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Topic:Pain Management

Pain management in horses involves various strategies and interventions designed to alleviate discomfort and improve the well-being of equine patients. It encompasses pharmacological approaches, such as the use of non-steroidal anti-inflammatory drugs (NSAIDs), opioids, and other analgesics, as well as non-pharmacological methods like physical therapy, acupuncture, and environmental modifications. Effective pain management aims to address both acute and chronic pain conditions, which can result from injuries, surgeries, or diseases such as laminitis and arthritis. This page aggregates peer-reviewed research studies and scholarly articles that explore the mechanisms, efficacy, and safety of different pain management techniques in horses, contributing to the understanding and advancement of equine veterinary care.
Guidelines for the recognition and assessment of pain in animals. Prepared by a working party of the Association of Veterinary Teachers and Research Workers.
The Veterinary record    March 22, 1986   Volume 118, Issue 12 334-338 doi: 10.1136/vr.118.12.334
Despite some views to the contrary the working party of the Association of Veterinary Teachers and Research Workers considers that it has been demonstrated that it is possible to prepare guidelines for the recognition and assessment of pain in experimental animals. The detailed information readily available on species specific signs is limited and it has been particularly difficult to obtain such signs for the smaller mammals and for the non-mammalian species.
Lameness: diagnosing the site of pain.
Equine veterinary journal    March 1, 1986   Volume 18, Issue 2 89-91 doi: 10.1111/j.2042-3306.1986.tb03551.x
Hopes R.No abstract available
Eikenella corrodens osteomyelitis of the axis in a foal.
Journal of the American Veterinary Medical Association    February 1, 1986   Volume 188, Issue 3 298-299 
Richardson DW.Eikenella corrodens, a previously unrecognized pathogen in the horse, was isolated from the spinous process of the axis of a colt with signs of severe neck pain. Dorsal laminectomy (excising the infected spinous process and lamina) was performed and the colt was treated with antibiotics for 6 weeks. Recovery was uncomplicated.
Sedative and analgesic effects of detomidine in horses and cattle. Based on a symposium. Turku, Finland, September 2-4, 1985.
Acta veterinaria Scandinavica. Supplementum    January 1, 1986   Volume 82 1-206 
No abstract available
Analgesic and sedative effects of detomidine compared to xylazine in a colic model using i.v. and i.m. routes of administration.
Acta veterinaria Scandinavica. Supplementum    January 1, 1986   Volume 82 85-95 
Lowe JE, Hilfiger J.No abstract available
Effect of postoperative pethidine on the anaesthetic recovery period in the horse.
Equine veterinary journal    January 1, 1986   Volume 18, Issue 1 70-72 doi: 10.1111/j.2042-3306.1986.tb03543.x
Taylor PM.No abstract available
Dose-related effects of ethylketazocine on nociception, behaviour and autonomic responses in the horse.
The Journal of pharmacy and pharmacology    January 1, 1986   Volume 38, Issue 1 40-45 doi: 10.1111/j.2042-7158.1986.tb04464.x
Kamerling SG, Dequick DJ, Weckman TJ, Tobin T.Sensitive methods for measuring the analgesic, physiological and behavioural effects of opioids in the horse have recently been developed. Fentanyl, a prototypic mu-opiate receptor agonist, has been previously shown to produce a syndrome characterized by marked analgesia and locomotor stimulation as well as tachycardia, tachypnoea and behavioural arousal. To determine whether other opiate receptors mediate some of the actions of the narcotic analgesics in the horse, an agent with activity at kappa- and to lesser extent mu-receptors was studied using a vigorous experimental protocol. Like fenta...
Complications associated with left dorsal displacement of the large colon in the horse.
Journal of the American Veterinary Medical Association    December 15, 1985   Volume 187, Issue 12 1379-1380 
Markel MD, Orsini JA, Gentile DG, Freeman DE, Tulleners EP, Harrison IW.Four horses operated on for left dorsal displacement of the large colon (LDDLC) had major intraoperative or postoperative complications. One horse was euthanatized during surgery because of extensive necrosis of the large colon. Three horses that were discharged after surgical correction of LDDLC were readmitted with signs of abdominal pain between 5 weeks and 13 months after surgery. Two horses had recurrence of LDDLC, and the third horse had an omental adhesion attached to and obstructing the pelvic flexure. The displacements were corrected, the adhesion was broken down, and the horses were ...
[Clinical use of various non-steroidal anti-inflammatory agents in horses and cattle].
Nordisk veterinaermedicin    November 1, 1985   Volume 37, Issue 6 329-337 
Hesselholt M, Friis C.No abstract available
Visceral analgesia: effects of xylazine, butorphanol, meperidine, and pentazocine in horses.
American journal of veterinary research    October 1, 1985   Volume 46, Issue 10 2081-2084 
Muir WW, Robertson JT.The visceral analgesic, cardiorespiratory, and behavioral effects induced by xylazine, butorphanol, meperidine, and pentazocine were determined in 9 adult horses with colic. Colic was produced by inflating a balloon in the horses' cecum. Heart rate, respiratory rate, mean arterial blood pressure, and cardiac output increased after cecal balloon inflation. Xylazine and butorphanol decreased the hemodynamic response to cecal balloon inflation. Meperidine and pentazocine had minimal effects on the cardiorespiratory changes induced by cecal balloon inflation. Xylazine produced the most pronounced ...
An investigation on the use of cryosurgery for treatment of bone spavin, splint, and fractured splint bone injuries in standardbred horses.
Cryobiology    October 1, 1985   Volume 22, Issue 5 468-476 doi: 10.1016/0011-2240(85)90158-0
McKibbin LS, Paraschak DM.Bone spavin, splint, and fractured splint bone injuries have been treated with varying methodologies at Wheatley Hall Farm Equine Clinic. Cryosurgery is the most successful. With cryosurgery the small, pain-producing afferent C fibers are destroyed, and painful neuromas do not return. Injured sites were cryosurgically treated with liquid nitrogen for a double freeze-thaw period of 45 sec. 5 sec, 45 sec. Before and after treatment comparisons were conducted on study standardbreds. In all three injury groups, results showed that the standardbreds tended to race as well or with improved times and...
Malignant edema in horses.
Journal of the American Veterinary Medical Association    October 1, 1985   Volume 187, Issue 7 732-736 
Rebhun WC, Shin SJ, King JM, Baum KH, Patten V.Malignant edema (clostridial myositis) was diagnosed in 9 horses with signs of illness that included fever, depression, painful muscular swellings, and toxemia. The infection followed intramuscular injections in 8 horses and developed in a puncture wound in 1 horse. Treatment consisted of surgical fenestration of the involved muscle, high doses of penicillin, nonsteroidal anti-inflammatory agents and analgesics, and supportive fluid therapy. Five horses recovered and 4 died. Those that died had advanced signs of the disease at admission.
Closed reduction and blind cross-pinning for repair of a proximal tibial fracture in a foal.
Journal of the American Veterinary Medical Association    October 1, 1985   Volume 187, Issue 7 743-745 
Juzwiak JS, Milton JL.A 4-day-old foal underwent repair of a proximal metaphyseal fracture of the tibia. After closed reduction, fixation was achieved by use of blind cross-pinning. Thirty-five days after surgery, radiography demonstrated complete healing. The foal was mildly lame 4 months after repair of the fracture. Blind cross-pinning may be considered as a method of repair for certain long bone fractures in small foals.
Case of quadrilateral flexural contracture in a 10-year-old pony.
The Veterinary record    June 29, 1985   Volume 116, Issue 26 685-687 doi: 10.1136/vr.116.26.685
Wyn-Jones G, Peremans KY, May SA.The management of a case of quadrilateral flexural contracture in a 10-year-old pony is described. The animal was restored to normal appearance and function through a combination of surgical desmotomy and management techniques; the importance of analgesia and exercise as adjuncts to surgery is emphasised. The aetiology and pathogenesis of the condition in the immature animal and the adult is compared and a possible association is made between this condition and palmar fibromatosis (Dupuytren's contracture) occurring in man.
Comparison of carbonated lidocaine and lidocaine hydrochloride for caudal epidural anesthesia in horses.
American journal of veterinary research    June 1, 1985   Volume 46, Issue 6 1375-1377 
Schelling CG, Klein LV.A double-blind comparison of carbonated lidocaine and lidocaine hydrochloride in caudal epidural anesthesia was performed in 8 horses. Among 5 horses with successfully paired bilateral caudal epidural blockades, no significant differences in onset time, duration, or sensory blockade were demonstrated. In the present study, carbonated lidocaine did not offer an advantage over the hydrochloride salt for caudal epidural anesthesia in the horse.
A method for studying cutaneous pain perception and analgesia in horses.
Journal of pharmacological methods    June 1, 1985   Volume 13, Issue 3 267-274 doi: 10.1016/0160-5402(85)90027-0
Kamerling SG, Weckman TJ, DeQuick DJ, Tobin T.Pain perception and its alteration by analgesic drugs is difficult to measure in the horse. The latency to onset of flexion of a limb in response to a noxious thermal stimulus has been used as a nociceptive end point for analgesic studies in many species. While this method has been employed in the horse, it may be confounded by the spontaneous locomotor activity observed after administration of narcotic analgesics. Consequently, an alternative method of assaying narcotic analgesia that did not involve the equine locomotor apparatus was developed. This report describes the use of the heat-evoke...
Intra-articular anaesthesia of the equine hock.
In practice    May 1, 1985   Volume 7, Issue 3 92-96 doi: 10.1136/inpract.7.3.92
Dyson S.No abstract available
Effect of experimental vascular occlusion on small intestinal motility in ponies.
Equine veterinary journal    May 1, 1985   Volume 17, Issue 3 219-224 doi: 10.1111/j.2042-3306.1985.tb02476.x
Davies JV, Gerring EL.Small intestinal ischaemia is a cause of pain in man and horses. Occlusion of the vascular supply to Thiry loops in experimental ponies caused severe discomfort and loss of motility within a few minutes but these effects could not be reproduced by a similar procedure in intact gut preparations. However, embolisation of the mural vascular network produced ischaemia of the small intestine of anaesthetised ponies which led to a cessation of motility in the affected segments, though unaffected segments became hypermotile with a characteristic motility pattern. These results suggest the need for re...
Spinal fluid concentrations of mepivacaine in horses and procaine in cows after thoracolumbar subarachnoid analgesia.
American journal of veterinary research    May 1, 1985   Volume 46, Issue 5 1020-1024 
Skarda RT, Muir WW, Ibrahim AI.The CSF concentrations of mepivacaine in 10 Standardbred horses and of procaine in 10 Holstein cows given the drugs by thoracolumbar subarachnoid injection were determined. Mepivacaine hydrochloride was injected into the horses (502 +/- 60.5 kg) at an average dosage of 30 mg (1.5 ml of 20 mg/ml solution). Analgesia was produced 7.5 +/- 4.3 minutes after injection, extended between spinal cord segments T13 and L3 on both sides of the spinal column, and lasted 47 +/- 18.7 minutes at the T18 dermatome. Procaine hydrochloride was injected into cows (614 +/- 51.5 kg) at a dosage ranging between 75 ...
Practical guidelines for the conduct of field anaesthesia in the horse.
Equine veterinary journal    March 1, 1985   Volume 17, Issue 2 151-154 doi: 10.1111/j.2042-3306.1985.tb02077.x
Brouwer GJ.No abstract available
Diskospondylitis in five horses.
Journal of the American Veterinary Medical Association    February 1, 1985   Volume 186, Issue 3 270-272 
Adams SB, Steckel R, Blevins W.Diskospondylitis was diagnosed in 5 horses admitted to the Purdue University Large Animal Clinic during a 3-year period. Each horse had evidence of cervical pain. Clinical signs and radiography were useful for identifying the diskospondylitis. Cerebrospinal fluid was normal.
[Functional anatomy of the visceral arteries in the abdominal cavity of the horse. Considerations with reference to intestinal colic].
Tierarztliche Praxis    January 1, 1985   Volume 13, Issue 2 191-198 
König HE, Amselgruber W.The microscopic structure of the arteries was investigated in the gastro-intestinal tract of the horse. The median artery was also studied for comparative purposes. The adventitia is responsible for the holding and suspension of the visceral arteries. Disturbances in this system are considered to be a prime factor leading to chronically deficient blood flow. This is associated with pain which is generally classified as colics.
Investigating the CO2 laser for plantar digital neurectomy in horses.
Lasers in surgery and medicine    January 1, 1985   Volume 5, Issue 5 515-517 doi: 10.1002/lsm.1900050511
Montgomery TC, McNaughton SD.A histological study of plantar digital nerve sections cut with a carbon dioxide laser in horses was conducted. A series of nerve cuts were made with variable power densities to determine the appropriate theoretical level which would yield the most desired tissue effects. Power densities in the lower ranges used appeared to provide tissue effects judged most likely to prevent neuroma formation through increased thermal sealing of the proximal stump at the axon level. Clinical observation and follow-up of horses subjected to laser neurectomy tend to support the reported concept that the laser i...
Effects of cryotherapy on the palmar and plantar digital nerves in the horse.
American journal of veterinary research    January 1, 1985   Volume 46, Issue 1 7-12 
Schneider RK, Mayhew IG, Clarke GL.The duration of anesthetic effect and the histopathologic changes resulting from a controlled freeze of the palmar and plantar digital nerves in the horse were evaluated. Two techniques were compared: (i) nerves were frozen by direct application of the cryoprobe after surgical exposure and (ii) nerves were frozen by percutaneous application of the cryoprobe to the overlying skin. Return of skin sensation and ability to detect a stimulus were used to determine return of nerve function. The duration of anesthetic effect was significantly (P less than 0.005) longer for nerves frozen after surgica...
Differential effects of phenylbutazone and local anesthetics on nociception in the equine.
European journal of pharmacology    December 15, 1984   Volume 107, Issue 1 35-41 doi: 10.1016/0014-2999(84)90088-8
Kamerling SG, Dequick DJ, Weckman TJ, Sprinkle FP, Tobin T.The effects of procaine, mepivacaine and phenylbutazone on pain perception in the equine were studied using two behavioral assays of nociception; the thermal evoked hoof withdrawal reflex and skin twitch reflex. Pain perception threshold was measured as the latency from onset of thermal stimuli to reflex withdrawal of the forelimb or contraction of the cutaneous musculature. Procaine 2% and mepivacaine 2% prolonged the hoof withdrawal reflex latency when administered locally by producing a block of the palmar and metacarpal nerves. Significant analgesia lasted 90 min and 210 min for procaine a...
Plasma mepivacaine concentrations after caudal epidural and subarachnoid injection in the horse: comparative study.
American journal of veterinary research    October 1, 1984   Volume 45, Issue 10 1967-1971 
Skarda RT, Muir WW, Ibrahim AI.The venous plasma concentrations of mepivacaine were determined in 7 adult mares (420 +/- 17.1 kg) given an injection of a 2% solution of the hydrochloride at either the sacral (S2-3 to S5-C1) epidural space or the midsacral (S2-3) subarachnoid space. An average dose of 91.4 +/- 15.7 mg (4.6 +/- 0.8 ml) was needed to produce caudal epidural analgesia (CEA) and 26.7 +/- 5.4 mg (1.3 +/- 0.3 ml) to produce caudal subarachnoid analgesia (CSA). Maximal caudal analgesia extended from spinal cord segments S-1 to coccyx during CEA and CSA. The onset of analgesia as measured by response to superficial ...
The twitch in horses: a variant of acupuncture.
Science (New York, N.Y.)    September 14, 1984   Volume 225, Issue 4667 1172-1174 doi: 10.1126/science.6089344
Lagerweij E, Nelis PC, Wiegant VM, van Ree JM.The twitch procedure in horses attenuates the increase in the heart rate evoked by pain-inducing stimuli and the reaction of the animals to such stimuli. Endorphin systems are probably involved in the effectiveness of the twitch, since its action is blocked by naloxone and its application increases plasma concentrations of immunoreactive beta-endorphin. The mode of action of the twitch cannot be explained by the generally accepted theory of divertive pain and may resemble that of classical acupuncture.
Surgical management of proximal articular fracture of the patella in a horse.
Journal of the American Veterinary Medical Association    September 1, 1984   Volume 185, Issue 5 543-545 
Colbern GT, Moore JN.A patellar fracture was identified radiographically in the right stifle of a mature Tennessee Walking Horse stallion. The horse was markedly lame (grade IV/V) on the right hindlimb. Due to the articular nature and small size of the fragment, surgical removal via arthrotomy was selected. A dorsomedial approach to the femoropatellar joint was used. The horse recovered well and has returned to training as a show horse by 8 months following surgery.
Nerve blocks and lameness diagnosis in the horse.
In practice    July 1, 1984   Volume 6, Issue 4 102-107 doi: 10.1136/inpract.6.4.102
Dyson S.No abstract available
Anesthesia for cesarean section in large animals.
Modern veterinary practice    July 1, 1984   Volume 65, Issue 7 522-524 
McGrath CJ.Respiratory minute volume, blood volume, RBC mass and cardiac output increase while the functional residual capacity decreases during late pregnancy. General anesthetics reach the fetus in high concentrations and tend to persist in the fetus after delivery. Use of small doses of a combination of anesthetics is recommended. Ephedrine increases vascular tone and cardiac output. Glycopyrrolate and fentanyl-droperidol are used to restrain sows for cesarean section. Morphine alone or with acepromazine works well in depressed sows. Acepromazine or xylazine, used with ketamine, is good in restraining...
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