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Topic:Horses

"Horses" is a broad topic that encompasses various aspects of equine biology, behavior, and management. This category includes studies on the anatomy, physiology, and genetics of horses, as well as their behavior, nutrition, and care. Research in this area may also cover the historical and cultural significance of horses, their roles in agriculture, sport, and therapy, and the challenges associated with their conservation and welfare. The page aggregates peer-reviewed research articles and scholarly studies that explore the multifaceted relationships between humans and horses, examining both scientific and socio-economic perspectives.
Determination of acyclovir in horse plasma and body fluids by high-performance liquid chromatography combined with fluorescence detection and heated electrospray ionization tandem mass spectrometry.
Biomedical chromatography : BMC    October 1, 2008   Volume 23, Issue 2 132-140 doi: 10.1002/bmc.1093
Maes A, Garré B, Desmet N, van der Meulen K, Nauwynck H, De Backer P, Croubels S.Two methods are presented for the determination of 'respectively' the plasma protein unbound and total concentration of acyclovir in horse plasma and body fluids: first, a liquid-liquid extraction was performed on plasma, combined with HPLC-fluorescence detection for the total plasma concentration; second a more sensitive method using high-performance liquid chromatography combined with heated electrospray ionization tandem mass spectrometry (LC-HESI-MS/MS) was described for plasma and for body fluids analysis. To obtain the unbound concentration of acyclovir in plasma, a simple deproteinizati...
Voluntary intake and digestibility in horses: effect of forage quality with emphasis on individual variability.
Animal : an international journal of animal bioscience    October 1, 2008   Volume 2, Issue 10 1526-1533 doi: 10.1017/S1751731108002760
Edouard N, Fleurance G, Martin-Rosset W, Duncan P, Dulphy JP, Grange S, Baumont R, Dubroeucq H, Pérez-Barbería FJ, Gordon IJ.Food intake is a key biological process in animals, as it determines the energy and nutrients available for the physiological and behavioural processes. In herbivores, the abundance, structure and quality of plant resources are known to influence intake strongly. In ruminants, as the forage quality declines, digestibility and total intake decline. Equids are believed to be adapted to consume high-fibre low-quality forages. As hindgut fermenters, it has been suggested that their response to a reduction in food quality is to increase intake to maintain rates of energy and nutrient absorption. Al...
Alpha-tocopherol protects against oxidative damage to lipids of the rod outer segments of the equine retina.
Veterinary journal (London, England : 1997)    October 1, 2008   Volume 182, Issue 3 463-468 doi: 10.1016/j.tvjl.2008.08.008
Terrasa AM, Guajardo MH, Marra CA, Zapata G.Oxidative stress is a possible risk factor for eye diseases. Lipid peroxidation is one of the major events induced by oxidative stress and is particularly active in polyunsaturated fatty acid (PUFA)-rich biomembranes. This work evaluated endogenous lipid antioxidants, in vitro non-enzymatic lipid peroxidation of rod outer segment membranes (ROS), the fatty acid composition during oxidative damage of total lipids from equine retina and ROS, and the protective action of alpha-tocopherol (alpha-Toc). The major lipid soluble antioxidant was alpha-Toc followed by retinoids and carotenoids. The reti...
Cystic fibrosis and the isolation of Pseudomonas aeruginosa from horses.
The Veterinary record    September 30, 2008   Volume 163, Issue 13 399-400 doi: 10.1136/vr.163.13.399-c
Moore JE, Goldsmith CE, Millar BC, Rooney PJ, Buckley T, Dooley JS, Rendall J, Elborn JS.No abstract available
[The horse as an athlete: an animal model of choice for sports medicine: sonographic studies of joint disorders].
Bulletin de l\'Academie nationale de medecine    September 30, 2008   Volume 192, Issue 3 521-540 
Denoix JM.Equine diagnostic sonography was initially used for the diagnosis and documentation of tendon injuries. Since 1990, this technique, along with radiography, has become an indispensable imaging procedure for the diagnosis of equine joint injuries. Sonography provides precise diagnostic information on the synovial membrane and fluid, the articular cartilage, subchondral bone and joint margins, the ligaments and menisci, and the anatomical structures involved in periarticular swelling or enlargement. Improvements in ultrasound machines and better superficial and deep image resolution allow us to e...
Evaluation of clinical examination for differential diagnosis of lameness by navicular apparatus or heel pain in horses.
Pakistan journal of biological sciences : PJBS    September 30, 2008   Volume 11, Issue 13 1754-1756 doi: 10.3923/pjbs.2008.1754.1756
Sardari K, Kazemi H.To evaluation of clinical examination for differential diagnosis of navicular region pain from other forms of palmar heel pain in the forelimb in horses the present study was undertaken. Thirty four horses with lameness referable to the palmar aspect of the hoof based on their response to the palmar digital nerves analgesia were divided into 2 groups based on their response to both distal interphalangeal joint and navicular bursa analgesia. Horses that were profoundly improved by both analgesic blocks (distal interphalangeal joint and navicular bursa) were considered to have navicular region p...
Estimation of genetic parameters on conformation traits of the Iranian Arab horses population.
Pakistan journal of biological sciences : PJBS    September 27, 2008   Volume 11, Issue 2 280-284 doi: 10.3923/pjbs.2008.280.284
Gharahveysi S, Kashan NE, Gerami A, Torshizi RV.Arab horse is a popular pure breed in Iran and is registered by World Arabian Horse Organization (WAHO). There is no scientific study and research about this breed. In this research 13 conformation traits on a random sample of the Iranian Arab horses studied. The estimate of variance components estimated by Animal Model and Derivative Free Restricted Maximum Likelihood (DF-REML) approach and DF-REML software. Heritability of conformation traits is also evaluated. The range of estimated heritability were (0.050 +/- 0.008) neck length and (0.614 +/- 0.087) croup height. Results indicated that, c...
Molecular identification of Streptococcus equi subsp. equi and Streptococcus equi subsp. zooepidemicus in nasal swabs samples from horses suffering respiratory infections in Iran.
Pakistan journal of biological sciences : PJBS    September 27, 2008   Volume 11, Issue 3 468-471 doi: 10.3923/pjbs.2008.468.471
Jannatabadi AA, Mohammadi GR, Rad M, Maleki M.The objective of this study was to evaluate the existence of Streptococcus equi subsp. equi and Streptococcus equi subsp. zooepidemicus as probable agents associated with naturally occurring infection of the equine upper respiratory disease in Mashhad area. Nasal swabs samples from thirty horses with upper respiratory tract infections were collected. The bacteria isolated and identified were Streptococcus equi subsp. equi (1 isolate), Streptococcus equi subsp. zooepidemicus (25 isolates), Pasteurella sp. (11 isolates), Staphylococcus sp. (17 isolates), Bacillus sp. (4 isolates), Pseudomonas sp...
Lymphoproliferative disease with features of lymphoma in the central nervous system of a horse.
Journal of comparative pathology    September 27, 2008   Volume 139, Issue 4 256-261 doi: 10.1016/j.jcpa.2008.07.008
Morrison LR, Freel K, Henderson I, Hahn C, Smith SH.Lymphoma (malignant lymphoma, lymphosarcoma) is uncommon in horses in the United Kingdom. This report describes an unusual form of lymphoproliferative disease with features of lymphoma restricted to the central nervous system (CNS) and with no evidence of a primary lesion elsewhere. Immunohistochemical examination defined an overwhelming predominance of T lymphocytes with admixed B lymphocytes and activated macrophages. This case exemplifies the challenges associated with definitive diagnosis of lymphoproliferative disease of the equine CNS.
Single nucleotide polymorphisms of interleukin-1 beta related genes and their associations with infection in the horse.
Developments in biologicals    September 27, 2008   Volume 132 347-351 doi: 10.1159/000317184
Horin P, Osickova J, Necesankova M, Matiasovic J, Musilova P, Kubickova S, Hubertova D, Vyskocil M, Rubes J.In previous work, we found significant associations of horse chromosome 15 (ECA15) microsatellite markers HMSO1 and HTG06 with two horse infections, Rhodococcus equi and Lawsonia intracellularis, respectively. Interleukin-1 beta subunit and interleukin-1 receptor antagonist encoding genes (IL1B and IL1RN) could be considered as candidate genes underlying the associations reported. Therefore, we identified single nucleotide polymorphisms (SNPs) within three interleukin-1 beta functionally related genes: IL1B, IL1RN and Casp1 (interleukin-1 beta converting enzyme/caspasel encoding gene). Using a...
Trypanosoma evansi: A comparison of PCR and parasitological diagnostic tests in experimentally infected mice.
Experimental parasitology    September 26, 2008   Volume 121, Issue 1 1-7 doi: 10.1016/j.exppara.2008.09.013
Fernández D, González-Baradat B, Eleizalde M, González-Marcano E, Perrone T, Mendoza M.Trypanosoma evansi is the causative agent of equine trypanosomosis, disease that affects horse's productivity and health. Parasitological and molecular methods are mostly used to detect the infection. The aim of this work was evaluate PCR sensitivity to detect T. evansi using the primers 21/22-mer, ITS1, ESAG 6/7 and TBR 1/2 designed from repetitive (multicopies) genomic sequences. The results were compare with two parasitological tests in mice, micro-haematocrite centrifugation technique and direct microscopic examination. The results shows (a) that the minimum amount of DNA from blood of hig...
Methicillin-resistant Staphylococcus aureus and animals: zoonosis or humanosis?
The Journal of antimicrobial chemotherapy    September 26, 2008   Volume 62, Issue 6 1181-1187 doi: 10.1093/jac/dkn405
Morgan M.Methicillin-resistant Staphylococcus aureus (MRSA) is increasing worldwide. Occasionally, animals are colonized or infected incidentally with human strains. Recently, however, new strains of MRSA emerging from within the animal kingdom, particularly in pigs, are causing human infection. MRSA has been reported in species as diverse as companion animals, horses and pigs, through to chinchillas, bats and parrots. In contrast, whereas strains of community-associated MRSA, the majority of which carry genes encoding Panton-Valentine leucocidin, are spreading rapidly in human populations, only sporad...
Effect of a single dose of dexamethasone on glucose homeostasis in healthy horses by using the combined intravenous glucose and insulin test.
Journal of animal science    September 26, 2008   Volume 87, Issue 1 131-135 doi: 10.2527/jas.2008-1179
Haffner JC, Eiler H, Hoffman RM, Fecteau KA, Oliver JW.Sustained dexamethasone administration to horses results in insulin resistance, which may predispose them to laminitis. A single dose of dexamethasone is commonly used as a diagnostic aid, yet the effect of a single dose of dexamethasone on glucose homeostasis in horses is not well defined. The objective of this study was to characterize the change in glucose dynamics over time in response to a single dose of dexamethasone. A combined glucose-insulin tolerance test (CGIT) was performed on 6 adult geldings before and at 2, 24, and 72 h postdexamethasone (40 microg/kg of BW, i.v.); a minimum of ...
Astrocytic and microglial response and histopathological changes in the brain of horses with experimental chronic Trypanosoma evansi infection.
Revista do Instituto de Medicina Tropical de Sao Paulo    September 25, 2008   Volume 50, Issue 4 243-249 doi: 10.1590/s0036-46652008000400011
Lemos KR, Marques LC, Aquino LP, Alessi AC, Zacarias RZ.This study aimed to characterize astrocytic and microglial response in the central nervous system (CNS) of equines experimentally infected with T. evansi. The experimental group comprised males and females with various degrees of crossbreeding, ages between four and seven years. The animals were inoculated intravenously with 10(6) trypomastigotes of T. evansi originally isolated from a naturally infected dog. All equines inoculated with T. evansi were observed until they presented symptoms of CNS disturbance, characterized by motor incoordination of the pelvic limbs, which occurred 67 days aft...
Detection of West Nile virus infection in horses, Italy, September 2008. Macini P, Squintani G, Finarelli AC, Angelini P, Martini E, Tamba M, Dottori M, Bellini R, Santi A, Loli Piccolomini L, Po C.No abstract available
A GYS1 gene mutation is highly associated with polysaccharide storage myopathy in Cob Normand draught horses.
Animal genetics    September 24, 2008   Volume 40, Issue 1 94-96 doi: 10.1111/j.1365-2052.2008.01778.x
Herszberg B, McCue ME, Larcher T, Mata X, Vaiman A, Chaffaux S, Chérel Y, Valberg SJ, Mickelson JR, Guérin G.Glycogen storage diseases or glycogenoses are inherited diseases caused by abnormalities of enzymes that regulate the synthesis or degradation of glycogen. Deleterious mutations in many genes of the glyco(geno)lytic or the glycogenesis pathways can potentially cause a glycogenosis, and currently mutations in fourteen different genes are known to cause animal or human glycogenoses, resulting in myopathies and/or hepatic disorders. The genetic bases of two forms of glycogenosis are currently known in horses. A fatal neonatal polysystemic type IV glycogenosis, inherited recessively in affected Qu...
Advanced age in horses affects divisional history of T cells and inflammatory cytokine production.
Mechanisms of ageing and development    September 24, 2008   Volume 129, Issue 11 656-664 doi: 10.1016/j.mad.2008.09.004
Adams AA, Breathnach CC, Katepalli MP, Kohler K, Horohov DW.A number of model systems have been employed to investigate age-associated changes in immune function. The purpose of the current study was to characterize senescent T cells and to investigate the inflamm-aging phenomenon both in vitro and in vivo using the old horse as a model. We examined whether decreased T cell proliferation induced by Con A is caused by increased apoptosis. We also utilized intracellular CFSE to analyze changes within each round of cell proliferation, in particular cytokine production. Intracellular staining with flow cytometry, RT-PCR, and ELISA were used to measure pro-...
Activation of peripheral blood monocytes results in more robust production of IL-10 in neonatal foals compared to adult horses.
Veterinary immunology and immunopathology    September 21, 2008   Volume 127, Issue 1-2 167-173 doi: 10.1016/j.vetimm.2008.09.013
Sponseller BA, de Macedo MM, Clark SK, Gallup JM, Jones DE.Foals are particularly vulnerable to infection by Rhodococcus equi during the first 2 weeks of life whereas mature horses are not. While an innate immunodeficiency likely accounts for this clinically relevant vulnerability, the factors that contribute to infection by R. equi have not been fully elucidated. In this study, we demonstrate that cells of the monocyte lineage, including monocytes, macrophages, and dendritic cells, that have been activated with LPS and IFN-gamma, respond with a statistically significant, greater amount of cytokine mRNA production of IL-10, IL-12p35, and IL-12p40 than...
Evaluation of orally administered valacyclovir in experimentally EHV1-infected ponies.
Veterinary microbiology    September 21, 2008   Volume 135, Issue 3-4 214-221 doi: 10.1016/j.vetmic.2008.09.062
Garré B, Gryspeerdt A, Croubels S, De Backer P, Nauwynck H.The purpose of the current study was to investigate the therapeutic efficacy of valacyclovir against EHV1 in a controlled study. Eight naïve Shetland ponies were inoculated with 10(6.5) TCID(50) of the neuropathogenic strain 03P37. Four ponies were treated with valacyclovir at a dosage of 40mg/kg bodyweight, 3 times daily, for 5 (n=2) or 7 (n=2) consecutive days, while the other four ponies served as untreated controls. The treatment regimen started 1h before inoculation. Ponies were monitored daily for clinical signs. At 0, 1, 2, 3, 4, 5, 7, 9, 11, 14, 17 and 21 days post inoculation (d pi),...
Contractile behavior of the forelimb digital flexors during steady-state locomotion in horses (Equus caballus): an initial test of muscle architectural hypotheses about in vivo function.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology    September 20, 2008   Volume 152, Issue 1 100-114 doi: 10.1016/j.cbpa.2008.09.007
Butcher MT, Hermanson JW, Ducharme NG, Mitchell LM, Soderholm LV, Bertram JE.The forelimb digital flexors of the horse display remarkable diversity in muscle architecture despite each muscle-tendon unit having a similar mechanical advantage across the fetlock joint. We focus on two distinct muscles of the digital flexor system: short compartment deep digital flexor (DDF(sc)) and the superficial digital flexor (SDF). The objectives were to investigate force-length behavior and work performance of these two muscles in vivo during locomotion, and to determine how muscle architecture contributes to in vivo function in this system. We directly recorded muscle force (via ten...
Anaplasma phagocytophilum in horses and ticks: a preliminary survey of Central Italy.
Comparative immunology, microbiology and infectious diseases    September 20, 2008   Volume 33, Issue 1 73-83 doi: 10.1016/j.cimid.2008.08.002
Passamonti F, Veronesi F, Cappelli K, Capomaccio S, Coppola G, Marenzoni ML, Piergili FD, Verini SA, Coletti M.Anaplasma phagocytophilum, the causative agent of granulocytic ehrlichiosis, affects several species of wild and domesticated mammals, including horses. In this work we compared direct and indirect methods to evaluate A. phagocytophilum presence in Central Italy: 135 sera were screened by IFA for A. phagocytophilum and other haemopathogens (Theileria equi and Babesia caballi). Each horse was also tested for A. phagocytophilum 16S rRNA with a nested-PCR technique. In order to examine the risk of A. phagocytophilum transmission, 114 ticks were examined for the presence of A. phagocytophilum by P...
Correlation of quantitative computed tomographic subchondral bone density and ash density in horses.
Bone    September 19, 2008   Volume 44, Issue 2 316-319 doi: 10.1016/j.bone.2008.08.129
Drum MG, Les CM, Park RD, Norrdin RW, McIlwraith CW, Kawcak CE.The purpose of this study was to compare subchondral bone density obtained using quantitative computed tomography with ash density values from intact equine joints, and to determine if there are measurable anatomic variations in mean subchondral bone density. Five adult equine metacarpophalangeal joints were scanned with computed tomography (CT), disarticulated, and four 1-cm(3) regions of interest (ROI) cut from the distal third metacarpal bone. Bone cubes were ashed, and percent mineralization and ash density were recorded. Three-dimensional models were created of the distal third metacarpal...
Missense mutation in exon 2 of SLC36A1 responsible for champagne dilution in horses.
PLoS genetics    September 19, 2008   Volume 4, Issue 9 e1000195 doi: 10.1371/journal.pgen.1000195
Cook D, Brooks S, Bellone R, Bailey E.Champagne coat color in horses is controlled by a single, autosomal-dominant gene (CH). The phenotype produced by this gene is valued by many horse breeders, but can be difficult to distinguish from the effect produced by the Cream coat color dilution gene (CR). Three sires and their families segregating for CH were tested by genome scanning with microsatellite markers. The CH gene was mapped within a 6 cM region on horse chromosome 14 (LOD = 11.74 for theta = 0.00). Four candidate genes were identified within the region, namely SPARC [Secreted protein, acidic, cysteine-rich (osteonectin)], SL...
What is your diagnosis? Caudodistally displaced lateral humeral epicondylar fracture.
Journal of the American Veterinary Medical Association    September 18, 2008   Volume 233, Issue 6 873-874 doi: 10.2460/javma.233.6.873
Bordelon KL, Mathis SC, Munroe JL.No abstract available
Determination of threshold concentrations of multiple allergenic extracts for equine intradermal testing using normal horses in three seasons.
Veterinary dermatology    September 18, 2008   Volume 19, Issue 5 305-313 doi: 10.1111/j.1365-3164.2008.00696.x
Baxter CG, Vogelnest LJ.Forty-one normal horses were evaluated for reactivity to intradermally injected aqueous allergens to determine allergen threshold concentrations (TC), with potential relevance to equine intradermal testing (IDT). Horses were tested three times over 1 year to assess seasonal variation in reactivity, using three to five serial dilutions of 27 allergens each time. Injection sites were evaluated after 15 min, 1 h, 4 h and 24 h. The highest allergen concentration at which or = 2, scale of 0 to 4) at 15 min was considered the TC. The TC was determined for nine pollens (2000 to > 6000 PNU mL(-1))...
Computed tomography-guided brain biopsy for in vivo diagnosis of a cholesterinic granuloma in a horse.
Journal of the American Veterinary Medical Association    September 18, 2008   Volume 233, Issue 6 950-954 doi: 10.2460/javma.233.6.950
Vanschandevijl K, Gielen I, Nollet H, Vlaminck L, Deprez P, van Bree H.An 8-year-old warmblood mare was evaluated following an acute onset of neurologic abnormalities. Results: Computed tomography of the head revealed large masses in both lateral ventricles, and a presumptive diagnosis of cholesterinic granuloma was made. Results: Freehand biopsy of the intracranial masses was performed under computed tomographic guidance, and histologic examination of biopsy specimens confirmed the diagnosis. No adverse effects associated with the brain biopsy procedure were encountered. Clinical signs resolved, and long-term follow-up did not reveal any recurrence of neurologic...
Effects of vitamin E and selenium on serum trace and major elements in horses.
Biological trace element research    September 17, 2008   Volume 125, Issue 3 223-228 doi: 10.1007/s12011-008-8109-8
Yur F, Dede S, Deger Y, Kilicalp D.The combined effects of vitamin E and selenium were studied in native Anatolian horses subject to strenuous exercise. The concentrations of copper, zinc, iron, calcium, potassium, and magnesium were determined in serum by atomic absorption spectrometry in two study groups (n = 25 each), one of which served as untreated controls. After exercising the horses by running 1,500 m in about 7 min, only the copper level and the copper/zinc ratio significantly increased (p < 0.05), but the concentrations of calcium, potassium, iron, and magnesium remained unchanged. In horses treated with vitamin E ...
Western Equine Encephalitis submergence: lack of evidence for a decline in virus virulence.
Virology    September 17, 2008   Volume 380, Issue 2 170-172 doi: 10.1016/j.virol.2008.08.012
Forrester NL, Kenney JL, Deardorff E, Wang E, Weaver SC.The incidence of Western Equine Encephalitis (WEE) in humans and equids peaked during the mid-20th century and has declined to fewer than 1-2 human cases annually during the past 20 years. Using the mouse model, changes in WEE virus (WEEV) virulence were investigated as a potential explanation for the decline in the number of cases. Evaluation of 10 WEEV strains representing a variety of isolation locations, hosts, and all decades from the 1940's to the 1990's yielded no evidence of a decline in virulence. These results suggest that ecological factors affecting human and equine exposure should...
Hemorheopathy in exercising horses.
Clinical hemorheology and microcirculation    September 16, 2008   Volume 40, Issue 1 73-75 
Boucher JH, Connes P.No abstract available
Allometric scaling of echocardiographic measurements in healthy Spanish foals with different body weight.
Research in veterinary science    September 16, 2008   Volume 86, Issue 2 325-331 doi: 10.1016/j.rvsc.2008.08.001
Rovira S, Muñoz A, Rodilla V.Scaling in biology is usually allometric, and therefore, the size of the heart may be expressed as a power function of body weight (BW). The present research analyses the echocardiographic measurements in 68 healthy Spanish foals weighed between 70 and 347kg in order to determine the correct scaling exponent for the allometric equation. The echocardiographic parameters measured were: left ventricular internal dimensions (LVID), free wall thickness (LVFWT), interventricular septum thickness (IVST) at systole (s) and diastole (d), EPSS (distance between the point E of the mitral valve and the in...