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Topic:Musculoskeletal System

The musculoskeletal system in horses encompasses the bones, muscles, tendons, ligaments, and joints that facilitate movement and provide structural support. This system is essential for locomotion, athletic performance, and overall health in equine species. The equine skeleton consists of approximately 205 bones, which are connected by joints and supported by a network of muscles and connective tissues. Tendons connect muscles to bones, while ligaments link bones to other bones, contributing to joint stability. The musculoskeletal system is subject to various conditions, including injuries, degenerative diseases, and developmental disorders, which can impact a horse's mobility and performance. This page compiles peer-reviewed research studies and scholarly articles that explore the anatomy, physiology, pathology, and treatment of musculoskeletal conditions in horses.
Segment-dependent expression of muscarinic acetylcholine receptors and G-protein coupling in the equine respiratory tract.
Veterinary research communications    December 15, 2006   Volume 31, Issue 2 207-226 doi: 10.1007/s11259-006-3396-z
Abraham G, Kottke C, Ammer H, Dhein S, Ungemach FR.Muscarinic receptors are considered to be of comparable clinical importance in chronic obstructive pulmonary disease (COPD) in equines and in humans. At present, data are scarce on the expression and distribution of probable subtypes of these receptors and their signalling pathways in airway segments, including lung parenchyma and bronchial and tracheal epithelium with the underlying smooth muscle in horses. Specific [N-methyl-3H]scopolamine chloride ([3H]NMS) binding to all three tissues was saturable and of high affinity, with KD values ranging between 1.6+/-0.7 and 1.9+/-0.3 nmol/L. [3H]NMS...
Novel findings regarding Glut-4 expression in adipose tissue and muscle in horses–a preliminary report.
Veterinary journal (London, England : 1997)    December 14, 2006   Volume 174, Issue 3 565-569 doi: 10.1016/j.tvjl.2006.10.022
Manso Filho HC, McKeever KH, Gordon ME, Costa HE, Watford M.One of the hallmarks of insulin resistance is a reduction in glucose transporter-4 (Glut-4) expression in adipose tissue but not in skeletal muscle. However, while Glut-4 has been demonstrated in skeletal and cardiac muscles in horses it has not been demonstrated in adipose tissue. The initial objectives of the present study were: (1) to test the hypothesis that Glut-4 expression would vary between selected key skeletal muscles; (2) to test the hypothesis that it would also vary between representative adipose tissue depots, and (3) to see whether expression would be greater in adipose tissue c...
Severe tear of the collateral sesamoidean ligament in a horse.
The Veterinary record    December 13, 2006   Volume 159, Issue 24 818-820 
Jacquet S, Coudry V, Denoix JM.No abstract available
Image fusion of computed tomographic and magnetic resonance images for the development of a three-dimensional musculoskeletal model of the equine forelimb. Zarucco L, Wisner ER, Swanstrom MD, Stover SM.Biomechanical models that compute the lengths and forces of muscle-tendon units are broadly applicable to the study of factors that promote injury and the planning and effects of orthopedic surgical procedures in equine athletes. A three-dimensional (3D) generic musculoskeletal model of the equine forelimb comprised of bony segment, muscle-tendon, and ligament information, was developed based on high-resolution computed tomographic (CT) and T1-weighted magnetic resonance (MR) images from an isolated forelimb of a Thoroughbred racehorse. Image fusion was achieved through coregistration of CT an...
Incomplete rupture of the gastrocnemius and superficial digital flexor muscles in a Quarter Horse stallion.
Journal of the American Veterinary Medical Association    December 6, 2006   Volume 229, Issue 11 1790-1794 doi: 10.2460/javma.229.11.1790
Toppin DS, Lori DN.A 16-year-old 500-kg (1,100-lb) Quarter Horse stallion was examined because of acute severe lameness involving the left hind limb. Results: Examination revealed signs of failure (concurrent flexion of the tarsus and extension of the stifle [femorotibial] joint) of the caudal component of the reciprocal apparatus. Results of radiographic evaluation ruled out fracture or joint injury as causes of the lameness. During the next 48 hours, the reciprocal apparatus on the left hind limb progressively deteriorated until the horse became non-weight bearing on the limb. Results: The horse wore a full-li...
Effects of sodium hyaluronate and methylprednisolone acetate on proteoglycan metabolism in equine articular chondrocytes treated with interleukin-1.
American journal of veterinary research    December 6, 2006   Volume 67, Issue 12 1980-1986 doi: 10.2460/ajvr.67.12.1980
Yates AC, Stewart AA, Byron CR, Pondenis HC, Kaufmann KM, Constable PD.To determine the effects of sodium hyaluronate (HA) in combination with methylprednisolone acetate (MPA) on interleukin-1 (IL-1)-induced inflammation in equine articular cartilage pellets. Methods: Chondrocytes collected from 7 horses euthanatized for problems unrelated to the musculoskeletal system. Methods: Chondrocyte pellets were treated with medium (negative control); medium containing IL-1 (positive control); or medium containing IL-1 with MPA only (0.05 or 0.5 mg/mL), HA only (0.2 or 2 mg/mL), or MPA (0.05 or 0.5 mg/mL) and HA (0.2 or 2 mg/mL) in combination. Proteoglycan (PG) synthesis...
Hoof trimming in horses.
The Veterinary record    December 5, 2006   Volume 159, Issue 23 787 
House C.No abstract available
Deep digital flexor tendon shortening as a treatment for distal interphalangeal joint hyperextension in a 2-year-old mare.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    December 5, 2006   Volume 19, Issue 4 250-254 
Kelmer G, Kramer J.Shortening of the deep digital flexor tendon was performed by tenotomy, overlapping and anastomosis. The procedure was performed on a two-year-old Quarter Horse Mare with distal interphalangeal joint hyperextension with subluxation and metatarsophalangeal joint hyperextension. These problems originated from damage to the digital flexor tendons, presumably due to previous distal limb trauma. The procedure markedly improved the mare's level of comfort, degree of ambulation and limb conformation. Two years following surgery the mare was comfortable at pasture.
Subchondral bone failure in overload arthrosis: a scanning electron microscopic study in horses.
Journal of musculoskeletal & neuronal interactions    December 5, 2006   Volume 6, Issue 3 251-257 
Norrdin RW, Stover SM.Mechanical overload leads to a common arthrosis in the metacarpal condyle of the fetlock joint of racehorses. This is usually asymptomatic but severe forms can cause lameness. Subchondral bone failure is often present and the predictability of the site provided an opportunity to study of the progression of bone failure from microcracks to actual collapse of subchondral bone. Twenty-five fetlock condyles from racehorses with various stages of disease were selected. Stages ranged from mild through severe subchondral bone sclerosis, to the collapse of bone and indentation or loss of cartilage kno...
Physiotherapy applied to the horse: a review.
Equine veterinary journal    November 28, 2006   Volume 38, Issue 6 574-580 doi: 10.2746/042516406x153247
Buchner HH, Schildboeck U.No abstract available
Post anaesthetic myopathy/neuropathy in horses undergoing magnetic resonance imaging compared to horses undergoing surgery.
Equine veterinary journal    November 28, 2006   Volume 38, Issue 6 497-501 doi: 10.2746/042516406x156505
Franci P, Leece EA, Brearley JC.Patient positioning and long anaesthetic duration required for magnetic resonance imaging (MRI) may result in a higher frequency of post anaesthetic myopathy/neuropathy syndrome (PAMNS) as compared to horses undergoing anaesthesia for surgery. Objective: Equine anaesthesia for MRI is associated with a higher frequency of PAMNS than anaesthesia for nonemergency, nonabdominal surgery. Methods: Anaesthetic and medical records of horses (n = 633) undergoing MRI or surgery between January 2001 and January 2005 (inclusive), were reviewed. Information obtained included patient details (breed, sex, ag...
Pressure algometry to quantify muscle pain in racehorses with suspected sacroiliac dysfunction.
Equine veterinary journal    November 28, 2006   Volume 38, Issue 6 558-562 doi: 10.2746/042516406x154804
Varcoe-Cocks K, Sagar KN, Jeffcott LB, McGowan CM.Despite the prevalence of orthopaedic injuries to horses, there is no objective means of quantifying the intensity of musculoskeletal pain. Objective: Mechanical nociceptive thresholds (MNT) can be measured repeatably by pressure algometry in horses and MNTs are correlated with both severity of clinical signs and subjective scores of muscle pain on palpation in horses with suspected sacroiliac dysfunction (SID). Methods: The technique of pressure algometry and its repeatability was tested at 4 anatomical sites on either side of the thoracolumbar and pelvic region in 12 Thoroughbreds in trainin...
Proximal interphalangeal joint arthrodesis using a combination plate-screw technique in 53 horses (1994-2003).
Equine veterinary journal    November 28, 2006   Volume 38, Issue 6 538-542 doi: 10.2746/042516406x154840
Knox PM, Watkins JP.A method for proximal interphalangeal joint (PIP joint) arthrodesis that provides a stable fixation and minimal duration of cast support is evaluated retrospectively. Objective: Evaluate the clinical use of a combined plate-screw method for PIP joint arthrodesis in a large number of horses. Methods: The records of 53 horses undergoing PIP joint arthrodesis were reviewed. Arthrodesis was performed with a dorsally placed 3-, 4- or 5-hole narrow dynamic compression plate (DCP) with 2 transarticular cortex screws placed in lag fashion either side of the plate. Subject details, clinical presentatio...
Magnetic resonance imaging, ultrasonography and histology of the suspensory ligament origin: a comparative study of normal anatomy of warmblood horses.
Equine veterinary journal    November 28, 2006   Volume 38, Issue 6 508-516 doi: 10.2746/042516406x156109
Bischofberger AS, Konar M, Ohlerth S, Geyer H, Lang J, Ueltschi G, Lischer CJ.The diagnosis of lameness caused by proximal metacarpal and metatarsal pain can be challenging. Magnetic resonance imaging (MRI) offers the possibility for further diagnosis but there have been no studies on the normal MRI appearance of the origin of the suspensory ligament (OSL) in conjunction with ultrasonography and histology. Objective: To describe the MRI appearance of the OSL in fore- and hindlimbs of sound horses and compare it to the ultrasonographic and histological appearance. The findings can be used as reference values to recognise pathology in the OSL. Methods: The OSL in the fore...
Genetic correlations between conformation traits and radiographic findings in the limbs of German Warmblood riding horses.
Genetics, selection, evolution : GSE    November 28, 2006   Volume 38, Issue 6 657-671 doi: 10.1186/1297-9686-38-6-657
Stock KF, Distl O.Studbook inspection (SBI) data of 20 768 German Warmblood mares and radiography results (RR) data of 5102 Hanoverian Warmblood horses were used for genetic correlation analyses. The scores on a scale from 0 to 10 were given for conformation and basic quality of gaits, resulting in 14 SBI traits which were used for the correlation analyses. The radiographic findings considered included osseous fragments in fetlock (OFF) and hock joints (OFH), deforming arthropathy in hock joints (DAH) and distinct radiographic findings in the navicular bones (DNB) which were analyzed as binary traits, and radio...
Prevalence of osteochondrosis in the limb joints of South German Coldblood horses.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine    November 16, 2006   Volume 53, Issue 10 531-539 doi: 10.1111/j.1439-0442.2006.00881.x
Wittwer C, Hamann H, Rosenberger E, Distl O.This study aimed to quantify the factors associated with the prevalence of the radiological signs of osteochondrosis (OC) and osteochondrosis dissecans (OCD) in South German Coldblood (SGC) horses. The prevalence of OC and OCD in fetlock and hock joints was analysed in 167 young coldblood horses with a mean age of 14 months. The presence of at least one osteochondrotic lesion (OC) in fetlock or hock joints was documented for 61.7% of the horses and 26.9% of the horses had osseus fragments. Osteochondrotic findings at the dorsal aspect of the sagittal ridge of the third metacarpal/metatarsal bo...
Myosin heavy chain composition in normal and atrophic equine laryngeal muscle.
Veterinary pathology    November 14, 2006   Volume 43, Issue 6 881-889 doi: 10.1354/vp.43-6-881
Adreani CM, Li ZB, Lehar M, Southwood LL, Habecker PL, Flint PW, Parente EJ.The myosin heavy chain (MHC) composition of a given muscle determines the contractile properties and, therefore, the fiber type distribution of the muscle. MHC isoform expression in the laryngeal muscle is modulated by neural input and function, and it represents the cellular level changes that occur with denervation and reinnervation of skeletal muscle. The objective of this study was to evaluate the pattern of MHC isoform expression in laryngeal muscle harvested from normal cadavers and cadavers with naturally occurring left laryngeal hemiplegia secondary to recurrent laryngeal neuropathy. L...
Treatment of chronic proximal suspensory desmitis in horses using focused electrohydraulic shockwave therapy.
Schweizer Archiv fur Tierheilkunde    November 2, 2006   Volume 148, Issue 10 561-568 doi: 10.1024/0036-7281.148.10.561
Lischer CJ, Ringer SK, Schnewlin M, Imboden I, Fürst A, Stöckli M, Auer J.The objective of the present clinical report was to investigate the short- and long-term outcomes of chronic proximal suspensory desmitis (PSD) treated with Extracorporeal Shockwave Treatment (ESWT). Fifty-two horses with chronic PSD in the forelimb (34 cases) or hindlimb (22 cases) were included in the study. Three horses had lesions in both hindlimbs and one in both forelimbs. The origin of the suspensory ligament was treated every three weeks for a total of three treatments using 2000 impulses applied by a focused ESWT device (Equitron) at an energy flux density of 0.15 mJ/ mm2. This treatm...
Altered homeostasis of extracellular matrix proteins in joints of standardbred trotters during a long-term training programme.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine    October 24, 2006   Volume 53, Issue 9 445-449 doi: 10.1111/j.1439-0442.2006.00877.x
Skiöldebrand E, Heinegård D, Olofsson B, Rucklidge G, Ronéus N, Ekman S.This study evaluates how strenuous training, age and lameness influence the release of cartilage oligomeric matrix protein (sf-COMP), aggrecan and collagen type II into synovial fluid in 28 (19.5-40 months) Standardbred trotters (STB), during a long-term training programme (24 months). All the horses were trained by the same trainer and were healthy on entering the training programme. Synovial fluid (sf) from the left middle carpal joint in each subject was sampled every third month. Enzyme-linked immunosorbent assay was used to determine the concentrations of sf-COMP, sf-aggrecan and sf-colla...
In vitro heterogeneity of osteogenic cell populations at various equine skeletal sites.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire    October 18, 2006   Volume 70, Issue 4 277-284 
McD○ LA, Anderson GI, Wright GM, Ryan DA.Bone cell cultures were evaluated to determine if osteogenic cell populations at different skeletal sites in the horse are heterogeneous. Osteogenic cells were isolated from cortical and cancellous bone in vitro by an explant culture method. Subcultured cells were induced to differentiate into bone-forming osteoblasts. The osteoblast phenotype was confirmed by immunohistochemical testing for osteocalcin and substantiated by positive staining of cells for alkaline phosphatase and the matrix materials collagen and glycosaminoglycans. Bone nodules were stained by the von Kossa method and counted....
MRI and CT diagnosis of acute desmopathy of the lateral collateral sesmoidean (navicular) ligament and long-term outcome in a horse.
Veterinary journal (London, England : 1997)    October 17, 2006   Volume 174, Issue 2 410-413 doi: 10.1016/j.tvjl.2006.08.003
Kofler J, Kneissl S, Malleczek D.Clinical, magnetic resonance imaging (MRI) and computed tomography (CT) findings of acute desmopathy of the lateral collateral sesmoidean (navicular) ligament (CSL) in a 13-year-old Hanoverian mare are presented. On admission to the clinic the horse showed a grade 5/6 left front-limb lameness at the walk, pain on coffin joint manipulation, and coffin joint effusion. Despite a positive palmar digital nerve block, radiographs and ultrasonography did not indicate reasons for the severe clinical signs. However, MRI revealed damage to the CSL and bone marrow oedema of the navicular bone (NB), where...
Levator labii superioris muscle transposition to treat oromaxillary sinus fistula in three horses.
Veterinary surgery : VS    October 10, 2006   Volume 35, Issue 7 596-600 doi: 10.1111/j.1532-950X.2006.00196.x
Brink P.To describe surgical transposition of the levator labii superioris muscle to treat oromaxillary sinus fistula in horses. Methods: Clinical study. Methods: Three horses with chronic oromaxillary sinus fistula. Methods: After severing its tendinous insertion, the muscle belly of the levator labii superioris muscle was retracted and transposed through the oromaxillary sinus fistula. The tendon exited the oral cavity through a full-thickness buccal incision created adjacent to the oral end of the fistula and was then tunneled subcutaneously in a ventral direction before being anchored by sutures t...
What are the relations between mechanics, gait parameters, and energetics in terrestrial locomotion?
Journal of experimental zoology. Part A, Comparative experimental biology    October 10, 2006   Volume 305, Issue 11 912-922 doi: 10.1002/jez.a.335
Hoyt DF, Wickler SJ, Dutto DJ, Catterfeld GE, Johnsen D.Are the different energy-conserving mechanics (i.e., pendulum and spring) used in different gaits reflected in differences in energetics and/or stride parameters? The analysis included published data from several species and new data from horses. When changing from pendulum to spring mechanics, there is a change in the slope of metabolic rate (MR) vs. speed in all species, in birds and quadrupeds there is no step increase, and in humans there are conflicting reports. At the trot-gallop transition, where quadrupeds are hypothesized to change from spring mechanics to some combination of spring a...
Joint work and power for both the forelimb and hindlimb during trotting in the horse.
The Journal of experimental biology    October 7, 2006   Volume 209, Issue Pt 20 3990-3999 doi: 10.1242/jeb.02471
Dutto DJ, Hoyt DF, Clayton HM, Cogger EA, Wickler SJ.The net work of the limbs during constant speed over level ground should be zero. However, the partitioning of negative and positive work between the fore- and hindlimbs of a quadruped is not likely to be equal because the forelimb produces a net braking force while the hindlimb produces a net propulsive force. It was hypothesized that the forelimb would do net negative work while the hindlimb did net positive work during trotting in the horse. Because vertical and horizontal impulses remain unchanged across speeds it was hypothesized that net work of both limbs would be independent of speed. ...
Myopathy in horses with pituitary pars intermedia dysfunction (Cushing’s disease).
Neuromuscular disorders : NMD    September 26, 2006   Volume 16, Issue 11 737-744 doi: 10.1016/j.nmd.2006.07.019
Aleman M, Watson JL, Williams DC, LeCouteur RA, Nieto JE, Shelton GD.Fifteen horses with pituitary pars intermedia dysfunction were studied. The horses were of various breeds and between 15 and 28 years of age. Control horses matched for breed and age were studied for comparison. Evaluations included complete blood cell count and serum biochemical analysis, electromyography, and gluteus medius muscle biopsies for histochemical, morphometric, and ultrastructural analysis. No differences were found between groups of horses on routine laboratory analysis or electromyography. We demonstrated that muscle wasting in diseased horses was the result of atrophy of types ...
Fracture rate in Thoroughbred racehorses is affected by dam age and parity.
Veterinary journal (London, England : 1997)    September 25, 2006   Volume 174, Issue 2 295-301 doi: 10.1016/j.tvjl.2006.07.023
Verheyen KL, Price JS, Wood JL.This study's aim was to determine the effects of dam age and parity on the rate of fracture in offspring in Thoroughbred racehorses in training for flat racing. It was hypothesised that first foals and those from older mares would have a higher fracture rate than subsequent foals and those from younger mares. A two-year observational cohort study collected data from eight trainers on 335 horses that were monitored since the start of their training as yearlings. Multivariable Poisson regression analyses showed that first foals had a significantly lower fracture rate than subsequent ones (RR=0.3...
Racing performance after arthroscopic removal of apical sesamoid fracture fragments in Thoroughbred horses age > or = 2 years: 84 cases (1989-2002).
Equine veterinary journal    September 22, 2006   Volume 38, Issue 5 446-451 doi: 10.2746/042516406778400655
Schnabel LV, Bramlage LR, Mohammed HO, Embertson RM, Ruggles AJ, Hopper SA.Studies have shown that surgical removal of apical fracture fragments in Standardbred racehorses carries the best prognosis for return to racing performance, but there are no reports involving mature Thoroughbred (TB) racehorses. Objective: To describe the incidence of apical proximal sesamoid fractures in TB racehorses and determine probability and quality of racing performance after arthroscopic removal of such fractures in TB racehorses age > or = 2 years. Methods: Medical records and pre- and post operative race records of TB racehorses age > or = 2 years that underwent arthroscopic surger...
A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    September 15, 2006   Volume 19, Issue 3 142-146 
Frisbie DD, Cross MW, McIlwraith CW.Histological measurements of the thickness of non-calcified and calcified cartilage, as well as the subchondral bone plate in five locations on the femoral trochlea and medial femoral condyles of species were used in preclinical studies of articular cartilage and compared to those of the human knee. Cadaver specimens were obtained of six human knees, as well as six equine, six goat, six dog, six sheep and six rabbit stifle joints (the animal equivalent of the human knee). Specimens were taken from the lateral trochlear ridge, medial trochlear ridge and medial femoral condyle. After histopathol...
Septic bicipital bursitis, tendonitis and arthritis of the scapulohumeral joint in a mare.
The Veterinary record    September 12, 2006   Volume 159, Issue 11 352-354 doi: 10.1136/vr.159.11.352
Forresu D, Lepage OM, Cauvin E.No abstract available
Standing thoracoscopy in the diagnosis of lymphosarcoma in a horse.
The Veterinary record    September 12, 2006   Volume 159, Issue 11 354-356 doi: 10.1136/vr.159.11.354
Pollock PJ, Russell T.No abstract available
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