using papillomaviral specific primers. Analysis of blood derived DNA samples failed to demonstrate the presence of papillomaviral DNA in any...
Marr CM, Reef VB, Brazil TJ, Thomas WP, Knottenbelt DC, Kelly DF, Baker JR, Reimer JM, Maxson AD, Crowhurst JS.This report describes the history, clinical, electrocardiographic and echocardiographic findings, treatment, outcome and post-mortem findings in seven horses with aorto-cardiac fistula. Affected horses included 5 stallions, one gelding and one mare; 2 each of the Thoroughbred, Arabian and Standardbred breeds and one Thoroughbred-cross with a mean +/- s.d. age of 12 +/- 4 years, range 6-18 years. The presenting signs were acute distress (four horses), exercise intolerance (two horses) and the lesion was detected during a routine examination in one horse. Five horses had monomorphic ventricular ...
Estberg L, Stover SM, Gardner IA, Johnson BJ, Jack RA, Case JT, Ardans A, Read DH, Anderson ML, Barr BC, Daft BM, Kinde H, Moore J, Stoltz J, Woods L.To investigate relationships of several racehorse characteristics and race conditions with risk of a catastrophic musculoskeletal injury (CMI) resulting in euthanasia in Thoroughbreds during racing in California in 1992. Methods: Retrospective longitudinal study. Methods: Thoroughbreds that incurred CMI during racing and all California race entrants in 1992. Methods: Necropsy records were reviewed, and race start information was obtained. Incidence risk of CMI/1,000 race entrants was estimated. Relationships between CMI during racing and race-meet, entrant age and sex, race type and length, an...
Potter K, Anez D.A 17-year-old Quarter Horse mare was examined to determine the cause of a vulvar mass. Differential diagnoses for the swollen, ulcerated tissue included hypersensitivity reaction to insect stings or bites and cutaneous neoplasia. During the next 4 months, the mass enlarged involving the skin of the perineum and ventral aspect of the abdomen with secondary dependent edema of both hind limbs. Histologic examination of biopsy and necropsy specimens revealed changes consistent with a diagnosis of mycosis fungoides (cutaneous T-cell lymphoma). Diagnostic features included invasion of neoplastic lym...
Harris DB, Harris RC, Wilson AM, Goodship A.Muscle ATP loss with exercise has implications both to the causes of fatigue and muscle damage. To study this at the single muscle fibre level, five trained thoroughbred horses performed consecutive 90 second gallops on an inclined treadmill followed by a final gallop to fatigue. Biopsies of the m. gluteus medius were taken at rest, post-exercise and during 24 hour recovery. Blood lactate was 20.0 mmol litre-1 or more, and plasma NH3 300-800 mumol litre-1, following the final gallop. Minimal changes occurred in the plasma markers, CK and AST. ATP loss with exercise was 32.2 (SD 12.2) per cent....
Koepf EK, Hewitt J, Vo H, Macgillivray RT, Burtnick LD.We have generated and characterized the cDNA from equine smooth muscle that encodes gelsolin, an actin-modulating protein. Overlapping cDNA clones synthesized by the reverse transcriptase/polymerase chain reaction and clones isolated from a horse genomic library provided the complete primary structure for the intracellular isoform of gelsolin, while cDNA complemented with protein sequence data produced the full-length primary transcript of the gelsolin isoform found circulating in equine plasma. The deduced amino acid sequences of the intracellular and secreted versions of equine gelsolin infe...
The Journal of heredityMarch 6, 1998
Volume 89, Issue 1 104-106 doi: 10.1093/jhered/89.1.104
Duffield DA, Goldie PL.In a study of 2,786 tobiano and non-tobiano horses involved in paint horse breeding programs throughout the United States, the inheritance of the tobiano color pattern gene was tracked in pedigrees using the tightly linked polymorphic albumin gene. The dominant tobiano allele (T(o)), which produces the tobiano spotting pattern in horses, was in coupling with both AIA and AIB alleles at the albumin locus. The frequency of the T(o):AIA linkage phase among all the homozygous tobiano horses in this study including offspring and parents (N = 127), was 0.08. The T(o):AIB linkage phase was the most f...
Mancebo OA, Verdi JH, Bulman GM.On the basis of positive skin snips for Onchocerca cervicalis microfilariae (MF), 45 horses were chosen from 48 in a total of 257 screened on 12 locations in the northeast Province of Formosa (Argentina), and randomly assigned to two treatment groups of 20 horses each, and a nontreated control group of five horses. On Day 14 post-treatment (PT), skin snip samples in the ivermectin-treated (0.2 mg/kg) group were negative for normal viable microfilariae (MF), while horses in the control group maintained their pretreatment level of infection. On the same Day in the moxidectin-treated (0.4 mg/kg) ...
Monahan CM, Chapman MR, Taylor HW, French DD, Klei TR.Three groups of foals were raised under different management programs in this study: Group 1 (n = 6) and Group 2 (n = 6) were raised with their dams on pasture; Group 3 foals (n = 5) were raised under parasite-free conditions. Mares and foals of Group 1 received daily pyrantel tartrate (PT) treatment with their pelleted feed ration, whereas mares and foals of Groups 2 and 3 received only the pelleted ration. Pasture-reared foals were weaned and moved to a heavily contaminated pasture for 5 weeks. Group 1 foals continued to receive daily PT treatment whereas Group 2 foals received only the pell...
Boersema JH, Eysker M, van der Aar WM.The reappearance of strongyle eggs in the faeces of horses treated with moxidectin (0.4 mg/kg of body weight) was compared with that in the faeces of horses treated with ivermectin (0.2 mg/kg of body weight). The study was performed from December 1995 till June 1996. Horses were infected naturally in the preceding grazing period. Two groups of 24 horses each were treated with moxidectin and ivermectin respectively at week 0. No side effects were seen after treatment. Horses were housed from week -1 till week 17. From week 17 onwards the horses were on pasture. Faecal samples were taken from ea...
Fernández AS, Larsen M, Nansen P, Grønvold J, Henriksen SA, Wolstrup J.A plot experiment was conducted to investigate the ability of the nematode-trapping fungus Duddingtonia flagrans to reduce the transmission of infective horse strongyle larvae from deposited dung onto surrounding herbage. At three different times during the summer 1995, three groups of horses, naturally infected with large and small strongyles, were fed different doses of D. flagrans spores, while a fourth group of animals served as non-fungal controls. Faeces from all four groups of horses were deposited as artificial dung pats on a parasite-free pasture. Every second week for 8 weeks after d...
Williamson RM, Gasser RB, Middleton D, Beveridge I.The intestinal tracts of 130 horses were examined for infection with Anoplocephala perfoliata at necropsy. Fifty horses (38.5%) harboured the tapeworm, and the site of attachment of each worm was recorded using predetermined anatomical landmarks. The worms were attached in four regions of the gastrointestinal tract: 17% of the worms were found at the ileocaecal junction, 81% on the caecal wall, 1.7% in the terminal ileum and 0.2% in the ventral colon. The severity of lesions produced at the sites of attachment was related to the number of worms attached. Due to the small area of the ileocaecal...
Borgsteede FH, van Beek G.The prevalence of metazoan parasites in the stomach and small intestine was investigated in 70 horses slaughtered in the period February 1994-July 1994. Most horses were young (1.5-3 years) and in good condition. Trichostrongylus axei was the most prevalent parasite species in the stomach (51.4%), followed by Gasterophilus intestinalis (41.4%) and Habronema spp. (4.3%). In the small intestine, Parascaris equorum (28.6%) and Paranoplocephala mamillana (1.4%) were found. The mean worm burden of T. axei was 957 (max. 8502), of G. intestinalis 21 (max. 84), of Habronema spp. 3 (max. 5), and of P. ...
Sheoran AS, Sponseller BT, Holmes MA, Timoney JF.Equine strangles, caused by the clonal pathogen Streptococcus equi, is a source of serious economic loss despite the widespread use of commercial vaccines. The anti-phagocytic 58 kDa M-like protein (SeM) is an important protective antigen. The objective of this study was to define differences, if any, between SeM-specific convalescent serum and mucosal IgA and IgG subisotypes and those induced by vaccination with commercial strangles vaccine. SeM-specific opsonophagocytic IgGb was the predominant serum antibody in horses intramuscularly vaccinated or recently recovered from infection. Infectio...
Foster AP, Cunningham FM.Equine eosinophils and neutrophils are believed to play an important part in the protection of horses against parasitic and bacterial invasion. Eosinophils may also play a key role in the pathogenesis of equine inflammatory conditions such as the allergic skin disease, insect hypersensitivity. The factors which stimulate the respiratory burst of equine eosinophils and neutrophils are poorly understood. The first aim of the present study was to determine the effects of the phorbol ester, phorbol myristate acetate (PMA), which is believed to activate intracellular protein kinase C, and opsonised...
Sahagun-Ruiz A, Waghela SD, Holman PJ, Chieves LP, Wagner GG.A DNA probe from Babesia caballi (Bc1) was selected by antibody screening of a genomic library. The Bc1 probe hybridized specifically to B. caballi genomic DNA. A polymerase-chain-reaction-based assay for B. caballi DNA was developed from primers deduced from the probe nucleotide sequence. An amplified product of 1.6 kb was detected from as little as 500 fg B. caballi template DNA. Sensitivity increased 1000-fold when the biotin-labeled Bc1 probe was hybridized to the amplicons in a Southern blot.
Norrdin RW, Kawcak CE, Capwell BA, McIlwraith CW.Gross examination of metacarpo-/metatarsophalangeal (fetlock) joints from racehorses revealed defects on the condylar surface that ranged from cartilage fibrillation and erosion to focal cartilage indentations and cavitation in subchondral bone characteristic of traumatic osteochondrosis. Because these lesions represented a spectrum of mechanically induced arthrosis in which microdamage is thought to play a role, a histologic study of sagittal sections was made to study the morphogenesis. Subchondral bone failure developed beneath a flattened section of the condyle where the margin of the sesa...
Konkle DM, Nelson KM, Lunn DP.An outbreak of cryptosporidiosis occurred at a veterinary hospital, involving multiple species, including humans. The index case was an infected dairy calf that presented with diarrhea. Several other cases of cryptosporidial diarrhea subsequently developed during a 1-month period. The key features of this outbreak were the multiple species affected, the increased morbidity in immunocompromised neonates, and the failure of implemented control measures to contain the disease.
Wagner B, Brandt K, Sheoran A, Holmes MA, Deegen E, Leibold W.The functional properties of different immunoglobulin isotypes in equine recurrent uveitis (ERU) has not been investigated yet. Here, we describe the quantitative determination of total immunoglobulin levels and isotype differentiation in the vitreous of four horses with ERU as compared to that of seven healthy horses. In contrast to almost equal amounts of total immunoglobulin in the vitreous of both groups, remarkable differences were found: All four of the horses with ERU had significantly higher IgA contents in their vitreous as compared to the control group. However, the other isotypes mo...
Hardy J, Robertson JT, Reed SM.Chronic constrictive pericarditis was diagnosed in a 6-year-old Thoroughbred mare based on the clinical findings of right congestive heart failure, hyperechoic pericardium without pericardial effusion, and a dip-and-plateau shape of the right ventricular pressure curve with equilibration of the diastolic pressures in all cardiac chambers. Treatment was attempted by partial pericardiectomy using a right lateral thoracotomy approach. Because of severe epicardial involvement recurrence of the constrictive pathology was noted 6 weeks after the surgical procedure. However, in selected cases in whic...
To evaluate the etiology of skeletal changes noted in equid vertebrae from a 19- century context near Belgrade, Serbia. A vertebral column consisting of 15 fused thoracic vertebrae (T2-T16), with right ribs fused to T4 and T5 and small remnants of ribs articulating with T4, T5 and T6 on the left side were accidentally recovered during industrial exploitation of sand. The specimen was subjected to morphological analysis and collagen fingerprinting by mass spectrometry for species identification. In order to determine the absolute temporal context, radiocarbon dating was employed. Pathological c...
Bugno M, Slota E, Witarski W, Gerber V, Klukowska-Roetzler J.The results obtained in the present study enabled the physical map of the donkey genome to be extended with markers associated with recurrent airway obstruction (RAO), a major performance-limiting disease of Equidae. The equine BAC clone containing the IL4R and CLCA1 genes were localized to EAS 14q13 and EAS 6q15 respectlivy by fluorescent in situ hybridization. Identification of their locus confirmed the distribution of syntenic regions between the domestic horse and the domestic donkey within the chromosomes analysed.
Fulton IC, MacLean AA, O'Rielly JL, Church S.Bilateral superior check ligament desmotomy was performed on 31 Thoroughbred and 17 Standardbred horses as the sole method of treatment for superficial digital flexor tendonitis. Horses resumed racing between 6 and 19 months after surgery. Horses that were able to compete in 5 or more races without injury to the tendon again were considered to have had a successful return to racing. Twenty-five Thoroughbreds were suitable for later study and 13 of these (52%) raced on 5 or more occasions. Fifteen Standardbreds were suitable for later study and 10 of these (66%) raced on 5 or more occasions. Wi...
Sumner-Smith G, Bell M, Manley P, Caddell E, Hoare J.The advances made by the use of a telemetric system in the study of bone strain in a free-moving horse are reported. A rosette strain gauge was bonded to the craniomedial aspect of the metacarpus of the horse. Attachment of a miniature FM transmitter to lead wires facilitated telemetric transmission of of resistance changes which corresponded to limb movement. During 3 different gaits, the trace pattern remained similar, although frequency and amplitude varied. The tracings were similar to those reported in other species in which nontelemetric transmission was used.
O'Callaghan MW, Pascoe JR, Tyler WS, Mason DK.Latex was injected under pressure into bronchial and pulmonary arteries of the inflated lungs of Thoroughbreds and transverse sections taken to calculate the area of lesions resulting from exercise-induced pulmonary haemorrhage. Extensive areas of dense brown haemosiderin varying from 0 to 45 per cent of total lung volume were identified, predominantly in the dorsocaudal lungfields. Bronchial arterial proliferation appeared to have replaced the pulmonary supply in affected areas of the lung. Closely associated with the staining and bronchial arterialisation, there was widespread small airway d...
Wnuk M, Oklejewicz B, Lewinska A, Zabek T, Bartosz G, Slota E, Bugno-Poniewierska M.The fluorescence in situ hybridization (FISH) technique is widely used in animal cytogenetics. Contrary to FISH procedure, primed in situ DNA synthesis (PRINS) does not require the DNA probe preparation (design, synthesis, gel purification of PCR products and labeling). The PRINS method with primers used as 'DNA probes' is both PCR-sensitive and allows for chromosomal localization of DNA sequences. Here, we show the application of PRINS reaction with one unlabeled oligonucleotide pair to identify 18S rDNA loci in three different animal species: domestic pig (Sus scrofa), red fox (Vulpes vulpes...
Jensen AM, Ahmed W, Elbrønd VS, Harrison AP.It has been proposed that manipulating proprioceptive signals of the equine distal limb as part of a rehabilitation process in cases of musculoskeletal pain or neurologic deficits can be used to correct postural control and restore normal motor programs. This trial has examined the effect of treatment with a light-weight and loose-fitting bell boot (82 g) on an imbalance of muscle gluteus superficialis function in horses as measured using acoustic myography (AMG). Eight horses were trained over a 60-minute period every 3 days for 6 weeks, a protocol based on preliminary findings. Acoustic my...
Patterson SD, Bell K, Manton VJ.A detailed biochemical characterization of four of the five previously described alleles of the plasma protease inhibitor (Pi) system of Equus przewalskii was performed using both one- and two-dimensional electrophoretic techniques. The proteins have been characterized in terms of isoelectric point, relative molecular mass, inhibitory activity to bovine trypsin and chymotrypsin, immunochemical cross-reactivity, terminal sialic acid content and enzyme:inhibitor complex formation and the oxidation sensitivity of this interaction. Using these functional criteria, only three loci (Spi 1, 2 and 3) ...
Skrabalak DS, Covey TR, Henion JD.Several important corticosteroids were qualitatively determined in the plasma and urine of horses by micro-liquid chromatography-mass spectrometry (micro-LC-MS). The sensitivity and specificity of micro-LC-MS are demonstrated as is the ability of micro-LC-MS to deal with endogenous interferences. In turn, the relative amount of dexamethasone and its major unconjugated metabolite were determined in equine urine by micro-LC-MS; the conclusions drawn are reported.
Heitmann C, Levin LS.Tissue expansion in the upper extremity is a valuable technique with expanding indications and expected outcomes. The primary indications are coverage problems after trauma, but the technique is also applicable to defects caused by treatment of hemangioma, nevi, tattoos, or hypertrophic scars as well as correction of unstable tissue or as an alternative to free tissue transfer. The advantage of expansion-specifically, match in tissue texture and retention of sensibility-may be more important in the hand and upper extremity than in other areas. The inevitable capsule that forms around the expan...
Turner AS, Tucker CM.A randomised double-blind clinical trial of 28 horses was undertaken to evaluate the efficacy of isoxsuprine hydrochloride at four different doses:- 0.0 mg/kg bodyweight (bwt) (placebo), 0.6 mg/kg bwt, 1.2 mg/kg bwt and 1.8 mg/kg bwt for treatment of navicular disease. The results showed that horses treated with isoxsuprine hydrochloride (N = 22) responded significantly with respect to clinical assessment score (P less than 0.01) when compared with the control group (N = 6). Furthermore, there were no dose-related differences in the responses of the horses treated with increasing levels of iso...
Ford TS, Vaala WE, Sweeney CR, Skand D, Saik JE.A 15-year-old Quarter Horse gelding was examined because of chronic intermittent colic of 40 days' duration. The clinical signs included acute onset of depression, ptyalism, abdominal splinting, and rolling within an hour of eating. An intramural mass of the esophagus was identified during esophagoscopy. A large soft-tissue density surrounding the distal portion of the esophagus, creating a stricture, was identified on an esophagogram. With the horse slightly sedated, pleuroscopy was performed, allowing direct visualization and biopsy of the mass. The histopathologic diagnosis was squamous cel...
Ripatti T, Koskela P, Kotimaa M, Koskinen E, Mäenpää PH.Over periods of 22 and 14 months, IgG antibody concentrations in serum samples obtained monthly from 14 mares and 19 foals, respectively, were measured by use of ELISA against antigens of the following environmental microbes: Aspergillus umbrosus, Penicillium brevicompactum, Rhodotorula glutinis, Absidia corymbifera, Aspergillus fumigatus, Humicola grisea, Micropolyspora faeni, and Thermoactinomyces vulgaris. The mares and foals were on pasture from early June until early October, then were stabled during the winter season until the following June. In the mares, increased antibody concentratio...
Sloan PB, White B, Santschi EM.Osteochondrosis dissecans (OCD) is common in the femoropatellar joint in Thoroughbred yearlings for sale at auction and there is no consensus on the effect on racing outcomes. Objective: Describe femoropatellar OCD in juvenile Thoroughbreds and compare the racing performance of affected Thoroughbred horses to siblings and unaffected horses from the same sale. Methods: Retrospective case-control study of juvenile horses born 2010-2016. Methods: Radiographic reports from 27 Thoroughbred auctions of weanling (5-11 months of age) and yearling (12-22 months of age) horses were reviewed to ident...
Simoens P, Van den Broeck W, Lauwers H.Vascular corrosion casts of 12 equine, 15 bovine and 50 porcine eyes were studied scanning electron microscopically for the presence of posterior ciliary veins. These veins drain a postequatorial segment of the choroid and emerge near the posterior bulbar pole. They complement the four vorticose veins that emerge near or at the equatorial zone of the eyeball and the slender choroidoretinal veins that drain the peridiscal area of the choroid. Posterior ciliary veins were observed in all equine and bovine eyes examined. In these species they presented a large variation in size, number and positi...
Lamb MM, Barrett JG, White NA, Werre SR.Desmopathy of the distal interphalangeal joint collateral ligament is a common cause of lameness in the horse and carries a variable prognosis for soundness. Intralesional treatment has been proposed for improving outcome; however, limited reports describe methods for injecting this ligament. The purpose of this study was to compare accuracy of low-field magnetic resonance imaging (MRI) vs. radiography for injecting the collateral ligament of the distal interphalangeal joint. Equine cadaver digit pairs (n = 10) were divided by random assignment to injection of the ligament by either technique....
Nakashima M, Noda H, Hasegaea M, Ikai A.We studied the oxygenation of mammalian hemoglobins: mouse (Mus musculus molossinus), rabbit (Oryctolagus cuniculus domesticus), Japanese monkey (Macaca fuscata), man (Homo sapiens), sheep (Ovis aries), llama (Lama glama), pig (Sus scrofa domesticus), cow (Bos taurus domesticus) and horse (Equus caballus), in the absence of 2,3-diphosphoglycerate (DPG) and compared their oxygen affinity in relation to the body weight. The negative correlation between body weight and the oxygen affinity of the whole blood, observed by Schmidt-Nielsen and Larimer (1958), was not observed in the absence of DPG. O...
Munsterman AS, VanderBroek AR, Kottwitz JJ, Watson VE.To compare a novel suture loop method for intestinal biopsies (SLB) with a two-layer, hand-sutured biopsy (HSB) technique in equine small and large intestines. Methods: Experimental, randomized, ex vivo study. Methods: Eight healthy adult horses. Methods: The duodenum, aboral jejunum, and ventral and dorsal large colon were harvested after euthanasia and divided into three sections each. The sections were randomized to SLB, HSB, or control (C, no biopsy) groups. Tissue samples were excised after placement of a suture loop formed by a 4S Roeder knot and oversewn with a Cushing pattern using bar...
Baumwart CA, Doherty TJ, Schumacher J, Willis RS, Adair HS, Rohrbach BW.To determine the effectiveness of preinduction hyperbaric oxygen treatment (HBOT) in ameliorating signs of experimentally induced endotoxemia in horses. Methods: 18 healthy adult horses. Methods: Horses were randomly assigned to 1 of 3 equal-sized treatment groups to receive normobaric ambient air and lipopolysaccharide (LPS), HBOT and LPS, or HBOT and physiologic saline (0.9% NaCl) solution. Horses were physically examined, and blood was obtained for a CBC and to determine concentration or activity of plasma tissue necrosis factor-α, blood lactate, and blood glucose before the horses were tr...
Khairoun A, Hawkins JF, Moore GE, Lescun TB, Adams SB.Superficial digital flexor tendinitis (SDFT) and proximal suspensory desmitis (PSD) are common causes of lameness in horses. Current treatment options include rest, controlled exercise, administration of anti-inflammatories, intralesional injections, surgery, and electrohydraulic shock wave therapy (ESWT). ESWT is safe, noninvasive, and is used to treat a variety of musculoskeletal abnormalities. Medical records between 2010 and 2021 were reviewed. Horses were separated into two categories: (group 1: ≥ 3 ESWT treatments; group 2: < 3 ESWT treatments). Our objective was to examine the effe...
Sexton PE, Bristol FM.Bacteriology, histology, and scanning electron microscopy were used to evaluate uterine involution in 27 mares treated with daily injections of 150 mg of progesterone and 10 mg of estradiol-17 beta, commencing within 18 hours of parturition. These findings were compared with those for 24 untreated mares at postpartum day 10 or 11. The treatment resulted in significantly (P less than 0.05) greater uterine gland proliferation. Gland density was significantly (P less than 0.05) greater in mares treated for 6 to 10 days than in those treated 2 to 5 days. The proportion of ciliated cells to secreto...
Pedersoli WM, Belmonte A, Purohit RC, Ravis WR.The pharmacokinetics of gentamicin were studied in six healthy mature horses of mixed breeding and of both sexes. A parenteral preparation of gentamicin sulfate (5% aqueous solution) was administered rapidly (IV) at the dosage level of 5 mg/kg of body weight. Venous blood samples were taken at 0 (base line), 0.083, 0.25, 0.5, 0.75, 1, 2, 4, 8, 12, 24, 36, 48, 72, 96, and 120 hours after gentamicin administration. Serum gentamicin was measured by a radioimmunoassay technique. The gentamicin concentration data was fitted to a one- and two-compartment open model with first-order elimination from ...
Snow DH, Frigg M.The bioavailability of ascorbic acid administered to thoroughbreds by intramuscular injection was investigated. For intramuscular injection two preparations were studied, and the percentage bioavailability up to 24 h of 10 g of ascorbic acid was 95% +/- 22 in four horses and 60% in two horses with preparations A and B, respectively. Bioavailability at 24 h in three horses injected subcutaneously with 10 g of preparation B was 82%. Intramuscular injection of both preparations was apparently well tolerated while subcutaneous injection of preparation B (pH 6.0) was associated with marked irritanc...
Kluciński W, Winnicka A, Olszewski M, Sikora J, Sitarska E, Niemiałtowski M, Muzylak M, Bylinka G, Wyszyński M.The aim of this study was to compare phagocytic activity of polymorphonuclear cells (PMNs) from the bronchoalveolar lavage of clinically healthy horses and those with severe chronic bronchiolitis. Research was carried out on 28 horses. Chronic inflammation of the lower airways was diagnosed in nine horses. Cells from the respiratory tract were lavaged according to accepted methods. For comparison, PMNs were isolated from peripheral blood of all investigated horses. The phagocytic activity of PMNs was determined in relation to two standard strains of Staphylococcus aureus, Staph, aureus Smith w...
Panciera RJ, Slusher SA, Hayes KE.Simultaneous and successive occurrence of ovarian teratoma and granulosa cell tumor is reported in 2 mares. Simultaneous occurrence of the tumors may obscure clinical diagnosis. Whereas size, unilaterality, and the cystic nature of each may be similar, differentiating features include the potentially palpable presence of bone, cartilage, or teeth in teratoma, and the hormone-induced behavioral and reproductive effects of granulosa cell tumors. Thorough examination of surgical specimens may reveal the existence of a neoplastic process, previously obscured by the more obvious presence of another...
Serafini R, Varner DD, Bissett W, Blanchard TL, Teague SR, Love CC.The effect of flash-freezing storage temperature on stallion sperm DNA has not been evaluated. Commonly, sperm are flash-frozen at various temperatures to preserve sperm DNA prior to analysis. It is unclear whether the temperature at which sperm are frozen and stored may affect the results of DNA assays. In this study, the neutral comet assay was used to evaluate the effect of flash-freezing storage temperature (freezer [-60 °C], dry ice [-78.5 °C], liquid nitrogen [-196 °C]) compared to fresh sperm DNA structure. In addition, intra- and inter-assay and intra- and inter-stallion variabil...
