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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
The collateral ligaments of the distal interphalangeal joint: magnetic resonance imaging and post mortem observations in 25 lame and 12 control horses.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 6 538-544 doi: 10.2746/042516408X313661
Dyson S, Blunden T, Murray R.Magnetic resonance imaging (MRI) is used with increasing frequency to diagnose injuries of the collateral ligaments (CLs) of the distal interphalangeal (DIP) joint, but the results have not been verified by histology and the mechanism of injury is poorly understood. Objective: Abnormal signal intensity and tissue contour represents change in tissue structure detected on histology. Objective: To compare results in horses free from and those with chronic lameness and to describe possible progression of lesions. Methods: One or both feet of horses free from lameness (Group N: n = 12) and with foo...
Epiphyseal cartilage canal blood supply to the distal femur of foals.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 5 433-439 doi: 10.2746/042516408X300269
Olstad K, Ytrehus B, Ekman S, Carlson CS, Dolvik NI.The developmental pattern of the cartilage canal blood supply to epiphyseal growth cartilage has been linked to osteochondrosis (OC) in the tarsus of foals. This pattern has not yet been described in the distal femur, another site frequently affected by OC. Objective: To describe the developmental pattern of the blood supply to the distal femoral epiphyseal growth cartilage in 8 Standardbred foals age 0-7 weeks. Methods: One foal was sacrificed weekly from birth to age 7 weeks (n=8) to undergo a barium perfusion procedure to demonstrate vessels within cartilage canals of one hindlimb. The dist...
Phospholipid compositions of sera and synovial fluids from dog, human and horse: a comparison by 31P-NMR and MALDI-TOF MS.
Journal of animal physiology and animal nutrition    May 20, 2008   Volume 93, Issue 4 410-422 doi: 10.1111/j.1439-0396.2008.00822.x
Fuchs B, Bondzio A, Wagner U, Schiller J.Alterations of the phospholipid (PL) compositions of body fluids are assumed to be indicative of inflammatory diseases, e.g. rheumatoid arthritis (RA). Recently, we have shown that particularly the phosphatidylcholine/lysophosphatidylcholine (PC/LPC) ratio determined in human synovial fluids (SF) and sera represents a reliable measure of the inflammatory state in RA patients. However, it is not yet clear to what extent the PC/LPC ratio is also affected by nutrition habits. In the present study, the PL and the corresponding acyl chain compositions of human body fluids (SF and serum of RA patien...
Developments in stallion semen evaluation.
Theriogenology    May 20, 2008   Volume 70, Issue 3 448-462 doi: 10.1016/j.theriogenology.2008.04.023
Varner DD.The conventional approach to evaluation of stallion semen dates back several decades, and includes evaluation of spermatozoal concentration, semen volume, spermatozoon morphological characteristics, and spermatozoal motility patterns initially and following in-vitro storage. While an analysis performed in this manner does have predictive value, incorporation of some more newly developed techniques may improve the predictive value of the examination. This communication addresses some newer tests that can be applied today for evaluation of semen, as well some tests that may be available in the c...
Risk factors for epiploic foramen entrapment colic in a UK horse population: a prospective case-control study.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 4 405-410 doi: 10.2746/042516408X312149
Archer DC, Pinchbeck GL, French NP, Proudman CJ.Epiploic foramen entrapment (EFE) is a common cause of small intestinal strangulation in the horse and its epidemiology requires further investigation. Objective: To identify horse- and management-level risk factors for EFE and to explore reasons for the apparent seasonality of this condition. Objective: Horses exhibiting certain behaviours and those exposed to particular management practices that vary seasonally are at increased risk of EFE. Methods: A prospective unmatched, multicentre case-control study was conducted over 24 months in the UK. Data on 77 cases and 216 control horses were obt...
Penile and preputial squamous cell carcinoma in the horse: a retrospective study of treatment of 77 affected horses.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 6 533-537 doi: 10.2746/042516408X281171
van den Top JG, de Heer N, Klein WR, Ensink JM.The most common penile and preputial neoplasm in the horse is the squamous cell carcinoma (SCC), but no large surveys of treatment and effects of the grade of the tumour, based on the degree of differentiation, on outcome of affected horses are available. Objective: Analysis of treatment of male horses affected with SCC of the external genitalia and long-term results of treatment. Methods: Seventy-seven cases of SCC were evaluated. Data recorded included treatment, outcome, post operative histopathology and retrospective tumour grading. Results: Treatments included: cryosurgery, excision, part...
Detection of calprotectin and its correlation to the accumulation of neutrophils within equine large colon during ischaemia and reperfusion.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 4 393-399 doi: 10.2746/042516408X302500
Grosche A, Morton AJ, Polyak MM, Matyjaszek S, Freeman DE.The cytosolic protein complex, calprotectin, is abundant in neutrophils and could be used to improve the ability to localise and assess neutrophil infiltration in the equine intestine during ischaemia and reperfusion (I/R), but further study is required. Objective: To assess the number of calprotectin-containing cells by immunohistochemistry in correlation with direct counting and scoring of neutrophils in the equine colon during I/R. Methods: One and 2 h ischaemia of the left dorsal colon were induced, followed by 30 min reperfusion under general anaesthesia or by 18 h reperfusion after anaes...
Quantitative morphology of the equine laminar junction in relation to capsule shape in the forehoof of Standardbreds and Thoroughbreds.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 5 473-480 doi: 10.2746/042516408X313652
Thomason JJ, Faramarzi B, Revill A, Sears W.Differences in hoof morphology have largely been underappreciated in the literature until recently, and it is these that hold the key to interpreting functional adaptation in the hoof. Objective: Primary laminar morphology correlates with hoof capsule shape; and breeds with different hoof shapes and loadings show different patterns of correlation. Methods: Seventeen measurements of capsule shape and 3 of primary epidermal laminae (PEL) morphology (spacing, orientation and curvature) were made on right and left front hooves from 27 Standardbred and 25 Thoroughbred horses, and tested for breed d...
A clinical approach to managing the mare with placentitis.
Theriogenology    May 20, 2008   Volume 70, Issue 3 435-440 doi: 10.1016/j.theriogenology.2008.04.022
Macpherson ML, Bailey CS.Placental infections in the mare are a diagnostic and therapeutic challenge. The following article will review techniques for identifying placental infections, approaches for treating placentitis, and methods for managing these mares after foaling.
Effects of bites by the European adder (Vipera berus) in seven Swedish horses.
The Veterinary record    May 20, 2008   Volume 162, Issue 20 652-656 doi: 10.1136/vr.162.20.652
Anlén KG.The effects on seven horses of bites by the European adder (Vipera berus) are described and compared with previously available information. The clinical signs varied from local swelling and mild systemic signs to severe systemic signs, including systemic inflammatory response, severe tissue necrosis, ventricular tachycardia and dysphagia. Two of the horses were treated with 'Zagreb' antiserum, and three that were not treated with antiserum were euthanased owing to complications related to the bites.
Regional pulmonary veno-occlusion: a newly identified lesion of equine exercise-induced pulmonary hemorrhage.
Veterinary pathology    May 20, 2008   Volume 45, Issue 3 316-326 doi: 10.1354/vp.45-3-316
Williams KJ, Derksen FJ, de Feijter-Rupp H, Pannirselvam RR, Steel CM, Robinson NE.Exercise-induced pulmonary hemorrhage (EIPH) is common in horses following intense exertion, occurring in up to 75% of racing Thoroughbreds and Standardbreds. In spite of this, the pathogenesis of EIPH is poorly understood. In 7 racing Thoroughbred horses with EIPH, 6 sections were collected from the left and right lung, representing the cranial, middle, and caudal region of the dorsal and ventral lung (84 sites total). Grossly, both right and left lungs had numerous dark brown to blue-black foci along the caudodorsal visceral pleura. Tissue sections were stained with hematoxylin-eosin, Masson...
Characterisation of the inflammatory reaction in equine idiopathic focal eosinophilic enteritis and diffuse eosinophilic enteritis.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 4 386-392 doi: 10.2746/042516408X312112
Mäkinen PE, Archer DC, Baptiste KE, Malbon A, Proudman CJ, Kipar A.Idiopathic focal eosinophilic enteritis (IFEE) and diffuse eosinophilic enteritis (DEE) are primary eosinophilic intestinal conditions without a known cause that are associated with an increasing number of surgical colic cases. Histology may be helpful in defining disease aetiology and pathogenesis. Objective: To characterise further the inflammatory infiltrate in equine IFEE and to compare the condition with DEE. Methods: Twenty-three IFEE cases and 5 DEE cases were examined by light microscopy including immunohistology to identify infiltrating leucocytes. Inflammatory infiltrates in mucosa a...
Equine gastrointestinal motility research: where we are and where we need to go.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 4 422-428 doi: 10.2746/042516408X312932
Hudson NP, Merritt AM.Equine gastrointestinal motility is a central issue in cases of equine colic, post operative convalescence and alimentary conditions encountered in practice. There are significant syndromes of intestinal dysmotility in the horse such as obstructive disorders and post operative ileus that are still poorly understood. This review describes the various areas of research that aim to elucidate the pathogenesis of intestinal hypo- or hypermotility by research methods, which include studies at the cellular level, and those that employ in vitro or in vivo techniques of evaluating the physiology and me...
Effects of topical administration of 1% brinzolamide on intraocular pressure in clinically normal horses.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 7 662-665 doi: 10.2746/042516408X297426
Germann SE, Matheis FL, Rampazzo A, Burger D, Roos M, Spiess BM.Only few drugs with limited efficacy are available for topical treatment of equine glaucoma. Objective: To evaluate the effect of topical administration of 1% brinzolamide on intraocular pressure (IOP) in clinically normal horses. Methods: Healthy mature horses (n = 20) with normal ocular findings, were studied. The IOP was measured 5 times daily (07.00, 11.00, 15.00, 19.00 and 23.00 h) over 10 days. On Days 1 and 2, baseline values were established. On Days 3-5 one eye of each horse was treated with one drop of 1% brinzolamide every 24 h immediately following the 07.00 h measurement. On Days ...
Intra-articular stabilisation of the equine cricoarytenoid joint.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 6 584-588 doi: 10.2746/042516408X313643
Cheetham J, Witte TH, Rawlinson JJ, Soderholm LV, Mohammed HO, Ducharme NG.The success of laryngoplasty is limited by abduction loss in the early post operative period. Objective: To determine the efficacy of polymethylmethacrylate (PMMA) in stabilising the cricoarytenoid joint (CAJ) and reducing the force on the laryngoplasty suture. Objective: Injection into the cricoarytenoid joint resists the forces produced by physiological laryngeal air flows and pressures thereby reducing the force experienced by the laryngoplasty suture. Methods: Ten cadaver larynges were collected at necropsy and PMMA was injected into one CAJ at selected random. Each larynx was subjected to...
Exercise induced stress in horses: selection of the most stable reference genes for quantitative RT-PCR normalization.
BMC molecular biology    May 19, 2008   Volume 9 49 doi: 10.1186/1471-2199-9-49
Cappelli K, Felicetti M, Capomaccio S, Spinsanti G, Silvestrelli M, Supplizi AV.Adequate stress response is a critical factor during athlete horses' training and is central to our capacity to obtain better performances while safeguarding animal welfare. In order to investigate the molecular mechanisms underlying this process, several studies have been conducted that take advantage of microarray and quantitative real-time PCR (qRT-PCR) technologies to analyse the expression of candidate genes involved in the cellular stress response. Appropriate application of qRT-PCR, however, requires the use of reference genes whose level of expression is not affected by the test, by ge...
Persistently infected horses are reservoirs for intrastadial tick-borne transmission of the apicomplexan parasite Babesia equi.
Infection and immunity    May 19, 2008   Volume 76, Issue 8 3525-3529 doi: 10.1128/IAI.00251-08
Ueti MW, Palmer GH, Scoles GA, Kappmeyer LS, Knowles DP.Tick-borne pathogens may be transmitted intrastadially and transstadially within a single vector generation as well as vertically between generations. Understanding the mode and relative efficiency of this transmission is required for infection control. In this study, we established that adult male Rhipicephalus microplus ticks efficiently acquire the protozoal pathogen Babesia equi during acute and persistent infections and transmit it intrastadially to naïve horses. Although the level of parasitemia during acquisition feeding affected the efficiency of the initial tick infection, infected t...
Gastric and small intestinal ileus as a cause of acute colic in the post parturient mare.
Equine veterinary journal    May 17, 2008   Volume 40, Issue 4 368-372 doi: 10.2746/042516408X302483
Hillyer MH, Smith MR, Milligan PJ.Ileus (functional obstruction of aboral gastrointestinal transit) is an uncommon cause of gastrointestinal dysfunction and colic in the horse. A number of specific conditions have been previously reported in association with ileus. This report describes the recognition of primary gastric and small intestinal ileus of undetermined cause in a series of post parturient mares. Objective: To describe the clinical features, treatment and outcome of a series of episodes of primary gastric and small intestinal ileus. Methods: A retrospective study was performed of colic episodes seen in an equine prac...
Granulomatous pneumonia, lymphadenopathy, and hepatopathy in an adult horse with repeated injection of BCG.
Journal of veterinary internal medicine    May 17, 2008   Volume 22, Issue 4 1056-1060 doi: 10.1111/j.1939-1676.2008.0104.x
van den Boom R, Veldhuis Kroeze EJ, Klein WR, Houwers DJ, van der Zanden AG, Sloet van Oldruitenborgh-Oosterbaan MM.No abstract available
The effect of metformin on measurements of insulin sensitivity and beta cell response in 18 horses and ponies with insulin resistance.
Equine veterinary journal    May 17, 2008   Volume 40, Issue 5 493-500 doi: 10.2746/042516408X273648
Durham AE, Rendle DI, Newton JE.Laminitis in equids is a very common debilitating disease, and insulin resistance (IR) and hyperinsulinaemia are increasingly recognised as important predisposing factors. Pharmacological modification of IR and hyperinsulinaemia might reduce the risk of laminitis. Objective: Metformin, a drug commonly prescribed for treatment of human IR, may also decrease IR in equids. Methods: Eighteen horses and ponies with IR and recurrent laminitis were treated with 15 mg/kg bwt metformin per os q. 12 h. Each animal served as its own control by comparing pre- and post treatment proxies for IR, insulin sen...
Medical and surgical management of uroperitoneum in a foal.
The Canadian veterinary journal = La revue veterinaire canadienne    May 17, 2008   Volume 49, Issue 4 401-403 
Butters A.A 4-day-old, male, American paint foal was presented for abdominal distention, respiratory distress, and diarrhea. Bladder rupture and uroperitoneum were diagnosed following abdominal ultrasonography and abdominocentesis. The defect in the dorsocranial part of the bladder wall was surgically repaired. Un poulain American Paint mâle âgé de quatre jours est présenté pour ballonnement abdominal, détresse respiratoire et diarrhée. Une rupture de la vessie et un uropéritoine sont diagnostiqués après une échographie et une paracentèse abdominale. Le défaut dans la partie dorso-crânial...
The effects of Strongylus vulgaris parasitism on eosinophil distribution and accumulation in equine large intestinal mucosa.
Equine veterinary journal    May 17, 2008   Volume 40, Issue 4 379-384 doi: 10.2746/042516408X295464
Rötting AK, Freeman DE, Constable PD, Moore RM, Eurell JC, Wallig MA, Hubert JD.Eosinophilic granulocytes have been associated with parasite or immune-mediated diseases, but their functions in other disease processes remain unclear. Cause and timing of eosinophil migration into the equine gastrointestinal mucosa are also unknown. Objective: To determine the effects of intestinal parasitism on eosinophils in equine large intestinal mucosa. Methods: Large intestinal mucosal samples were collected from horses and ponies (n = 16) from the general veterinary hospital population, ponies (n = 3) raised in a parasite-free environment, ponies experimentally infected with 500 infec...
Massive pulmonary thromboembolism in six horses.
Equine veterinary journal    May 17, 2008   Volume 40, Issue 5 514-517 doi: 10.2746/042516408X297444
Norman TE, Chaffin MK, Perris EE, Edwards JF, David JB, Cohen ND, Reuss S.This report involves 6 cases in which medical records and post mortem findings were reviewed leading to the diagnosis of massive pulmonary thromboembolism (MPTE). All horses were mature and MPTE has not been recognised previously as a sequel to generalised systemic illness in mature horses. The clinical data and pathological findings of the cases are reported and the authors conclude that MPTE is an uncommon but important complication of medical and surgical disorders in mature horses. In 3 of the cases, the condition was nonfatal suggesting that some horses having developed PTE survive and th...
Theriogenology question of the month.
Journal of the American Veterinary Medical Association    May 16, 2008   Volume 232, Issue 10 1473-1475 doi: 10.2460/javma.232.10.1473
Estrada A, Ferrer MS, Brounts SH, Milligan MA, Lillich JD, Debey B.No abstract available
Postpartum colic in a mare caused by pneumouterus.
The Veterinary record    May 16, 2008   Volume 162, Issue 19 626-627 doi: 10.1136/vr.162.19.626
Livesey LC, Carson RL, Stanton MB.No abstract available
Effects of altrenogest treatment of mares in late pregnancy on parturition and on neonatal viability of their foals. Neuhauser S, Palm F, Ambuehl F, Aurich C.In this study, effects of altrenogest treatment (0.088 mg/kg daily) given to mares during late gestation until parturition on the time and the process of foaling, neonatal adaptation and postnatal development were analysed. The number of animals was 6 in the treatment group and 7 in the control group. Gestational length tended to be shorter in mares given altrenogest. Birth weight of the foals and weight of the placenta did not differ between groups. The second stage of parturition was prolonged in the altrenogest-treated mares (p<0.05). Foals born to altrenogest-treated mares had a significan...
Immunophysiological responses of horses to a 12-hour rest during 24 hours of road transport.
The Veterinary record    May 16, 2008   Volume 162, Issue 19 609-614 doi: 10.1136/vr.162.19.609
Stull CL, Morrow J, Aldridge BA, Stott JL, McGlone JJ.Thirty-eight mature horses were assigned to one of two equal groups to evaluate two treatments consisting of either 24 hours of continuous road transport (24T) or two 12-hour periods of transport separated by off-loading, resting and feeding the horses for 12 hours (12/12T). A subset of six horses from each group served as controls for the other group. The horses were loaded into a commercial straight-deck trailer and travelled loose in one of two standard-sized compartments. After the journeys the horses were put back into their paddocks for a 24-hour recovery period. Venous blood samples wer...
Gastrointestinal stromal tumour and hypoglycemia in a Fjord pony: case report.
Acta veterinaria Scandinavica    May 16, 2008   Volume 50, Issue 1 9 doi: 10.1186/1751-0147-50-9
Haga HA, Ytrehus B, Rudshaug IJ, Ottesen N.Neoplasia may cause hypoglycemia in different species including the horse, but hypoglycemia has not previously been reported in the horse associated with gastrointestinal stromal tumours. Methods: A case of a gastrointestinal stromal tumour in a Fjord pony with severe recurrent hypoglycemia is presented. The mechanism causing the hypoglycemia was not established. Conclusions: This case indicates that a gastrointestinal stromal tumour may cause hypoglycemia also in the horse.
[Construction of an infectious clone of equine infectious anemia virus by N-glycosylation reverse-mutations].
Wei sheng wu xue bao = Acta microbiologica Sinica    May 16, 2008   Volume 48, Issue 3 287-292 
Han X, Quan Y, Gao X, Xiang W, Zhou J.To elucidate the role of N-glycosylation in fetal donkey dermal cell (FDD)-attenuated equine infectious anemia virus (EIAV), we constructed an N-glycosylation reverse-mutation molecular clone, pLGN191N236N246. This viral molecular clone was derived from the infectious clone pLGFD3-8 by site-directed mutagenesis. This clone was used to transfect fetal donkey dermal (FDD) cells. Infectious characteristics of transfectants were monitored by RT-PCR, indirect immune fluorescence and reverse transcriptase activity assay. After three passages in FDD cells, viral replications in the supernatant of cel...
Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in Standardbred racehorses.
Journal of the American Veterinary Medical Association    May 16, 2008   Volume 232, Issue 10 1515-1520 doi: 10.2460/javma.232.10.1515
Waselau M, Sutter WW, Genovese RL, Bertone AL.To determine outcome of Standardbred racehorses with moderate to severe midbody suspensory ligament desmitis (MSD) treated by means of ultrasound-guided intralesional injection of a single dose of platelet-rich plasma (PRP) followed by a program of gradually increased exercise. Methods: Nonrandomized clinical trial. Methods: 9 Standardbred racehorses. Methods: Following injection of PRP, horses were allowed a controlled, gradual return to exercise. Race records for the year prior to injury and for 3 consecutive years after horses returned to racing were reviewed. For comparison purposes, race ...