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Topic:Heart Murmur

Heart murmurs in horses are audible vibrations or sounds produced by turbulent blood flow within the heart or large blood vessels. These sounds are detected during auscultation and can vary in intensity, timing, and duration. Heart murmurs may be associated with structural heart abnormalities, such as valvular insufficiencies or septal defects, or they might occur in the absence of any underlying pathology, often termed "innocent" murmurs. The evaluation of heart murmurs involves assessing their characteristics and potential impact on the horse's cardiovascular function. This page compiles peer-reviewed research studies and scholarly articles that explore the etiology, classification, and clinical implications of heart murmurs in equine patients.
Effect of left-sided valvular regurgitation on mortality and causes of death among a population of middle-aged and older horses.
The Veterinary record    January 6, 2009   Volume 164, Issue 1 6-10 doi: 10.1136/vr.164.1.6
Stevens KB, Marr CM, Horn JN, Pfeiffer DU, Perkins JD, Bowen IM, Allan EJ, Campbell J, Elliott J.The effect of left-sided valvular regurgitation (LSVR) on the mortality of middle-aged and older horses was investigated in a prospective cohort study involving 19 yards and 1153 horses. The horses were examined to determine whether they had a cardiac murmur and its type, and their age, sex, breed type and occupation were recorded. They were followed up at intervals of two years by postal questionnaire, and after four years information on 773 horses was available. There was no significant difference in the mortality of the horses with and without LSVR, but small horses had a significantly high...
Heart murmurs and valvular regurgitation in thoroughbred racehorses: epidemiology and associations with athletic performance.
Journal of veterinary internal medicine    March 10, 2008   Volume 22, Issue 2 418-426 doi: 10.1111/j.1939-1676.2008.0053.x
Young LE, Rogers K, Wood JL.Cardiac murmurs associated with valvular regurgitation occur commonly in conditioned performance horses, but their association with athletic performance is unknown. Objective: Cardiac valvular regurgitation has a negative association with race performance. Methods: Five hundred and twenty-six "race fit" Thoroughbred racehorses engaged in either flat (race distance 1,000-2,500 m) or jump racing (race distance 3,200-6,400 m). Methods: Cardiac auscultation and color flow Doppler (CFD) echocardiography were performed on 777 occasions. The associations between the presence and severity of either an...
Measurements of right ventricular internal dimensions and their relationships to severity of tricuspid valve regurgitation in national hunt thoroughbreds.
Equine veterinary journal. Supplement    April 4, 2007   Issue 36 171-177 doi: 10.1111/j.2042-3306.2006.tb05535.x
Helwegen MM, Young LE, Rogers K, Wood JL.The effect of tricuspid valve regurgitation (TR) in right ventricular (RV) chamber size has not been reported. Methods: An echocardiographic and auscultation study was conducted on 394 race-fit National Hunt Thoroughbreds (TBs) in 4 training yards. Auscultation was performed on each horse and audible murmurs of TR graded using a 1-6 scale. Echocardiography was also performed and standard, 2-dimensional (2D), short (SA) and long axis (LA) images of the RV obtained from a right parasternal location. An m-mode image was recorded from an SA view of the RV just below the level of the tricuspid valv...
Streptococcus equi meningoencephalomyelitis in a foal.
Journal of the American Veterinary Medical Association    September 5, 2006   Volume 229, Issue 5 721-724 doi: 10.2460/javma.229.5.721
Finno C, Pusterla N, Aleman M, Mohr FC, Price T, George J, Holmberg T.A 4-month-old American Paint Horse colt was evaluated because of acute onset of ataxia, left-sided head tilt, and fever and a recently noticed heart murmur. Upper respiratory tract infection caused by Streptococcus equi subsp equi had been diagnosed at 3 months of age. Results: Hematologic abnormalities included leukocytosis, mature neutrophilia, monocytosis, and mild anemia. Analysis of a CSF sample revealed high total protein concentration and total nucleated cell count; nucleated cells consisted mainly of degenerate neutrophils. Results of a real-time PCR assay were positive for S equi subs...
Diagnostic challenge: lethargy and weakness in an Arabian foal with cardiac murmurs. Ventricular septal defect (VSD).
Australian veterinary journal    July 11, 2006   Volume 84, Issue 6 209-212 doi: 10.1111/j.1751-0813.2006.tb12801.x
Hughes KJ.No abstract available
Echocardiographic evidence of an aortico-pulmonary septal defect in a 4-day-old thoroughbred foal. Valdes-Martinez A, Eades SC, Strickland KN, Roberts ED.We describe the echocardiographic findings in a 4-day-old thoroughbred foal with an aortico-pulmonary septal defect. The foal had labored breathing, cyanotic mucous membranes and a continuous grade 5/6 heart murmur with point of maximal intensity over the base of the heart on the right side. Echocardiographically, there was a large communication between the aorta and the pulmonary artery just dorsal to the base of the heart. The cardiac anomaly seen during the echocardiographic exam was confirmed at necropsy where a large communication between the two great vessels was observed. These findings...
Total anomalous pulmonary venous connection in a foal. Seco Diaz O, Desrochers A, Hoffmann V, Reef VB.An 8-day-old Arabian-Morgan cross colt underwent cardiac evaluation. The foal was tachycardic, tachypneic, exercise intolerant and had a loud right-sided heart murmur and cyanotic mucous membranes. Total anomalous pulmonary venous connection was diagnosed with echocardiography and confirmed at postmortem examination. Total anomalous pulmonary venous connection is a very rare congenital cardiac abnormality that has not been reported before in the horse.
[Influence of detomidine on echocardiographic function parameters and cardiac hemodynamics in horses with and without heart murmur].
Schweizer Archiv fur Tierheilkunde    April 6, 2004   Volume 146, Issue 3 119-126 doi: 10.1024/0036-7281.146.3.119
Gehlen H, Kroker K, Deegen E, Stadler P.30 warmblood horses were examined before and after sedation with 20 micrograms/kg BW detomidine, to determine changes of cardiac function parameters, using B-mode, M-mode and Doppler echocardiography. 15 horses showed a heart murmur, but no clinical signs of cardiac heart failure, 15 horses had neither a heart murmur nor other signs of cardiac disease. After sedation with detomidine we could recognise a significant increase of end-diastolic left atrium diameter, an increase of end-systolic left ventricular diameter and aortic root diameter. The end-systolic thickness of papillary muscle and in...
Parachute left atrioventricular valve causing stenosis and regurgitation in a Thoroughbred foal.
Journal of veterinary internal medicine    August 2, 2003   Volume 17, Issue 4 579-582 doi: 10.1111/j.1939-1676.2003.tb02482.x
McGurrin MK, Physick-Sheard PW, Southorn E.No abstract available
An assessment of the terminology used by diplomates and students to describe the character of equine mitral and aortic valve regurgitant murmurs: correlations with the physical properties of the sounds.
Journal of veterinary internal medicine    May 31, 2003   Volume 17, Issue 3 332-336 doi: 10.1111/j.1939-1676.2003.tb02457.x
Naylor JM, Wolker RE, Pharr JW.Twenty students and 16 diplomates listened to 7 recordings made from 7 horses with either aortic (n = 3) or mitral valve (n = 4) regurgitant murmurs. A total of 30 different terms were used to describe the character of these murmurs. However, only 4 terms were used in a repeatable and consistent manner. Most people described the character of a given mitral or aortic valve murmur with 1 or 2 terms. Diplomates drew from a pool of terms that was about half the size of that used by students--8.1 +/- 2.0 terms for diplomats (mean +/- 1 SD) versus 13.1 +/- 1.8 terms for students (P > .001). Only blo...
Congestive heart failure in horses: 14 cases (1984-2001).
Journal of the American Veterinary Medical Association    May 23, 2002   Volume 220, Issue 10 1512-1515 doi: 10.2460/javma.2002.220.1512
Davis JL, Gardner SY, Schwabenton B, Breuhaus BA.To identify clinical signs, underlying cardiac conditions, echocardiographic findings, and prognosis for horses with congestive heart failure. Methods: Retrospective study. Methods: 14 horses. Methods: Signalment; history; clinical signs; clinicopathologic, echocardiographic, and radiographic findings; treatment; and outcome were determined by reviewing medical records. Results: All 14 horses were examined because of a heart murmur; tachycardia was identified in all 14. Twelve horses had echocardiographic evidence of enlargement of 1 or more chambers of the heart. Other common clinical finding...
Hematuria and a complex congenital heart defect in a newborn foal.
The Canadian veterinary journal = La revue veterinaire canadienne    May 11, 2002   Volume 43, Issue 5 375-377 
Spiro I.A 16-hour-old foal was referred for evaluation of hematuria. A pansystolic heart murmur and left thoracic thrill were detected; laboratory diagnostics and ultrasonography identified a complex congenital heart defect. The diagnosis was confirmed at postmortem.
An assessment of the ability of diplomates, practitioners, and students to describe and interpret recordings of heart murmurs and arrhythmia.
Journal of veterinary internal medicine    January 31, 2002   Volume 15, Issue 6 507-515 doi: 10.1892/0891-6640(2001)0152.3.co;2
Naylor JM, Yadernuk LM, Pharr JW, Ashburner JS.The ability of clinicians, ie, 10 veterinary students, 10 general practitioners, and 10 board certified internists, to describe and interpret common normal and abnormal heart sounds was assessed. Recordings of heart sounds from 7 horses with a variety of normal and abnormal rhythms, heart sounds, and murmurs were analyzed by digital sonography. The perception of the presence or absence of the heart sounds S1, S2, and S4 was similar for clinicians irrespective of their level of training and was in agreement with the sonographic interpretation on 89, 82, and 78% of occasions, respectively. Howev...
Aortic root disease in four horses.
Journal of the American Veterinary Medical Association    August 24, 2001   Volume 219, Issue 4 491-459 doi: 10.2460/javma.2001.219.491
Sleeper MM, Durando MM, Miller M, Habecker PL, Reef VB.Clinical findings in 4 horses with aortic root disease are described. Three of the horses had aneurysms of the right aortic sinus, and in 2 of the 3, the aneurysm ruptured, creating a fistula between the aorta and right ventricle. One of these horses had had a murmur since birth, and the aortic sinus aneurysm may have been a congenital anomaly. In a second horse, the aneurysm may have been an acquired condition that developed secondary to chronic aortic regurgitation. Another horse had a large subendocardial hematoma associated with dissection of blood from the aorta to the interventricular se...
Concentration of cardiac troponin I in a horse with a ruptured aortic regurgitation jet lesion and ventricular tachycardia.
Journal of the American Veterinary Medical Association    July 26, 2000   Volume 217, Issue 2 231-235 doi: 10.2460/javma.2000.217.231
Cornelisse CJ, Schott HC, Olivier NB, Mullaney TP, Koller A, Wilson DV, Derksen FJ.An 18-year-old Thoroughbred gelding was evaluated because of sudden onset of ventricular tachycardia and signs of colic. Three years earlier, a diastolic decrescendo murmur, consistent with aortic regurgitation, had been detected, but the horse continued to perform well and compete successfully. Cardiac ultrasonographic examination revealed a defect in the interventricular septum below the aortic root, and serum concentrations of cardiac troponin I (cTnI) were higher than those measured in clinically normal horses. Repeated development of tachyarrhythmia during hospitalization prompted a decis...
Effect of age and training on murmurs of atrioventricular valvular regurgitation in young thoroughbreds.
Equine veterinary journal    June 3, 2000   Volume 32, Issue 3 195-199 doi: 10.2746/042516400776563563
Young LE, Wood JL.Cardiac auscultation was carried out on 111 Thoroughbred horses age 2-5 years to test the hypothesis that athletic training might influence the development of atrioventricular (AV) valve regurgitation in young Thoroughbreds. Murmurs of valvular regurgitation were identified and graded on a 1-6 scale. There were 2 sources of auscultation data: 1) 55 2-year-old horses that were examined by auscultation before training commenced and 9 months later when at race fitness; 2) 56 horses age 2-5 years that were examined on one occasion only (25 2-year-olds, 23 3-year-olds, five 4-year-olds and five 5-y...
Prevalence and clinical importance of heart murmurs in racehorses.
Journal of the American Veterinary Medical Association    May 9, 2000   Volume 216, Issue 9 1441-1445 doi: 10.2460/javma.2000.216.1441
Kriz NG, Hodgson DR, Rose RJ.To determine the prevalence of various types of heart murmurs in Thoroughbred racehorses and assess their association with performance by echocardiography and review of the horses' race records for the preceding 2 years. Methods: Clinical and retrospective study. Methods: 846 Thoroughbred racehorses. Methods: Cardiac auscultations were performed by 3 individuals; for 30 horses, Doppler echocardiographic examinations were also performed. Statistical analyses of race records for 753 horses were performed to assess association of heart murmurs with performance. Results: Heart murmurs were detecte...
Atrial fibrillation associated with central nervous symptoms and colic in a horse: a case of equine cardiomyopathy.
The veterinary quarterly    May 1, 1998   Volume 20, Issue 2 73-76 doi: 10.1080/01652176.1998.9694843
Wijnberg ID, van der Kolk JH, van Garderen E, Binkhorst GJ.A 18-year-old Dutch Warmblood mare was referred for colic. Upon arrival, lethargy, blindness, head pressing, ataxia, and circling were the main clinical signs. On rectal examination a hard mass and oedema around the cranial mesenteric artery were palpated. Plasma liver enzyme activities and the ammonia level were elevated. Atrial fibrillation with a pulse frequency of 36-52 beats per minute was noticed. On both sides a holosystolic murmer with the maximum intensity on the right side could be auscultated. Postmortem examination revealed eccentric hypertrophy of the right atrium and a pale spott...
Aorto-cardiac fistulas in seven horses. Marr CM, Reef VB, Brazil TJ, Thomas WP, Knottenbelt DC, Kelly DF, Baker JR, Reimer JM, Maxson AD, Crowhurst JS.This report describes the history, clinical, electrocardiographic and echocardiographic findings, treatment, outcome and post-mortem findings in seven horses with aorto-cardiac fistula. Affected horses included 5 stallions, one gelding and one mare; 2 each of the Thoroughbred, Arabian and Standardbred breeds and one Thoroughbred-cross with a mean +/- s.d. age of 12 +/- 4 years, range 6-18 years. The presenting signs were acute distress (four horses), exercise intolerance (two horses) and the lesion was detected during a routine examination in one horse. Five horses had monomorphic ventricular ...
Severe mitral regurgitation in horses: clinical, echocardiographic and pathological findings.
Equine veterinary journal    February 12, 1998   Volume 30, Issue 1 18-27 doi: 10.1111/j.2042-3306.1998.tb04084.x
Reef VB, Bain FT, Spencer PA.Forty-three horses with mitral regurgitation (MR) and congestive heart failure were examined, using M-mode, 2-dimensional real-time and Doppler echocardiography. There was no breed or sex predisposition when compared to the general hospital population. The mean +/- s.d. age of affected horses was 7.6 +/- 8.1 years. Horses with MR and congestive heart failure had significant increases in mean values for left ventricular chamber size, left atrial size and heart rate and significant decreases in interventricular septal and left ventricular free wall thickness. Significant increases in pulmonary a...
[Heart diseases in foals. A literature review exemplified by 2 case reports].
Tijdschrift voor diergeneeskunde    July 1, 1996   Volume 121, Issue 13 382-387 
de Groot J, Sloet van Oldruitenborgh-Oosterbaan MM, van der Linda-Sipman JS, Kalsbeek HC.A review of the congenital and acquired heart diseases of foals is given on the basis of two patients. A 3-month-old foal with a history of collapse after exercise had a systolic murmur on all heart valves on both sides. Necropsy revealed endocarditis ulcerosa of the left atrioventricular valves. A 6-week-old foal with systolic murmur on the left atrioventricular valves and on the aorta showed, on ultrasonography, signs of endocarditis of the atrioventricular valves. This foal recovered after a long course of antibiotics.
Clarification on foal with cyanoses and intense murmur.
Journal of the American Veterinary Medical Association    May 1, 1996   Volume 208, Issue 9 1381 
Schott HC, Southwood LL, Tobias AH.No abstract available
Cyanosis and intense murmur in a neonatal foal.
Journal of the American Veterinary Medical Association    March 15, 1996   Volume 208, Issue 6 835-839 
Southwood LL, Tobias AH, Schott HC, Leroux AJ, Barbee DD.No abstract available
The development of clinical cardiology.
Equine veterinary journal. Supplement    September 1, 1995   Issue 19 2 
Holmes JR.No abstract available
Colour flow Doppler echocardiography in normal horses.
Equine veterinary journal. Supplement    September 1, 1995   Issue 19 47-55 doi: 10.1111/j.2042-3306.1995.tb04989.x
Blissitt KJ, Bonagura JD.Colour flow Doppler echocardiography is a technique that is used with two-dimensional (2-D) echocardiography to study blood flow patterns in the heart and blood vessels. This method was used to define normal flow patterns and to evaluate valvular function in 40 clinically normal Thoroughbred and Thoroughbred cross horses. Flow patterns from 10 standardised echocardiographic images were described in relation to anatomic landmarks and timing during the cardiac cycle. Consistent intracardiac flow patterns were identified in the normal horses. High velocity flow signals or regurgitant jets were re...
Colour flow Doppler echocardiography in horses with cardiac murmurs.
Equine veterinary journal. Supplement    September 1, 1995   Issue 19 82-85 doi: 10.1111/j.2042-3306.1995.tb04993.x
Blissitt KJ, Bonagura JD.Thirty-two horses with cardiac murmurs typical of tricuspid, mitral and aortic regurgitation were studied using colour flow Doppler echocardiography. The dimensions and duration of any regurgitant signals, recorded at the cardiac valve suspected as being the site of origin of the murmur, were measured. Results were compared with flow signals described at the valves of normal horses (Blissitt and Bonagura 1995). Horses with murmurs suggestive of tricuspid (n = 8) and aortic (n = 8) regurgitation showed larger regurgitant signals at the tricuspid and aortic valves respectively, than has been rep...
Echocardiography.
Equine veterinary journal. Supplement    September 1, 1995   Issue 19 5-17 
Bonagura JD, Blissitt KJ.Echocardiography encompasses a number of specific imaging techniques. The two-dimensional (2-D) echocardiogram is used to identify lesions of the heart and great vessels, assess myocardial function and provide a template for guiding contrast echocardiography, colour-coded Doppler echocardiography and spectral Doppler studies. M-mode echocardiography is used to measure cardiac size and ventricular function and can be combined with contrast or colour-coded Doppler studies for accurate timing of flow events. Pulsed wave and continuous wave Doppler echocardiography display the direction and veloci...
Heart murmurs in horses: determining their significance with echocardiography.
Equine veterinary journal. Supplement    September 1, 1995   Issue 19 71-80 doi: 10.1111/j.2042-3306.1995.tb04992.x
Reef VB.Physiological flow murmurs occur frequently in horses and may be difficult to distinguish from murmurs associated with underlying cardiac disease. The significance of heart murmurs auscultated in horses is often difficult to determine if the horse is not exhibiting any clinical signs or if the signs, such as poor performance, are nonspecific. A complete echocardiographic examination (M-mode, 2-dimensional (2-D) and Doppler) provides an objective assessment of the severity of the horse's underlying cardiac disease. Valvular regurgitation and ventricular septal defects (VSDs) occur frequently an...
Physiological valvular regurgitation in clinically normal young racehorses: prevalence and two-dimensional colour flow Doppler echocardiographic characteristics.
Equine veterinary journal. Supplement    September 1, 1995   Issue 19 56-62 doi: 10.1111/j.2042-3306.1995.tb04990.x
Marr CM, Reef VB.Colour flow Doppler echocardiographic examinations were performed on 15 horses; 10 Thoroughbreds and 5 Standardbreds; 9 mares, 5 geldings and 1 stallion; mean +/- s.d. 3.4 +/- 1.1 years. Cardiac murmurs were audible in 12 horses (80%), but these had characteristics consistent with functional murmurs in all horses. A standardised two-dimensional (2-D) and M-mode echocardiographic examination was unremarkable in all horses except that aortic valve prolapse was identified in 3 horses, tricuspid valve prolapse in 2 horses and mitral valve prolapse was present in one horse. Colour flow Doppler echo...
Evaluation of ventricular septal defects in horses using two-dimensional and Doppler echocardiography.
Equine veterinary journal. Supplement    September 1, 1995   Issue 19 86-95 doi: 10.1111/j.2042-3306.1995.tb04994.x
Reef VB.Ventricular septal defects (VSDs) were diagnosed in 27 horses; in 26 affected horses systolic murmurs were detected over both sides of the chest. Holodiastolic decrescendo murmurs were also detected in 5 horses. Standardbreds and Arabian horses were over-represented, while Thoroughbred horses were under-represented, when compared to the hospital population (P < 0.0001). Five horses had previously raced successfully, one 2-year-old was training successfully and close to racing, and 4 horses had competed successfully in other types of competition. Eleven horses had a history of exercise intolera...