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Topic:Veterinary Medicine
Veterinary medicine for horses encompasses the study and application of medical practices to diagnose, treat, and prevent diseases in equine species. This field involves a comprehensive understanding of equine anatomy, physiology, pathology, and pharmacology. Veterinary practitioners employ a range of diagnostic tools and therapeutic interventions to address health issues in horses, including lameness, gastrointestinal disorders, respiratory conditions, and infectious diseases. Preventative care, such as vaccination and deworming programs, is also a significant aspect of equine veterinary medicine. This page gathers peer-reviewed research studies and scholarly articles that explore various aspects of veterinary medicine as it pertains to horses, including advancements in diagnostic techniques, treatment protocols, and preventive health strategies.
Streptokinase-dependent delayed activation of horse plasminogen. Complete activation of purified horse plasminogen to plasmin was obtained with a 1:10 molar ratio of streptokinase to plasminogen after 5 min of incubation at 37 degrees C. At a 1:1 molar ratio, maximal activity did not appear until 15-30 min, while at a ratio of 6:1 complete activation was delayed for 120-180 min. Gel filtration studies of isotopically labeled streptokinase and horse plasminogen suggest that the delay was due to impaired formation of a streptokinase-plasminogen complex. The predominant streptokinase moiety within the streptokinase-plasmin complex which forms from the streptok...
Ross River virus activity along the south coast of New South Wales. The sera of 468 blood donors and 63 domestic animals, collected from the south coast of New South Wales, were tested for the presence of antibodies to Ross River virus. Antibodies were detected in 7% of human sera, 25% of cow sera and 65% of horse sera. Using the blood donors as 'human sentinels', seroconversions were demonstrated in two donors from the Nowra-Kiama region and from a patient in the same area; none of the three had been outside of the study area during the period of seroconversion or at the time of infection. Of the 15 seropositive horses, 6 (40%) had lived continuously since bi...
Circulating endotoxin-like substance(s) and altered hemostasis in horses with gastrointestinal disorders: an interim report. Twenty-three horses with clinical signs of gastrointestinal disease were evaluated once or serially during the course of the disease for the presence or absence of circulating endotoxin-like substances (ET+ or ET-) and whether the horses were negative, positive, or very positive for serum fibrin/fibrinogen degradation products (FDP-, FDP+, or FDP++). In addition, platelet count, activated partial thromboplastin time (APTT), and 1-stage prothrombin time (OSPT) were measured. When examined initially, 5 horses were ET-/FDP-, 8 were ET-/FDP+, 7 were ET+/FDP-, 3 were ET+/FDP+, and none was ET+/FDP+...
Limb mechanics as a function of speed and gait: a study of functional strains in the radius and tibia of horse and dog. Rosette strain gauges were attached to the midshaft of the radius and tibia of two horses and two dogs, which ran on a treadmill through their entire range of speed and gait. The relative magnitudes of the principal strains on the opposite cortices of each bone remained constant through the stance phase of the stride, and their orientation varied by a maximum of only 14 degrees through the entire speed range. The maximum strain rate increased linearly with speed, but the peak strain magnitude was also dependent upon the gait used, increasing incrementally by up to 59% at the transition from wa...
Studies on the physiopathology of chronic obstructive pulmonary disease in the horse. VII. Percentage venous admixture. The percentage venous admixture was calculated in 21 clinically normal horses and ponies and in 13 horses and ponies with chronic obstructure pulmonary disease (COPD). The oxygen contents of pulmonary end-capillary blood, arterial and mixed venous blood were calculated from blood and respiratory gas values and substituted in the shunt equation. The mean percentage venous admixture of the COPD subjects was significantly greater than that of the normal subjects. It was concluded that a larger proportion of alveoli in the lungs of COPD subjects were hypoventilated than that of alveoli of the norm...
Hereditary lethal arthrogryposis (“muscle contracture”) in horses. In 4 female foals of the Norwegian horse breed, "Fjord Horse", congenital arthrogryposis of the limbs are described. The disorder was mainly limited to the hind limbs and associated with polydactylia and partly with brachygnathia superior and cleft palate. The defective foals were paternal halfsisters of 4 normal foals (1 female + 3 males), sired by the stallion "Bingo" 1804, which was phenotypically quite normal. The disorder being lethal, is possibly caused by a sex-limited or a strongly sex-influenced dominant gene.
Immunogenicity of equine herpesvirus type 1 (EHV1) and equine rhinovirus type 1 (ERhV1) following inactivation by betapropiolactone (BPL) and ultraviolet (UV) light. Some kinetic data on the inactivation of equine herpesvirus type 1 (EHV1) and equine rhinovirus type 1 (ERhV1) by betapropiolactone (BPL) and ultraviolet (UV) irradiation are reported. 0.25% BPL at 37 degrees C for 1 h reduced the titre of EHV1 by greater than 10(3 . 4) and of ERhV1 by greater than 10(4 . 1) TCID50/ml. UV irradiation (334 microW/cm2) produced similar reductions in titre after 2 min. These data were used as a basis for inactivating EHV1 and ERhV1 by the combined action of BPL and UV irradiation. Viruses were exposed to 0.1% BPL for 1 h at 4 degrees C with constant stirring, fol...
Some effects of chronic mercuric chloride intoxication on renal function in a horse. Chronic mercuric chloride intoxication in an aged horse given 0.8 mg Hg/kg/day for 14 weeks was manifest by signs of progressive respiratory difficulty and renal disease. The effects were not self-limiting after mercury was withdrawn, and the animal was destroyed six weeks later. Renal function changes included heavy glycosuria, modest proteinuria, phosphaturia, reduced urine osmolality, gradually increasing urine production, reduced glomerular filtration rate, and terminally, azotemia. The condition bore similarities to the Fanconi syndrome in man. Urinary gamma-glutamyl transpeptidase, alkal...
Segmental thoracolumbar spinal (subarachnoid) analgesia in conscious horses. A new technique for producing segmental subarachnoid analgesia in adult horses without causing complete loss of locomotor control is described. A 17-gauge Huber point (Tuohy) needle was used to place a catheter with a stylet into the subarachnoid space at the lumbosacral intervertebral space in 13 adult horses (weighing 500 +/- 60 kg, representing both sexes) and to advance the catheter craniad to the thoracolumbar area. The position of the catheter was confirmed radiographically. A 2% mepivacaine hydrochloride solution (1.5 ml, 30 mg) was injected through the catheter at a rate of 0.5 ml/60 s...
Xylazine hydrochloride-induced hyperglycemia and hypoinsulinemia in thoroughbred horses. The effects of intravenous xylazine (1.1 mg/kg) were studied in six thoroughbred horses (five mares and a stallion). Plasma glucose concentration increased to 168% of control at 45 min and decreased to 112% of control at 180 min. Insulin had decreased to 31% of control at 15 min. Thereafter, insulin concentration increased, reaching its highest concentration at 150 min. The mechanism for these changes is not fully understood and further investigation is indicated.
Pulmonary effects of intravenous histamine in the conscious pony: dose-response relationships and reproducibility. In standing sedated ponies, we measured dynamic lung compliance (Cdyn) and pulmonary resistance (RL) during IV infusion of various doses of histamine; this was done in a given pony 3 times at 1-week intervals between experiments. Histamine doses causing a decrease in Cdyn of 50% and 75% and an increase in RL of 300% and 600% (ED50Cdyn, ED75Cdyn, ED300RL and ED600RL, respectively) were interpolated from the histamine dose-response curves. We also measured respiratory frequency, tidal volume, minute ventilation, functional residual capacity, arterial oxygen tension, arterial carbon dioxide tensi...
Fractures of the distal phalanx in horses. Nineteen cases of fracture of the distal phalanx in horses are reviewed. This represented 1.1% of the total number of horses seen at Murdoch University Veterinary Hospital (MUVH) over a 32-month period. All horses were managed conservatively. Eight horses made a complete recovery. Three are being trained again and are not lame. Four horses made a limited recovery. Two horses are still resting and one horse was killed humanely when it still showed lameness after 2 years. One horse was killed humanely after the fracture was first diagnosed.
Experimental lead toxicosis in ponies: comparison of the effects of smelter effluent-contaminated hay and lead acetate. Grass hay produced in the Coeur d'Alene River Basin of northern Idaho was fed to a group of 4 ponies. The hay contained Pb in concentration of 423 +/- 82 mg/kg and Cd in concentration of 10.8 +/- 1.4 mg/kg, resulting in daily exposures of the ponies to approximately 7.4 mg of Pb/kg and 0.19 mg of Cd/kg/day. The results in this group of ponies were compared with those from a group fed noncontaminated grass hay and given a daily dose of 10 mg of Pb/kg of body weight, in the form of lead acetate. Clinical toxicologic signs, hematologic changes, and blood and tissue Pb concentrations were similar ...
Isolation of the contagious equine metritis organism from colts and fillies in the United Kingdom and Ireland. Between January 1978 and August 1982 the streptomycin resistant strain of the contagious equine metritis organism (CEMO) was isolated from 15 colts and two fillies in the United Kingdom and Ireland. A first season stallion was also suspected of having initiated an outbreak of contagious equine metritis (CEM) at the beginning of the 1982 breeding season. A detailed investigation of the breeding history of the dams and sires of each positive individual indicated that in a number of cases the CEMO was acquired either in utero or following transmission at the time of parturition. In several other ...
Respiratory tract immune response to microbial pathogens. Effective resistance to respiratory tract infection depends principally on specific immunity on mucosal surfaces of the upper or lower respiratory tract. Respiratory tract immune response comprises antibody and cell-mediated systems and may be induced most readily by surface presentation of replicating agents but can result from parenteral or local presentation of highly immunogenic antigens. Upper and lower respiratory tract systems differ in immunologic competence, with the lungs having a greater inventory of protective mechanisms than the trachea or nose. Several effective vaccines have bee...
