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Topic:Musculoskeletal System

The musculoskeletal system in horses encompasses the bones, muscles, tendons, ligaments, and joints that facilitate movement and provide structural support. This system is essential for locomotion, athletic performance, and overall health in equine species. The equine skeleton consists of approximately 205 bones, which are connected by joints and supported by a network of muscles and connective tissues. Tendons connect muscles to bones, while ligaments link bones to other bones, contributing to joint stability. The musculoskeletal system is subject to various conditions, including injuries, degenerative diseases, and developmental disorders, which can impact a horse's mobility and performance. This page compiles peer-reviewed research studies and scholarly articles that explore the anatomy, physiology, pathology, and treatment of musculoskeletal conditions in horses.
Effect of long-term administration of an injectable enrofloxacin solution on physical and musculoskeletal variables in adult horses.
Journal of the American Veterinary Medical Association    January 11, 2000   Volume 217, Issue 10 1514-1521 doi: 10.2460/javma.2000.217.1514
Bertone AL, Tremaine WH, Macoris DG, Simmons EJ, Ewert KM, Herr LG, Weisbrode SE.To evaluate clinical safety of administration of injectable enrofloxacin. Methods: Randomized controlled clinical trial. Methods: 24 adult horses. Methods: Healthy horses were randomly allocated into 4 equal groups that received placebo injections (control) or IV administration of enrofloxacin (5 mg/kg [2.3 mg/lb], 15 mg/kg [6.8 mg/lb], or 25 mg/kg [11.4 mg/lb] of body weight, q 24 h) for 21 days. Joint angles, cross-sectional area of superficial and deep digital flexor and calcaneal tendons, carpal or tarsal osteophytes or lucency, and midcarpal and tarsocrural articular cartilage lesions wer...
Response of newborn foals with thyroid musculoskeletal disease to adrenocorticotrophic hormone (ACTH).
Journal of reproduction and fertility. Supplement    January 1, 2000   Issue 56 709-715 
Card CE, Manning ST.Fetal maturation and equine parturition are not understood fully, although the adrenal and thyroid glands are thought to have regulatory roles. Thyroidectomized equine fetuses undergo prolonged gestation, and spontaneous diseases such as thyroid musculoskeletal disease and gestational fescue endophyte exposure are also associated with delayed parturition. Thyroid musculoskeletal disease is characterized by: histologically hyperplastic thyroid glands, chondro-osseous dysplasia and dysgenesis, angular limb deformity, low resting thyroxine and triiodothyronine concentrations, and lack of response...
Time of contact and step length: the effect of limb length, running speed, load carrying and incline.
The Journal of experimental biology    December 23, 1999   Volume 203, Issue Pt 2 221-227 doi: 10.1242/jeb.203.2.221
Hoyt DF, Wickler SJ, Cogger EA.Using published values for twelve species of birds and mammals, we investigated the effects of limb length and running speed on time of contact and step length. In addition, we measured the time of contact in horses trotting up a 10 % incline and when carrying a load averaging 19 % of their body mass. From these values, we calculated stride period and step length. Our analysis of the interspecific data yielded the following relationship between time of contact (t(c) in s) and leg length (L in m) and running speed (v in m s(-)(1)): t(c)=0.80L(0.84)/v(0.87) (r(2)=0.97). Both exponents in this re...
Radiological study to evaluate suspected scapulohumeral joint dysplasia in Shetland ponies.
Equine veterinary journal    December 22, 1999   Volume 31, Issue 6 510-514 doi: 10.1111/j.2042-3306.1999.tb03860.x
Boswell JC, Schramme MC, Wilson AM, May SA.A radiological study was performed to test the hypothesis that osteoarthritis of the scapulohumeral joint in Shetland ponies is secondary to shoulder dysplasia. Animals were selected into 3 groups: Group 1: Shetland ponies with a radiological and clinical diagnosis of scapulohumeral osteoarthritis (n = 8); Group 2: Shetland ponies without forelimb lameness (n = 12); Group 3: Horses/ponies without a history or clinical signs of forelimb lameness (n = 22). Anatomical indices were measured from mediolateral radiographs of a scapulohumeral joint from each animal. There was a significant difference...
Therapeutics of musculoskeletal disease in the horse.
The Veterinary clinics of North America. Equine practice    December 10, 1999   Volume 15, Issue 3 589-602 doi: 10.1016/s0749-0739(17)30134-7
Kollias-Baker C.Therapeutic medications play a crucial role in the successful therapy of many musculoskeletal diseases that occur in horses. For example, appropriate antibiotic therapy is extremely important in the treatment of diseases caused by infections with microorganisms such as botulism, tetanus, osteomyelitis, and muscle abscesses. In addition, numerous prescription medications and nutritional supplements are available for the treatment of osteoarthritis in horses. Many of these agents currently on the market fall into a new class of drugs called SADMO agents. Unfortunately, the efficacy and mechanism...
Analgesia.
The Veterinary clinics of North America. Equine practice    December 10, 1999   Volume 15, Issue 3 705-723 doi: 10.1016/s0749-0739(17)30140-2
Clark JO, Clark TP.Critical to reducing patient morbidity as well as heightened ethical awareness, alleviation of pain in animals has become integral to medical case management and surgical procedures. Pharmacotherapy is directed at peripheral nociceptors, primary and secondary spinal neurons, and pain-processing areas in the CNS. Accordingly, three primary pharmacologic strategies have evolved: drugs that bind to and activate opioid receptors, drugs that bind to and activate alpha 2 receptors, and drugs that reduce de novo prostaglandin synthesis. In horses, the two predominant types of pain encountered are mus...
Modes of local drug delivery to the musculoskeletal system.
The Veterinary clinics of North America. Equine practice    December 10, 1999   Volume 15, Issue 3 603-622 doi: 10.1016/s0749-0739(17)30135-9
Anderson BH, Ethell MT.A number of methods for the local delivery of drugs to musculoskeletal tissues in the horse are now available. Further research is required to document the disposition of drugs delivered by such methods and to correlate this information with efficacy. Perhaps the greatest potential area for the methods discussed is the treatment of synovial and bone infections. To be able to provide high and sustained therapeutic concentrations of antimicrobials to the site of infection should increase the chances of success in such cases. These methods of drug delivery need to be used in conjunction with othe...
Effects of prior exercise on muscle metabolism during sprint exercise in horses.
Journal of applied physiology (Bethesda, Md. : 1985)    November 24, 1999   Volume 87, Issue 5 1914-1922 doi: 10.1152/jappl.1999.87.5.1914
McCutcheon LJ, Geor RJ, Hinchcliff KW.The effect of warm-up exercise on energy metabolism and muscle glycogenolysis during sprint exercise (Spr) was examined in six fit Standardbred horses exercised at 115% of maximal O(2) consumption (VO(2 max)) until fatigued, 5 min after each of three protocols: 1) no warm-up (NWU); 2) 10 min at 50% of VO(2 max) [low-intensity warm-up (LWU)]; and 3) 7 min at 50% VO(2 max) followed by 45-s intervals at 80, 90, and 100% VO(2 max) [high-intensity warm-up (HWU)]. Warm-up increased (P < 0.0001) muscle temperature (T(m)) at the onset of Spr in LWU (38.3 +/- 0.2 degrees C) and HWU (40.0 +/- 0. 3 de...
What is your diagnosis? Femoral and tibial subchondral bone cysts in a horse.
Journal of the American Veterinary Medical Association    October 26, 1999   Volume 215, Issue 8 1097-1098 
Bueno AC, Kaneps AJ, Watrous BJ.No abstract available
Predilection sites of Trichinella spiralis larvae in naturally infected horses.
Journal of helminthology    October 20, 1999   Volume 73, Issue 3 233-237 doi: 10.1017/s0022149x99000360
Pozio E, Paterlini F, Pedarra C, Sacchi L, Bugarini R, Goffredo E, Boni P.A total of 120 muscle tissues from three horses naturally infected with Trichinella spiralis were examined. The head was the most infected site. In particular, the muscles harbouring the highest number of larvae were: musculus buccinator (12, 411 and 1183 larvae g-1), the tongue (11, 615 and 1749 larvae g-1), m. levator labii maxillaris (17,582 and 1676 larvae g-1), and the masseter (4.9, 289 and 821 larvae g-1). Compared with the diaphragm, the number of larvae per gram was from 3.5 to 6.8 times higher in the tongue, from 3.5 to 6.5 higher in m. levator labii maxillaris, and from 2.5 to 4.6 h...
Evaluation of different projections for radiographic detection of tarsal degenerative joint disease in Icelandic horses. Eksell P, Uhlhorn H, Carlsten J.Radiographs from 196 tarsi in 98 Icelandic horses were evaluated to compare the accuracy of four different projections in detecting radiographic signs of degenerative joint disease in the distal tarsus. The extent and localization of tarsal degenerative joint disease found in one projection when reading all four projections of the same tarsus together was compared with the combined findings from all four projections. The results of reading individual radiographic projections without knowledge of the other three projections was also evaluated. Degenerative joint disease was detected most freque...
Correlation between surface electromyography and kinematics of the hindlimb of horses at trot on a treadmill.
Cells, tissues, organs    October 12, 1999   Volume 165, Issue 2 113-122 doi: 10.1159/000016681
Robert C, Valette JP, Degueurce C, Denoix JM.The purpose of this study was to demonstrate the feasibility of surface electromyography in the horse and to correlate electromyographic activity with kinematic data. Surface electromyography of seven hindlimb muscles was recorded in five horses at trot on a treadmill. Simultaneously, kinematic analysis of the hindlimb was performed using a three-dimensional system and a unidirectional accelerometer was attached to the hoof. Electromyographic activities of the gluteus medius, vastus lateralis and two parts of the biceps femoris started in the late part of the swing phase and ended in the late ...
What is your diagnosis? Bilateral separation of the proximal femoral epiphysis from the metaphysis (type-I Salter-Harris fracture).
Journal of the American Veterinary Medical Association    October 8, 1999   Volume 215, Issue 7 933-934 
Blaik MA, Hudson JA.No abstract available
Results of bone scintigraphy in racing standardbred horses: 64 cases (1992-1994).
Journal of the American Veterinary Medical Association    October 8, 1999   Volume 215, Issue 7 982-991 
Ehrlich PJ, Dohoo IR, O'Callaghan MW.To document anatomic patterns of scintigraphic uptake and related orthopedic disease associated with racing activity in Standardbred horses. Methods: Retrospective study. Methods: 64 Standardbred horses evaluated for lameness. Methods: Medical records at the time of discharge were reviewed, and information regarding signalment; history; results of lameness examination, scintigraphy, and radiography; diagnosis; and treatment were obtained. Results: 274 areas of increased radiopharmaceutical uptake were identified. Scintigrams of 218 limbs (106 forelimbs, 112 hind limbs) were available for revie...
Hyperkalaemic periodic paralysis in horses: a review.
Equine veterinary journal    October 3, 1999   Volume 31, Issue 5 362-367 doi: 10.1111/j.2042-3306.1999.tb03834.x
Meyer TS, Fedde MR, Cox JH, Erickson HH.No abstract available
Bioavailability of racemic ketoprofen in healthy horses following rectal administration.
Research in veterinary science    September 30, 1999   Volume 67, Issue 2 203-204 doi: 10.1053/rvsc.1999.0303
Corveleyn S, Henrist D, Remon JP, Van Der Weken G, Baeyens W, Haustraete J, Aboul-Enein HY, Sustronck B, Deprez P.Ketoprofen (KTP) is a chiral non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class, approved by the FDA for the allevation of pain associated with musculoskeletal disorders in horses. The present study was designed to examine the bioavailability of ketoprofen enantiomers after rectal administration of the racemate to healthy horses. One gram of racemic ketoprofen was injected intravenously and administered rectally as a fat based suppository in a cross-over design study (n = 4). Blood samples were analysed for KTP enantiomers using HPLC. After IV administration, the S(+) ena...
Lameness associated with the bicipital bursa in an Arab stallion.
The Veterinary record    September 29, 1999   Volume 145, Issue 7 194-198 doi: 10.1136/vr.145.7.194
Booth TM.Severe, chronic lameness in the left forelimb of a five-year-old Arab stallion was localised to the bicipital bursa by local anaesthesia and gamma scintigraphy. Radiographic and ultrasonographic examinations of the proximal humeral tubercles and bicipital bursa revealed new bone production in the region of the intertubercular grooves and irregularities in the density of the soft tissues of the bicipital tendon and bursa. An endoscopic examination of the bicipital bursa with a standard arthroscope under general anaesthesia was a useful diagnostic procedure. The stallion was euthanased, and mark...
An in vitro biomechanical comparison of two fixation methods for transverse osteotomies of the medial proximal forelimb sesamoid bones in horses.
Veterinary surgery : VS    September 24, 1999   Volume 28, Issue 5 355-367 doi: 10.1111/j.1532-950x.1999.00355.x
Wilson DA, Keegan KG, Carson WL.This study compared the mechanical properties of the normal intact suspensory apparatus and two methods of fixation for repair of transverse, midbody fractures of the proximal sesamoid bones of adult horses: transfixation wiring (TW) and screws placed in lag fashion (LS). Methods: An in vitro, paired study using equine cadaver limbs mounted in a loading apparatus was used to test the mechanical properties of TW and LS. Methods: Seventeen paired (13 repaired, 4 normal) equine cadaver limbs consisting of the suspensory apparatus third metacarpal bone, and first and second phalanges. Methods: The...
Validity of saddle pressure measurements using force-sensing array technology–preliminary studies.
Veterinary journal (London, England : 1997)    September 18, 1999   Volume 158, Issue 2 113-119 doi: 10.1053/tvjl.1998.0334
Jeffcott LB, Holmes MA, Townsend HG.Back pain is a common and poorly understood clinical problem. An important factor in this regard is the induction or exacerbation of back pain from badly designed or poorly fitting saddles. This study used a pressure-sensing mat to investigate saddle fit. The aims of the study were to confirm the accuracy and reliability of the force-sensing array technology when used to measure pressure beneath the saddles of horses, and to collect some initial data from normal healthy horses with well-fitting saddles. Experiments were undertaken to establish that a linear relationship existed between the tot...
Intramuscular desmoid tumor (musculoaponeurotic fibromatosis) in two horses.
Veterinary pathology    September 18, 1999   Volume 36, Issue 5 468-470 doi: 10.1354/vp.36-5-468
Valentine BA, Del Piero F, Edwards RB.Intramuscular desmoid tumors (musculoaponeurotic fibromatosis) were discovered in two young adult horses. The tumor in one horse was in the lateral cervical musculature, and that in the second horse occurred in the pectoral musculature. Histopathologic features were similar in both horses and included proliferation of fibroblasts and cells expressing muscle actin (myofibroblasts), with extensive dissecting fibrosis within muscle. These features are similar to those of desmoid tumors in humans, particularly those also known as musculoaponeurotic fibromatosis. Dissection of these lesions reveale...
Results of physical inspection before races and race-related characteristics and their association with musculoskeletal injuries in Thoroughbreds during races.
Journal of the American Veterinary Medical Association    September 7, 1999   Volume 215, Issue 5 654-661 
Cohen ND, Mundy GD, Peloso JG, Carey VJ, Amend NK.To estimate the relative risk of injury among horses deemed to be at increased risk of injury on the basis of prerace physical inspection findings and to examine the association of injury during races with race-related characteristics. Methods: Cohort study. Methods: 2,187 Thoroughbred horses that started 3,227 races in Kentucky. Methods: All race starts for which a horse was deemed to be at increased risk of injury on the basis of prerace physical inspection findings and a random sample of race starts for which horses were not deemed at increased risk of injury were included in the study. Fin...
The mechanisms and consequences of structural failure of the foot.
The Veterinary clinics of North America. Equine practice    September 3, 1999   Volume 15, Issue 2 437-461 doi: 10.1016/s0749-0739(17)30154-2
Hood DM.Many of the difficulties in managing the horse with chronic laminitis are associated with the foot's mechanical failure. The occurrence of digital collapse cannot be viewed in isolation as the primary therapeutic focus. The circulatory, metabolic, and growth pattern changes induced by the foot's mechanical collapse often serve as major limiting factors to successful rehabilitation. From the discussion above, it is obvious that a significant amount of research is needed to better understand the biomechanical pathologies of the failed foot.
Identification of an ossicle associated with the palmar aspect of the carpus in the horse. Martens P.An ossicle associated with the palmar aspect of the carpus is described in five horses. The size of the ossicle varied from 3 x 4 mm to approximately 12 x 10 mm. The ossicles were located at the junction of the proximal and distal rows of carpal bones, between the palmaromedial aspect of the fourth carpal bone and the ulnar carpal bone. In 3 horses they were bilateral, in one horse unilateral, and only one limb was examined in the remaining horse. In all horses it was an incidental finding and not regarded to be a pathologic entity.
Pharmacokinetics of carprofen enantiomers in equine plasma and synovial fluid – a comparison with ketoprofen.
Journal of veterinary pharmacology and therapeutics    August 14, 1999   Volume 22, Issue 3 196-201 doi: 10.1046/j.1365-2885.1999.00202.x
Armstrong S, Tricklebank P, Lake A, Frean S, Lees P.Carprofen is a Non Steroidal Anti-Inflammatory Drug (NSAID) which is widely used for the treatment of musculoskeletal disorders in horses. The commercial preparation is a racemic mixture of two enantiomers (R and S carprofen). We used HPLC to measure plasma and synovial fluid R and S carprofen concentrations following a single intravenous (i.v.) dose, and computer modelling to determine the pharmacokinetic parameters of the enantiomers in these two body fluids. A comparison was made with results from an identical experiment using ketoprofen. The plasma elimination half lives of R and S carprof...
The relationship between mechanical work and energy expenditure of locomotion in horses.
The Journal of experimental biology    August 10, 1999   Volume 202, Issue Pt 17 2329-2338 doi: 10.1242/jeb.202.17.2329
Minetti AE, ArdigO LP, Reinach E, Saibene F.Three-dimensional motion capture and metabolic assessment were performed on four standardbred horses while walking, trotting and galloping on a motorized treadmill at different speeds. The mechanical work was partitioned into the internal work (W(INT)), due to the speed changes of body segments with respect to the body centre of mass, and the external work (W(EXT)), due to the position and speed changes of the body centre of mass with respect to the environment. The estimated total mechanical work (W(TOT)=W(INT)+W(EXT)) increased with speed, while metabolic work (C) remained rather constant. A...
Morphological character of the shoulder and leg skeleton in Przewalski’s horse (Equus przewalskii).
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft    July 31, 1999   Volume 181, Issue 4 403-407 doi: 10.1016/S0940-9602(99)80138-1
Sasaki M, Endo H, Yamagiwa D, Yamamoto M, Arishima K, Hayashi Y.The skeletal feature was observed in Przewalski's horse (Equus przewalskii) and the domestic horse (E. caballus). As results of the observations, remarkable differences were found in the scapula. The caudal border of the scapula in Przewalski's horse is curved in the caudal direction more than that of the domestic horse. Moreover, in the domestic horse, the sharp caudal border is formed by the shift of the outer muscular line (Linea muscularis) to the border. In Przewalski's horse, however, the caudal border is rounded because the outer muscular line does not shift to the border but lies besid...
Inhibition of articular cartilage degradation in culture by a novel nonpeptidic matrix metalloproteinase inhibitor.
Annals of the New York Academy of Sciences    July 23, 1999   Volume 878 594-597 doi: 10.1111/j.1749-6632.1999.tb07737.x
Billinghurst RC, O'Brien K, Poole AR, McIlwraith CW.No abstract available
Analysis of myosin heavy chains at the protein level in horse skeletal muscle.
Journal of muscle research and cell motility    July 21, 1999   Volume 20, Issue 2 211-221 doi: 10.1023/a:1005461214800
Rivero JL, Serrano AL, Barrey E, Valette JP, Jouglin M.Combined methodologies of enzyme-linked immunosorbent assay (ELISA), sodium dodecyl sulphate polyacrilamide gel electrophoresis (SDS-PAGE), immunoblotting, traditional myofibrillar ATPase (mATPase) histochemistry and immunocytochemistry of whole biopsied samples were used to study myosin heavy chain (MHC) isoforms in the equine gluteus medius muscle. The ELISA technique allowed the quantification of the three MHC isoforms known to be present in different horse muscles: slow (MHC-I) and two fast (termed MHC-IIA and MCH-IIX). The SDS-PAGE method resolved MHCs in three bands: MHC-I, MHC-IIX and M...
Ultrasonographic anatomy of the accessory ligament of the superficial digital flexor tendon in horses.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 186-191 doi: 10.1111/j.2042-3306.1999.tb03170.x
Denoix JM, Busoni V.The ultrasonographic anatomy of the accessory ligament of the superficial digital flexor tendon (AL-SDFT) in the horse is presented. Comparison between anatomical sections of isolated limbs and ultrasound scans of the distal antebrachium in sound horses enabled the authors to establish the normal reference ultrasonographic images of this structure. The AL-SDFT inserts 7-14 cm above the antebrachiocarpal joint on the palmaromedial aspect of the radius. Ultrasonographically it appears as an uniformly echogenic structure located deep to the median artery. The knowledge of ultrasonographic anatomy...
The science and art of angular limb deformity correction.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 182-183 doi: 10.1111/j.2042-3306.1999.tb03168.x
Bramlage LR.No abstract available