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Topic:Veterinary Medicine

Veterinary medicine for horses encompasses the study and application of medical practices to diagnose, treat, and prevent diseases in equine species. This field involves a comprehensive understanding of equine anatomy, physiology, pathology, and pharmacology. Veterinary practitioners employ a range of diagnostic tools and therapeutic interventions to address health issues in horses, including lameness, gastrointestinal disorders, respiratory conditions, and infectious diseases. Preventative care, such as vaccination and deworming programs, is also a significant aspect of equine veterinary medicine. This page gathers peer-reviewed research studies and scholarly articles that explore various aspects of veterinary medicine as it pertains to horses, including advancements in diagnostic techniques, treatment protocols, and preventive health strategies.
Structure determination of the disialylated poly-(N-acetyllactosamine)-containing O-linked carbohydrate chains of equine chorionic gonadotropin.
Glycoconjugate journal    February 1, 1994   Volume 11, Issue 1 35-41 doi: 10.1007/BF00732430
Hokke CH, Roosenboom MJ, Thomas-Oates JE, Kamerling JP, Vliegenthart JF.The disialylated poly-(N-acetyllactosamine)-containing O-linked oligosaccharide alditols, released by alkaline borohydride treatment of the enzymically N-deglycosylated beta-subunit of equine chorionic gonadotropin, were purified by fast protein liquid chromatography (FPLC) on Mono Q and analysed by fast ion bombardment mass spectrometry (FAB-MS) and 1H-NMR spectroscopy. The identified oligosaccharide alditols have the following structure: [Formula: see text]
Preparation and characterization of monoclonal antibodies against equine chondrocytes, osteoblasts and osteocytes.
Zentralblatt fur Veterinarmedizin. Reihe A    February 1, 1994   Volume 41, Issue 1 31-36 doi: 10.1111/j.1439-0442.1994.tb00062.x
Katayama Y, Oikawa M, Kaneko M, Yoshihara T, Yoshikawa H, Yoshikawa T.Three monoclonal antibodies capable of individually recognizing chondrocytes, osteoblasts and osteocytes were prepared. EB-1 reacted with a 55-kDa antigen on the chondrocyte membrane, EB-2 with a 110-kDa antigen on the membrane of osteoblasts and/or partial osteocytes, and EB-3 with a 130-kDa antigen on the membrane of osteocytes. These monoclonal antibodies may be useful probes for studying the differentiation and maturation of osteogenic cells.
[Basic principles and effects of hippotherapy within the comprehensive treatment of paraplegic patients].
Die Rehabilitation    February 1, 1994   Volume 33, Issue 1 39-43 
Exner G, Engelmann A, Lange K, Wenck B.A total of 67 patients, both paraplegic and quadriplegic, had participated in a hippotherapy programme over a study period of almost 18 months, with positive effects found relative to spasticity, certain pain syndromes, as well as contraction syndromes associated with impaired joint mobility. Frequently the only effective measure at all, and moreover of astonishingly lasting effect, the spasticity-reducing treatment turned out especially beneficial. Along with these statistically supported findings, a number of associated effects were noted in the physiotherapy and, especially, the nursing sec...
Ovarian follicular growth and development in mammals.
Biology of reproduction    February 1, 1994   Volume 50, Issue 2 225-232 doi: 10.1095/biolreprod50.2.225
Fortune JE.Evidence from several species indicates that the initial stages of follicular growth proceed very slowly. In contrast, the stages after antrum formation are much more rapid. Atresia seems to be most prevalent as follicles approach the size at which they could be recruited for potential ovulation. Although most follicles become atretic around that stage, a few are recruited into a cohort or wave of follicles that continue to grow beyond the stage at which atresia normally occurs. Next, a species-specific number of follicles is selected for dominance. In some species (e.g. rats, primates, pigs),...
Detection of Borna disease virus RNA in naturally infected animals by a nested polymerase chain reaction.
Journal of virological methods    February 1, 1994   Volume 46, Issue 2 133-143 doi: 10.1016/0166-0934(94)90098-1
Zimmermann W, Dürrwald R, Ludwig H.Borna disease virus in naturally infected horses, a donkey and sheep was detected for the first time by amplification of viral RNA using PCR. In contrast to a control group of healthy horses, brain tissue was positive by this assay in all animals with neurological symptoms. The use of a second round of PCR with nested primers following Southern hybridization confirmed the specificity and increased the sensitivity of the test. Comparison with conventional methods recommends this technique for monitoring of BDV infections at a molecular level.
Kinetic evaluation of muscle damage during exercise by calculation of amount of creatine kinase released.
The American journal of physiology    February 1, 1994   Volume 266, Issue 2 Pt 2 R434-R441 doi: 10.1152/ajpregu.1994.266.2.R434
Volfinger L, Lassourd V, Michaux JM, Braun JP, Toutain PL.To quantify the extent of muscle alteration during prolonged exercise, the release rate of creatine kinase (CK) from striated muscle was measured in six horses during a rest period (6 h) and during three exercise tests (15, 30, and 60 km) at a constant speed of 200 m/min. CK clearance was measured after intravenous bolus administration (150 U/kg) of a CK solution obtained from horse muscle. The CK steady-state volume of distribution was 0.059 +/- 0.0215 l/kg, the terminal half-life was 123 +/- 28 min, and the plasma clearance was 0.36 +/- 0.10 ml.kg-1 x min-1. After an intramuscular CK adminis...
Trimethoprim/sulfonamide combinations in the horse: a review.
Journal of veterinary pharmacology and therapeutics    February 1, 1994   Volume 17, Issue 1 64-73 doi: 10.1111/j.1365-2885.1994.tb00524.x
Van Duijkeren E, Vulto AG, Van Miert AS.The indications for use, side-effects, and pharmacokinetic parameters of trimethoprim, sulfonamides and their combinations in the horse are reviewed. Trimethoprim/sulfonamide (TMPS) combinations are used for the treatment of various diseases caused by gram-positive and gram-negative bacteria, including infections of the respiratory tract, urogenital tract, alimentary tract, skin joints and wounds. TMPS combinations can be administered orally, since absorption from the gastrointestinal tract is relatively good. However, peak serum concentrations can vary significantly between individual horses....
Comparison of oral erythromycin formulations in the horse using pharmacokinetic profiles.
Journal of veterinary pharmacology and therapeutics    February 1, 1994   Volume 17, Issue 1 17-23 doi: 10.1111/j.1365-2885.1994.tb00516.x
Ewing PJ, Burrows G, MacAllister C, Clarke C.The pharmacokinetic properties of four erythromycin formulations were compared in six adult horses after administration of single and multiple oral doses. Formulations of erythromycin administered were estolate and phosphate given 37.5 mg/kg every 12 h and 25 mg/kg every 8 h, and stearate and ethylsuccinate given 25 mg/kg every 8 h. Areas under the curve (AUC) and maximum plasma erythromycin concentrations (Cmax) were equal or greater (P > or = 0.05) following administration of erythromycin phosphate and stearate compared with those values following administration of erythromycin estolate or e...
Characterization of A/eq-1 virus isolated during the equine influenza epidemic in India.
Acta virologica    February 1, 1994   Volume 38, Issue 1 25-26 
Singh G.The equine influenza virus, Ludhiana/5/87, isolated from the clinical material during the epidemic of equine influenza in India in 1987 was inhibited in haemagglutination-inhibition test by the antiserum against the prototype A/eq/Prague/1/56 (H7N7) virus and by post-epidemic horse sera. In haemagglutinin and neuraminidase analysis, the A/eq/Ludhiana/5/87 isolate appeared similar to the prototype A/eq/Prague/1/56 virus and was characterized as the H7N7 subtype.
‘Bishoping’ of horses.
The Veterinary record    January 29, 1994   Volume 134, Issue 5 124 doi: 10.1136/vr.134.5.124-a
Kertez P.No abstract available
‘Bishoping’ of horses.
The Veterinary record    January 29, 1994   Volume 134, Issue 5 124 doi: 10.1136/vr.134.5.124-b
Griffiths RB.No abstract available
Adrenocortical carcinoma in a 12-year-old mare.
The Veterinary record    January 29, 1994   Volume 134, Issue 5 113-115 doi: 10.1136/vr.134.5.113
van der Kolk JH, Mars MH, van der Gaag I.A 12-year-old Dutch warmblood mare was examined because it had suffered colic intermittently for a few years and had lost weight in the previous two months. Palpation per rectum revealed a large firm mass in the left sublumbar region; the mass was classified post mortem as an adrenocortical carcinoma. The basal plasma cortisol concentration (at 10.00) of the mare was 94 nmol/litre, within the normal range. As in another case of adrenocortical neoplasm, a functional tumour could not be demonstrated. Only one of the 21 horses with a neoplasm of the pituitary-adrenocortical axis examined by the a...
Sedation of horses with romifidine and butorphanol.
The Veterinary record    January 22, 1994   Volume 134, Issue 4 90-91 doi: 10.1136/vr.134.4.90
Browning AP, Collins JA.Combinations of romifidine and butorphanol were used to sedate 55 horses for a variety of surgical, therapeutic and diagnostic procedures. Eighteen of the horses were given the drugs separately, romifidine first followed by butorphanol four minutes later, and 37 were given the drugs together. The levels of sedation and ataxia were assessed and graded, and there were no statistically significant differences between the two methods of administration. The side effects were typical of the alpha-2 agonists, including bradycardia, heart block and some sweating. Box-walking was observed in one horse....
Prevalence and factors associated with development of laminitis in horses with duodenitis/proximal jejunitis: 33 cases (1985-1991).
Journal of the American Veterinary Medical Association    January 15, 1994   Volume 204, Issue 2 250-254 
Cohen ND, Parson EM, Seahorn TL, Carter GK.Medical records of 116 horses admitted to the Texas Veterinary Medical Center between Jan 1, 1984 and Dec 31, 1991 with duodenitis/proximal jejunitis (DPJ) were reviewed. The prevalence of laminitis was 28.4% (33/116; 95% confidence interval: 20.2 to 36.6%). The prevalence of DPJ and DPJ-associated laminitis did not appear to vary significantly by year during the study period. Anamnesis, physical examination, clinicopathologic data, and initial treatment recorded at the time of admission were reviewed to determine risk factors associated with development of laminitis associated with DPJ. A tre...
[An outbreak of equine arteritis virus infection in a riding school].
Tijdschrift voor diergeneeskunde    January 15, 1994   Volume 119, Issue 2 30-32 
van Gorkom LP, van Wessum R, van den Hoven R.A major part of the residing horses and ponies of a riding school in Noord-Holland became affected by a febrile disorder that included anorexia, depression, conjunctivitis, urticaria, edema of the legs and laborious locomotion. All remaining horses fell ill within one week. Based on the clinical symptoms the disorder was diagnosed as vasculitis. With serology the causative agent of the disorder appeared to be equine arteritis virus.
Effect of oxytetracycline on metacarpophalangeal and distal interphalangeal joint angles in newborn foals.
Journal of the American Veterinary Medical Association    January 15, 1994   Volume 204, Issue 2 246-249 
Madison JB, Garber JL, Rice B, Stumf AJ, Zimmer AE, Ott EA.Thirty-five newborn foals were assigned to 1 of 3 groups and treated with 0.9% NaCl solution (saline; group 1; n = 12), oxytetracycline (44 mg/kg of body weight; group 2; n = 12), or 2-pyrrolidone (oxytetracycline vehicle; group 3; n = 11) in saline solution during the first 36 hours after birth. Serum biochemical analyses were performed on samples obtained from group-1 and group-2 foals before treatment and 24 and 96 hours after treatment. Lateral to medial radiographic views of the forelimbs were obtained before treatment and 24 and 96 hours after treatment in all foals. Metacarpophalangeal ...
Investigation of the metabolism of azaperone in the horse.
Journal of chromatography    January 14, 1994   Volume 652, Issue 1 23-33 doi: 10.1016/0378-4347(93)e0384-3
Chui YC, Esaw B, Laviolette B.Urine samples collected from a horse after intramuscular administration of 40 mg of azaperone were extracted at pH 10 before and after acid hydrolysis. The extracts were concentrated and analysed by LC-MS-MS. Two N-dealkylated metabolites, N-despyridinylazaperol and N-despyridinylazaperone, and a low concentration of azaperone were detected in the unhydrolysed urine. Six metabolites; hydroxyazaperol, two hydroxyazaperones, azaperol, N-despyridinylazaperol and N-despyridinylazaperone were detected in the hydrolysed urine extracts. Using XAD-2 resin extraction, three glucuronide conjugated azape...
Genetics of racing performance in the Japanese Thoroughbred horse:: I. Description of the data.
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie    January 12, 1994   Volume 111, Issue 1-6 121-127 doi: 10.1111/j.1439-0388.1994.tb00445.x
Oki H, Willham RL, Sasaki Y.The Japan Racing Association (JRA) operates 10 national racecourses with both turf and dirt tracks. JRA formulates the rules for horseracing; registers owners, colors, and horses using foal registration; and licenses all JRA trainers and jockeys. In 1990, at the 10 racecourses there were 288 racing days, 3,353 races, and some 38,397 horses. Horse breeding is concentrated in 7 locations with 93% of the Thoroughbreds foaled each year coming from Hokkaido. Thoroughbred flat racing comprise 92% of all races held. Two year olds race together and nearly 40% of their races are run at 1200 m. Some 39%...
Serum hypoxanthine and xanthine concentrations in horses heterozygous for combined immunodeficiency.
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie    January 12, 1994   Volume 111, Issue 1-6 148-151 doi: 10.1111/j.1439-0388.1994.tb00448.x
Kettler MK, Weil MR, Mascotti K, Perryman LE.A group of diseases termed combined immunodeficiency (CID) results in a severe form of immunodeficiency. While CID in humans has two genetics bases, in Arabian it is inherited in an autosomal recessive manner. Kettler et al. (1989) determined that uric acid was significantly (p 0.05) between carrier and non-carrier horse's serum levels of hypoxanthine or xanthine. These data, combined with our previous ones suggest that an enzymatic lesion in the purine salvage pathway may occur at the urate oxidase step. ZUSAMMENFASSUNG: Serum-Hypoxanthin- und -Xanthin-Spiegel in Pferden mit Heterozygotie fÃ...
Distribution and morphology of immunoreactive gonadotropin-releasing hormone (GnRH) neurons in the basal forebrain of ponies.
The Journal of comparative neurology    January 8, 1994   Volume 339, Issue 2 269-287 doi: 10.1002/cne.903390207
Melrose PA, Pickel C, Cheramie HS, Henk WG, Littlefield-Chabaud MA, French DD.Recent reports have indicated that analysis of changes in the staining characteristics of gonadotropin-releasing hormone (GnRH) neurons and characterization of morphological plasticity of the related structural framework may help to elucidate the physiological mechanisms involved in neuroendocrine control of mammalian reproduction. Whether comparative studies will facilitate this process or simply elucidate species-specific mechanisms is not yet clear. The present study was performed in order to begin analysis of GnRH neurons in a seasonally breeding species that exhibits an unusually long ovu...
Follicular fluid lipoproteins in the mare: evaluation of HDL transfer from plasma to follicular fluid.
Biochimica et biophysica acta    January 3, 1994   Volume 1210, Issue 2 226-232 doi: 10.1016/0005-2760(94)90125-2
Le Goff D.Using a density gradient ultracentrifugal procedure, we have separated equine plasma and follicular fluid high-density lipoproteins (HDL). The density distribution of the follicular fluid HDL was clearly displaced towards the highest densities in comparison with that of plasma HDL. Similarly, an analysis of size distributions showed a decrease in follicular fluid HDL diameters (4.2 to 9.2 nm) compared to plasma HDL (5.5 to 9.5 nm). HDL were isolated into three subfractions on the basis of the disposition of the Sudan Black stained bands in the centrifuge tubes. Concentrations of each subfracti...
Respiratory mechanics of the horse during the first year of life.
Respiration physiology    January 1, 1994   Volume 95, Issue 1 21-41 doi: 10.1016/0034-5687(94)90045-0
Koterba AM, Wozniak JA, Kosch PC.This study investigated the developmental changes in the mechanical properties of the respiratory system in growing horses. Pulmonary mechanics and lung volumes were serially measured in anesthetized foals during the first year of life. Quasi-static pressure-volume curves were generated, and functional residual capacity (FRC) was measured using a closed nitrogen equilibration technique. At birth, chest wall compliance normalized to body weight was substantially less than that reported in other less precocious newborn species, while lung compliance normalized to body weight was similar to value...
Therapeutic horseback riding.
Journal of the American Veterinary Medical Association    January 1, 1994   Volume 204, Issue 1 131-133 
Potter JT, Evans JW, Nolt BH.No abstract available
Influence of intra-articular sodium hyaluronate and polysulphated glycosaminoglycans on the biochemical composition of equine articular surface repair tissue.
Equine veterinary journal    January 1, 1994   Volume 26, Issue 1 40-42 doi: 10.1111/j.2042-3306.1994.tb04328.x
Barr AR, Duance VC, Wotton SF, Waterman AE.The influence of repeated intra-articular injections of sodium hyaluronate and polysulphated glycosaminoglycan on the repair of full-thickness osteochondral defects was examined in the midcarpal joints of ponies. The study showed no significant difference between treated and control groups with regard to total collagen content, uronic acid content or the relative proportions of Type I and Type II collagen in the repair tissue, indicating that the drugs did not affect the biochemical composition of the repair tissue 11 weeks after defect induction.
Caffeine clearance in the horse.
Veterinary research communications    January 1, 1994   Volume 18, Issue 5 367-372 doi: 10.1007/BF01839287
Schumacher J, Spano JS, Wilson RC, DeGraves FJ, Duran SH, Ruffin DC.The pharmacokinetic properties of intravenously administered caffeine were studied in 10 horses using a commercially available automated enzyme immunoassay. The harmonic mean for the distribution half-life was 5.2 min (range 1.4-18.7). The harmonic mean for the elimination half-life was 10.18 h (range 6.82-20.92). The harmonic mean of the volume of distribution was 0.32 L/kg (range 0.22-0.53). There was no correlation between the dose of caffeine/kg body weight and the elimination half-life (Spearman's coefficient of rank correlation = 0.19).
Parasitic protozoa of horses: a subject of burgeoning concern.
Equine veterinary journal    January 1, 1994   Volume 26, Issue 1 4-5 doi: 10.1111/j.2042-3306.1994.tb04318.x
Taylor MA.No abstract available
Mechanisms of exercise-induced pulmonary hemorrhage in the equine athlete.
Biomedical sciences instrumentation    January 1, 1994   Volume 30 33-38 
Erickson HH, Lowe BS.This article discusses exercise-induced pulmonary hemorrhage (EIPH), a pathophysiological syndrome which occurs worldwide in the equine athlete. It reviews the history of EIPH, the incidence in performance horses, the etiology, studies performed on the treadmill to determine the mechanisms of EIPH, and the most likely causes of stress failure of the pulmonary capillaries.
Solitary osteochondroma of the nasal bone in a horse.
The Cornell veterinarian    January 1, 1994   Volume 84, Issue 1 25-31 
Adair HS, Duncan RB, Toal RL.A 3-year-old Appaloosa stallion with a 4 cm x 4 cm x 2.5 cm mass protruding from his nasal bone was evaluated. Radiographs revealed an osseous mass, with a radiopaque outer margin and several radiolucent areas within the body of the mass. The mass was surgically removed and evaluated histopathologically. The histopathological diagnosis was osteochondroma. This case represent the first reported occurrence of an osteochondroma arising from intramembraneous bone in the horse.
Measurements of urethral pressure profiles in the male horse.
Equine veterinary journal    January 1, 1994   Volume 26, Issue 1 55-58 doi: 10.1111/j.2042-3306.1994.tb04332.x
Ronen N.Urinary tract pressure profiles were evaluated in 6 clinically normal geldings over 3 consecutive days. This was performed by introducing a 1.3 m-long cuffed catheter into the urinary tract, under xylazine sedation (0.8 mg/kg, iv). The method was reproducible. The mean (+/- sd) intra-vesicular pressure (IVP) and maximal urethral closure pressures (MUCP) were 10.3 (+/- 1.7) and 129.8 (+/- 19.6) cmH2O, respectively, and the ratio between MUCP and IVP was 13.2 (+/- 2.5). A gelding with urinary incontinence showed a significantly lower MUCP (73.4 cmH2O), and an MUCP to IVP ratio of 8.0. It was con...
Survey of equine hepatic encephalopathy in France in 1992.
The Veterinary record    January 1, 1994   Volume 134, Issue 1 18-19 doi: 10.1136/vr.134.1.18
Zientara S, Trap D, Fontaine JJ, Gicquel B, Sailleau C, Plateau E.No abstract available