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Topic:Surgery

Surgery for horses encompasses a range of procedures performed to diagnose, treat, or manage various medical conditions. These procedures may involve soft tissue or orthopedic interventions and require specialized techniques to accommodate the unique anatomical and physiological characteristics of equines. Common surgical procedures in horses include colic surgery, fracture repair, and arthroscopy. The success of equine surgery depends on numerous factors, including the type of procedure, the horse's overall health, and post-operative care. This page compiles peer-reviewed research studies and scholarly articles that explore surgical techniques, outcomes, and advancements in equine surgical practices.
Use of a chronic soft tissue expansion device to facilitate blepharoplasty in a horse with lower-lid cicatricial ectropion with a 14-year follow-up.
Veterinary ophthalmology    July 20, 2020   Volume 23, Issue 5 899-904 doi: 10.1111/vop.12806
Whittaker CJ, Reynolds BD, McCarthy PM, Taylor SF, Major D, Caruso KA, Smith J.A 3-year-old Thoroughbred filly presented to a referral equine hospital for surgical correction of a severe cicatricial lateral lower eyelid ectropion OD, with secondary exposure keratitis. The severity of the ectropion deemed that conventional ectropion repairs would be unsuccessful. Therefore, a soft tissue expansion device was used to create sufficient local tissue for a rotational graft with tension-relieving horizontal incisions to be performed to facilitate closure and acceptable eyelid apposition. The keratitis had resolved by two months postoperatively. There were no long-term complica...
Arthroscopic debridement of short frontal plane proximal phalanx fractures preserves racing performance.
Equine veterinary journal    July 18, 2020   Volume 53, Issue 2 267-276 doi: 10.1111/evj.13275
Elzer EJ, Bramlage LR.Outcomes have been reported for a limited number of short frontal plane fractures of the proximal phalanx following nonsurgical treatment and internal fixation. Objective: To describe a new approach, arthroscopic debridement, of short frontal plane fractures of the proximal phalanx in flat-racing Thoroughbreds and post-operative racing outcome. Methods: Retrospective case-control study. Methods: Medical records of 81 Thoroughbred racehorses treated with arthroscopic debridement for frontal plane fractures of the proximal phalanx were reviewed. Diagnostic images and operative reports were used ...
Clinical use of computer-assisted orthopedic surgery in horses.
Veterinary surgery : VS    July 17, 2020   Volume 49, Issue 6 1075-1087 doi: 10.1111/vsu.13486
de Preux M, Klopfenstein Bregger MD, Brünisholz HP, Van der Vekens E, Schweizer-Gorgas D, Koch C.To describe clinical applications of computer-assisted orthopedic surgery (CAOS) in horses with a navigation system coupled with a cone beam computed tomography unit. Methods: Retrospective clinical case series. Methods: Thirteen adult horses surgically treated with CAOS. Methods: Medical records were searched for horses that underwent CAOS between 2016 and 2019. Data retrieved included signalment, diagnosis, lameness grade prior to surgery, surgical technique and complications, anesthesia and surgery time, and information pertaining to the perioperative case management and outcome. Results: I...
BEVA primary care clinical guidelines: Wound management in the horse.
Equine veterinary journal    July 17, 2020   Volume 53, Issue 1 18-29 doi: 10.1111/evj.13289
Freeman SL, Ashton NM, Elce YA, Hammond A, Hollis AR, Quinn G.There are currently no evidence summaries on wounds in the horse. Objective: To develop evidence-based guidelines on wound management in the horse. Methods: Evidence review using the GRADE framework. Methods: Research questions were proposed by a panel of veterinarians, and developed into PICO format. Evidence in the veterinary literature was evaluated using the GRADE evidence-to-decision framework. Searches for human evidence summaries were conducted in the NICE, Cochrane and JBI databases. Final recommendations were based on both veterinary and human evidence. Conclusions: The research quest...
Bidirectional knotless barbed versus conventional smooth suture for closure of surgical wounds in inguinal castration in horses.
BMC veterinary research    July 17, 2020   Volume 16, Issue 1 250 doi: 10.1186/s12917-020-02449-6
Adler DMT, Østergaard S, Jørgensen E, Jacobsen S.Castration of the stallion is one of the most frequently performed surgical procedures in the horse. Recently barbed suture materials for surgical wound closure were introduced to the market with manufacturers claiming that these sutures enhance speed and security as they eliminate the need to tie knots. Recently, it has been suggested that this type of suture may increase postoperative complications. This study aimed at investigating and comparing a bidirectional absorbable knotless barbed suture (KBS) to a conventional smooth suture (SS) for wound closure of inguinal castrations in the horse...
Endoscopy Guided Photoablation of Endometrial Cysts using a 980 nm Laser with a Contact Fiber in Mares.
Journal of visualized experiments : JoVE    July 16, 2020   Issue 161 doi: 10.3791/61569
Ponthier J, de la Rebière G, Salciccia A, Deleuze S.In mares, endometrial cysts are associated with endometriosis and can cause maternal recognition failure or compromise and delay pregnancy diagnoses. Historical treatments were invasive and had adverse effects on the endometrium. Hysteroscopically guided laser therapy is easy and effective for endometrial cysts resection, with no deleterious effects for the endometrium. A 110 cm long and 1.0 cm wide endoscope is sterilely introduced in the uterus through the open cervix of an estrous mare after vulvar cleaning. The uterus is slowly infused with less than 1 L of physiologic solution and the las...
Moody Mares-Is Ovariectomy a Solution?
Animals : an open access journal from MDPI    July 16, 2020   Volume 10, Issue 7 1210 doi: 10.3390/ani10071210
Melgaard DT, Korsgaard TS, Thoefner MS, Petersen MR, Pedersen HG.Unwanted behaviour in mares is a commonly presenting problem to the veterinarian. This behaviour may range from the mare being uncooperative or aggressive when handled on the ground, kicking, bucking or rearing when ridden or being aggressive towards other horses. This purpose of the study was to evaluate whether bilateral ovariectomy in mares with unwanted behaviour improved the mare's behaviour and/or rideability from the owner's perspective. The mares were grouped and compared statistically based on their histological classification as having either "normal" or neoplastic ovaries. This stud...
Influence of a purpose-built frame on the accuracy of computer-assisted orthopedic surgery of equine extremities.
Veterinary surgery : VS    July 11, 2020   Volume 49, Issue 7 1367-1377 doi: 10.1111/vsu.13484
de Preux M, Vidondo B, Koch C.To determine the influence of a purpose-built frame on the accuracy of screw placement during computer-assisted orthopedic surgery (CAOS) of the equine extremity. Methods: Experimental cadaveric study. Methods: Twenty-four paired equine cadaveric limbs obtained from seven horses. Methods: Three 4.5-mm cortex screws were inserted in lag technique in three different planes of orientation in the proximal phalanx (P1) by means of CAOS. In the study group (n = 12 limbs), the tracker was anchored on a purpose-built frame designed to stabilize the extremity. In the control group (n = 12 limbs), a con...
Post-operative pain behaviour associated with surgical castration in donkeys (Equus asinus).
Equine veterinary journal    July 8, 2020   Volume 53, Issue 2 261-266 doi: 10.1111/evj.13306
de Oliveira MGC, Luna SPL, Nunes TL, Firmino PR, de Lima AGA, Ferreira J, Trindade PHE, Júnior RAB, de Paula VV.Recognising pain in donkeys is challenging because they are stoic. Objective: To identify the responses of donkeys before and after surgical pain. Methods: Prospective, short-term longitudinal pre- and post-intervention observations. Methods: Forty adult donkeys underwent surgical castration after sedation with intravenous (IV) xylazine, induction with guaiphenesin/thiopental IV and maintenance of anaesthesia with isoflurane and local anaesthetic blockade. Four hours after recovery from anaesthesia, flunixin meglumine 1.1 mg/kg, dipyrone 10 mg/kg and morphine 0.2 mg/kg IV were administered....
The contribution of the middle cerebral artery and callosal artery to the vascularisation of the Facies convexa of the brain in horses with reference to the equine-specific cartographic pattern of the neopallium.
Folia morphologica    July 8, 2020   Volume 80, Issue 2 237-247 doi: 10.5603/FM.a2020.0065
Böing L, Heun F, Gasse H.The extremely complex surface architecture of the equine brain does not allow a uniform transfer of anatomical data from other mammalian species, e.g., dog or cat. Rather, a special approach is required to elucidate the equine-specific patterns of cerebral vascular ramifications. Therefore, a novel cartographic system was applied. Prior attention was paid to the A. cerebri media (MCA) and to the A. corporis callosi (CA), as they spread over the widest part of the neopallium's Facies convexa (i.e. the lateral and dorsal surface), thus being of particular interest in terms of surgical treatment ...
Arthroscopic approach and intra-articular anatomy of the equine discomandibular joint compartment of the temporomandibular joint.
Veterinary surgery : VS    July 7, 2020   Volume 49, Issue 7 1326-1333 doi: 10.1111/vsu.13487
Carmalt JL, Tucker ML.To develop an arthroscopic approach to the discomandibular joint (DMJ), the ventral compartment of the temporomandibular joint (TMJ) of the horse. Methods: Experimental study. Methods: Nine cadaveric equine heads and two live horses. Methods: A 2.5-mm 30° arthroscope was used to explore the DMJ after joint distension. The first portal was created caudally, allowing placement of a rostral portal under visual guidance. Nasotracheal intubation of the live horses allowed mandibular manipulation, which is required for complete visualization of the joint. Results: A novel injection technique allowe...
Outcome and complications following transrectal and transabdominal large intestinal trocarization in equids with colic: 228 cases (2004-2015).
Journal of the American Veterinary Medical Association    July 1, 2020   Volume 257, Issue 2 189-195 doi: 10.2460/javma.257.2.189
Schoster A, Altermatt N, Torgerson PR, Bischofberger AS.To describe outcome and complications after large intestinal trocarization in equids with colic and identify factors associated with nonsurvival and clinically relevant peritonitis (CRP). Methods: 228 (198 horses, 24 ponies, and 6 donkeys and mules) equids with colic that underwent large intestinal trocarization. Methods: Medical records from 2004 through 2015 were reviewed for equids with colic that underwent large intestinal trocarization. Factors associated with nonsurvival in all (ie, surgically and medically treated) equids and with CRP in medically only treated equids were identified. Me...
Teratoma Associated With Testicular Tissue in a Female-Like Horse With 64,XY (SRY-Positive) Disorder of Sex Development.
Journal of equine veterinary science    June 30, 2020   Volume 92 103177 doi: 10.1016/j.jevs.2020.103177
Sant'Anna Monteiro da Silva E, Zanzarini Delfiol DJ, Fabris VH, Mendonça Santos B, Nogueira GM, Oliveira Guimarães GB, Paulo de Oliveira Nogueira P....A four-year-old female-like Quarter Horse was admitted for clinical evaluation because of masculinized-aggressive behavior and lack of estrous signs. On external inspection, a hypertrophied clitoris and prominent muscles were observed. On gynecological examination, apparently normal mammary glands, vulva, vagina, and cervix were noted. On the other hand, the uterus had no tone and was smaller than normal. The left gonad was very soft on palpation and the right gonad was mostly firm, irregular, and wider than the left gonad. On ultrasound examination, there were no signs of regular ovarian stru...
Platelet-rich Plasma Combined With a Sterile 3D Polylactic Acid Scaffold for Postoperative Management of Complete Hoof Wall Resection for Keratoma in Four Horses.
Journal of equine veterinary science    June 27, 2020   Volume 92 103178 doi: 10.1016/j.jevs.2020.103178
Leonardi F, Angelone M, Biacca C, Battaglia B, Pecorari L, Conti V, Costa GL, Ramoni R, Grolli S.Keratoma is a nonmalignant horse tumor that grows in the space between the horn of the hoof and the distal phalanx. Keratoma causes lameness in the horse, and surgical excision is the treatment of choice. Four horses underwent removal of a keratoma by complete hoof wall resection. The remaining wound was treated with platelet-rich plasma (PRP) combined with a sterile three-dimensional polylactic acid scaffold. The PRP was applied at 3, 6, 9, 12, 15, and 18 days postoperatively. The surgical site was cleaned with gauzes and swabs soaked in Ringer's lactate solution before applying PRP and the ...
Copro-prevalence of Fasciola hepatica in Chilean breed horses in the province of Concepción, Chile. Muñoz L, Sepúlveda-Calderón P, Villaguala-Pacheco C, Aqueveque CL.The aim of this research was to assess the copro-prevalence of Fasciola hepatica in owned Chilean breed horses (Equus caballus) residing in the province of Concepción, Chile. The study was carried out throughout October 2017. Samples were taken from all (100%) Chilean breed horse (124 specimens; 45 females and 79 males, aged between 7 months and 24 years old) from the Concepción province. A rectal stool sample was obtained from each animal. This was analyzed using the Army Medical School method (AMS III) technique to detect F. hepatica eggs. Information about the horse's age, sex, previous f...
Wound Retractor Laparoscopic Port System for Standing Laparoscopic Cryptorchidectomy in the Horse: A Case Report.
Journal of equine veterinary science    June 23, 2020   Volume 92 103168 doi: 10.1016/j.jevs.2020.103168
Lacitignola L, Imperante A, De Siena R, Acquafredda C, Trisciuzzi R, Stabile M, Confalonieri E, Crovace AM, Staffieri F.Cryptorchidectomy is the most commonly performed laparoscopic procedure in horses. However, its use for the extraction of an abdominal testis has disadvantages such as loss of a resected testis from grasp and fragmentation of the specimen because of the excessive tension required for extraction through a thick body wall. The ring wound retractor laparoscopic port system was recently used in human and small animal surgery to perform laparoscopic-assisted procedures and retrieve large specimens from the abdomen. In the present case, the wound retractor was placed as the ventral port in the right...
Descemet’s membrane detachments, ruptures, and separations in ten adult horses: Clinical signs, diagnostics, treatment options, and preliminary results.
Veterinary ophthalmology    June 11, 2020   Volume 23, Issue 4 611-623 doi: 10.1111/vop.12793
Rodriguez Galarza RM, McMullen RJ.To describe the clinical presentation, diagnostic imaging results, and treatment outcomes of a series of presumed spontaneous Descemet's membrane detachments (DMD), ruptures, or separations (DMRS) in the adult horse. Methods: Ten adult horses of various breeds with DMD or DMRS. Methods: Descemet's membrane detachments/DMRS were diagnosed via slit lamp biomicroscopy, ultrasound biomicroscopy (UBM), and/or optical coherence tomography (OCT). Penetrating keratoplasty (PK) with heterologous corneal donor tissue (n = 1), superficial lamellar keratectomy, and Gundersen inlay flaps alone (GF, n =Â...
Equine granulosa cell tumours among other ovarian conditions: Diagnostic challenges.
Equine veterinary journal    June 10, 2020   Volume 53, Issue 1 60-70 doi: 10.1111/evj.13279
Renaudin CD, Kelleman AA, Keel K, McCracken JL, Ball BA, Ferris RA, McCue PM, Dujovne G, Conley AJ.Granulosa cell tumours (GCT) are the most common ovarian tumours in mares. While the classical presentation may not represent diagnostic challenges, diagnosis is not easy in the early stages. Objective: Illustrate the variability in the presentation and serum biomarkers associated with ovarian abnormalities in the mare. Methods: Retrospective case series. Methods: Nonclassical cases of GCTs and other ovarian conditions were identified and behaviour, GCT endocrine results, palpation and ultrasonographic findings are described and the diagnostic value of each is discussed. Results: Mares in this...
Ultrasonography and Surgical Treatment of an Unusual Case of Urethral Calculus in an Arabian Horse.
Journal of equine veterinary science    June 6, 2020   Volume 92 103150 doi: 10.1016/j.jevs.2020.103150
Abu-Seida AM, Shamaa AA.This case report records an obstructive urolithiasis due to a large calcium carbonate urethral stone in an 11-year-old Arabian stallion. The stallion had colicky pain, anuria, and reduction in food and water intakes. Palpation of the penis revealed rhythmic contractions of the urethra, a hard mass in the penile urethra at the level of the ischial arch, and a dilated urethra proximal to the mass. Rectal examination revealed a distended and turgid urinary bladder. Passing a urethral catheter revealed a complete urethral obstruction at the level of the ischial arch. Ultrasonography revealed a cal...
Transcutaneous Lateral Alveolar Ostectomy for Standing Surgical Extraction of Mandibular First Molar in an 8-Year-Old Miniature Horse.
Journal of veterinary dentistry    June 5, 2020   Volume 37, Issue 1 29-34 doi: 10.1177/0898756420928327
Limone LE, Baratt RM.An 8-year-old, 125 kg (275 lb) female miniature horse was evaluated for a persistently thickened left mandible and cutaneous fistula. Pulp horn defects were identified in pulp horns 1 and 3 of tooth 309 and occlusal pulp exposure was detected with a dental explorer. Radiography of the left mandibular dental quadrant revealed changes consistent with apical infection of tooth 309. Following the failure of oral extraction, a standing surgical approach was taken for transcutaneous lateral alveolar ostectomy and extraction. Roots were sectioned at the level of the furcation and elevated from the su...
Clinical Assessment of an Ipsilateral Cervical Spinal Nerve Block for Prosthetic Laryngoplasty in Anesthetized Horses.
Frontiers in veterinary science    June 2, 2020   Volume 7 284 doi: 10.3389/fvets.2020.00284
Morris TB, Lumsden JM, Dunlop CI, Locke V, Sommerauer S, Hurcombe SDA.The nociceptive blockade of locoregional anesthesia prior to surgical stimulation can decrease anesthetic agent requirement and thereby potential dose-dependent side effects. The use of an ipsilateral second and third cervical spinal nerve locoregional anesthetic block for prosthetic laryngoplasty in the anesthetized horses has yet to be described. Anesthetic records of 20 horses receiving locoregional anesthesia prior to laryngoplasty were reviewed and compared to 20 horses of a similar patient cohort not receiving locoregional anesthesia. Non-blocked horses were 11 times more likely to requi...
Actinomyces as a Cause of Osteomyelitis of the Nasofrontal Suture in a Gelding.
Journal of equine veterinary science    May 30, 2020   Volume 91 103148 doi: 10.1016/j.jevs.2020.103148
Boorman S, Boone L, Weatherall K, Caldwell F.A 7-year-old American Quarter Horse gelding was referred to the JT Vaughan Large Animal Teaching Hospital at Auburn University, College of Veterinary Medicine, for an investigation of a recurrent swelling of the nasofrontal region. Computed tomography examination of the skull was most consistent with a sequestrum of the left nasofrontal suture with associated focal osteomyelitis and left conchofrontal sinusitis. Surgery to remove the sequestrum, debride the devitalized bone, and flush the left conchofrontal sinus was performed. A microbial culture was obtained at the time of surgery, which yie...
Bacterial translocation in horses with colic and the potential association with surgical site infection: a pilot study.
The Veterinary record    May 29, 2020   Volume 187, Issue 2 68 doi: 10.1136/vr.105788
Hann M, Timofte D, Isgren CM, Archer DC.Surgical site infection (SSI) is a leading cause of morbidity in horses undergoing emergency exploratory laparotomy for the treatment of acute colic. The exact mechanism by which SSI develops in these cases is unclear. This prospective observational study investigated whether bacterial translocation occurs in horses with acute colic and if there is an association between bacterial translocation and development of SSI. Peripheral venous blood (PVB) and peritoneal fluid (PF) samples were collected on admission and PF samples were collected at the end of surgery from horses presenting for investi...
A pilot study of optical neuronavigation-guided brain biopsy in the horse using anatomic landmarks and fiducial arrays for patient registration.
Journal of veterinary internal medicine    May 29, 2020   Volume 34, Issue 4 1642-1649 doi: 10.1111/jvim.15813
Santistevan L, Easley J, Ruple A, Monck S, Randall E, Wininger F, Packer RA.Optical neuronavigation-guided intracranial surgery has become increasingly common in veterinary medicine, but its use has not yet been described in horses. Objective: To determine the feasibility of optical neuronavigation-guided intracranial biopsy procedures in the horse, compare the use of the standard fiducial array and anatomic landmarks for patient registration, and evaluate surgeon experience. Methods: Six equine cadaver heads. Methods: Computed tomography images of each specimen were acquired, with the fiducial array rigidly secured to the frontal bone. Six targets were selected in ea...
Effectiveness of a paraverterbral nerve block versus local portal blocks for laparoscopic closure of the nephrosplenic space: A pilot study.
Veterinary surgery : VS    May 28, 2020   Volume 49, Issue 5 1007-1014 doi: 10.1111/vsu.13452
Delli-Rocili MM, Cribb NC, Trout DR, Thomason JJ, Valverde A.To compare the effectiveness of a paravertebral nerve block vs local portal blocks for laparoscopic closure of the nephrosplenic space in standing sedated research horses. Methods: Randomized clinical trial. Methods: Twelve horses were randomly allocated to two groups (n = 6 per group), paravertebral block of nerves T , L , and L or local blocks of the three laparoscopic portals. Methods: Horses were sedated with dexmedetomidine (4 μg/kg IV and constant rate infusion [CRI] of 2.5 μg/kg/h) and morphine (50 μg/kg IV and CRI of 30 μg/kg/h). According to group allocation, 20 mL of either lid...
Clinical effects of two doses of butorphanol with detomidine for intravenous premedication of healthy warmblood horses.
Veterinary anaesthesia and analgesia    May 22, 2020   Volume 47, Issue 5 681-685 doi: 10.1016/j.vaa.2019.11.010
de Grauw J, van Loon T.To compare the effects of two different doses of butorphanol combined with detomidine administered intravenously (IV) on quality of sedation, degree of ataxia and anaesthetic induction in horses. Methods: Randomized, blinded, clinical study. Methods: A total of 40 client-owned healthy warmblood horses scheduled for elective surgery under general anaesthesia. Methods: Horses were randomly allocated to be administered 8 μg kg-1 detomidine IV plus either 20 or 50 μg kg-1 butorphanol IV, with the principal investigator blinded to group allocation. Head height was measured before drug injection a...
The Use of Pneumatic Impact Lithotripsy in a Laparoscopic Retrieval Pouch for Removal of Large Cystoliths in Two Female Horses.
Journal of equine veterinary science    May 21, 2020   Volume 91 103125 doi: 10.1016/j.jevs.2020.103125
Sassot LN, Ragle CA, Farnsworth KD, Heaton K, Jones ARE.Two mares, aged 15 and 21 years, were examined because of urinary incontinence, intermittent hematuria, and urine scalding. On admission of both horses, physical parameters were within normal limits and urine scalding of the skin at the ventral perineum was noted. Transrectal palpation and cystoscopy revealed a large type I cystolith (>10 cm) with associated hyperemia and focal ulceration of the bladder mucosa. In horse 1, hemogram, serum biochemical analysis, and renal ultrasound were not performed because of owner finances. In horse 2, results from hematological and serum biochemical analys...
An alternative arthroscopic approach to the caudal pouches of the equine lateral femorotibial joint.
Equine veterinary journal    May 19, 2020   Volume 52, Issue 6 857-862 doi: 10.1111/evj.13274
O'Neill HD, Bladon BM.Current arthroscopic approaches to the caudal pouches of the lateral femorotibial joint are challenging and risk iatrogenic nerve and cartilage injury. Objective: Describe an alternative arthroscopic approach to the caudal pouches of the lateral femorotibial joint in the horse and report intra-articular abnormalities observed during diagnostic stifle arthroscopy of these pouches. Methods: Descriptive cadaver anatomical and clinical study. Methods: An approach to the caudal pouches of the lateral femorotibial joint was developed during clinical surgery using an arthroscopic portal in the poplit...
Mesh closure of epiploic foramen by ventral laparotomy in 17 horses with entrapment.
The Veterinary record    May 15, 2020   Volume 187, Issue 6 e43 doi: 10.1136/vr.105684
Grulke S, Salciccia A, Arévalo Rodríguez JM, Sandersen C, Caudron I, Serteyn D, de la Rebière de Pouyade G.Epiploic foramen entrapment (EFE) of small intestine is a severe cause of strangulating small intestinal obstruction (SSI) with long-term survival seeming lower than for other causes of SSI in horses. Different techniques via laparoscopy or laparotomy for epiploic foramen (EF) closure have been developed. This study describes a technique of peroperative mesh closure of the EF in clinical cases and their long-term follow up. In the study period of 5.5 years, 36 horses were admitted to the clinic with EFE. Of these, 17 horses had peroperative mesh closure, with resection anastomosis in 4 cases a...
Homing and Engraftment of Intravenously Administered Equine Cord Blood-Derived Multipotent Mesenchymal Stromal Cells to Surgically Created Cutaneous Wound in Horses: A Pilot Project.
Cells    May 8, 2020   Volume 9, Issue 5 doi: 10.3390/cells9051162
Mund SJK, Kawamura E, Awang-Junaidi AH, Campbell J, Wobeser B, MacPhee DJ, Honaramooz A, Barber S.Limb wounds on horses are often slow to heal and are prone to developing exuberant granulation tissue (EGT) and close primarily through epithelialization, which results in a cosmetically inferior and non-durable repair. In contrast, wounds on the body heal rapidly and primarily through contraction and rarely develop EGT. Intravenous (IV) multipotent mesenchymal stromal cells (MSCs) are promising. They home and engraft to cutaneous wounds and promote healing in laboratory animals, but this has not been demonstrated in horses. Furthermore, the clinical safety of administering >1.00 × 108 alloge...
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