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Topic:Horses

"Horses" is a broad topic that encompasses various aspects of equine biology, behavior, and management. This category includes studies on the anatomy, physiology, and genetics of horses, as well as their behavior, nutrition, and care. Research in this area may also cover the historical and cultural significance of horses, their roles in agriculture, sport, and therapy, and the challenges associated with their conservation and welfare. The page aggregates peer-reviewed research articles and scholarly studies that explore the multifaceted relationships between humans and horses, examining both scientific and socio-economic perspectives.
Peripheral primitive neuroectodermal tumor in a two-year-old paint horse. Facemire PR, Facemire LM, Honnold SP.A 2-year-old gelding presented with a history of lethargy and anorexia. Physical examination revealed pleural and abdominal fluid, as well as several masses in the scrotum. The horse became acutely dyspneic despite 7 days of supportive care. Because of the poor prognosis, the owners elected euthanasia. Gross necropsy findings included multiple masses in the scrotum and inguinal canals and along the dorsal peritoneal cavity. The neoplasm infiltrated the kidneys, liver, spleen, mesenteric lymph nodes, mesentery, and abdominal surface of the diaphragm. Histologically, the neoplasm is composed of ...
Occurrence of hemotrophic mycoplasmas in horses with correlation to hematological findings.
Veterinary microbiology    May 22, 2012   Volume 160, Issue 1-2 43-52 doi: 10.1016/j.vetmic.2012.05.016
Dieckmann SM, Hoelzle K, Dieckmann MP, Straube I, Hofmann-Lehmann R, Hoelzle LE.Hemotrophic mycoplasmas (HM) are small, cell wall-less bacteria and infections are known for a wide range of animals. One possible indication of equine HM infection was given in 1978, when a 'haemobartonellosis' outbreak was diagnosed in Nigerian horses by microscopy. However the first molecular proof of HM in horses was not reported until 2010, when a fragment of about 900 bp of the 16S rRNA of the equine HM was obtained. This sequence was used for the development of a SYBR green I real-time PCR assay specific for equine HM. The lower detection limit of the PCR was ten 16S rDNA copy numbers p...
Gene and protein expression of cartilage canal and osteochondral junction chondrocytes and full-thickness cartilage in early equine osteochondrosis.
Veterinary journal (London, England : 1997)    May 22, 2012   Volume 194, Issue 3 319-325 doi: 10.1016/j.tvjl.2012.04.023
Riddick TL, Duesterdieck-Zellmer K, Semevolos SA.The objective of this study was to investigate the expression of several regulatory factors associated with cartilage maturation in horses with early osteochondrosis (OC) compared to normal controls. The hypothesis was that expression levels of Indian hedgehog (Ihh), parathyroid hormone-related peptide (PTH-rP), vascular endothelial growth factor (VEGF), platelet-derived growth factor-A (PDGF-A), and matrix metalloproteinase-13 and -3 (MMP-13, -3) would be increased in OC. Articular cartilage and osteochondral samples were collected from the femoropatellar joints from seven OC and eight normal...
Pharmacokinetics of a continuous rate infusion of ceftiofur sodium in normal foals.
Journal of veterinary pharmacology and therapeutics    May 21, 2012   Volume 36, Issue 1 99-101 doi: 10.1111/j.1365-2885.2012.01403.x
Wearn JM, Davis JL, Hodgson DR, Raffetto JA, Crisman MV.No abstract available
Autosomal genetic diversity in non-breed horses from eastern Eurasia provides insights into historical population movements.
Animal genetics    May 21, 2012   Volume 44, Issue 1 53-61 doi: 10.1111/j.1365-2052.2012.02371.x
Warmuth V, Manica A, Eriksson A, Barker G, Bower M.Many events in the history of eastern Eurasia, including the process of domestication itself, the initial spread of domestic horses and subsequent movements, are believed to have affected the genetic structure of domestic horse populations in this area. We investigated levels of within- and between-population genetic diversity in 'non-breed horses' (working horses sampled in remote areas) from 17 locations in Asia and parts of Eastern Europe, using 26 autosomal microsatellite loci. Non-breed horses have not been subject to the same intensity of artificial selection and closed breeding as have ...
Aortic rupture and aorto-pulmonary fistulation in the Friesian horse: characterisation of the clinical and gross post mortem findings in 24 cases.
Equine veterinary journal    May 20, 2012   Volume 45, Issue 1 101-106 doi: 10.1111/j.2042-3306.2012.00580.x
Ploeg M, Saey V, de Bruijn CM, Gröne A, Chiers K, van Loon G, Ducatelle R, van Weeren PR, Back W, Delesalle C.In horses, aortic sinus of Valsalva aneurysms or tears in the aortic root are well-recognised conditions in breeding stallions, often leading to sudden death. A more uncommon form of aortic rupture, located proximal to the ligamentum arteriosum has been reported in 3 Friesian horses. Objective: The purpose of this study was to phenotypically characterise aortic rupture and aorto-pulmonary fistulation in Friesian horses in terms of clinical and post mortem data based on 24 cases. Methods: Friesian horses that were diagnosed with aortic rupture and aorto-pulmonary fistulation over a period of 13...
Allopregnanolone infusion induced neurobehavioural alterations in a neonatal foal: is this a clue to the pathogenesis of neonatal maladjustment syndrome?
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 109-112 doi: 10.1111/j.2042-3306.2011.00504.x
Madigan JE, Haggettt EF, Pickles KJ, Conley A, Stanley S, Moeller B, Toth B, Aleman M.Increased plasma progestagen concentrations have been reported in foals with neonatal maladjustment syndrome (NMS). These steroids may cross the blood-brain barrier and have dampening effects in the central nervous system. Objective: To evaluate if the infusion of a progesterone derivative (allopregnanolone) in a healthy neonatal foal would induce clinical signs compatible with NMS. Methods: A healthy neonatal foal from a healthy mare with a normal gestation (length, no complications), birth and placenta was infused with allopregnanolone to observe its neurobehavioural effects. Heparinised blo...
The importance of ultrasonographic pneumatosis intestinalis in equine neonatal gastrointestinal disease.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 64-68 doi: 10.1111/j.2042-3306.2011.00478.x
de Solis CN, Palmer JE, Boston RC, Reef VB.Recognising the presence of a necrotising component of the gastrointestinal disease may be clinically useful in ill equine neonates. Objective: To study the importance of abdominal sonograms in neonatal foals suffering from gastrointestinal conditions and to describe the clinical features of necrotising gastrointestinal disease. Objective: There is a subgroup of neonates with sonographically detectable pneumatosis intestinalis (PI), reflecting a necrotising disease. Methods: Records of foals aged < or = 7 days hospitalised from 2005 to 2009 with signs of gastrointestinal disease were evaluated...
The impact of birthweight on mare health and reproductive efficiency, and foal health and subsequent racing performance.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 26-29 doi: 10.1111/j.2042-3306.2011.00479.x
Whittaker S, Sullivan S, Auen S, Parkin TD, Marr CM.Although low birthweight is a risk factor for neonatal illness, the impact of high birthweight on the health of foals and mares, and on the foals' long-term athletic capability, is unknown. Objective: To investigate whether: 1) foals that are excessively heavy are associated with an increased prevalence of maternal illness in the first month post partum and reproductive dysfunction in the following season; 2) excessively light or heavy foals are at an increased risk of illness in the first month of life; and 3) birthweight is associated with racing success. Methods: Veterinary records from 230...
Multicentre clinical research and the veterinary clinician.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 3-4 doi: 10.1111/j.2042-3306.2011.00519.x
Furr M.No abstract available
Feeding the foal for immediate and long-term health.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 149-156 doi: 10.1111/j.2042-3306.2011.00522.x
Becvarova I, Buechner-Maxwell V.The nutrition and nutritional status of the mare, as well as foal's nutrient intake from colostrum, milk and creep feed, are critical factors that are known to influence the growth period of the foal. Long-term effects of mare and foal nutrition are not well recognised or understood in the horse but may have the greatest impact on the animal's health and use when mature. Both under- and overfeeding can negatively influence important characteristics such as bone development and neurological function The risk of developing debilitating diseases such as metabolic syndrome may also be increased by...
Endocrine adaptations in the foal over the perinatal period.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 130-139 doi: 10.1111/j.2042-3306.2011.00505.x
Fowden AL, Forhead AJ, Ousey JC.In adapting to life ex utero, the foal encounters a number of physiological challenges. It has to assume the nutritional, respiratory and excretory functions of the placenta and activate full regulatory control over its own internal environment for the first time. To achieve this, there must be structural and functional changes to a wide range of tissues including several endocrine glands. In most species, including the horse, these maturational changes begin in late gestation and continue into the first few days of neonatal life. Consequently, during this perinatal period, there are major cha...
Prevalence of gastric and duodenal ulceration in 691 nonsurviving foals (1995-2006).
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 76-79 doi: 10.1111/j.2042-3306.2011.00449.x
Elfenbein JR, Sanchez LC.Gastric ulcer disease is reported to be a significant cause of morbidity in foals, but the prevalence of ulcers in this population has not recently been evaluated. Objective: To determine the prevalence of gastric and duodenal ulceration in nonsurviving foals, and the association of ulceration with the body system of primary diagnosis. Secondary objectives were to evaluate a potential association between age and ulcer prevalence and to evaluate the use of antacid medication in the neonatal hospital population during the study years. Methods: Necropsy records were searched for all equine access...
Intraoperator, intraobserver and interoperator variability of echocardiographic measurements in healthy foals.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 69-75 doi: 10.1111/j.2042-3306.2011.00503.x
Slack J, Durandot MM, Belcher CN, Collins N, Palmer L, Ousey J, Birks EK, Marr CM.The repeatability of various echocardiographic measurements is unknown. Objective: To determine the intraoperator, intraobserver and interoperator variability of echocardiographic measures in healthy foals. Methods: Echocardiographic examinations were carried out on 6 healthy foals by 3 experienced echocardiographers. Intraoperator variability was determined by having a single echocardiographer obtain and measure images from 6 foals scanned on 3 consecutive days. Interoperator and intraobserver variability were determined by having 3 echocardiographers each obtain images from an additional 6 s...
Prostaglandins and the regulation of parturition in mares.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 140-148 doi: 10.1111/j.2042-3306.2011.00506.x
Ousey JC, Fowden AL.Prostaglandins play an essential role during the perinatal period in the mare. Prostaglandin concentrations are low for the majority of pregnancy due to the regulatory action of progestagens on those enzymes responsible for metabolism of prostaglandins. Towards term, prostaglandin concentrations gradually increase, closely associated with upregulation of the fetal hypothalamo-pituitary-adrenal axis, stimulation of the prostaglandin synthesising enzyme PGHS-2 and changes in the ratio of progestagens and oestrogens. Recent evidence in the mare indicates that proinflammatory cytokines are key med...
Hypothalamic-pituitary-adrenal axis function in pony foals after neonatal ACTH-induced glucocorticoid overexposure.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 38-42 doi: 10.1111/j.2042-3306.2011.00448.x
Jellyman JK, Allen VL, Forhead AJ, Holdstock NB, Fowden AL.The effects of overexposure to glucocorticoids during early life of the foal on the subsequent HPA programming of the hypothalamic-pituitary-adrenal axis are unknown. Objective: To test the hypotheses that excess glucocorticoid exposure in early life subsequently increases both basal plasma concentrations of cortisol and the adrenocortical responsiveness to exogenous adrenocorticotropic hormone (ACTH). Methods: Foals received either saline (0.9% NaCl, n = 9) or long-acting ACTH (0.125 mg i.m. b.i.d., n = 6) for 5 days from Day 1 to increase endogenous cortisol concentrations. Long-term indwell...
Comparing the pharmacokinetics of a fourth generation cephalosporin in three different age groups of New Forest ponies.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 52-56 doi: 10.1111/j.2042-3306.2011.00501.x
Smiet E, Haritova A, Heil BA, Fink-Gremmels J, Wijnberg ID.To compare the pharmacokinetics of the fourth generation cephalosporin, cefquinome, in neonatal foals, 6-week-old foals and mature New Forest ponies in order to recommend appropriate dosage regimens for use of this drug. Methods: Cefquinome was administered i.v. at 1 mg/kg bwt twice a day (q. 12 h), 1 mg/kg bwt 3 times a day (q. 8 h) or 4.5 mg/kg bwt q. 12 h to each age group (n = 6). Plasma cefquinome concentrations were analysed using high-performance liquid chromatography combined with electrospray tandem mass spectrometry. Results: Both foal age groups had comparable pharmacokinetic data e...
Treatment with histamine-type 2 receptor antagonists and omeprazole increase the risk of diarrhoea in neonatal foals treated in intensive care units.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 80-86 doi: 10.1111/j.2042-3306.2011.00499.x
Furr M, Cohen ND, Axon JE, Sanchez LC, Pantaleon L, Haggett E, Campbell R, Tennent-Brown B.The use of anti-ulcer medication in the neonatal intensive care unit (ICU) is common due to the concern for development of catastrophic gastric ulcerdisease. In man, however, the use of acid-suppressive medication has been shown in some studies to be a substantial riskfactorfor the development of Clostridium difficile-associated diarrhoea (CDAD), bacteraemia and neonatal sepsis. Objective: The purpose of the study reported herein is to evaluate the influence of anti-ulcer medications on the development of diarrhoea in the neonatalfoal. Objective: The use of anti-ulcer medication does not alter...
Energy expenditure of critically ill neonatal foals.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 48-51 doi: 10.1111/j.2042-3306.2011.00500.x
Jose-Cunilleras E, Viu J, Corradini I, Armengou L, Cesarini C, Monreal L.Nutritional support in critically ill neonatal foals is of great importance given their high metabolic rate and minimal stores of energy and protein. Nutrient requirements of healthy growing foals have been estimated based on daily milk intake; however, little is known about the resting energy expenditure (REE) of sick foals. Objective: To determine REE in critically ill neonatal foals (sepsis and/or hypoxic-ischaemic encephalopathy [HIE] and compare this with REE in control foals. Methods: Critically ill newborn foals admitted to the Fundació Hospital Clinic Veterinari, Universitat Autònoma...
Factors influencing placental development and function in the mare.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 113-119 doi: 10.1111/j.2042-3306.2011.00452.x
Wilsher S, Allen WR.The development of the equine placenta involves a series of stage-specific events which ensure that the fetus is nourished throughout its 11 months of gestation. Initially, placental exchange to the developing embryo is histotrophic, via the yolk sac but, as the allantochorion develops and microcotyledons form, haemotrophic nutrition plays the major role in sustaining the increasing demands of the growing fetus. This review describes the development of the allantochorionic placenta of the mare and discusses some of the factors that influence its growth, size and functions and, hence, its contr...
Acute pancreatitis in two five-day-old Appaloosa foals.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 96-99 doi: 10.1111/j.2042-3306.2011.00435.x
Ollivett TL, Divers TJ, Cushing T, Priest H, Dawson DR, Peters R, Stokol T.Severe acute pancreatitis (SAP) in foals is rare and treatment has not been documented. This paper describes the clinical, haematological and ultrasonographic findings as well as attempted treatment of SAP in two 5-day-old Appaloosa fillies. Clinical signs, including colic, diarrhoea and coma, may be mistaken for sepsis or neonatal encephalopathy. Hyperlipaemic serum and peritoneal fluid, and elevated serum and peritoneal fluid amylase and lipase activities aided the diagnosis. Severe acute pancreatitis should be included as a differential in an acutely ill foal with diarrhoea, colic, cerebral...
Hospital treatment as a foal does not adversely affect future sales performance in Thoroughbred horses.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 87-90 doi: 10.1111/j.2042-3306.2011.00477.x
Corley KT, Corley MM.Many Thoroughbred foals are intended to be sold at public auction. The impact of disease conditions necessitating hospital treatment as a foal on future sales performance is unknown. Objective: To determine whether Thoroughbred horses that were treated in a hospital before age 125 days and presented to public auction sell for a different mean price than controls. Methods: Foals aged < 125 days, treated at a hospital in Ireland in 2007 or 2008 and presented for sale to a public auction recorded on a publicly accessible database were selected for inclusion in the study. The sales outcome of thes...
Dysphagia associated with presumed pharyngeal dysfunction in 16 neonatal foals.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 105-108 doi: 10.1111/j.2042-3306.2011.00451.x
Holcombe SJ, Hurcombe SD, Barr BS, Schott HC.Dysphagia due to pharyngeal dysfunction occurs in human neonates and is associated with prematurity and hypoxic episodes. This syndrome probably occurs in neonatal foals but has not been reported. Objective: The objectives of this study were to describe 1) a series of neonatal foals with dysphagia due to pharyngeal dysfunction; 2) the progression, treatment and resolution of the dysphagia; 3) the comorbidities; and 4) the prognosis for life and athleticism for affected foals. Methods: Records from 3 referral equine hospitals were reviewed from neonatal foals with dysphagia of pharyngeal origin...
Clinical findings in 10 foals with bacterial meningoencephalitis.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 100-104 doi: 10.1111/j.2042-3306.2011.00508.x
Viu J, Monreal L, Jose-Cunilleras E, Cesarini C, Añor S, Armengou L.Bacterial meningoencephalitis is a severe complication in septic foals and there is scarce and often unclear information in the equine literature. Objective: To report the most frequent clinical signs, clinicopathological findings, causative agents, treatments given and outcome of a group of foals with confirmed bacterial meningoencephalitis. Methods: Foals aged < 6 months of age admitted to the Universitat Autonoma de Barcelona (2004-2009) with confirmed bacterial meningoencephalitis were retrospectively included in the study Diagnosis of bacterial meningoencephalitis was made by cerebrospina...
Necrosis of the femoral condyles in a four-week-old foal: clinical, imaging and histopathological features.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 91-95 doi: 10.1111/j.2042-3306.2011.00498.x
Haggett EF, Foote AK, Head MJ, McGladdery AJ, Powell SE.A 4-week-old Thoroughbred filly foal with a history of sepsis was evaluated for right hindlimb lameness. Bilateral femoropatellar and femorotibial joint effusions were detected. Ultrasonography and radiography of the right stifle revealed signs of joint collapse and periarticular swelling. Computed tomography revealed abnormalities in the bone density of the medial femoral condyle of the right hindlimb and lateral femoral condyle of the left hindlimb. Euthanasia was recommended based on the severity of the lesions. Gross and microscopic examinations revealed extensive separation of the articul...
The impact of peer-reviewed literature on equine neonatal care.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 5-6 doi: 10.1111/j.2042-3306.2011.00520.x
Dunkel B, Giguère S.No abstract available
Association of admission L-lactate concentration in hospitalised equine neonates with presenting complaint, periparturient events, clinical diagnosis and outcome: a prospective multicentre study.
Equine veterinary journal. Supplement    May 19, 2012   Issue 41 57-63 doi: 10.1111/j.2042-3306.2011.00509.x
Borchers A, Wilkins PA, Marsh PM, Axon JE, Read J, Castagnetti C, Pantaleon L, Clark C, Qura'n L, Belgrave R, Trachsel D, Levy M, Bedenice D....Admission L-lactate concentration is a useful and commonly measured biomarker not previously prospectively evaluated in a large multicentre study of critically ill neonatal foals. Objective: To evaluate overall outcome and the association of survival and L-lactate concentration at admission ([LAC]ADMIT) by periparturient history, presenting complaint and clinicians' major diagnosis for ill neonatal foals. Methods: Thirteen university and private equine referral hospitals enrolled 643 foals over the 2008 foaling season. Case details, historical, clinical and clinicopathological data were entere...
Specific detection of all members of the Venezuelan Equine Encephalitis complex: development of a RT-Nested PCR.
Journal of virological methods    May 18, 2012   Volume 186, Issue 1-2 203-206 doi: 10.1016/j.jviromet.2012.05.009
Pisano MB, Seco MP, Ré VE, Farías AA, Contigiani MS, Tenorio A.Venezuelan Equine Encephalitis (VEE) complex belongs to alphavirus genus in the family Togaviridae. Several species of this complex are pathogenic to humans. VEE infections can produce severe or mild disease, and many cases remain undiagnosed. A specific and sensitive reverse transcriptase nested polymerase chain reaction (RT-Nested PCR) method was developed for the detection of all VEE subtypes, including Rio Negro Virus (RNV) (subtype VI), which circulates only in Argentina. Degenerated primers were designed and thermal cycling parameters were standardized. This technique is suitable for rap...
Prevalence, risk factors and clinical signs predictive for equine pituitary pars intermedia dysfunction in aged horses.
Equine veterinary journal    May 18, 2012   Volume 45, Issue 1 74-79 doi: 10.1111/j.2042-3306.2012.00578.x
McGowan TW, Pinchbeck GP, McGowan CM.Equine pituitary pars intermedia dysfunction (PPID) is an ageing-related neurodegenerative disorder. The prevalence and risk factors for PPID using seasonally adjusted basal adrenocorticotropic hormone (ACTH) concentrations in aged horses have not been previously reported. Objective: To determine the prevalence, risk factors and clinical signs predictive for PPID in a population of horses aged ≥ 15 years in Queensland, Australia. Methods: Owner-reported data was obtained using a postal questionnaire distributed to an equestrian group. A subgroup of surveyed owners were visited and a veterina...
Seasonal changes in the combined glucose-insulin tolerance test in normal aged horses.
Journal of veterinary internal medicine    May 18, 2012   Volume 26, Issue 4 1035-1041 doi: 10.1111/j.1939-1676.2012.00939.x
Funk RA, Wooldridge AA, Stewart AJ, Behrend EN, Kemppainen RJ, Zhong Q, Johnson AK.Equine metabolic syndrome (EMS) is an increasingly recognized problem in adult horses. Affected horses are often obese and predisposed to the development of laminitis, especially in the spring and summer months. In addition, in the summer and fall months, increases in endogenous insulin concentrations, a marker of EMS, have been reported. Objective: The purpose of this study was to evaluate seasonal changes in results of the combined glucose-insulin tolerance test (CGIT), a diagnostic test for EMS. Methods: Nine healthy, aged horses with no history of laminitis and no clinical signs of EMS. Me...