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Topic:Infectious Disease

Infectious diseases in horses encompass a range of illnesses caused by bacteria, viruses, fungi, or parasites. These diseases can affect various systems within the equine body, leading to symptoms that range from mild discomfort to severe systemic illness. Common infectious diseases in horses include equine influenza, strangles, equine herpesvirus, and West Nile virus. These diseases can be transmitted through direct contact with infected animals, contaminated surfaces, or vectors such as insects. Understanding the mechanisms of transmission, pathogenesis, and immune response is essential for effective prevention and control. This page compiles peer-reviewed research studies and scholarly articles that explore the epidemiology, diagnosis, treatment, and management of infectious diseases in horses.
Elimination of schistosomiasis japonica from formerly endemic areas in mountainous regions of southern China using a praziquantel regimen.
Veterinary parasitology    December 31, 2014   Volume 208, Issue 3-4 254-258 doi: 10.1016/j.vetpar.2014.12.031
Li H, Dong GD, Liu JM, Gao JX, Shi YJ, Zhang YG, Jin YM, Lu K, Cheng GF, Lin JJ.Schistosomiasis japonica is a major public health problem in China. Domestic animals play a major role in the transmission of Schistosoma japonicum to humans. To better understand the epidemiology of schistosomiasis japonica in domestic animals in the mountainous areas of China, we performed a 5-year longitudinal study of schistosomiasis in cattle and horses in Yunnan Province from 2009 to 2013. We also performed a concurrent drug-based intervention study in three settlement groups in Yunnan Province aimed at developing an effective means of controlling transmission in this region. The prevale...
Characterisation of immune responses in healthy foals when a multivalent vaccine protocol was initiated at age 90 or 180 days.
Equine veterinary journal    December 30, 2014   Volume 47, Issue 6 667-674 doi: 10.1111/evj.12350
Davis EG, Bello NM, Bryan AJ, Hankins K, Wilkerson M.Protection from infectious disease requires antigen-specific immunity. In foals, most vaccine protocols are delayed until 6 months to avoid maternal antibody interference. Susceptibility to disease may exist prior to administration of vaccination at age 4-6 months. Objective: The aim of this investigation was to characterise immune activation among healthy foals in response to a multivalent vaccine protocol and compare immune responses when foals were vaccinated at age either 90 or 180 days. Methods: Randomised block design. Methods: Twelve healthy foals with colostral transfer were blocked fo...
West Nile virus-specific immunoglobulin isotype responses in vaccinated and infected horses.
American journal of veterinary research    December 24, 2014   Volume 76, Issue 1 92-100 doi: 10.2460/ajvr.76.1.92
Khatibzadeh SM, Gold CB, Keggan AE, Perkins GA, Glaser AL, Dubovi EJ, Wagner B.To compare antibody responses of horses naturally infected with West Nile virus (WNV) and those vaccinated against WNV, to identify whether vaccination interferes with the ability to diagnose WNV infection, and to determine the duration of antibody responses after vaccination. Methods: Sera from horses naturally infected with WNV (n = 10) and adult WNV-naïve horses before and after vaccination with a live canarypox virus-vectored vaccine (7) or a killed virus vaccine (8). Methods: An established WNV IgM capture ELISA was used to measure IgM responses. Newly developed capture ELISAs were used ...
Serologic assessment of possibility for MERS-CoV infection in equids.
Emerging infectious diseases    December 23, 2014   Volume 21, Issue 1 181-182 doi: 10.3201/eid2101.141342
Meyer B, García-Bocanegra I, Wernery U, Wernery R, Sieberg A, Müller MA, Drexler JF, Drosten C, Eckerle I.No abstract available
MDR ST2179-CTX-M-15 Escherichia coli co-producing RmtD and AAC(6′)-Ib-cr in a horse with extraintestinal infection, Brazil.
The Journal of antimicrobial chemotherapy    December 23, 2014   Volume 70, Issue 4 1263-1265 doi: 10.1093/jac/dku520
Leigue L, Warth JF, Melo LC, Silva KC, Moura RA, Barbato L, Silva LC, Santos AC, Silva RM, Lincopan N.No abstract available
[Surveillance of West Nile fever in horses in the Czech Republic from 2011 to 2013]. Sedlák K, Zelená H, Křivda V, Šatrán P.The West Nile virus (WNV) is an important mosquito-borne flavivirus occurring around the world. Occasionally found in Central Europe, the virus spread massively through whole Hungary between 2008 and 2009. The aim of our study was to determine the recent prevalence of the WNV infection in horses in the Czech Republic. Methods: Overall, 2349 serum samples, collected from healthy unvaccinated adult horses in the Czech Republic between 2011 and 2013, were tested. A commercially available competitive ELISA kit (cELISA) was used for this purpose and positive samples were confirmed by virus neutrali...
Recombinant antigens rLipL21, rLoa22, rLipL32 and rLigACon4-8 for serological diagnosis of leptospirosis by enzyme-linked immunosorbent assays in dogs.
PloS one    December 19, 2014   Volume 9, Issue 12 e111367 doi: 10.1371/journal.pone.0111367
Ye C, Yan W, Xiang H, He H, Yang M, Ijaz M, Useh N, Hsieh CL, McDonough PL, McDonough SP, Mohamed H, Yang Z, Chang YF.Animal leptospirosis is one of the most common zoonotic diseases in the United States and around the world. In a previous study, we applied four recombinant antigens, rLipL21, rLoa22, rLipL32 and rLigACon4-8 of Leptospira interrogans (L. interrogans) for the serological diagnosis of equine leptospirosis (Ye et al, Serodiagnosis of equine leptospirosis by ELISA using four recombinant protein markers, Clin. Vaccine. Immunol. 21:478-483). In this study, the same four recombinant antigens were evaluated for their potential to diagnose canine leptospirosis by ELISA. A total of 305 canine sera that ...
Re-emergence of a genetic outlier strain of equine arteritis virus: Impact on phylogeny.
Virus research    December 17, 2014   Volume 202 144-150 doi: 10.1016/j.virusres.2014.12.009
Steinbach F, Westcott DG, McGowan SL, Grierson SS, Frossard JP, Choudhury B.Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory and reproductive disease of equids, which is notifiable in some countries including the Great Britain (GB) and to the OIE. Herein, we present the case of a persistently infected stallion and the phylogenetic tracing of the virus strain isolated. Discussing EAV occurrence and phylogenetic analysis we review features, which may aid to harmonise and enhance the classification of EAV.
Protection against Hendra at equestrian events.
Australian veterinary journal    December 17, 2014   Volume 92, Issue 11 N13 
Balzer M.No abstract available
Role of enhanced vector transmission of a new West Nile virus strain in an outbreak of equine disease in Australia in 2011.
Parasites & vectors    December 12, 2014   Volume 7 586 doi: 10.1186/s13071-014-0586-3
van den Hurk AF, Hall-Mendelin S, Webb CE, Tan CS, Frentiu FD, Prow NA, Hall RA.In 2011, a variant of West Nile virus Kunjin strain (WNVKUN) caused an unprecedented epidemic of neurological disease in horses in southeast Australia, resulting in almost 1,000 cases and a 9% fatality rate. We investigated whether increased fitness of the virus in the primary vector, Culex annulirostris, and another potential vector, Culex australicus, contributed to the widespread nature of the outbreak. Methods: Mosquitoes were exposed to infectious blood meals containing either the virus strain responsible for the outbreak, designated WNVKUN2011, or WNVKUN2009, a strain of low virulence th...
Identification of Suitable Areas for African Horse Sickness Virus Infections in Spanish Equine Populations.
Transboundary and emerging diseases    December 5, 2014   Volume 63, Issue 5 564-573 doi: 10.1111/tbed.12302
Sánchez-Matamoros A, Sánchez-Vizcaíno JM, Rodríguez-Prieto V, Iglesias E, Martínez-López B.African horse sickness (AHS) is one of the most important vector-borne viral infectious diseases of equines, transmitted mainly by Culicoides spp. The re-emergence of Culicoides-borne diseases in Europe, such as the recent bluetongue (BT) or Schmallenberg outbreaks, has raised concern about the potential re-introduction and further spread of AHS virus (AHSV) in Europe. Spain has one of the largest European equine populations. In addition, its geographical, environmental and entomological conditions favour AHSV infections, as shown by the historical outbreaks in the 1990s. The establishment of ...
Piroplasms in feral and domestic equines in rural areas of the Danube Delta, Romania, with survey of dogs as a possible reservoir.
Veterinary parasitology    December 4, 2014   Volume 206, Issue 3-4 287-292 doi: 10.1016/j.vetpar.2014.10.018
Gallusová M, Qablan MA, D'Amico G, Oborník M, Petrželková KJ, Mihalca AD, Modrý D.Rural areas of Romania, particularly the localities covering Danube Delta, are still not sufficiently explored in terms of epidemiological aspects, despite the large density of domestic animals living in close contact with people and natural environment of the Danube Delta Biosphere Reserve. Between 2010 and 2012, a survey on equine piroplasmids species was performed in this area, using a total of 178 horses, 15 donkeys and 177 dogs from 18 localities inside and outside the Danube Delta. None of the sampled hosts showed any clinical symptoms typical for equine piroplasmoses. A 25.4% overall pr...
Pathology in practice. A equuli septicemia in a neonatal foal.
Journal of the American Veterinary Medical Association    December 3, 2014   Volume 245, Issue 12 1339-1341 doi: 10.2460/javma.245.12.1339
Adu-Addai B, Smedley RC, Mullaney TP.No abstract available
Seroprevalence of Toxoplasma gondii in recreational horses in two metropolitan cities of Southwestern Nigeria.
African journal of medicine and medical sciences    December 1, 2014   Volume 43 Suppl 47-50 
Ayinmode AB, Oluwayelu DO, Sule WF, Obebe OO.Toxoplasma gondii (T. gondii), an obligate intracellular protozoan parasite is a known etiological factor of reproductive problems and encephalomyelitis in animals and humans. This study investigated the seroprevalence of T gondii infection in recreational horses in two metropolitan cities of southwestern Nigeria. Serum samples were randomly collected from a total of 157 horses in Lagos and Ibadan. Samples were assayed for the presence of T gondii antibodies using the Modified Agglutination Test (MAT). A total of 22 (14%) of the 157 sampled horses were positive for T gondii antibodies by MAT w...
Endoparasites of horses from the Formiga city, located in center-west region of the state of Minas Gerais, Brazil. Teixeira WF, Felippelli G, Cruz BC, Maciel WG, Fávero FC, Gomes LV, Buzzulini C, Prando L, Bichuette MA, Lopes WD, Oliveira GP, Costa AJ.With the aim of studying the endoparasite fauna of horses from the Formiga city, located in center-west region of the state of Minas Gerais, 25 animals that were naturally infected with helminths were evaluated. By means of parasitological necropsies, different endoparasites were found. The subfamily Cyathostominae presented the highest incidence, followed by Trichostrongylus axei, Oxyuris equi, Triodontophorus serratus, Strongyloides westeri, Strongylus edentatus, Habronema muscae, Parascaris equorum, Probstmayria vivipara, Strongylus vulgaris, Gasterophilus nasalis, Anoplocephala magna and A...
Equine disease surveillance: quarterly summary.
The Veterinary record    November 29, 2014   Volume 175, Issue 21 530-533 doi: 10.1136/vr.g6835
Equine influenza in England and Scotland, Significant numbers of outbreaks of equine herpesvirus 1 neurological disease in the USA, Summary of surveillance testing, April to June 2014. These are among matters discussed in the most recent quarterly equine disease surveillance report, prepared by Defra, the Animal Health Trust and the British Equine Veterinary Association.
Focus on: Hendra virus in Australia.
The Veterinary record    November 29, 2014   Volume 175, Issue 21 533-534 doi: 10.1136/vr.g6836
Hughes K.Cases of Hendra virus infection in horses in Australia have been seen regularly since the virus was first isolated in 1994. Kristopher Hughes, associate professor of equine medicine at Charles Sturt University in Australia, gives an overview of how knowledge of the virus has developed in the past 20 years.
Prevalence of methicillin-resistant Staphylococcus haemolyticus in companion animals: a cross-sectional study.
Annals of clinical microbiology and antimicrobials    November 28, 2014   Volume 13 56 doi: 10.1186/s12941-014-0056-y
Ruzauskas M, Siugzdiniene R, Klimiene I, Virgailis M, Mockeliunas R, Vaskeviciute L, Zienius D.Among coagulase-negative staphylococci, Staphylococcus haemolyticus is the second most frequently isolated species from human blood cultures and has the highest level of antimicrobial resistance. This species has zoonotic character and is prevalent both in humans and animals. Recent studies have indicated that methicillin-resistant S. haemolyticus (MRSH) is one of the most frequent isolated Staphylococcus species among neonates in intensive care units. The aim of this study was to determine the presence of MRSH in different groups of companion animals and to characterize isolates according the...
Draft Genome Sequence of Taylorella equigenitalis Strain MCE529, Isolated from a Belgian Warmblood Horse.
Genome announcements    November 26, 2014   Volume 2, Issue 6 doi: 10.1128/genomeA.01214-14
Hébert L, Touzain F, de Boisséson C, Breuil MF, Duquesne F, Laugier C, Blanchard Y, Petry S.Taylorella equigenitalis is the causative agent of contagious equine metritis (CEM), a sexually transmitted infection of horses. We herein report the genome sequence of T. equigenitalis strain MCE529, isolated in 2009 from the urethral fossa of a 15-year-old Belgian Warmblood horse in France.
Hepacivirus infection in domestic horses, Brazil, 2011-2013.
Emerging infectious diseases    November 25, 2014   Volume 20, Issue 12 2180-2182 doi: 10.3201/eid2012.140603
Gemaque BS, Junior Souza de Souza A, do Carmo Pereira Soares M, Malheiros AP, Silva AL, Alves MM, Gomes-Gouvêa MS, Pinho JR....No abstract available
New multiplex PCR method for the simultaneous diagnosis of the three known species of equine tapeworm.
Veterinary parasitology    November 25, 2014   Volume 207, Issue 1-2 56-63 doi: 10.1016/j.vetpar.2014.11.002
Bohórquez GA, Luzón M, Martín-Hernández R, Meana A.Although several techniques exist for the detection of equine tapeworms in serum and feces, the differential diagnosis of tapeworm infection is usually based on postmortem findings and the morphological identification of eggs in feces. In this study, a multiplex polymerase chain reaction (PCR)-based method for the simultaneuos detection of Anoplocephala magna, Anoplocephala perfoliata and Anoplocephaloides mamillana has been developed and validated. The method simultaneously amplifies hypervariable SSUrRNA gene regions in the three tapeworm species in a single reaction using three pairs of pri...
The impact of different equine influenza vaccine products and other factors on equine influenza antibody levels in Thoroughbred racehorses.
Equine veterinary journal    November 24, 2014   Volume 47, Issue 6 662-666 doi: 10.1111/evj.12353
Ryan M, Gildea S, Walsh C, Cullinane A.More knowledge of equine influenza (EI) vaccine usage in training yards and the factors that influence serological response to vaccination are required to determine evidence-based vaccination strategies. Objective: The aim of this study was to ascertain the vaccination history of a population of Thoroughbred racehorses and identify factors that impacted on their antibody titres against EI. Methods: Observational field study. Methods: The study population consisted of 102 vaccinated Thoroughbred horses in training on a single premises. The vaccination histories recorded in their official passpo...
Spatial and temporal distribution of West Nile virus in horses in Israel (1997-2013)–from endemic to epidemics.
PloS one    November 17, 2014   Volume 9, Issue 11 e113149 doi: 10.1371/journal.pone.0113149
Aharonson-Raz K, Lichter-Peled A, Tal S, Gelman B, Cohen D, Klement E, Steinman A.With the rapid global spread of West Nile virus (WNV) and the endemic state it has acquired in new geographical areas, we hereby bring a thorough serological investigation of WNV in horses in a longstanding endemic region, such as Israel. This study evaluates the environmental and demographic risk factors for WNV infection in horses and suggests possible factors associated with the transition from endemic to epidemic state. West Nile virus seroprevalence in horses in Israel was determined throughout a period of more than a decade, before (1997) and after (2002 and 2013) the massive West Nile f...
Serosurveillance of infectious agents in equines of the Central Valley of Costa Rica.
Open veterinary journal    November 16, 2014   Volume 4, Issue 2 107-112 
Jiménez D, Romero-Zuñiga JJ, Dolz G.Blood samples from 181 equines from the Central Valley of Costa Rica were collected in the year 2012 to determine the presence of antibodies against selected infectious agents in horses and to determine the risk factors associated with these agents. The presence of antibodies against Equine Infectious Anemia Virus (EIAV), Equine Herpes Virus 1 and 4 (EHV-1 and EHV-4), West Nile Virus (WNV), Influenza A Virus (IAV), Equine Viral Arteritis Virus (EVAV), Babesia caballi, Theileria equi, Neospora caninum and Chlamydia abortus was determined using commercial assays, and risk factors associated with...
A Systematic Review of Recent Advances in Equine Influenza Vaccination.
Vaccines    November 14, 2014   Volume 2, Issue 4 797-831 doi: 10.3390/vaccines2040797
Paillot R.Equine influenza (EI) is a major respiratory disease of horses, which is still causing substantial outbreaks worldwide despite several decades of surveillance and prevention. Alongside quarantine procedures, vaccination is widely used to prevent or limit spread of the disease. The panel of EI vaccines commercially available is probably one of the most varied, including whole inactivated virus vaccines, Immuno-Stimulating Complex adjuvanted vaccines (ISCOM and ISCOM-Matrix), a live attenuated equine influenza virus (EIV) vaccine and a recombinant poxvirus-vectored vaccine. Several other strateg...
Monoclonal antibody-based competitive enzyme-linked immunosorbent assay to detect antibodies to O:4 Salmonella in the sera of livestock and poultry.
Journal of microbiological methods    November 13, 2014   Volume 108 1-3 doi: 10.1016/j.mimet.2014.11.002
Aribam SD, Ogawa Y, Matsui H, Hirota J, Okamura M, Akiba M, Shimoji Y, Eguchi M.Serotyping is an important element for surveillance of Salmonella. In this study, an anti-O:4 Salmonella monoclonal antibody-based competitive enzyme-linked immunosorbent assay that could identify Salmonella infection in cow, pig, horse, and chicken was developed. This detection system can therefore be useful for a wide range of animals and for humans.
Rhodococcus equi pneumonia in foals: an assessment of the early diagnostic value of serum amyloid A and plasma fibrinogen concentrations in equine clinical practice.
Veterinary journal (London, England : 1997)    November 13, 2014   Volume 203, Issue 2 211-218 doi: 10.1016/j.tvjl.2014.08.033
Passamonti F, Vardi DM, Stefanetti V, Marenzoni ML, Prato S, Cévese P, Coletti M, Pepe M, Casagrande Proietti P, Olea-Popelka F.Early diagnosis and prevention of Rhodococcus equi pneumonia in foals represent important goals for equine clinicians. Recent protocols for diagnosis and treatment of Rhodococcosis in foals typically rely on a multimodal approach based on sonographic evidence suggestive of pyogranulomas, sonographic abscess scores and laboratory findings including plasma fibrinogen concentrations, blood biochemistry testing and platelet and leukocyte counts. The aim of this study was to assess the utility of weekly testing of serum amyloid A (SAA) and plasma fibrinogen concentrations in foals to achieve early ...
Seroprevalence of Anaplasma phagocytophilum in well maintained horses from northern Tunisia.
Tropical biomedicine    November 11, 2014   Volume 31, Issue 3 432-440 
Ben Said M, Belkahia H, Héni MM, Bouattour A, Ghorbel A, Gharbi M, Zouari A, Darghouth MA, Messadi L.The aim of the present study was to determine the seroprevalence of Anaplasma phagocytophilum in 343 well maintained horses belonging to 11 horse stables located in northern Tunisia with indirect immunofluorescence test. Overall, 16.3% (56/343) of tested animals were positive. Anti-A. phagocytophilum antibodies were present in horses located in all studied governorates except the governorate of Ben Arous. Nine horse stables out of 11 contained positive animals, the seroprevalence of each one varied from nought to 50%. Seroprevalence varied according to gender, breed and type of activity, contr...
A unique evolution of the s2 gene of equine infectious anemia virus in hosts correlated with particular infection statuses.
Viruses    November 10, 2014   Volume 6, Issue 11 4265-4279 doi: 10.3390/v6114265
Wang XF, Wang S, Liu Q, Lin YZ, Du C, Tang YD, Na L, Wang X, Zhou JH.Equine infectious anemia virus (EIAV) is a member of the Lentivirus genus in the Retroviridae family that exhibits a genomic structure similar to that of HIV-1. The S2 accessory proteins play important roles in viral replication in vivo and in viral pathogenicity; however, studies on S2 evolution in vivo are limited. This study analyzed the evolutionary characteristics of the S2 gene of a pathogenic EIAV strain, EIAVLN40, in four experimentally infected horses. The results demonstrated that 14.7% (10 of 68 residues) of the stable amino acid mutations occurred longitudinally in S2 during a 150-...
In contrast to other species, α-Galactosylceramide (α-GalCer) is not an immunostimulatory NKT cell agonist in horses.
Developmental and comparative immunology    November 10, 2014   Volume 49, Issue 1 49-58 doi: 10.1016/j.dci.2014.11.005
Dossa RG, Alperin DC, Garzon D, Mealey RH, Brown WC, Jervis PJ, Besra GS, Cox LR, Hines SA.α-GalCer is a potent immunomodulatory molecule that is presented to NKT cells via the CD1 antigen-presenting system. We hypothesized that when used as an adjuvant α-GalCer would induce protective immune responses against Rhodococcus equi, an important pathogen of young horses. Here we demonstrate that the equine CD1d molecule shares most features found in CD1d from other species and has a suitable lipid-binding groove for presenting glycolipids to NKT cells. However, equine CTL stimulated with α-GalCer failed to kill cells infected with R. equi, and α-GalCer did not increase killing by C...