"Horses" is a broad topic that encompasses various aspects of equine biology, behavior, and management. This category includes studies on the anatomy, physiology, and genetics of horses, as well as their behavior, nutrition, and care. Research in this area may also cover the historical and cultural significance of horses, their roles in agriculture, sport, and therapy, and the challenges associated with their conservation and welfare. The page aggregates peer-reviewed research articles and scholarly studies that explore the multifaceted relationships between humans and horses, examining both scientific and socio-economic perspectives.
Barth AD, Barber SM, McKenzie NT.A two month old Thoroughbred filly was presented with signs of depression, grinding of the teeth, frothing of the mouth and abdominal pain. These signs had persisted for two weeks despite treatment with mineral oil, dioctyl sodium sulfosuccinate, meperidine and antibiotics. A variety of diagnostic tests were done, the only abnormal finding was a stress leukon. On exploratory laparotomy the stomach was dilated with fluid and gas and the pyloric canal was constricted. Pyloroplasty resulted in correction of the condition. The etiological possibilities are discussed. This is believed to be the fir...
Milne DW, Gabel AA, Muir WW, Skarda RT, Hamlin RL, Pipers FS.In a double-blind study under simulated racing conditions, six Standardbred horses, which had been trained for 12 weeks, were given 1 mg of furosemide/kg of body weight or saline solution IV 15 minutes before the first of two warm-up workouts (1.6 km at 60-minute intervals). Sixty minutes later, 135 minutes after drug or placebo injection, these horses were driven 1.6 km at maximum speed. Heart rate, respiratory rate, cardiac output, pulmonary trunk pressure, body temperature, PCV, arterial oxygen, and plasma lactic acid were recorded during and after the first warm-up workout and after a simu...
Cappugi G, Manao G, Camici G, Ramponi G.The amino acid sequence of horse muscle acylphosphatase is given in the present paper. The carboxymethylated enzyme consists of a single polypeptide chain of 98 amino acid residues with an acetyl group blocking the NH2 terminus and a tyrosine at the COOH terminus. The calculated molecular weight of the native protein, a mixed disulfide with glutathione, is 11,365. The carboxymethylated protein was cleaved by cyanogen bromide. The three expected fragments were purified; moreover, an additional fragment, derived from a partial failure of cleavage at methionine-24, was purified and characterized....
Mirck MH.The use of trichlorfon as an anthelmintic in horses has increased since it was combined with mebendazole and febantel, and became commercially available as Telmin-trichlorfon and Rintal-plus respectively. Field studies showed that these combined preparations frequently gave rise to cases of poisoning. Mild to severe colic was observed up to six hours after treatment, diarrhoea and/or anorexia continuing to be present for one to six days after administration. The 'horse weight measurer' introduced by Janssen Pharmaceutica is not sufficiently accurate to prevent overdosage. It is advisable only ...
Greet TR, Jeffcott LB, Whitwell KE, Cook WR.The paper describes the assessment and practical implications of a laryngeal adductory reflex in a series of 30 ataxic and 64 non-ataxic horses. The reflex was evoked by slapping the saddle region just caudal to the withers. In normal horses this produced a flickering adductory movement of the contralateral arytenoid cartilage which was observed endoscopically. Abolition of the laryngeal response was encountered in in 3 situations:--(1) Disruption of the afferent impulse occurred in those horses in which there was significant spinal cord pathology affecting the pathway from the cranial thoraci...
Nickels FA, Brown CM, Breeze RG.A unilateral pulmonary granular cell tumor occurred in a Thoroughbred mare with longstanding respiratory disease wrongly attributed to chronic obstructive pulmonary disease. The clinical features, radiology and endoscopic appearance permitted an accurate diagnosis, which was supported by subsequent necropsy and histologic examination. Obstructive pulmonary disease was ruled out after measurement of arterial blood gases and maximum intrathoracic pressure changes, and after microscopic examination of the lung.
Dybdal NO, Gribble D, Madigan JE, Stabenfelt GH.The effects of prolonged exercise on plasma concentrations of corticosteroids, insulin, glucose, lactate and beta-hydroxybutrate were studied in a group of horses competing in a 160 km endurance ride. Of the 53 horses included in the study at the outset, 23 completed the course. Plasma corticosteroids increased while glucose and insulin decreased during exercise. Little change occurred in plasma lactate or beta-hydroxybutyrate. The parameters studied did not result in the finding of any consistent significant differences beteeen individuals that completed and those that did not complete the co...
Scott EA, Sandler GA.Blood flow (milliliter/minute) was measured in the medial palmar artery of 12 horses, using electromagnetic flow equipment. Extraluminal flow probes were surgically placed around the artery and base-line blood flows were recorded during surgical manipulation. After horses had recovered from anesthesia, blood flows were recorded each day for 11 days. According to mean average blood flows, horses were allotted to two groups: group 1--those with predominately normal flow characteristics, and group 2--those horses with predominately abnormal flow features. Average daily mean blood flows in the med...
Prescott JF, Johnson JA, Markham RJ.Four month-old foals were infected orally with 75 mL of a suspension of 5.0 x 10(8)Corynebacterium equi per mL. Two foals were killed after ten days and had scanty number of C. equi in the caeco-colic lymph nodes. No C. equi were recovered from the other two foals, killed 20 days after infection. No gross pathological change was detected in these four foals, although mild microscopic lesions were seen in the ileum of one foal. Results of lymphocyte blastogenesis using peripheral blood lymphocytes and C. equi antigens showed, however, that lymphocytes became sensitized to C. equi following this...
Dusek J, Munk Z.The study was based on the documentation of the Napajedla Stud Farm of the English Thoroughbred horse for 1888-1972. Evaluating the effect of the age of stallions on their fertility (leaving aside the variability of the age of their mothers), such an effect was found to be significant only in four out of the 26 studs evaluated. In 65% of the selected stallions, the correlation coefficients were found to be negative, but without statistical significance. However, the objective of the study was to evaluate stallions and mares parallelly as to their age variability and fertility. The relationship...
Jeffcott LB, Dalin G.The functional anatomy of the thoracolumbar (TL) spine is considered in relation to the horse's ability to perform at speed and to jump. The morphological features quite clearly show the relative inflexibility of the equine back and this was confirmed by some experimental studies. Fresh post mortem specimens from 5 Thoroughbreds were used to estimate the limits of dorsoventral movement of the TL spine from mid-thoracic to the cranial lumbar (T10-L2). The individual spinous processes could be moved a mean 1.1-6.0 mm on maximum ventroflexion and 0.8-3.8 mm on dorsiflexion. The overall flexibilit...
Rose RJ, Backhouse JW, Ilkiw JE.The electrocardiograms of 22 horses competing in a 3-day event were recorded before and after the event. In addition, blood samples were taken for determination of packed cell volume and total plasma protein before, during and after the speed and endurance phases (Day 2). The electrocardiograms of 13 horses showed various abnormalities before the event, most of which were T wave changes. As a result of competition in the event, there was a significant increase in the number of leads showing T wave abnormalities when the electrocardiograms taken before and after the event were compared. At all ...
Arko RJ, Wong KH.An infection model in laboratory mice for studying the bacterium (proposed name Haemophilus equigenitalis) causing contagious equine metritis is described. Small porous chambers were implanted subcutaneously into mice and after 1 to 3 weeks were inoculated with H equigenitalis. Infections that persisted for > 30 days were established by direct transfer of infective chamber fluid or by injection of laboratory-grown cultures. Immunization of mice with formaldehyde-treated cells induced significant, strain-related immunity to infection and did not appear to require complement as a protection medi...
Justines G, Sucre H, Alvarez O.Transplacental passage of Venezuelan equine encephalitis virus, epizootic strain P-676, occurred in four of nine fetuses studied. The mares were infected near term. Virus was recovered in high titer from fetal blood and organs, while no virus was detected in maternal blood but neutralizing antibodies were present. No evidence of in utero infection was found in two fetuses from mares infected with MF-8, another epizootic strain of Venezuelan equine encephalitis virus.
Akinboade OA, Awani O, Best O, Cole T.Summary Twelve (12) heavy horses of the Shire breed imported into Nigeria in 1974 died within two months after importation. This was because of inclement weather and non-availability of AHS vaccine.
Carmichael SW, Weber A, Winkler H.The uptake of nucleotides and catecholamines into chromaffin granules from adrenals of pigs and horses is similar to that previously seen in bovine chromaffin granules. The rate of [3H]ATP uptake at 2 mM-ATP concentration was 0.42 +/- 0.06 and 0.15 +/- 0.02 nmol/mg protein/min for pig and horse granules, respectively. The apparent Km's were 1.37 mM for pig granules, 0.89 mM for horse granules, and 1.2 mM for ox granules. The sensitivity of the uptake for nucleotides and catecholamine to specific inhibitors was found to be similar in granules from pig and ox, indicating that the same mechanisms...
Yoxall AT.This paper is an introduction to a series of commissioned articles on therapeutic medicine to be published in Equine Veterinary Journal under differing authorship, during the next 2 years. It presents an account of fundamental concepts common to the use of all drugs and introduces some pharmacokinetic principles to which reference will be made in later articles.
Littlejohn A.The arterial oxygen tension (PaO2) in clinically normal newborn foals at 1300 m above sea-level is considerably lower (less than 60 mmHg) than in similarly aged foals at lower altitudes. This figure is further reduced to less than 50 mmHg without adverse effect in newborn foals at 1300 m maintained under pentobarbitone anaesthesia for prolonged periods. Measurement of O2 dissociation curves indicates that haemoglobin becomes saturated at a lower blood O2 tension in newborn foals than adult horses.
Miyakoshi D, Higuchi T, Ikeda H, Sato M, Yoshimura S.To report a surgical technique and an outcome for the repair of a displaced, transverse scapular body fracture with locking compression plates (LCPs) in a colt. Methods: One 5 month old Thoroughbred colt. Methods: Case report. Methods: A colt sustained an unstable, comminuted, transverse fracture of the scapular body. Three 4.5/5.0 mm LCPs were used with 6.5 mm cancellous screws, 4.5 mm cortex screws, and 5.0 mm locking head screws. Implants were removed 2 months after surgery. Results: Surgical site infection was identified by purulent discharge at the distal aspect of the suture li...
Blikslager AT, Bristol DG, Bowman KF, Engelbert TA.To determine the feasibility of performing a single-incision loop colostomy for treatment of grade-3 rectal tears in horses. Methods: Retrospective case series. Methods: Seven adult horses with grade-3 rectal tears. Methods: A single-incision loop colostomy was performed with horses under general anesthesia (n = 6) or while restrained in standing stocks (n = 1). The rectal tear was lavaged via an endoscope. The colostomy was resected after the rectal tear healed. Results: Rectal tears ranged from 4 to 10 cm in diameter and were > 25 cm proximal to the anus. All horses survived colostomy surger...
Kramer J, Tornquist S, Erfle J, Sloeojan G.Large granular lymphocytes (LGL) occur as a leukemic or aleukemic neoplasia in humans,(1) rats,(2) cats,(3,4) dogs,(5) and horses.(6) The single case of equine LGL previously reported was aleukemic.(5) In contrast to this previous report of aleukemic equine LGL neoplasia, the leukemia in the case presented here established the antemortem diagnosis of LGL.
Wohlsein P, Harps O, Trautwein G.The clinical history, clinical, pathological and immunohistological findings of a four-month-old foal with generalised pemphigus foliaceus are presented. The typical lesions of this autoimmune skin disease are described and discussed.
Milne EM, Pemberton AD, McGorum BC, Dixon PM, Miller HR.The equine alpha-1 proteinase inhibitor (alpha 1PI) system differs from that of man in that the equine system consists of four closely-linked genes (Spi1-Spi4) whereas in man, a single gene encodes for alpha 1PI. We have previously found differences in the proportion of the Spi proteins in equine serum and bronchoalveolar lavage fluid (BALF). We therefore wished to determine whether, as reported in man, there was any molecular weight difference between the Spi proteins in serum and BALF. alpha 1PI and albumin from equine BALF migrated further towards the anode compared with serum alpha 1PI on ...
Ralston SL, Sullins KE, Stashak TS.The effect of 60% resection of the large colon vs ischemic insult without resection on the ability of horses to digest grass hay was investigated. Digestion trials were performed on 9 horses before surgery (base line) and 3 weeks, 6 weeks, and 6 months after surgery. The percentage of apparent digestion of crude protein, crude fiber, nitrogen-free extract, calcium, phosphorus, magnesium, manganese, copper, and zinc was calculated. Horses that had resection (n = 5) had decreased apparent digestion of crude protein, crude fiber, and phosphorus 3 weeks after surgery, compared with those in horses...
Bertone AL, Cockerell GL, Lee RE, Stashak TS.Light microscopy, morphometry, and scanning electron microscopy were used to examine the mucosal morphologic features of 7 intestinal specimens (3 from the small intestine; 4 from the large intestine) from each of 8 horses 1 year after sham operation (group 1; n = 3) or extensive large-colon resection (group 2; n = 5). Qualitative light microscopic examination did not reveal differences between groups, but morphometry revealed significantly (P less than 0.05) greater intercrypt area and distance in horses with colon resection and this was most pronounced in the cecum and remaining right ventra...
Reginato GM, Xavier NV, Alonso BB, Lima DP, Pereira Sirqueira TC, Carregaro AB.The study evaluated the effect of a 1/10 dose of flunixin meglumine administered into the governing vessel 1 (GV1) acupoint in horses that underwent castration. Twenty animals received 0.02 mg/kg detomidine intravenously, followed by 2.2 mg/kg ketamine and 0.1 mg/kg diazepam by the same route, and also a local anesthesia with 30 mL lidocaine. As postoperative analgesia, the animals received 1.1 mg/kg flunixin meglumine IV (FIV) or 0.11 mg/kg flunixin meglumine into the GV1 acupoint (FGV). Behavioral parameters were assessed 12 hours before the procedure (baseline) and at 4, 6, 12, and 2...
Doff SC, Wenderlein J, Wiesinger A, Hiereth S, Ulrich S, Straubinger RK.Lyme borreliosis is a vector-borne disease in humans and animals caused by bacteria from the sensu lato complex (sl). The possible transmission of sl from companion animals to humans via ticks makes this disease important in terms of One Health approaches. Thus, early and accurate diagnosis and treatment are of utmost importance. Today's standard for the detection of specific antibodies against sl is a two-tiered test system based on an ELISA for screening combined with a line immunoassay (LIA) for confirmation. In this study, 200 canine and 200 equine serum samples with known antibody status...
Gossett KA, McCoy DJ, Jowett PL, Kearney MT.Nitrofurazone solution containing 0.2% nitrofurazone and 99.8% polyethylene glycol was given to 4 healthy horses (2 L in 2 L of lactated Ringer solution, intraperitoneally). Horses developed hypovolemia, hyperosmolality, and mixed respiratory and metabolic acidosis. These changes were largely attributable to polyethylene glycol, but a contribution of nitrofurazone cannot be excluded. Intraperitoneal infusion of nitrofurazone solution in horses is contraindicated.
Firth EC, Goedegebuure SA.The long bone ends of foals with infectious disease were sawn into sagittal slabs, washed and inspected. Tissue suspected to be abnormal on the basis of change of colour and consistency was radiographed, and then decalcified and examined histologically. The exact site of 140 focal osteomyelitis lesions from 18 foals was determined. There were more lesions in the epiphysis than the metaphysis. Epiphyseal lesions were in specific sites within a given epiphysis, and in most epiphyses the lesions were at the site of thickest cartilage. Metaphyseal lesions in the metacarpal, metatarsal and distal r...
Lacitignola L, De Luca P, Imperante A, Tommasa SD, Crovace A.The aim of this study was to evaluate the use of a single-portal endoscopic desmotomy of the PAL with the use of Arthrex - Centerline™. Ten horse distal front limbs from horses free of PAL disease were prepared for tenoscopy of the digital flexor tendon sheath (DFTS). A dual-port endoscopic desmotomy with a hook knife was performed in 5 specimens (Group A) and single port Arthrex-Centerline™ Desmotomy was performed in another 5 specimens (Group B). The performing time, judgments of the surgeon, number of blade passages, and gross anatomy were evaluated. The performing time and surgeon judg...
Geschwind II, Dewey R, Hughes JP, Evans JW, Stabenfeldt GH.Plasma levels of LH were determined by heterologous radioimmunoassay utilizing highly purified equine LH as standard. Samples were taken regularly from eleven mares for twenty-six oestrous cycles over a period of 10 weeks. The mean cycle length was 20-5 +/- 3-1 (S.D.) days, and ovulation occurred on average 4-3 +/- 1-6 (S.D.) days from the time heat was first detected. Levels of LH were persistently low from Days 5 to 16 of the cycle (ovulation = Day 0). They then increased slowly over a number of days and continued to rise beyond the levels observed at any time during the immediate preovulato...
History of psychiatryFebruary 18, 2006
Volume 16, Issue Pt 4 (no 64) 467-471 doi: 10.1177/0957154X05051459
Papakostas YG, Daras MD, Liappas IA, Markianos M.Anthropophagic horses have been described in classical mythology. From a current perspective, two such instances are worth mentioning and describing: Glaucus of Potniae, King of Efyra, and Diomedes, King of Thrace, who were both devoured by their horses. In both cases, the horses' extreme aggression and their subsequent anthropophagic behaviour were attributed to their madness (hippomania) induced by the custom of feeding them with flesh. The current problem of 'mad cow' disease (bovine spongiform encephalopathy) is apparently related to a similar feed pattern. Aggressive behaviour in horses c...
Ohmuro K, Okada K, Satoh A, Murakami K, Satake S, Asahina M, Numakunai S, Ohshima K.A thoroughbred horse, gelding, gray color, aged 19 years old had cutaneous melanomas from the root to the middle of the tail, and throughout the connective tissues of the whole body. Histologically, the tumors were diagnosed as mature melanotic melanomas characteristically deposited with abundant melanin pigment. Examined with an electron microscope, melanosomes were electron opaque without internal structure (stage IV), or as mature granular and lamellar types. Most of them were fused with each other, and formed compound melanosomes, which was similar to internal melanin aggregates in shape. ...
