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Topic:Veterinary Research

Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
A comparison of porosity, fabric and fractal dimension as predictors of the Young’s modulus of equine cancellous bone.
Medical engineering & physics    January 15, 1999   Volume 20, Issue 8 588-593 doi: 10.1016/s1350-4533(98)00063-0
Haire TJ, Hodgskinson R, Ganney PS, Langton CM.The purpose of this study was to compare the structural parameters of fabric and fractal dimension as predictors of the Young's modulus of equine cancellous bone. Eight 15 mm cubes of cancellous bone were obtained from three equine third metacarpal bones. Young's modulus was determined for the three orthogonal directions. The fabric and fractal dimension were calculated for each of the six exposed faces of each cube. Fractal dimension plus porosity provided a higher explanatory power for Young's modulus (R2 = 78.7%. P < 0.0001) than fabric plus porosity (R2 = 69.2%, P < 0.0001). Fractal ...
Pharmacokinetics of cisapride in the horse.
Journal of veterinary pharmacology and therapeutics    January 14, 1999   Volume 21, Issue 6 433-436 doi: 10.1046/j.1365-2885.1998.00168.x
Steel CM, Bolton JR, Preechagoon Y, Charles BG.The purpose of this study was to determine the pharmacokinetics and absolute bioavailability of cisapride after intravenous (i.v.) and intragastric (i.g.) administration in healthy, adult horses. Five animals received single doses of 0.1 mg/kg, 0.2 mg/kg and 0.4 mg/kg cisapride by the i.g. route in an open, randomized fashion on different occasions separated by a washout period of at least 48 h. Four of these horses were also given a single i.v. dose of 0.1 mg/kg cisapride. Jugular venous blood was collected periodically up to 24 h after dosing. Plasma cisapride concentrations were measured by...
Eight new equine dinucleotide repeat microsatellites at the NVHEQ26, NVHEQ29, NVHEQ31, NVHEQ40, NVHEQ43, NVHEQ90, NVHEQ98 and NVHEQ100 loci.
Animal genetics    January 12, 1999   Volume 29, Issue 6 470 
Røed KH, Midthjell L, Bjørnstad G.No abstract available
Equine developmental osteochondral lesions: the role of biomechanics.
Veterinary journal (London, England : 1997)    January 12, 1999   Volume 156, Issue 3 167-168 doi: 10.1016/s1090-0233(98)80119-6
Whitton RC.No abstract available
Fourteen new polymorphic equine microsatellites.
Animal genetics    January 12, 1999   Volume 29, Issue 6 469-470 
George LA, Miller LM, Valberg SJ, Mickelson JR.No abstract available
Biochemical markers of bone metabolism in horses: potentials and limitations?
Veterinary journal (London, England : 1997)    January 12, 1999   Volume 156, Issue 3 163-165 doi: 10.1016/s1090-0233(98)80117-2
Price JS.No abstract available
[Demonstration of intraocular leptospira in 4 horses suffering from equine recurrent uveitis (ERU)].
Berliner und Munchener tierarztliche Wochenschrift    January 9, 1999   Volume 111, Issue 11-12 415-417 
Brem S, Gerhards H, Wollanke B, Meyer P, Kopp H.Vitreous samples from 43 horses which underwent vitrectomy because of equine recurrent uveitis (ERU) were cultured for leptospires. Out of 4 vitreous samples (4/43 = 9%), leptospires could be isolated. In 3 cases, serovar grippotyphosa, and in one case, a serovar out of the serogroup Australis were identified. So for the first time, in several horses with ERU in vivo cultures of vitreous material were positive for leptospires. A strong evidence of association between leptospiral infection and uveitis is discussed for many years. In this investigation the leptospiral etiology is confirmed. Vitr...
Availability of equine medicines.
The Veterinary record    January 9, 1999   Volume 143, Issue 23 643 
Mantell JA.No abstract available
Effects on the intramuscular blood flow and cardiopulmonary function of anaesthetised ponies of changing from halothane to isoflurane maintenance and vice versa.
The Veterinary record    January 9, 1999   Volume 143, Issue 23 629-633 
Lee YH, Clarke KW, Alibhai HI.The effects on intramuscular blood flow and cardiopulmonary parameters of changing from anaesthesia with halothane to isoflurane and vice versa were investigated in six ponies (small horses). Anaesthesia was induced with xylazine, ketamine and diazepam, maintained for one hour with halothane at an end tidal concentration of 1 per cent and then with isoflurane at 1.5 per cent for a further hour (halo/iso). On another occasion the order in which the volatile agents were administered was reversed (iso/halo). After one hour of anaesthesia the mean (sd) arterial blood pressure (MAP) and cardiac out...
Organisation of the equine immunoglobulin constant heavy chain genes. II. Equine cgamma genes.
Veterinary immunology and immunopathology    January 8, 1999   Volume 66, Issue 3-4 273-287 doi: 10.1016/s0165-2427(98)00182-2
Overesch G, Wagner B, Radbruch A, Leibold W.The number of immunoglobulin G constant heavy chain genes (cgamma genes) varies broadly among mammalian species, reflecting structural and functional differences between expressed immunoglobulin G (IgG) isotypes and allotypes. Up to now equine IgG isotypes have been defined only at the biochemical and serological level. It is still not clear how many IgG isotypes exist in horses and whether there are any allotypes. Here, we describe the isolation and characterisation of equine cgamma genes. An equine genomic lambda phage library was screened with a human cgamma4 probe. Cross-hybridising equine...
[The intraspecific differentiation of Przhewalski’s horse and the domestic horse by 5 molecular genetic markers].
TSitologiia i genetika    January 8, 1999   Volume 32, Issue 3 97-103 
Glazko VI, Oblap RV, Iasinetskaia NA, Kushnir AN.Analysis of albumin, transferrin, receptor to vitamin D, esterase, alpha 1-beta glycoprotein polymorphisms in Przhewalski's horse, Orlov's and Russian trotters, Guzul and Yakutian domestic horse breeds was carried out. The data about similarity of intraspecies differentiation of Przewalski's horse's populations and interbreed distinctions were obtained. Locus-specific particularities of genetic structures of investigated animal groups were revealed.
Equine neutrophil myeloperoxidase in plasma: design of a radio-immunoassay and first results in septic pathologies.
Veterinary immunology and immunopathology    January 8, 1999   Volume 66, Issue 3-4 257-271 doi: 10.1016/s0165-2427(98)00192-5
Deby-Dupont G, Grülke S, Caudron I, Mathy-Hartert M, Benbarek H, Deby C, Lamy M, Serteyn D.The strangulated intestinal pathologies of horses are accompanied by a local activation of the neutrophils, that can be revealed by measuring the tissular enzymatic activity of the granulocytic enzyme myeloperoxidase (MPO). To estimate the possible spreading of this neutrophil activation to the systemic circulation, we designed a radioimmunoassay (RIA) for equine neutrophil myeloperoxidase (MPO) (EC 1.11.1.7) using a specific rabbit antiserum. MPO was labeled with 1 mCi 125I by a technique of self-labeling in the presence of 10(-4) M hydrogen peroxide. The RIA was performed by incubation of 10...
Comparative efficacy evaluation of moxidectin gel and ivermectin paste against internal parasites of equines in Brazil.
Veterinary parasitology    January 7, 1999   Volume 80, Issue 1 29-36 doi: 10.1016/s0304-4017(98)00186-1
Costa AJ, Barbosa OF, Moraes FR, Acuña AH, Rocha UF, Soares VE, Paullilo AC, Sanches A.A total of 24 male and female equines of mixed breed, 10-20 months of age and naturally infected with internal parasites was utilized in a controlled test to evaluate the efficacy of a moxidectin 2% gel formulation at the dosage of 0.4 mg moxidectin per kg of live weight and an ivermectin 1.87% commercial paste formulation at the dosage 0.2 mg ivermectin per kg applied orally. Animals were allocated into three groups of eight horses each based on pre-treatment eggs per gram (EPG) counts and treatments were randomized among the groups. One group was kept as untreated controls. One animal in the...
Conformationally restricted carbamate inhibitors of horse serum butyrylcholinesterase.
Bioorganic & medicinal chemistry letters    January 5, 1999   Volume 8, Issue 19 2747-2750 doi: 10.1016/s0960-894x(98)00484-3
Lin G, Chen GH, Ho HC.Conformationally restricted carbamate inhibitors, exo-2-norbornyl-N-butylcarbamate (1), endo-2-norbornyl-N-butylcarbamate (2), l-adamantyl-N-butylcarbamate (3), and 2-adamantyl-N-butylcarbamate (4) as active site-directed irreversible inhibitors of horse serum butyrylcholinesterase are investigated for values of the dissociation constant (KI), the carbamylation constant (k2), and the bimolecular rate constant (ki). Compound 1 is the most potent inhibitor of the enzyme and the values of KI and ki are 20 nM and 1.1 x 10(5) M-1sec-1, respectively.
Effect of regular training on the myocardial and plasma concentrations of taurine and alpha-amino acids in thoroughbred horses.
Amino acids    January 1, 1999   Volume 15, Issue 3 241-251 doi: 10.1007/BF01318863
King N, Suleiman MS.Exercise induces significant changes in the free intracellular amino acid pool in skeletal muscle but little is known of whether such changes also occur in cardiac muscle. In this study the effect of regular exercise on the size and the constituents of the free amino acid pool in the hearts and in the plasma of thoroughbred horses was investigated. The total free intracellular amino acid pool in the hearts of control horses was 30.9 +/- 1.2 mumol/g wet weight (n = 6). Glutamine but not taurine was present at the highest concentration (13.5 +/- 0.9 and 7.7 +/- 0.69 mumol/g wet weight for glutam...
Developments in equine nutrition: comparing the beginning and end of this century.
The Journal of nutrition    December 30, 1998   Volume 128, Issue 12 Suppl 2698S-2703S doi: 10.1093/jn/128.12.2698S
Harris PA.In the first part of this century, there was little advancement in horse nutrition and little research was undertaken. However, in the last few years, there has been a great increase in interest in this whole area. This review surveys some of the more recent developments and how they have influenced feeding practices and also compares these with those feeding practices found at the start of this century. The review concentrates on the nutrition of the adult horse in work, exploring in particular what they are fed and how the nutrient value of these feeds is evaluated.
Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease.
Veterinary research communications    December 30, 1998   Volume 22, Issue 7 493-503 doi: 10.1023/a:1006131217140
Venugopalan CS, Beadle RE, Seahorn TL, Holmes EP.The response of parenchymal strips from guinea-pig lungs to tracheobronchial lavage fluid (TBLF) collected from 8 normal horses and from 8 affected with summer pasture-associated obstructive pulmonary disease (SPAOPD) was determined. TBLF was collected during the summer (July) and winter (February) seasons. The serum/TBLF urea nitrogen ratio was used to standardize the mediator concentration in the TBLF. Four strips were used from each guinea-pig. The first strip did not receive any antagonist and served as the control. The second, third and fourth strips received antagonists of PGE2, LTD4 and...
[Evaluation of the portable blood analyser i-STAT].
Schweizer Archiv fur Tierheilkunde    December 24, 1998   Volume 140, Issue 12 507-512 
Tschudi PR.The purpose of this study was to compare the results of horse blood examinations on a portable blood analysis system, i-STAT SDI, with conventional laboratory equipment and to verify the accuracy and precision. The precision within run was high and the coefficients of variation ranged from 0 to 3.85%. The comparative analysis of patient samples with routine methods showed a very strong positive correlation with correlation coefficients above 0.96 for blood gases, pH, glucose, urea, hemoglobin, hematocrit, sodium and potassium, with the exception of chloride where it was 0.867. The i-STAT syste...
Production of gelatinases and tissue inhibitors of matrix metalloproteinases by equine ovarian stromal cells In vitro.
Biology of reproduction    December 22, 1998   Volume 60, Issue 1 1-7 doi: 10.1095/biolreprod60.1.1
Song L, Porter DG, Coomber BL.Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) play very important roles in extracellular matrix (ECM) remodeling in ovarian follicle growth and ovulation. Equine follicles are embedded in cortex that is at the center of the ovary, and they must expand/emigrate to the fossa, the only site in the ovary for ovulation. Therefore, equine ovarian stromal cells (EOSC) are probably involved in ECM remodeling during follicle growth. This study examined whether cultured EOSC synthesize gelatinases and TIMPs, molecules essential for ECM remodeling in other systems. Results showed...
Evaluation of automated methods of measuring hemoglobin and hematocrit in horses.
American journal of veterinary research    December 19, 1998   Volume 59, Issue 12 1519-1522 
Sorrell-Raschi LA, Tomasic M.To evaluate the accuracy of 3 automated methods of determining Hct and hemoglobin (Hb) concentration, compared with manual methods. Animals-22 clinically normal adult horses of various breeds. Methods: A blood sample was obtained from each horse. Six dilutions (representing Hct of 0, 10, 20, 40, 60, or 70%) were prepared from each sample and analyzed, using 1 of 2 blood gas analyzers or a hemoximeter (for automated determinations) or the Wintrobe macrohematocrit and cyanmethemoglobin methods (for manual determinations). Regression analysis was used to determine mean slope relationships between...
Effect of irradiation with a low-intensity diode laser on the metabolism of equine articular cartilage in vitro.
American journal of veterinary research    December 19, 1998   Volume 59, Issue 12 1613-1618 
Ebert DW, Bertone AL, Roberts C.To determine whether irradiation with a low-intensity diode laser, which produces radiation at a wavelength of 810 nm, will induce nonthermal enhancement of chondrocyte metabolism. Methods: 144 grossly normal articular cartilage explants aseptically harvested from the femoral condyles of 6 adult horses. Methods: Treated cartilage explants were irradiated with a diode laser at 1 of 7 fluence levels that ranged from 8 to 1,600 J/cm2. Explants were incubated for 24 or 72 hours, labeled for 24 hours with [35S]Na2SO4, and assayed for newly synthesized sulfated glycosaminoglycan (GAG; measured incor...
Hoof size, shape, and balance as possible risk factors for catastrophic musculoskeletal injury of Thoroughbred racehorses.
American journal of veterinary research    December 19, 1998   Volume 59, Issue 12 1545-1552 
Kane AJ, Stover SM, Gardner IA, Bock KB, Case JT, Johnson BJ, Anderson ML, Barr BC, Daft BM, Kinde H, Larochelle D, Moore J, Mysore J, Stoltz J....To evaluate hoof size, shape, and balance as risk factors for catastrophic musculoskeletal injuries (CMI), including suspensory apparatus failure (SAF) and cannon bone condylar fracture (CDY) in Thoroughbred racehorses. Methods: 95 Thoroughbred racehorses that died between 1994 and 1996. Methods: 38 quantitative measures of hoof size, shape, and balance were obtained from orthogonal digital images of the hoof and were compared between case horses with forelimb CMI (70), SAF (43), and CDY (10) injuries and control horses whose death was unrelated to the musculoskeletal system (non-CMI, 25). Com...
[Radiologic description of the growth plates of the atlas and axis in foals].
Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere    December 19, 1998   Volume 26, Issue 6 341-345 
Maierl J, Zechmeister R, Schill W, Gerhards H, Liebich HG.Fractures of the first two cervical vertebrae, atlas and axis, may occur in foals for different reasons, e.g. in cases of a fall, going head over heels or when being hit by a hoof. The tentative clinical diagnosis can be confirmed by x-raying the standing animal, with aid of computed tomography in the anaesthetized foal respectively. The growth plates however, and their time of closure have to be considered when interpreting radiographs. In the atlas there are two ventrolateral plates and one dorsomedian cartilagineous plate. Only the dorsal plate, however, can be found in the dorsoventral pro...
Population pharmacokinetics of gentamicin in horses.
American journal of veterinary research    December 19, 1998   Volume 59, Issue 12 1589-1598 
Martín-Jiménez T, Papich MG, Riviere JE.To develop and validate a population pharmacokinetic model for gentamicin in horses, using retrospective clinical data. Methods: 62 horses that had been treated IV with multiple doses of gentamicin at our veterinary teaching hospital between 1987 and 1996. Procedure-46 horses were assigned to the study group, and 16 to the validation group. Detailed history of dosage, sample collection times, and selected pathophysiologic variables were recorded for each patient. Samples were analyzed by use of a fluorescence polarization immunoassay method. Pharmacostatistical analysis was conducted, using co...
Hyperthyroidism associated with a thyroid adenocarcinoma in a 21-year-old gelding.
Journal of veterinary internal medicine    December 19, 1998   Volume 12, Issue 6 475-477 doi: 10.1111/j.1939-1676.1998.tb02153.x
Ramirez S, McClure JJ, Moore RM, Wolfsheimer KJ, Gaunt SD, Mirza MH, Taylor W.No abstract available
[Diagnostic validity of thermography of lameness in horses].
Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere    December 19, 1998   Volume 26, Issue 6 346-354 
Weil M, Litzke LF, Fritsch R.Thirty-six lameness free horses and 119 horses with lameness of the distal forelimb including the carpus were evaluated through thermography. Examination was done with an infrared thermography camera "Thermovision 470" and a specially developed analyzing software program. Temperature differences between corresponding regions of the left and right forelimb were determined and scrutinized statistically between various lameness groups. By creating temperature differences between both limbs a parameter for skin temperature was found which is independent of surrounding temperature. In lameness free...
[New drugs for horses and agriculturally useful animals and changes in the pharmaceutical market since 1996].
Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere    December 19, 1998   Volume 26, Issue 6 301-306 
Kluge K, Ungemach FR.No abstract available
Effects of 6alpha-methylprednisolone acetate on an equine osteochondral fragment exercise model.
American journal of veterinary research    December 19, 1998   Volume 59, Issue 12 1619-1628 
Frisbie DD, Kawcak CE, Baxter GM, Trotter GW, Powers BE, Lassen ED, McIlwraith CW.To determine effects of intra-articularly administered 6alpha-methylprednisolone acetate (MPA) in exercised horses with carpal osteochondral fragmentation. Methods: 18 horses: 3 groups of 6 each. Methods: An osteochondral (chip) fragment was created in 1 randomly chosen middle carpal joint of each horse. Polyionic fluid (PF) was injected into both middle carpal joints of horses in the control group. In horses of the MPA-control group, MPA was injected into the middle carpal joint without an osteochondral fragment; a similar volume of PF was injected into the contralateral middle carpal joint. ...
Efficacy of a 2 per cent moxidectin gel against gastrointestinal parasites of ponies.
The Veterinary record    December 17, 1998   Volume 143, Issue 20 558-561 doi: 10.1136/vr.143.20.558
Bauer C, Cirak VY, Hermosilla C, Okoro H.The efficacy of moxidectin was evaluated in young ponies naturally infected with gastrointestinal parasites. Eight animals were treated orally with moxidectin at 0.4 mg/kg bodyweight and eight received only the vehicle. They were all necropsied two weeks later. Faecal samples were examined daily for egg counts and larval cultures. Parasites were recovered from total faecal samples collected daily and from the gastrointestinal tracts at necropsy. Moxidectin reduced the strongyle egg counts by > 99 per cent from three days after treatment but some individuals remained positive for 10 days. Th...
A review of leptospirosis in farm animals in Portugal.
Revue scientifique et technique (International Office of Epizootics)    December 16, 1998   Volume 17, Issue 3 699-712 doi: 10.20506/rst.17.3.1128
Rocha T.This paper presents a review of Leptospira infection in farm animals in Portugal which is based mainly on serological results obtained in the National Veterinary Research Laboratory between January 1987 and December 1993. Serum samples were tested by the microscopic agglutination test, at a minimum dilution of 1:100. Positive titres were obtained in 15.3% of the 9,543 bovine samples examined. Sejroe, Pomona, Hebdomadis, Tarassovi and Icterohaemorrhagiae were the principal serogroups which reacted in the tests. A total of 3,195 pigs were tested, of which 20.2% showed positive reactions. The mai...